The Multidisciplinary Preprint Platform


The Economic Impacts of Open Science: A Rapid Evidence Assessment
A common motivation for increasing open access to research findings and data is the potential to create economic benefits – but evidence is patchy and diverse. This study systematically reviewed ...
Recommendations for How to Respond When the Family is Hoping for a Miracle
Objective: To recommend how physicians can best respond to families whose hopes for a miracle via divine intervention influence their medical decisions, like, for example, making them not want to ...
Proprietary Algorithms for Polygenic Risk: Protecting Scientific Innovation or Hiding the Lack of It?
Direct-to-consumer genetic testing companies aim to predict the risks of complex diseases using proprietary algorithms. Companies keep algorithms as trade secrets for competitive advantage, but a market that thrives on ...
Using RAxML-NG in Practice
RAxML-NG is a new phylogentic inference tool that replaces the widely-used RAxML and ExaMLtree inference codes. Compared to its predecessors, RAxML-NG offers improvements in accur-acy, flexibility, speed, scalability, and user-friendliness. ...
Open Up: A Survey on Open and Non-anonymized Peer Reviewing
We present a discussion and analysis regarding the benefits and limitations of open and non-anonymized peer review based on literature results and responses to a survey on the reviewing process ...


Evaluation of the Genomic Basis for Alzheimer’s and Parkinson’s Diseases
Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common neurodegenerative disorders related to aging. Though several risk factors are shared between these two diseases, the exact relationship between ...
Constitutive Modeling of the Tensile Behavior of Recycled Polypropylene Based Composites
The effect of reprocessing on the quasi-static uniaxial tensile behavior of two commercial polypropylene (PP) based composites is experimentally investigated and modeled. In particular, the studied materials consist of an ...
Wheat Varietal Differences in Below Ground Biomass Revealed by a Semi-Quantitative Estimation of Wheat Root DNA in Soil Samples
Root research on field grown crops is hindered by the difficulty of estimating root biomass in soil. Root washing, the current standard method is laborious and expensive. Biochemical methods to ...
Eigen Artificial Neural Networks
This work has its origin in intuitive physical and statistical considerations. The problem of optimizing an artificial neural network is treated as a physical system, composed of a conservative vector ...
Geospatial-Temporal and Demand Models for Opioid Admissions, Implications for Policy
Background:  As the opioid epidemic continues, understanding the geospatial, temporal and demand patterns is important for policymakers to assign resources and interdict individual, organization, and country-level bad actors.  Methods:  GIS ...
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