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Preprint REVIEW | doi:10.20944/preprints202103.0245.v1

Is Early Life Adversity a Trigger towards Inflammageing?

Myriam Merz, Jonathan D. Turner

Subject: Life Sciences, Biochemistry Keywords: early life adversity; stress; psychosocial stress; hypothalamus-pituitary-adrenal axis; ageing; immuno-senescence; inflammageing; Developmental origins of health and disease

Online: 9 March 2021 (09:26:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202105.0400.v1

Designing a Multi-Epitope Vaccine against Dracunculus medinensis by Employing Immuno-Informatics and In Silico Approaches

Mian Talha Sarfraz, Marvah Mehmood Rana

Subject: Biology, Anatomy & Morphology Keywords: Immuno-informatics; Multi-epitope; Dracunculiasis

Online: 18 May 2021 (09:31:15 CEST)

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Preprint REVIEW | doi:10.20944/preprints202207.0160.v2

NIH SenNet Consortium: Mapping Senescent Cells in the Human Body to Understand Health and Disease

Patty J Lee, Philip Blood, Katy Börner, Judith Campisi, Feng Chen, Heike Daldrup-Link, Phil De Jager, Li Ding, Francesca E. Duncan, Oliver Eickelberg, Rong Fan, Toren Finkel, Vesna Garovic, Nils Gehlenborg, Carolyn Glass, Ziv Bar-Joseph, Pragati Katiyar, So-Jin Kim, Melanie Königshoff, George Kuchel, Haesung Lee, Jun H. Lee, Jian Ma, Qin Ma, Simon Melov, Kay Metis, Ana L. Mora, Nicolas Musi, Nicola Neretti, João F. Passos, Irfan Rahman, Juan Carlos Rivera-Mulia, Paul Robson, Mauricio Rojas, Ananda L. Roy, Birgit Schilling, Pixu Shi, Jonathan Silverstein, Vidyani Suryadevera, Jichun Xie, Jinhua Wang, An-Kwok Ian Wong, Laura Niedernhofer

Subject: Life Sciences, Cell & Developmental Biology Keywords: Cellular Senescence Network; Normal Aging; Senescence; Senescence-associated secretory phenotype; SenNet

Online: 15 September 2022 (12:52:05 CEST)

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Working Paper REVIEW

The ‘Jekyll and Hyde’ of Gluconeogenesis: Early-Life Adversity, Later Life Stress, and Metabolic Disturbances

Snehaa V. Seal, Jonathan D. Turner

Subject: Life Sciences, Biochemistry Keywords: glucose; glycogen; gluconeogenesis; early life adversity; acute stress; chronic stress; psychosocial stress; hypothalamus-pituitary-adrenal axis; ageing; immuno-senescence; inflamm-ageing; Developmental origins of health and disease

Online: 23 March 2021 (09:04:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202011.0515.v1

Proinflammatory Cytokines Perturb Mouse and Human Pancreatic Islet Circadian Rhythmicity and Induce Uncoordinated β-cell Clock Gene Expression via Nitric Oxide, Lysine Deacetylases and Immunoproteasomal Activity

Phillip Alexander Keller Andersen, Volodymyr Petrenko, Peter Horskjær Rose, Melissa Koomen, Nico Fischer, Seyed Mojtaba Ghiasi, Tina Dahlby, Charna Dibner, Thomas Mandrup-Poulsen

Subject: Life Sciences, Biochemistry Keywords: chronobiology; diabetes; epigenetics; immuno-metabolism; nitric oxide synthase

Online: 19 November 2020 (15:08:41 CET)

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Preprint REVIEW | doi:10.20944/preprints201811.0525.v1

CAR T-Cell Immunotherapy in Human and Veterinary Oncology: Changing the Odds against Hematological Malignancies

Jonathan P Mochel, Stephen C Ekker, Chad M Johannes, Albert E Jergens, Karin Allenspach, Agnes Bourgois-Mochel, Michael Knouse, Sebastien Benzekry, Wesley Wierson, Amy K LeBlanc, Saad S Kenderian

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: immuno-oncology; CAR T-cell; lymphoma; one health

Online: 21 November 2018 (11:34:58 CET)

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Preprint REVIEW | doi:10.20944/preprints202301.0302.v1

Ferroptosis and Senescence: A Systematic Review

Donatella Coradduzza, Antonella Congiargiu, Chen Zhichao, Angelo Zinellu, Ciriaco Carru, Serenella Medici

Subject: Chemistry, Medicinal Chemistry Keywords: ferroptosis; senescence; ageing; disease

Online: 17 January 2023 (09:07:35 CET)

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Background: Senescence is a cellular ageing process in all multicellular organisms. It is characterized by a decline in cellular functions and proliferation, resulting in increased cellular damage and death. This condition plays an essential role in the ageing process and significantly contributes to the development of age-related complications. On the other hand, ferroptosis is a systemic cell death characterized by excessive iron accumulation followed by the generation of reactive oxygen species (ROS). Oxidative stress is a common trigger of this condition and may be induced by various factors such as toxins, drugs, and inflammation. Ferroptosis is linked to numerous illnesses, including cardiovascular disease, neurodegeneration, and cancer. Relevance of these conditions to ageing and disease: Senescence is believed to contribute to the decline in tissue and organ function that occurs with ageing. It has also been linked to the development of age-related pathologies, such as cardiovascular diseases, diabetes, and cancer. In particular, senescent cells have been shown to produce inflammatory cytokines and other pro-inflammatory molecules that can contribute to these conditions. On the other hand, ferroptosis has been linked to the development of various health disorders, including neurodegeneration, cardiovascular disease, and cancer [1]. It is known to play a role in developing these diseases by promoting the death of damaged or diseased cells and contributing to the inflammation often associated with them. Both senescence and ferroptosis are complex processes that are still not fully understood. Further research is needed to thoroughly understand the role of these processes in ageing and disease, and to identify potential interventions to target these processes to prevent or treat age-related conditions. Objectives: This systematic review aims to assess the potential mechanisms underlying the link connecting senescence, ferroptosis, ageing, and disease.

Preprint REVIEW | doi:10.20944/preprints202205.0068.v1

Mechanisms and Therapeutic Perspectives of Chemotherapy-Induced Peripheral Neuropathy: An Update

Antonio Avallone, Sabrina Bimonte, Claudia Cardone, Cira Antonietta Forte, Marco Cascella, Arturo Cuomo

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: Chemotherapy-induced peripheral neuropathy; pain management; target therapy; immuno-therapy

Online: 6 May 2022 (09:14:17 CEST)

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Preprint REVIEW | doi:10.20944/preprints202108.0448.v2

Protein Biomarkers in Blood Reflect the Interrelationships between Stroke Outcome, Inflammation, Coagulation, Adhesion, Senescence and Cancer

Georg Fuellen, Jan Böhmert, Larissa Henze, Daniel Palmer, Uwe Walter, Soyoung Lee, Clemens Schmitt, Henrik Rudolf, Axel Kowald

Subject: Medicine & Pharmacology, General Medical Research Keywords: stroke; cellular senescence; coagulation; adhesion

Online: 14 October 2021 (15:21:58 CEST)

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Preprint REVIEW | doi:10.20944/preprints202105.0427.v1

Cellular Senescence: Pathogenic Mechanisms in Lung Fibrosis

Tanyalak Parimon, Miriam Hohmann, Changfu Yao

Subject: Life Sciences, Biochemistry Keywords: Cellular senescence; Lung fibrosis; Pathogenesis

Online: 19 May 2021 (07:35:10 CEST)

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Preprint REVIEW | doi:10.20944/preprints202105.0409.v1

Emerging Dynamics of Macrophage Cellular Senescence and Immunosenescence in Governing Organismal Aging and Disease: Concepts and Opportunities

Rohit Sharma

Subject: Life Sciences, Biochemistry Keywords: Macrophages; Senescence; Immunosenescence; Immunometabolism; Aging

Online: 18 May 2021 (10:15:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0354.v1

Multi-Walled Carbon Nanotubes (MWCNTs) Cause Cellular Senescence in TGF-β Stimulated Lung Epithelial Cells

Joseph Lucas, Qixin Wang, Thivanka Muthumalage, Irfan Rahman

Subject: Life Sciences, Biochemistry Keywords: MWCNT; senescence; pulmonary fibrosis; epithelial

Online: 14 May 2021 (17:05:25 CEST)

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Preprint REVIEW | doi:10.20944/preprints202102.0362.v1

Alzheimer’s Disease as a Chronic Maladaptive Polyamine Stress Response

Baruh Polis, David Karasik, Abraham Samson

Subject: Keywords: polyamines; arginase; senescence; aging; neurodegeneration

Online: 17 February 2021 (10:05:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints202007.0672.v1

Mathematical Connection Between Short Telomere Induced Senescence Calculation and Mortality Rate Data

Jerry B. Torrance, Steve Goldband

Subject: Medicine & Pharmacology, General Medical Research Keywords: aging; telomeres; senescence; mortality; disease

Online: 28 July 2020 (10:07:22 CEST)

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Preprint REVIEW | doi:10.20944/preprints201811.0382.v1

Jumonji C Demethylases in Cellular Senescence

Kelly E. Leon, Katherine M. Aird

Subject: Life Sciences, Cell & Developmental Biology Keywords: senescence; demethylases; epigenetics; histones; cancer

Online: 16 November 2018 (07:21:53 CET)

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Preprint REVIEW | doi:10.20944/preprints202211.0564.v1

Cellular Senescence, a Novel Area of Investigation for Metastatic Diseases

Francesca Faggioli, Micheal Velarde, Christopher D. Wiley

Subject: Life Sciences, Other Keywords: cellular senescence; metastasis; metabolic adaptation; invasion

Online: 30 November 2022 (04:23:43 CET)

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Preprint SHORT NOTE | doi:10.20944/preprints202009.0401.v2

The Hunger Games as the Key to Happily Ever After?

Jacques Deere, Clarice Xu, Celestine Adelmant, Aziz Aboobaker, Roberto Salguero-Gómez

Subject: Biology, Ecology Keywords: life history; longevity; senescence; stochastic environments

Online: 26 July 2022 (08:51:22 CEST)

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Preprint REVIEW | doi:10.20944/preprints202105.0310.v1

The Hoverfly and the Wasp: A Critique of the Hallmarks of Aging as a Paradigm

David Gems, João Pedro de Magalhães

Subject: Medicine & Pharmacology, Allergology Keywords: aging; geroscience; hallmarks; paradigm; senescence; theory

Online: 13 May 2021 (14:29:48 CEST)

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Preprint REVIEW | doi:10.20944/preprints202102.0127.v1

Skeletal Aging and Osteoporosis: Cellular Senescence and Beyond

Abhishek Chandra, Jyotika Rajawat

Subject: Life Sciences, Biochemistry Keywords: Osteoporosis; Senescence; SASP; Aging; Radiation; Senotherapeutic

Online: 3 February 2021 (17:00:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0442.v1

P21 Overexpression Promotes Cell Death and Induces Senescence in Human Glioblastoma

Moustafa A. Mansour, Masum Rahman, Ahmed A. Ayad, Arthur E Warrington, Terry C. Burns

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: P21; CDKN1A; glioblastoma; senescence; cancer senescence; gene overexpression; gene knock-in; CRISPR/Cas9; dCas; dCas-VPR

Online: 23 December 2022 (04:10:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints201709.0106.v1

Molecular Cloning, Expression and Functional Analysis of Interferon Regulatory Factor 5 (IRF 5) in Malabar Grouper (Epinephelus Malabaricus)

Thirunavukkarasu Periyasamy, Ming-Wei Lu

Subject: Life Sciences, Immunology Keywords: IRF5; transcriptional factors; immuno-stimulation; nervous necrosis virus; malabar grouper (epinephelus malabaricus)

Online: 22 September 2017 (08:58:20 CEST)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202206.0145.v1

Mirage or Miracle—Intraovarian Autologous Platelet Cytokines for Infertility and Menopause

E. Scott Sills

Subject: Medicine & Pharmacology, Obstetrics & Gynaecology Keywords: ovary; PRP; senescence; rejuvenation; hypoxia; telomere length

Online: 9 June 2022 (11:16:03 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints202204.0124.v1

Revisiting Epithelial Carcinogenesis

Luis Fernando Méndez-López

Subject: Life Sciences, Molecular Biology Keywords: Senescence; EMT; NF-κB; Inflammation; Epigenetics; Aging

Online: 13 April 2022 (10:22:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0637.v1

From Neural Stem Cells (NSC) to Glioblastoma (GBM): A Natural History of GBM Recapitulated in Vitro

Cristina Almengló, Pilar Caamaño, Máximo Fraga, Jesús Devesa, José A. Costoya, Víctor M. Arce

Subject: Medicine & Pharmacology, Oncology & Oncogenics Keywords: glioblastoma; neural stem cells; replicative senescence; metastasis

Online: 28 August 2020 (11:33:23 CEST)

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Preprint REVIEW | doi:10.20944/preprints202004.0532.v1

Potential Role of Cellular Senescence on Coronavirus Infections

Prem Chapagain

Subject: Biology, Physiology Keywords: cellular senescence; SARS-CoV-2; coronavirus; aging

Online: 30 April 2020 (13:58:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0091.v1

Sex Specific Differences in Response to Calorie Restriction in Skeletal Muscle of Young Rats

Margalida Torrens-Mas, Cayetano Navas-Enamorado, Devin Wahl, Andres Sanchez-Polo, Anna Picca, Jordi Oliver, Pilar Roca, Marta Gonzalez-Freire

Subject: Life Sciences, Molecular Biology Keywords: calorie restriction; aging; inflammation; autophagy; senescence.; skeletal muscle

Online: 6 September 2022 (11:01:40 CEST)

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Preprint REVIEW | doi:10.20944/preprints202105.0372.v1

Gut Microbiome and Cellular Senescence in the Context of Aging and Disease: An Emerging Frontier

Rohit Sharma

Subject: Life Sciences, Biochemistry Keywords: Aging; Microbiome; Probiotics; Cellular senescence; SASP; Stress; Immunity

Online: 17 May 2021 (08:51:53 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints202101.0514.v1

On the Origin of Carcinoma

Fernando Mendez

Subject: Life Sciences, Biochemistry Keywords: Senescence; Immortalization; Epithelial to Mesenchymal Transition; Carcinogenesis; Hypothesis

Online: 25 January 2021 (15:31:18 CET)

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Working Paper ARTICLE

Obesity Negatively Affects the Biological Functions of Mesenchymal Stromal Cells Derived from Bone Marrow, Subcutaneous and Visceral Fat of Young Mice

Nicola Alessio, Mustafa Acar, Ibrahim Demirsoy, Tiziana Squillaro, Dario Siniscalco, Giovanni Di Bernardo, Gianfranco Peluso, Servet Ozcan, Umberto Galderisi

Subject: Life Sciences, Other Keywords: obesity; mesenchymal stromal cells; cell cycle; senescence; differentiation

Online: 27 January 2020 (09:18:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints201908.0189.v1

OsWRKY5 Promotes Rice Leaf Senescence by Upregulating Senescence-Associated NAC Genes and Abscisic Acid Biosynthesis

Taehoon Kim, Kiyoon Kang, Suk-Hwan Kim, Gynheung An, Nam-Chon Paek

Subject: Biology, Plant Sciences Keywords: rice; leaf senescence; abscisic acid (ABA); OsWRKY; NAC

Online: 18 August 2019 (03:19:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0001.v1

A novel ALDH1A1 Inhibitor Blocks Platinum-Induced Senescence and Stemness in Ovarian Cancer

Vaishnavi Muralikrishnan, Fang Fang, Tyler C Given, Ram Podicheti, Mikhail Chtcherbinine, Shruthi Sriramkumar, Heather M O'Hagan, Thomas D. Hurley, Kenneth P. Nephew

Subject: Life Sciences, Molecular Biology Keywords: ovarian cancer; ALDH1A1; cancer stem cells; senescence; chemotherapy resistance

Online: 2 May 2022 (09:39:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0304.v1

Effect of Nr1d1 on Serpina3 Mediated Cell Senescence by Nuclear Receptor Nr4a3 in Mouse Heart-Derived Sca-1+CD31− Cells

Shiming Pu, Qian Wang, Qin Liu, Hongxia Zhao, Zuping Zhou, Qiong Wu

Subject: Life Sciences, Cell & Developmental Biology Keywords: Sca-1+CD31− cells; Nr1d1; cell senescence; Serpina3; Nr4a3

Online: 20 January 2022 (11:24:08 CET)

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Preprint REVIEW | doi:10.20944/preprints202110.0046.v1

Interconnections between Inflammageing and Immunosenescence During Ageing

Thibault Teissier, Eric Boulanger, Lynne S Cox

Subject: Life Sciences, Immunology Keywords: ageing; inflammation, cytokines, inflammageing; inflammageing; immunosenescence; immunosurveillance; senescence; SASP

Online: 4 October 2021 (11:00:22 CEST)

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Preprint REVIEW | doi:10.20944/preprints202107.0090.v1

From Molecular Biology to Epithelial Carcinogenesis

Fernando Mendez

Subject: Life Sciences, Biochemistry Keywords: Senescence; EMT; Inflammation; GRN; Attractors; Carcinomas; Cellular plasticity; Convergence

Online: 5 July 2021 (10:39:20 CEST)

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Preprint REVIEW | doi:10.20944/preprints202005.0388.v1

Gene Mutation and Epigenetic Modification Origin in Glioma Initiation: Are the GDNF and SOX1 Overexpression the Causes of Its Initiation?

Kouminin Kanwore, Xiao-xiao Guo, Ayanlaja Abdulrahman Abiola, Piniel Alphayo Kambey, Adekunle Adebayo Oluwafemi, Dianshuai Gao

Subject: Biology, Other Keywords: GDNF; SOX1; CAFs; senescence; aging cell; methylation; tumour; glioma

Online: 24 May 2020 (16:53:56 CEST)

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Preprint REVIEW | doi:10.20944/preprints202001.0087.v1

DPP-4/GLP-1 Axis as a Potential Therapeutic Target in Chronic Stress-related Vascular Aging and Atherosclerosis

Ying Wan, Limei Piao, Yongshan Nan, Xian-Wu Cehng

Subject: Biology, Animal Sciences & Zoology Keywords: Chronic stress; Vascular senescence; inflamamtion; atherosclerosis; dipeptidyl peptidase-4

Online: 9 January 2020 (13:05:26 CET)

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Preprint REVIEW | doi:10.20944/preprints201905.0101.v1

Evidence for immortality and autonomy as criteria for neoplasms has not been shown for the lesions resulting from most animal models of carcinogenesis

Xixi Dou, Mingjuan Lei, Haiyan Zhou, Lichan Chen, Lucas Zellmer, Qingwen Jia, Daizhou Zhang, Ningzhi Xu, Chengguang Wang, Dezhong Joshua Liao

Subject: Life Sciences, Other Keywords: Transgenic; Cancer; Carcinogenesis; Immortality; Autonomy; cancer stem cells; senescence

Online: 9 May 2019 (11:29:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0299.v1

Designing of Multiepitope Subunit Vaccine Against Leptospirosis Using Immunoinformatics Approach

Kopal Kapoor, Amrutlal Patel, Satyamitra Shekh, Chaitanya G. Joshi

Subject: Life Sciences, Immunology Keywords: Leptospirosis; Multi-epitope vaccine; immuno-informatics; T-cell epitope; B-cell epitope; docking; molecular dynamic simulation

Online: 16 December 2022 (08:15:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202008.0092.v1

COVID-19 Vaccine Candidates by Identification of B and T Cell Multi-Epitopes Against SARS-COV-2

Suresh Kumar, Sarmilah Mathavan, Wee Jia Jin, Nur Azznira Bt Azman, Devindren Subramanaiam, Nur Afiqah Binti Zainalabidin, Dhivashini Lingadaran, Zainah Binti Abdul Sattar, Danniya Lakshmi Manickam, Priscilla Sheba Anbananthan, Johan Ahmad Taqiyuddin, Yuvapriya Thevarajan

Subject: Keywords: COVID-19; SARS-CoV-2; epitopes; B-cell; T-cell; immuno informatics; MHC-I; MHC-II

Online: 4 August 2020 (11:18:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0330.v1

The Pivotal Role of Phenological Stage Enhanced by Plant Origin Preparations in the Process of Rhizogenesis of Rosa ‘Hurdal’ Stem Cuttings

Marta Monder, Maciej Niedzielski, Konrad Woliński

Subject: Life Sciences, Other Keywords: biostimulant; carotenoids; chlorophyll; IBA; leaf senescence; NAA; phenology; soluble proteins

Online: 21 December 2021 (12:40:44 CET)

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Preprint REVIEW | doi:10.20944/preprints202207.0423.v1

Is “Cellular Senescence” a Misnomer?

David Gems, Carina Kern

Subject: Life Sciences, Cell & Developmental Biology Keywords: Aging; cellular senescence; fibroblast; osteoarthritis; remodeling-associated secretory phenotype (RASP); remodeling activation

Online: 27 July 2022 (13:38:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0389.v1

Chemical Mechanism of Petal Color Change in Oenothera Flowers during Senescence

Yada Teppabut, Kin-ichi Oyama, Tadao Kondo, Kumi Yoshida

Subject: Chemistry, Organic Chemistry Keywords: cyanidin 3-O-glucoside; flower senescence; isosalipurposide; Oenothera; petal color change; quercitrin

Online: 28 May 2018 (08:49:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202211.0410.v1

Selenylated imidazo[1,2-a]pyridine induces cell senescence and oxidative stress in chronic myeloid leukemia cells

Gabriella Teles Burkner, Dhébora Albuquerque Dias, Kamylla Fernanda Souza de Souza, Anna Júlia Papa de Araújo, Denise Caroline Luiz Soares Basilio, Fernanda Tondello Jacobsen, Ana Carolina Rabello de Moraes, Saulo Euclides Silva-Filho, Marcos Filipe de Oliveira Cavalcante, Cassio Augusto de Oliveira Moraes, Sumbal Saba, Maria Lígia Rodrigues Macedo, Edgar Julian Paredes-Gamero1, Jamal Rafique, Eduardo Benedetti Parisotto

Subject: Chemistry, Medicinal Chemistry Keywords: Leukemia; imidazo[1,2-a]pyridines; selenide; oxidative stress; senescence; chronic myeloid leu-kemia.

Online: 22 November 2022 (07:49:44 CET)

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Preprint BRIEF REPORT | doi:10.20944/preprints202207.0144.v1

PKCeta Promotes Stress-induced Autophagy and Senescence in Breast Cancer Cells, Presenting A Target for Therapy

Noa Rotem-Dai, Amitha Muraleedharan, Etta Livneh

Subject: Life Sciences, Biochemistry Keywords: Protein Kinase C; PKCeta; autophagy; senescence; chemoresistance; oxidative stress; ER stress; 3MA; chloroquine

Online: 10 July 2022 (06:42:23 CEST)

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Preprint REVIEW | doi:10.20944/preprints202205.0037.v1

Immunomodulation of Melanoma by Chemo-Thermo-Immuno-Therapy Using Conjugates of Melano-Genesis Substrate NPrCAP and Magnetite Nanoparticles

Yasuaki Tamura, Akira Ito, Kazumasa Wakamatsu, Takafumi Kamiya, Toshihiko Torigoe, Hiroyuki Honda, Toshiharu Yamashita, Hisashi Uhara, Shosuke Ito, Kowichi Jimbow

Subject: Medicine & Pharmacology, Dermatology Keywords: Melanoma; Chemo-thermo-immuno-therapy; Melanogenesis; Magnetite nanoparticle; Drug delivery system; Heat shock protein; In situ vaccine therapy; Immune checkpoint inhibitor

Online: 5 May 2022 (12:23:27 CEST)

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Preprint REVIEW | doi:10.20944/preprints202204.0011.v1

Adipose Tissue Plasticity in Response to Pathophysiological Cues: A Connecting Link between Obesity and Its Associated Comorbidities

Michelantonio De Fano, Desirèe Bartolini, Cristina Tortoioli, Cristiana Vermigli, Massimo Malara, Francesco Galli, Giuseppe Murdolo

Subject: Medicine & Pharmacology, Other Keywords: adipose tissue; adipose precursor cells; obesity; senescence; oxidative stress; type 2 diabetes; cardiovascular disease

Online: 4 April 2022 (07:34:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0325.v1

Enrichment of the Information Extracted From Hyperspectral Reflectance Images for Noninvasive Phenotyping

Alexei Solovchenko, Boris Shurygin, Andrey Kuzin, Vitaly Velichko, Olga Solovchenko, Alexandr Nikolenko, Andrey Krylov

Subject: Biology, Agricultural Sciences & Agronomy Keywords: phenotyping; proximal sensing; reflectance imaging; vegetation indices; hyperspectral reflectance; chlorophylls; carotenoids; anthocyanins; senescence; ripening

Online: 21 December 2021 (12:23:13 CET)

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Preprint HYPOTHESIS | doi:10.20944/preprints202004.0143.v1

Inflamm-Aging: Why Older Men Are the Most Susceptible to SARS-Cov-2 Complicated Outcomes

Massimiliano Bonafè, Francesco Prattichizzo, Angelica Giuliani, Gianluca Storci, Jacopo Sabbatinelli, Fabiola Olivieri

Subject: Medicine & Pharmacology, Pathology & Pathobiology Keywords: SARS-CoV-2; COVID-19; IL-6; inflamm-aging; immune senescence; host-directed therapies

Online: 9 April 2020 (08:38:22 CEST)

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Preprint REVIEW | doi:10.20944/preprints202109.0189.v1

Epigenetic Clock, Circadian Rhythms and Cell Aging

Ekaterina Samoilova, Vladimir Belopasov, Evgenia Ekusheva, Chao Zhang, Alexander Troitskiy, Vladimir Baklaushev

Subject: Life Sciences, Molecular Biology Keywords: circadian clock; epigenetic clock; aging; senescence; reprogramming; methylome; DNA methylation; CpG-islands; induced pluripotent stem cells

Online: 10 September 2021 (15:13:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202001.0244.v1

Chronic Mild Stress Modified Epigenetic Mechanisms Leading to Accelerated Senescence and Impaired Cognitive Performance in Mice

Dolors Puigoriol-Illamola, Mirna Martínez-Damas, Christian Griñán-Ferré, Mercè Pallàs

Subject: Life Sciences, Molecular Biology Keywords: Stress; epigenetics; senescence; cognition; age-related cognitive decline; Alzheimer’s disease; SAMP8; SAMR1; oxidative stress; inflammation; autophagy

Online: 21 January 2020 (11:44:35 CET)

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Preprint REVIEW | doi:10.20944/preprints201806.0056.v1

mTORC Inhibitors as Broad-Spectrum Therapeutics for Age-Related Diseases

Hannah E. Walters, Lynne S. Cox

Subject: Medicine & Pharmacology, Other Keywords: mTOR; mTORC1; mTORC2; rapamycin; rapalogues; rapalogs; mTOR inhibitors; senescence; ageing; aging; cancer; neurodegeneration; immunosenescence; senolytics; biomarkers

Online: 5 June 2018 (09:49:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202012.0635.v1

Activation of Microbiota Sensor- Free Fatty Acid Receptor 2 Signaling Ameliorates Amyloid-Β Induced Neurotoxicity by Modulating Proteolysis/Senescence Axis

Atefeh Razazzan, Prashantha Karunakar, Sidharth Mishra, Shailesh Sharma, Shalini Jain, Hariom Yadav

Subject: Medicine & Pharmacology, Allergology Keywords: Free fatty acid receptor 2; microbiota; metabolite; sensor; G-coupled protein receptor; signaling; Alzheimer’s disease; senescence; C. elegans

Online: 24 December 2020 (14:56:00 CET)

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Preprint HYPOTHESIS | doi:10.20944/preprints202109.0437.v2

The Glial Aging & Senescence Hypothesis of Late-onset Alzheimer’s

Victor Lau, Leanne Ramer, Marie-Ève Tremblay

Subject: Life Sciences, Other Keywords: Alzheimer's; Cellular senescence; Neurodegeneration; Microglia; Astrocytes; Oligodendrocyte Progenitor Cells; TREM2; Braak staging; Oxidative stress; Phapoptosis; Amyloid-beta; Tau; Neuritic plaques

Online: 7 March 2022 (14:22:25 CET)

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Alzheimer’s disease (AD) predominantly occurs as a late-onset form (LOAD), involving neurodegeneration and cognitive decline with progressive memory loss. Over time, risk factors and aging promote accumulation of well-known AD pathologies in oxidative stress, amyloid-beta and tau protein pathology, as well as inflammation. Homeostatic glial functions regulate and suppress these AD pathologies; however, other glial states involve increased pro-inflammatory cytokine release and further pathology accumulation. Different stresses can additionally induce cellular senescence, or an irreversible differentiation process resulting in decreased supportive functions and increased, pro-inflammatory cytokine release. While these pathophysiological underpinnings all contribute to LOAD, they require temporal and mechanistic integration. This perspective hypothesizes that when individuals have threshold senescent glia accumulation, they transition from healthy cognition into mild cognitive impairment and LOAD diagnosis. Particularly, senescent microglia are predicted to represent a final threshold required for the tau pathology burden and spreading that corresponds to sustained neurodegeneration and dementia severity. We first explore age-related decline in glia that promote increases in AD pathologies, and then discuss emerging evidence linking oxidative stress, neurons containing tau pathology, and amyloid-beta to microglia, oligodendrocyte progenitor cell, and astrocyte senescence. Our hypothesis proposes that senescent astrocytes and oligodendrocyte progenitors pressure microglia to phagocytose neurons containing tau pathology. The resulting senescent microglia would form neuritic plaques and induce paracrine senescence transitioning into a progressive clinical dementia presentation. This predictive hypothesis can potentially account for why medications used to treat LOAD fail, as previous treatments have not reduced senescent glial burden. It is also coherent with the predominant hypotheses surrounding LOAD, generates testable hypotheses about LOAD, and increases rationale in testing senolytics as targeted treatments for LOAD arrest and reversal.

Preprint REVIEW | doi:10.20944/preprints202012.0795.v1

Advances in Cellular Immunotherapy: Understanding and Preventing T-cell Dysfunction

Valérie Janelle, Jean-Sébastien Delisle

Subject: Life Sciences, Biochemistry Keywords: T cells; chimeric antigen receptor; transgenic T-cell receptor; tumor-infiltrating lymphocytes; exhaustion; terminal differentiation; senescence; apoptosis; adoptive cell transfer; immunotherapy

Online: 31 December 2020 (12:16:55 CET)

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Preprint REVIEW | doi:10.20944/preprints201710.0006.v1

Fatty Acids, Antioxidants and Physical Activity in Brain Aging

Hércules Rezende Freitas, Gustavo da Costa Ferreira, Isis Hara Trevenzoli, Karen de Jesus Oliveira, Ricardo Augusto de Melo Reis

Subject: Medicine & Pharmacology, Nutrition Keywords: essential fatty acids; ascorbic acid; glutathione; aging; parkinson’s disease; alzheimer’s disease; senescence; nervous system; growth factors; neuroprotection; docosahexaenoic acid; α-linolenic acid.

Online: 2 October 2017 (08:59:13 CEST)

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Preprint REVIEW | doi:10.20944/preprints201901.0039.v1

Prevention of Hearing Loss by Alteration of the Systemic Immune System

Hiroshi Iwai, Muneo Inaba

Subject: Medicine & Pharmacology, General Medical Research Keywords: autoimmune sensorineural hearing loss; age-related sensorineural hearing loss; inflammation, immune senescence; interleukin 1 receptor type II -positive T cells; naturally occurring regulatory T cells; immune rejuvenation; thymus

Online: 4 January 2019 (11:37:31 CET)

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