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HIGHLY ACCESSED ARTICLES (PAST 30 DAYS)

Applications, Promises, and Pitfalls of Deep Learning for Fluorescence Image Reconstruction
Deep Learning is a recent and important addition to the computational toolbox available for image reconstruction in fluorescence microscopy. We review state-of-the-art applications such as image restoration, super-resolution, and light-field imaging, ...
Clinical Relevance of Genome-Wide Polygenic Score may Be Less than Claimed
A recent study claimed that genome-wide polygenic scores (GPSs) for five common diseases could identify individuals with risk equivalent to monogenic mutations. Receiver operator curve analyses were reported to have ...
Why Nature-Based Solutions to Climate Change Must Be Grounded in Sound Biodiversity Science
The current focus on afforestation in climate policy runs the risk of compromising both longterm carbon storage and human adaptation. It also works against efforts to stem the tide of ...
A Noninvasive Comparison Study between Human Gliomas with IDH1 and IDH2 Mutations by MR Spectroscopy
The oncogenes that are expressed in gliomas reprogram particular pathways of glucose, amino acid, and fatty acid metabolism. Mutations in isocitrate dehydrogenase genes (IDH1/2) in diffuse gliomas are associated with ...
Ideologies Behind the Halal Tourism Sector
A quick scan of the available literature on the subject of halal tourism reveals that many scholars and laypersons alike misconceive this concept. Whereas some suggest that halal tourism occurs ...

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Applying Cognitive Presence to Individual Educational Experience as a Framework for Reflection
Traditionally understood in reference to distance education, cognitive presence may be defined as "the extent to which the participants in any particular configuration of a community of inquiry can construct ...
Investigating the Effects of Transient Flow in Concrete-Lined Pressure Tunnels, and Developing a New Analytical Formula for Pressure Wave Velocity
One of the most common problems in concrete-lined pressure tunnels is the development of cracks in the concrete lining as a result of high internal transient pressure. Due to the ...
On a Line Trajectory in Lorentzian Spatial Motion
Based on the E. Study's map, explicit expressions were developed for the differential properties of Lorentzian one-parameter dual spherical motions that are coordinates systems independent. This eliminates the need of ...
The Energy Homeostasis Principle: Neuronal Energy Regulation Drives Local Network Dynamics Generating Behavior
A major goal of neuroscience is understanding how neurons arrange themselves into neural networks that result in behavior. Most theoretical and experimental efforts have focused on a top-down approach which ...
Heterogeneous Catalysis Under Flow for the 21st Century Fine Chemical Industry
Due to metal leaching and poor catalyst stability, the chemical industry’s fine chemical and pharmaceutical sectors have been historically reluctant to use supported transition metal catalysts to manufacture fine chemicals ...
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Comment of the Month, December 2018
Comment of the Month Competition
A New Look and a New Policy
Better visibility for preprints: Inclusion in Europe PMC

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