The Multidisciplinary Preprint Platform


Potential Natural Compounds for Preventing 2019-nCoV Infection
2019-nCoV, a novel coronavirus, caused the pneumonia outbreak in China and continue to expand. The host receptor for 2019-nCoV Angiotensin-converting enzyme 2 (ACE2), which is the same as the host ...
A Review on the Factors Contributing to 2019-nCoV Virus Outbreaks in Wuhan
The new coronavirus (2019-nCoV) in Wuhan has caused virus outbreaks in many provinces and cities in China, and several neighboring countries were also affected. In recent years, coronavirus several outbreaks ...
Ten Recommendations for Supporting Open Pathogen Genomic Analysis in Public Health Settings
Public health agencies are increasingly using pathogen whole genome sequencing (WGS) to support surveillance and epidemiologic investigations. As access to WGS has grown, greater amounts of molecular data have helped ...
Safeguarding Freshwater Life Beyond 2020: Recommendations for the New Global Biodiversity Framework from the European Experience
The drafting of a new Global Biodiversity Framework for the Convention on Biological Diversity (CBD) and Biodiversity Strategy for the European Union (EU) render 2020 a critical crossroad for biodiversity ...
Ultrasound-Guided Nerve Hydrodissection for Pain Management: An Updated Review of Anatomy and Techniques
Nerve hydrodissection (HD), a technique used when treating nerve entrapments, involves using an anesthetic or solution such as saline or 5% dextrose solution to separate the nerve from the surrounding ...


HSP70/IL-2 Treated NK Cells Effectively Cross the Blood Brain Barrier and Target Tumor Cells in a Rat Model of Induced Glioblastoma Multiforme (GBM)
Natural killer (NK) cell therapy is one of the most promising treatments for Glioblastoma Multiforme (GBM). However, this emerging technology is limited by the availability of sufficient numbers of fully ...
Exceptionally Rare Genomic Combinations to Skip Sex: Blending Old Ideas and New Data
The unusual occurrence and developmental diversity of asexual eukaryotes still remain a puzzle. Despite asexual organisms have a theorized two-fold reproductive advantage over sexuals, asexual lineages are rare among multicellular ...
Asians Do Not Exhibit Elevated Expression or Unique Genetic Polymorphisms for ACE2, the Cell-Entry Receptor of SARS-CoV-2
The recurrent coronavirus outbreaks in China (SARS-CoV and its relative, SARS-CoV-2) have raised speculations that perhaps Asians are somehow more susceptible to these coronaviruses. Here, we test this possibility based ...
Six-Month Physical Activity Versus Sclerostin and Interleukin 6 Concentration in Patients Receiving Renal Replacement Therapy by Hemodialysis – Pilot Study
Background: Chronic kidney disease and renal replacement therapy are associated with reduced physical activity, which may result in the presence of mineral-bone disorders and an increase in inflammation markers. The ...
Brief Exposure to Infants Activates Social and Intergroup Vigilance
Among humans, simply looking at infants can activate affiliative and nurturant behaviors. Yet it remains unknown whether mere exposure to infants also activates generalized defensiveness in the absence of immediate ...
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