Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Insulin-Like Growth Factor Binding Proteins and Cellular Senescence Are Involved in the Progression of Non-alcoholic Fatty Liver Disease and Fibrosis in a Mouse Model

Carolina Guzmán
* ORCID logo ,
Miriam G Bautista-Ubaldo
,
Adriana Campos Espinosa
ORCID logo ,
Ivette I Romero-Bello
,
Angel Daniel Santana-Vargas
ORCID logo ,
Gabriela Gutierrez-Reyes
Version 1 : Received: 26 February 2024 / Approved: 26 February 2024 / Online: 27 February 2024 (10:06:34 CET)

A peer-reviewed article of this Preprint also exists.

Guzmán, C.; Bautista-Ubaldo, M.G.; Campos-Espinosa, A.; Romero-Bello, I.I.; Santana-Vargas, Á.D.; Gutierrez-Reyes, G. Insulin-like Growth Factor Binding Proteins and Cellular Senescence Are Involved in the Progression of Non-Alcoholic Fatty Liver Disease and Fibrosis in a Mouse Model. Medicina 2024, 60, 429. Guzmán, C.; Bautista-Ubaldo, M.G.; Campos-Espinosa, A.; Romero-Bello, I.I.; Santana-Vargas, Á.D.; Gutierrez-Reyes, G. Insulin-like Growth Factor Binding Proteins and Cellular Senescence Are Involved in the Progression of Non-Alcoholic Fatty Liver Disease and Fibrosis in a Mouse Model. Medicina 2024, 60, 429.

Abstract

Background and Objectives: Non-alcoholic fatty liver disease (NAFLD) is highly prevalent world-wide. It progresses from simple steatosis to non-alcoholic steatohepatitis (NASH). Fibrosis is often present during NAFLD progression; however, factors determining which subjects develop NASH or fibrosis are unclear. Insulin-like growth factor binding proteins (IGFBP) is a family of secreted proteins involved in senescence and scarring mainly synthetized in the liver. Here we aimed to study the association of IGFBP and its induced senescence with the progression of NAFLD and liver fibrosis. Materials and Methods: 16 weeks old male C57BL/6 mice weighing 23 ± 3 g were fed either Methionine-Choline Deficient or control diet for 2, 8 or 12 weeks. Blood and liver samples were collected; histological assessment of NAFLD and fibrosis was performed. Fat contents were measured. Cellular senescence was evaluated in the liver. IGFBP levels were assessed in liver and serum. Data was expressed as Mean ± SD and analyzed by one-way ANOVA followed Tukey’s test. Lineal regression models were applied for NAFLD and fibrosis progression. p

Keywords

Insulin-like growth factor binding proteins; liver fibrosis; cellular senescence; steatohepatitis; steatosis.

Subject

Medicine and Pharmacology, Gastroenterology and Hepatology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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