The Multidisciplinary Preprint Platform


Early Hydroxychloroquine Is Associated with an Increase of Survival in COVID-19 Patients: An Observational Study
Background: Although no specific treatment for COVID 19 has been proven effective yet, some drugs with in vitro potential against SARS-CoV-2 virus have been proposed for clinical use. Hydroxychloroquine ...
Face Masks Against COVID-19: An Evidence Review
The science around the use of masks by the general public to impede COVID-19 transmission is advancing rapidly. Policymakers need guidance on how masks should be used by the general ...
Azithromycin and Hydroxychloroquine Accelerate Recovery of Outpatients with Mild/Moderate COVID-19
The challenge regarding COVID-19 is to prevent complications and fatal evolution. Azithromycin (AZM) and hydroxychloroquine (HCQ) have proven their antiviral effect in vitro. We aimed to assess the efficacy and ...
Re-thinking the Potential for Airborne Transmission of SARS-CoV-2
Evidence for the potential for airborne transmission of SARS-CoV-19 continues to accumulate, with important implications for healthcare workers, as well as the general public. Three lines of evidence support this ...
Reduced Vitamin K Status as A Potentially Modifiable Prognostic Risk Factor in COVID-19
Background: A significant proportion of SARS-CoV-2-infected patients develops respiratory failure. Thromboembolism is also prevalent in coronavirus disease 2019 (Covid-19). Vitamin K plays a role in coagulation and possibly also in ...


An Updated Primer on SARS-CoV-2 and the Evolving Covid-19 Pandemic
In this paper we first provide a primer on SARS-CoV-2 and Covid-19 delineating the etiopathogenesis, epidemiology, clinical manifestations and the natural history of the disease. We then trace the evolution ...
High Throughput Virtual Screening to Discover Inhibitors of the Main Protease of the Coronavirus SARS-CoV-2
We use state-of-the-art computer-aided drug design (CADD) techniques to identify prospective inhibitors of the main protease enzyme, 3CLpro of the SARS-CoV-2 virus causing COVID-19. From our screening of over one ...
Genetic Basis of Maize Resistance to Multiple-Insect Pests: Integrated Genome-Wide Comparative Mapping and Candidate Gene Prioritization
Several herbivores feed on maize in field and storage setups making the development of multiple-insect resistance a critical breeding target. In this study, an association mapping panel of 341 tropical ...
Is There Water Ice in the Lunar Polar Craters?
This literature review found that it is doubtful that there is water ice in the polar craters on the Moon. In the course of this review, the following findings were ...
Public Health And Population Perspective Of COVID-19 As A Global Pandemic
COVID-19 appeared as an infectious disease of global health emergency and highest public health concern of 21st century for this world due to its high speed of spread across the ...
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