Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Effect of Ferulago lutea (Poir.) Grande Essential Oil on Molecular Hallmarks of Skin Aging

Jorge M. Alves-Silva
,
Patrícia Moreira
ORCID logo ,
Carlos Cavaleiro
ORCID logo ,
Cláudia Pereira
ORCID logo ,
Maria Teresa Cruz
ORCID logo ,
Lígia Salgueiro
* ORCID logo
Version 1 : Received: 16 October 2023 / Approved: 23 October 2023 / Online: 23 October 2023 (15:25:57 CEST)

A peer-reviewed article of this Preprint also exists.

Alves-Silva, J.M.; Moreira, P.; Cavaleiro, C.; Pereira, C.; Cruz, M.T.; Salgueiro, L. Effect of Ferulago lutea (Poir.) Grande Essential Oil on Molecular Hallmarks of Skin Aging. Plants 2023, 12, 3741. Alves-Silva, J.M.; Moreira, P.; Cavaleiro, C.; Pereira, C.; Cruz, M.T.; Salgueiro, L. Effect of Ferulago lutea (Poir.) Grande Essential Oil on Molecular Hallmarks of Skin Aging. Plants 2023, 12, 3741.

Abstract

As global life expectancy continues to rise, we are challenged with maintaining health into old age, and research has thus concentrated on various strategies aimed at mitigating the effects of skin aging. Aromatic plants stand out as potential sources of anti-aging compounds due to their secondary metabolites, particularly essential oils (EO). The aim of this study was to ascribe to Ferulago lutea EO several biological activities that could be useful in the context of skin aging. The EO was obtained using hydrodistillation and characterized by gas chromatography-mass spectrometry (GC/MS). The anti-inflammatory potential was assessed using lipopolysaccharide (LPS)-stimulated macrophages. The effect on cell migration was disclosed using scratch wound assay. Lipogenesis was induced using T0901317, hyperpigmentation with 3-isobutyl-1-methylxantine (IBMX) and senescence with Etoposide. Our results show that the EO was characterized mainly by α-pinene and limonene. The EO was able to decrease nitric oxide (NO) release as well as iNOS and pro-IL-1β protein levels. The EO promoted wound healing while decreasing lipogenesis and having depigmenting effects. The EO also reduced senescence associated β-galactosidase and p21/p53 protein levels and nuclear accumulation of γH2AX. Overall, our study highlights the properties of F. lutea EO that make it a compelling candidate for dermocosmetics applications.

Keywords

Lipogenesis; depigmenting activity; aging; senescence; wound healing

Subject

Biology and Life Sciences, Aging

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0
Get PDF Cite Share 0
Bookmark BibSonomy Mendeley Reddit Delicious
×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.