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Preprint BRIEF REPORT | doi:10.20944/preprints202403.0978.v2

Real-Life Practice of Kelleni’s Protocol in Treatment and Post Exposure Prophylaxis of SARS CoV-2 Omicron HV.1 and JN.1 Subvariants

Mina Kelleni

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: SARS CoV-2; HV.1; JN.1; Post exposure prophylaxis; Kelleni’ s protocol; Nitazoxanide; NSAIDs

Online: 18 April 2024 (15:56:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1191.v1

Evaluation of Antitumor Activity of Reprogrammed Spleen CD8+ T-Cells in a Lewis Lung Cancer Mouse Model

Olga Pershina, Angelina Pakhomova, Natalia Ermakova, Edgar Pan, Evgenii G. Skurikhin, Darius Widera, Lubov Sandrikina, Lena Kogai, Mariia Zhukova, Vadim Zhdanov, Nikolai Kushlinskii, Sergey Morozov, Aslan Kubatiev, Alexander Dygai

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: reprogrammed spleen CD8+ T-cells; Lewis lung carcinoma; cancer stem cell; CD8+ and CD4+ T-cells; antimetastatic activity

Online: 18 April 2024 (14:22:11 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.1200.v1

Understanding Doppler Renal Resistive Index: An Exploration of Clinical and Theoretical Determinants

Heather Venables, Robert Iain Lennon, Manuchehr Soleimani

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: ultrasonography; doppler; resistive index; renal

Online: 18 April 2024 (14:05:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1207.v1

Coronary Computed Tomography Angiography - derived modified Duke index is associated with peri-coronary Fat Attenuation Index and predicts severity of coronary inflammation

Vasile-Bogdan Halațiu, Imre Benedek, Ioana-Patricia Rodean, Liliana-Oana Cojocariu, Theofana Mihăilă, Emanuel Blîndu, Aurelian Roșca, Botond - Barna Mátyás, Renata Gerculy, Florin Buicu, Theodora Benedek

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: CariHeart; cardiac computed tomography; coronary stenosis; inflammation

Online: 18 April 2024 (14:03:31 CEST)

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Background: The modified Duke index derived from coronary computed tomography angiography (CCTA) was designed to predict cardiovascular outcomes based on the severity of coronary ste-nosis. However, it does not take into consideration the presence or severity of peri-coronary in-flammation. The peri-coronary fat attenuation index (FAI) is a novel imaging marker determined by CCTA which reflects the degree of inflammation in the coronary tree in patients with coronary artery disease. Purpose: To assess the association between the modified Duke index assessed by CCTA, cardiovascular risk factors and peri-coronary inflammation in the coronary arteries of pa-tients with coronary artery disease. Methods: One hundred seventy-two patients who underwent CCTA for typical angina were assigned into two groups based on the modified Duke index: group 1 – patients with low index ≤ 3 (n=107) and group 2 – patients with high index > 3 (n=65). Demo-graphic, clinical and CCTA data were collected for all patients, and FAI analysis of coronary in-flammation was performed. Results: Patients with increased values of the modified Duke index were significantly older compared to those with a low index (61.83 ± 9.89 vs. 64.78 ± 8.9; p = 0.002). No differences were found between the two groups in terms of gender distribution, hypertension, hypercholesterolemia or smoking history (all p > 0.5). The FAI score was significantly higher in patients from group 2, who presented a significantly higher score of inflammation compared to the patients in group 1, especially at the level of the right coronary artery (FAI score 20.85 ± 15.80 vs. 14.61 ± 16.66; p = 0.01 for the right coronary artery, 13.85 ± 8.04 vs. 10.91 ± 6.5; p = 0.01 for the circumflex artery, and 13.26 ±10.18 vs. 11.37 ± 8.84; p = 0.2 for the left anterior descending artery). CaRi-Heart® analysis identified a significantly higher risk of future events among patients with a high modified Duke index (34.84 % ± 25.86 % versus 16.87 % ± 15.80 %; p

Preprint REVIEW | doi:10.20944/preprints202404.1239.v1

Molecular Pathogenesis of Ischemic and Hemorrhagic Strokes: Background and Therapeutic Approaches

Carlo Domenico Maida, Rosario Luca Norrito, Salvatore Rizzica, Marco Mazzola, Antonino Tuttolomondo

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Stroke; Ischemic; hemorrhagic; pathophysiology; Long non-coding RNAs; MicroRNAs; Stroke therapeutics

Online: 18 April 2024 (14:00:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0937.v2

Incidence of Thyroid Cancer in Bethesda III Thyroid Nodules: A Retrospective Analysis at a Single Endocrine Surgery Center

Iyad Hassan, Lina Hassan, Nahed Balalaa, Mohammad Askar, Hussa Alshehhi, Mohamed Almarzooqi

Subject: Medicine And Pharmacology, Surgery Keywords: FNAC, Bethesda classification, thyroid cancer; indeterminate nodules, thyroid nodules; ultrasound guided biopsy, thyroidectomy; ;

Online: 18 April 2024 (13:39:59 CEST)

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Background: Fine-needle aspiration cytology (FNAC) is widely used to diagnose and monitor thyroid nodules. The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) is the standard for interpreting FNAC specimens. The risk of malignancy in Bethesda III nodules also known as Atypia of Undetermined Significance (AUS) varies significantly throughout several studies published worldwide. This retrospective study examines the risk of cancer in thyroid FNAC categorized as Bethesda III, as identified in the final histopathology of thyroidectomy specimens at a single endocrine surgery center. Methods: This retrospective cohort analysis included 1038 consecutive patients who underwent elective thyroid surgery with complete follow up data between January 2020 and March 2024. Preoperative data on clinical and pathological characteristics have been collected. The final histopathology report from the thyroidectomy specimen was compared to the results of the preoperative FNAC on nodules that were judged to be Bethesda category III. Statistical methods were performed using SPSS version 29. Results: A total of 670 ultrasound-guided FNACs (64.5%) performed during the study period were included in the final analysis. The study population was predominantly female, represented by 79.6% of patients with a mean age of 42.5 (SD 12.1), while 20.4% were male and significantly older with mean age 45.13 years (p = 0.02). The FNAC inadequacy rate was 5.1%, which was associated with a high risk of malignancy (6 out of 34, 17.6%). Out of the total sample size of 170 patients classified as group III, 57 were found to have malignancies in final surgical histopathology, representing 33.5% of the cases within this category. The secondary gender-related outcome analysis showed that female patients classified under the Bethesda II category had a significantly higher risk of malignancy, with a rate of 21.2%, compared to males who had a malignancy rate of 3.4% in the same Bethesda category (p = 0.001, chi square test). However, female had more better prognostic non-invasive tumors than male (p = 0.02, chi square test). Conclusion: The study's results indicate that Bethesda categories II and III are associated with a higher risk of malignancy in comparison to the reports of the first and third editions of the TBSRTC, particularly for female patients classified under category II.

Preprint ARTICLE | doi:10.20944/preprints202404.1219.v1

Impact of lowering TSH cut-off on neonatal screening for congenital hypothyroidism in Minas Gerais, Brazil

Nathalia Teixeira Palla Braga, Jáderson Mateus Vilela Antunes, Enrico Antônio Colosimo, Vera Maria Alves Dias, José Nélio Januário, Ivani Novato Silva

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: congenital hypothyroidism; neonatal screening; cut-off; sensitivity.

Online: 18 April 2024 (11:14:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1212.v1

A Pig as a Model to Test Cardiovascular Devices

Yanina L. Rusakova, Denis S Grankin, Kseniya S. Yu. Podolskaya, Irina Yu. Jhuravleva

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: laboratory mini-pigs; transesophageal echocardiography; angiography; aortic morphometry

Online: 18 April 2024 (10:43:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1242.v1

Acute Exercise for the Hypertensive Elderly Affects the Whole-Body Capillary: A Single- Center Pilot Trial

MISA Miura, Masahiro Kohzuki, Chie Saito, Satoshi Sakai, Hisashi Sugaya, Shingo Koyama, Yasushi Matsui, Tohru Sakuma, Osamu Ito, Kunihiro Yamagata

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: ; nailfold capillary; acute exercise; hypertensive elderly; health related parameters ;

Online: 18 April 2024 (10:38:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1237.v1

The Direct Tendon Suture and Paratenon Repair Technique for Acute Tendinous Mallet Finger

Seungjun Lee, Seokchan Eun

Subject: Medicine And Pharmacology, Surgery Keywords: tendon injuries; mallet finger; suture techniques

Online: 18 April 2024 (10:34:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1246.v1

Reduction in Hippocampal Aβ Content During Gly-Pro-Glu Co-Administration Is Associated with Changes in Inflammation and IGF-I Signaling

Laura M. Frago, Emma Burgos-Ramos, María Rodríguez-Pérez, Sandra Canelles, Eduardo Arilla-Ferreiro, Jesús Argente, Manuela. G. Lopez, Vicente Barrios

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Alzheimer´s disease; cytokines; Gly-Pro-Glu; IGF-I signaling; inflammation

Online: 18 April 2024 (10:27:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1231.v1

Suppression of Ventilation-Induced Diaphragm Fibrosis through the Phosphoinositide 3-Kinase-γ in a Murine Bleomycin-Induced Acute Lung Injury Medel

Li-Fu Li, Chung-Chieh Yu, Chih-Yu Huang, Huang-Pin Wu, Chien-Ming Chu, Ping-Chi Liu, Yung-Yang Liu

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: apoptosis; diaphragm fibrosis; phosphoinositide 3-kinase-g; ventilator-induced diaphragm dysfunction

Online: 18 April 2024 (10:06:43 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.1240.v1

Hemodialysis Procedures for Stable Incident and Prevalent Patients to Optimize Hemodynamic Stability, Dialysis Dose, Electrolytes, and Fluid Balance

Stefano Stuard, Christophe Ridel, Mario Cioffi, Alijana Trost-Rupnik, Konstantin Gurevich, Marija Bojic, Yerkebulan Karibayev, Nilufar Mohebbi, Wojciech Marcinkowski, Vlasta Kupres, Jelena Maslovaric, Alon Antebi, Pedro Ponce, Mamdouh Nada, Maria Eva Baro Salvador, Jaroslav Rosenberger, Tomas Jirka, Kira Enden, Volodymyr Novakivskyy, Daniela Voiculescu, Martin Pachmann, Otto Arkossy

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Hemodialysis procedures; hemodynamic stability; dialysis dose; dialysis electrolytes balance; dialysis fluid balance

Online: 18 April 2024 (10:04:00 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202404.1066.v1

Development of Sensitive Anti-mouse CCR5 Monoclonal Antibodies Using the N-terminal Peptide Immunization

Rena Ubukata, Hiroyuki Suzuki, Tomohiro Tanaka, Tsunenori Ouchida, Guanjie Li, Mika K Kaneko, Yukinari Kato

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: mouse CCR5; monoclonal antibody; peptide immunization; flow cytometry; western blotting

Online: 18 April 2024 (09:29:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1232.v1

Comparing the Outcomes of Matched and Mismatched Unrelated Allogeneic Hematopoietic Stem Cell Transplantation with Different Anti-thymocyte Globulin Formulations. A Retrospective, Double-Centre Experience on Behalf of the Polish Adult Leukaemia Group

Ugo Giordano, Monika Mordak-Domagała, Małgorzata Sobczyk-Kruszelnicka, Sebastian Giebel, Lidia Gil, Krzysztof Dudek, Jarosław Dybko

Subject: Medicine And Pharmacology, Hematology Keywords: allogeneic hematopoietic stem cell transplantation; anti-thymocyte globulin; Thymoglobuline; Grafalon; graft-versus-host disease

Online: 18 April 2024 (09:15:41 CEST)

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Preprint REVIEW | doi:10.20944/preprints202403.1158.v2

Cancer Stem Cells, Loss of Function, and Stemness Recovery; Generation of New Functional Stem Cells in Cancer Cell Systems

Vladimir Niculescu

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: stem cell function; dysfunctionality; stress; DNA DSB; repair; genomic integrity

Online: 18 April 2024 (08:06:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1176.v1

Invasive Procedures Used in Tuberculosis With Questionable Indications: Report From Russia

Sergei Jargin

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: tuberculosis; surgery; bronchoscopy; surfactant; alcoholism; Russia

Online: 17 April 2024 (17:01:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1167.v1

Discovery of Novel Potential Prognostic Marker and Targeted Therapy to Overcome Chemotherapy Resistance in an Advanced Stage Wilms’ Tumor

Pongsakorn Choochuen, Natakorn Nokchan, Natthapon Khongcharoen, Wison Laochareonsuk, Komwit Surachat, Thirachit Chotsampancharoen, Thanit Sila, Surasak Sangkhathat

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Wilms’ tumor; Chemotherapy resistance; Biomarkers; Somatic mutation; Targeted therapy; Cancer-driver mutation

Online: 17 April 2024 (15:03:01 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.1095.v1

Evolution, Current Trends and Latest Advances of Endoscopic Spine Surgery: A Narrative Review

Sharvari Gunjotikar, Malcolm Pestonji, Masato Tanaka, Tadashi Komatsubara, Shashank J Ekade, Ahmed Heydar, Huynh Kim Hieu

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Endoscopic spinal surgery; full endoscopy; Biportal endoscopy; Lumbar endoscopy; Thoracic endoscopy; Cervical endoscopy

Online: 17 April 2024 (15:01:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1172.v1

Sound-Evoked Neural Activity in Normal Hearing Tinnitus: The Effect of Frequency and Simulation Side

Shahin Safazadeh, Remco A Renken, Marc Thioux, Pim van Dijk

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Tinnitus; Hyperacusis; Tonotopy; Auditory cortices; Parahippocampal gyrus

Online: 17 April 2024 (14:50:29 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202404.1175.v1

Metastatic Prostate Carcinoma in an Early 18th Century South German Abbot—Interdisciplinary Research Reveals Clues to His Final Disease History

Andreas G. Nerlich, Stephanie Panzer, Christine Lehn, Christian Hamann, Simon T. Donell, Oliver K. Peschel

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: cancer; skeleton; stable isotope; radiocarbon; immunohistochemistry

Online: 17 April 2024 (14:44:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1090.v1

Efficacy and Tolerability of Radiosurgery in Treating Benign Meningioma: A Dose Comparison Study from a Single-Center Analysis

Hyun Jeong Cho, Jong Min Lee, Sung Ho Park, Jun Bum Park, Na Young Jung

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: dose; edema; meningioma; stereotactic radiosurgery; toxicity

Online: 17 April 2024 (14:40:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1174.v1

Blood plasma lipidomic profile in atherosclerosis of brachiocephalic arteries

Anastasiia Lomonosova, Daria Gognieva, Aleksandr Suvorov, Artemy Silantiev, Alina Abasheva, Yana Vasina, Magomed Abdullaev, Anna Nartova, Nikolay Eroshchenko, Roman Komarov, Andrey Dzyundzya, Dmitry Shchekochikhin, Philipp Kopylov

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: atherosclerosis; lipidome; stroke; brachiocephalic arteries; atherosclerotic plaque; triacylglycerides; lipidomics; mass-spectrometry

Online: 17 April 2024 (14:36:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1177.v1

Association between the Use of Macrolides in Food-Producing Animals and Mycoplasma pneumoniae Macrolide Resistance: A Global Ecological Analysis

Chris Kenyon

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Macrolide resistance; Mycoplasma pneumoniae

Online: 17 April 2024 (14:33:05 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.1171.v1

Therapeutic Hypothermia for Severe Traumatic Brain Injury: an Overviews of Reviews and Future Prospects

Hitoshi Kobata

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: clinical trials; evacuated hematoma; meta-analysis; therapeutic hypothermia; traumatic brain in-jury

Online: 17 April 2024 (14:32:27 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202404.1145.v1

Real-World Case Series of Efgartigimod for Generalized Myasthenia Gravis：Well-Tailored Treatment Cycle Intervals Contribute to Sustained Symptom Control

Shingo Konno, Takafumi Uchi, Hideo Kihara, HIdeki Sugimoto

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: myasthnia gravis; efgartigimod; individualized treatment; real-world; cycle interval

Online: 17 April 2024 (13:34:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1154.v1

DNA Microarray and Bioinformatic Analysis Reveals the Potential of Whale Oil in Enhancing Hair Growth in a C57BL/6 Mice Model

Junko Shibato, Fumiko Takenoya, Ai Kimura, MIchio Yamashita, Satoshi Hirako, Randeep Rakwal, Seiji Shioda

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: DNA microarray; oil; minoxidil; hair growth; immunostaining; animal model

Online: 17 April 2024 (13:26:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1153.v1

Fracture Resistance Analysis of 3D-Printed and Prefabricated Artificial Teeth for Removable Dentures

Mariya Dimitrova, Rada Kazakova, Angelina Vlahova

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: 3D – printing; CAD/CAM; fracture resistance; removable dentures; prefabricated teeth; fracture toughness

Online: 17 April 2024 (13:23:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1136.v1

Hospitalisations Due to Dental Infection—A Clinical Audit From a Public Hospital

Mafaz Ullah, Muhammad Irshad, Albert Yaacoub, Eric Carter, Stephen Cox

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Dental Caries; Dental Infection; Odontogenic Infection; Hospitalisation; Morbidity

Online: 17 April 2024 (12:01:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1138.v1

Overall Survival and Prognostic Factors in Metastatic Triple-Negative Breast Cancer: an NCDB Analysis

Meghana Kesireddy, Lina Elsayed, Valerie K Shostrom, Priyal Agarwal, Samia Asif, Amulya Yellala, Jairam Krishnamurthy

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: metastatic triple negative breast cancer; overall survival; prognostic factors

Online: 17 April 2024 (12:01:26 CEST)

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Background: Metastatic triple-negative breast cancer (TNBC) is aggressive with a poor median overall survival (OS), ranging from 8 to 13 months. There exists considerable heterogeneity in the survival at the individual patient level. To better understand the survival heterogeneity and improve risk stratification, our study aims to identify the factors influencing survival utilizing a large patient sample in the National Cancer Database (NCDB). Methods: Women diagnosed with metastatic TNBC from 2010 to 2020 in the NCDB were included. Demographic, clinic-pathological, treatment data, and overall survival (OS) outcomes were collected. Kaplan-Meier curves were used to estimate OS. The log-rank test was used to identify OS differences between groups for each variable in the univariate analysis. For the multivariate analysis, the Cox proportional hazard model with backward elimination was used to identify factors affecting OS. Adjusted hazard ratios and 95% confidence intervals are presented. Results: 2,273 women had a median overall survival of 13.6 months. Factors associated with statistically significantly worse OS included older age, higher comorbidity scores, specific histologies, higher number of metastatic sites, presence of liver or other site metastases in those with only one metastatic site (excluding brain metastases), presence of cranial and extra-cranial metastases, lack of chemotherapy, lack of immunotherapy, lack of surgery to distant sites, lack of radiation to distant sites, and receipt of palliative treatment to alleviate symptoms. In the multivariate analysis, comorbidity score, histology, number of metastatic sites, immunotherapy, and chemotherapy had a statistically significant effect on the OS. Conclusions: Through NCDB analysis, we have identified prognostic factors for metastatic TNBC. These findings will help improve prognostication at diagnosis, optimize treatment strategies, and facilitate patient stratification in future clinical trials.

Preprint ARTICLE | doi:10.20944/preprints202404.1116.v1

3-Dimensional Soft Tissue Analysis (3DSTA) of Subcrestally Placed Implants: Relating Biologic Stability with Morphologic Achievements.

Won Chiyun

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Biologic Width; Implant; Emergency Profile; Subcrestal; Subcrestal Placement; CBCT; 3-Dimensional Analysis; Junctional Epithelium; Connective Tissue

Online: 17 April 2024 (11:50:28 CEST)

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Objectives (Purpose) This study aims to evaluate the outcomes of the Subcrestally Placed Implant (SPI) technique in single molar cases, focusing on biological stability and aesthetics. It proposes a schematic model to elucidate the interplay between the biological stability of soft tissues and bone around the SPI and the morphological requisites that Implant Abutment Prostheses (IAP) must fulfill to effectively replace natural teeth. Materials and methods I examined 20 cases using the SPI technique with Internal Platform Switching (IPS) design implants for single molar replacements to assess their stability. Routine check-ups utilized plain panoramic X-rays to measure changes in crestal bone on the mesial and distal sides. Additionally, 10 cases with CBCT X-rays taken more than one year after the initial surgery underwent a novel 3-dimensional soft tissue analysis (3DSTA). Measurements included placement depths (PD), soft tissue thickness (STT) at central (cPD, cSTT) and peripheral areas (pPD, pSTT), the length of the Transitional Zone (TZ) on mesial, distal, facial, and lingual aspects, and crestal bone thickness (CBT) at buccal and lingual sites. Results Panoramic analyses showed minimal changes in crestal bone (mean changes of pPD were less than 0.1 mm) over an average period of 3.3 years. Average measurements were as follows: cPD was 1.7 mm, pPD was 2.7 mm, cSTT was 0.2 mm, pSTT was 0.6 mm, TZ length was 3.8 mm, buccal CBT was 3.0 mm, and lingual CBT was 3.7 mm. Conclusions CBCT analyses of the topographical relationships between soft tissue and crestal bone with IAP for SPIs demonstrated stable results over an average 3-year period. The consistency in the relationship between crestal bone and surrounding soft tissue can be ascribed to biological structural integrity. The study classified peri-implant soft tissues into subcrestal and supracrestal (transitional zone – TZ) segments, exploring their characteristics through dimensional measurements and assessing mechanical resistance. Further histological study is needed to identify specific features of each segment.

Preprint COMMUNICATION | doi:10.20944/preprints202404.1062.v1

Retrospective Analysis to Optimize the Detection of MET Exon 14 Skipping Mutations in Non-Small Cell Lung Cancer

Jang Jih Lu, Shu-Hui Tsai, Lee-Chung Lin, Tsung-Hsi Chueh

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: METex14; Oncomine Focus Assay; reverse transcription PCR

Online: 17 April 2024 (11:36:48 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.1113.v1

Evolving Biomarkers in Kidney Transplantation

Maurizio Salvadori, alberto rosati, Giuseppina Rosso

Subject: Medicine And Pharmacology, Transplantation Keywords: Kidney rejection; biomarkers; subclinical rejection; donor derived cell free DNA; gene expression profile; urinary cytokines

Online: 17 April 2024 (11:18:54 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.1134.v1

Atrial Fibrillation, Atrial Myopathy and Thromboembolism: The Additive Value of Echocardiography and Possible New Horizons for Risk Stratification

Alessandro Campora, Matteo Lisi, Maria Concetta Pastore, Giulia Elena Mandoli, Yu Fu Ferrari Chen, Annalisa Pasquini, Andrea Rubboli, Michael Henein, Matteo Cameli

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Atrial fibrillation; Atrial myopathy; left atrial strain

Online: 17 April 2024 (09:26:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1088.v1

Ultrasonic Evaluation of the Achilles Tendon in Patients Treated for Congenital Clubfoot

Luisella Pedrotti, Barbara Bertani, Gabriella Tuvo, Redento Mora, Fabrizio Nasi, Federica Manzoni, Luca Marin, Francesco Moro, Federica De Rosa

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: ultrasound; congenital clubfoot; tenotomy; subcutaneous rupture

Online: 17 April 2024 (08:59:35 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.1130.v1

Innovation at the Intersection: Emerging Translational Research in Neurology and Psychiatry

Masaru Tanaka, Simone Battaglia, Lydia Giménez-Llort, Chong Chen, Piril Hepsomali, Alessio Avenanti, László Vécsei

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: ageing; Alzheimer’ s disease; Parkinson’ s disease; spinal injuries; stem cells; depression; stroke; deep brain stimulation; machine learning; dysmenorrhea

Online: 17 April 2024 (08:43:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1122.v1

Electronic Heart (ECG) Monitoring at Birth and Newborn Resuscitation

Sarah Mende, Syed Ahmed, Lise DeShea, Edgardo Szyld, Birju A. Shah

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: electrocardiogram; heart rate; neonatal resuscitation

Online: 17 April 2024 (08:33:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1118.v1

Polycyclic Aromatic Hydrocarbons (PAHs) in Grilled Marshmallows

Maciej Maciejczyk, Beata Janoszka, Magdalena Szumska, Beata Pastuszka, Sławomir Waligóra, Aleksandra Damasiewicz - Bodzek, Agnieszka Nowak, Krystyna Tyrpień-Golder

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: PAHs; marshmallows; chromatography

Online: 17 April 2024 (08:08:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1115.v1

Low Number of Baselines γδ T Cells Increase the Risk of SARS-CoV-2 Post-Vaccination Infection

Juan Carlos Andreu-Ballester, Lorena Galindo-Regal, Carmen Cuellar, Francisca López-Chuliá, Carlos García-Ballesteros, Leonor Fernández-Muga, Antonio Llombart-Cussac, María Victoria Domínguez-Márquez

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: SARS-CoV-2; vaccine; antibodies; α β T cells; γ δ T cells

Online: 17 April 2024 (08:00:55 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.1089.v1

Phenolic Compounds from Cherries and Berries for Chronic Disease Management and Cardiovascular Risk Reduction

Filomena Carvalho, Radhia Aitfella Lahlou, Luís Manuel Lopes Rodrigues da Silva

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: cherries; berries; red fruits; phenolic compounds; cardiovascular diseases

Online: 17 April 2024 (07:54:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1114.v1

Live-Birth Incidence of Isolated D-Transposition of Great Arteries – the Shifted Trend Due to Early Diagnosis

Andreea Florentina Stancioi-Cismaru, Marina Dinu, Andreea Carp-Veliscu, Razvan Grigoras Capitanescu, Razvan Cosmin Pana, Ovidiu Costinel Sirbu, Florentina Tanase, Florentina Gratiela Dita, Maria Adelina Popa, Mihai Robert Robu, Mihaela Gheonea, Stefania Tudorache

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: transposition of great arteries; ultrasound; prenatal diagnosis; termination of pregnancy; live-birth incidence; counseling

Online: 17 April 2024 (07:54:03 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.1071.v1

Managing Patients with Immune-Mediated Inflammatory Diseases on Disease-Modifying Antirheumatic Drug Therapy in a COVID-19 Endemic World: A Narrative Review and Expert Insights

Kok Ooi Kong, Pinyo Rattanaumpawan, Nguyen Chau Tuan, Cao Thanh Ngoc, Yee-Chun Chen, Ahlam Al Marzooqi

Subject: Medicine And Pharmacology, Internal Medicine Keywords: COVID-19; SARS-CoV-2; DMARDs; immunocompromised; immune-mediated inflammatory disease; rheumatic disease ;

Online: 16 April 2024 (17:29:36 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.1068.v1

A Review of Fetal Development in Pregnancies with Maternal Type 2 Diabetes Mellitus (T2DM)‐ Associated Hypothalamic‐Pituitary‐Adrenal (HPA) Axis Dysregulation: Exploring Links to Pregestational Prediabetes

Mathuli Ngema, Nombuso Duduzile Xulu, Phikelelani Siphosethu Ngubane, Andile Khathi

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: type 2 diabetes mellitus; prediabetes; pregnancy; Maternal HPA axis; fetal HPA axis; programming; fetal development; placenta; glucocorticoids; metabolic diseases

Online: 16 April 2024 (17:24:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1083.v1

Burnout in Medical Specialists Redeployed to Emergency Care During the COVID-19 Pandemic

Carol Nash

Subject: Medicine And Pharmacology, Emergency Medicine Keywords: burnout; medical specialists; COVID-19; emergency care; public health; coping strategies; Lazarus; interventions; patient care

Online: 16 April 2024 (17:04:22 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202404.1015.v1

Salvage Therapy with Rezafungin for Candida parapsilosis Spondylodiscitis: a Case Report from Expanded Access Program

Giulio Viceconte, Antonio Riccardo Buonomo, Nunzia Esposito, Letizia Cattaneo, Teresa Somma, Maria Michela Scirocco, Ciro Gabriele Mainolfi, Ivan Gentile

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: rezafungin; Candida; spondylodiscitis; osteomyelitis

Online: 16 April 2024 (16:24:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1077.v1

Impact of Nutrient Intake on Body Composition in Very Low Birth Weight Infants Following Early Progressive Enteral Feeding

Rasa Brinkis, Kerstin Albertsson-Wikland, Kastytis Šmigelskas, Aurika Vanckavičienė, Ilona Aldakauskienė, Rasa Tamelienė, Rasa Verkauskienė

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: preterm; very low birth weight; newborn; nutrient intake; body composition; dual X-ray absorptiometry

Online: 16 April 2024 (15:51:26 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202404.1070.v1

Prostate Adenocarcinoma with Signet-Ring Cells and Features of Mucin. A Clinical Case and Literature Review

Migle Sakalauskaite, Ausra Garnelyte, Ignas Civilka, Audrius Dulskas, Marius Kincius, Aušvydas Patašius

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Prostate cancer; signet-ring cell-like carcinoma; features of mucin

Online: 16 April 2024 (15:47:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1044.v1

Real World Safety and Outcome of First Line Pembrolizumab Monotherapy for Metastatic NSCLC with PDL-1 Expression ≥ 50%: A National Italian Multicentric Cohort (“PEMBROREAL” Study)

Alessandro Cafaro, Flavia Foca, Oriana Nanni, Marco Chiumente, Marina Coppola, Alberto Russi, Elena Svegliati, Paolo Baldo, Sabrina Orzetti, Fiorenza Enrico, Federico Foglio, Davide Pinnavaia, Vito Ladisa, Claudia Lauria Pantano, Rosa Lerose, Patrizia Nardulli, Simona Ferraiuolo, Piera Maiolino, Immacolata De Stasio, Federica Gradellini, Anna Rita Gasbarro, Rossella Santeramo, Gisella Carrucciu, Riccardo Provasi, Mario Cirino, Paola Cristina Cappelletto, Elisabetta Fonzi, Alessandra Pasqualini, Stefano Vecchia, Marianna Veraldi, Adele Emanuela De Francesco, Lucio Crinò, Angelo Delmonte, Carla Masini

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Pembrolizumab; Non-small cell lung cancer; real-world data; Immunotherapy; observational study

Online: 16 April 2024 (14:06:32 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202404.1067.v1

Intracranial Manifestation in Classical Hodgkin’s Lymphoma, Case Series and Review of the Literature

Karan Bir Singh, Krithika Muthyala, Daniel Pierotti, Brett Martin, Esther Morrison, Matthew Pearson, Omar Alkharabsheh

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Central nervous system (CNS) 1, intracranial lesion 2, Hodgkin lymphoma 3, relapse 4, refractory 5, neuroimaging 6, ring enhancing 7, immunotherapy 8, chemotherapy 9

Online: 16 April 2024 (14:00:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1040.v1

Effectiveness of a Dual-Task Intervention Involving Exercise and Vocalized Cognitive Tasks

Masahiro Abo, Toyohiro Hamaguchi

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: cross-step training; dual task; MoCA-J; CS-30

Online: 16 April 2024 (13:59:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1035.v1

Elevating Skincare Science: Grape Seed-Extract Encapsulation for Dermatological Care

Maria Leonor de Castro, João Azevedo-Silva, Diana Valente, Adriana Machado, Tânia Ribeiro, João Paulo Ferreira, Manuela Pintado, Oscar Ramos, Sandra Borges, Sara da Silva

Subject: Medicine And Pharmacology, Dermatology Keywords: Grape by-products; Phenolic compounds; Liposomes; Sustainability; Skincare

Online: 16 April 2024 (13:58:05 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.1060.v1

The Platform Technology Approach to mRNA Product Development and Regulation

John Howard SKERRITT, Carolyn Tucek-Szabo, Brett Sutton, Terry Nolan

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: mRNA, vaccine development, drug development, regulation

Online: 16 April 2024 (13:56:02 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202404.1038.v1

Perceptions of COVID-19 Vaccination among Organ Transplant Recipients

River Lerner, Panos Arvanitis, Dorra Guermazi, Dimitrios Farmakiotis

Subject: Medicine And Pharmacology, Transplantation Keywords: COVID-19; vaccine; transplant; vaccine hesitancy; vaccine attitudes; public health

Online: 16 April 2024 (11:39:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1025.v1

Pre-infection Nutritional Status, Oxidative Stress, and One-Year Long COVID Persistence in Patients Undergoing Hemodialysis: A Prospective Cohort Study

Natalia Stepanova, Lesya Korol, Tetyana Ostapenko, Valeriia Marchenko, Olga Belousova, Lyudmila Snisar, Iryna Shifris, Mykola Kolesnyk

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: long COVID; hemodialysis; controlling nutritional status score; undernutrition; oxidative stress; persistence

Online: 16 April 2024 (11:10:40 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.1037.v1

Uterine Tumor Resembling Ovarian Sex Cord Tumor (UTROSCT): A Rare Polyphenotypic Neoplasm

Giovanna Giordano, Debora Guareschi, Elena Thai

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Uterine Tumor Resembling Ovarian Sex Cord Stromal Tumor; Uterine mesenchymal neoplasm; Polyphenotypic Neoplasm; Prognosis.

Online: 16 April 2024 (10:50:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1026.v1

2D Shear Wave Elastography of the Thyroid in Clinically Healthy Dogs of Different Age Groups

Denise J. Ramos, Tamiris Disseli, Diego R. Gomes, Luiz Paulo N. Aires, Stefany T. Tinto, Diana V. V. Salazar, Mariane M. F. Pereira, Brenda S. P. Miranda, Ana Paula L. Oliveira, Bruna B. Lima, Ricardo A. R. Uscategui, Marcus Antônio R. Feliciano

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: dogs; diagnostic imaging; elastography; stiffness; thyroid; ultrasound

Online: 16 April 2024 (10:42:39 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.1013.v1

Computational Pharmaceutics: A Comprehensive Review of Past Achievements, Present Applications, and Future Challenges

Yogesh Chaudhari, Manisha Chaudhari, Abhijeet Puri, Mahesh Nemade

Subject: Medicine And Pharmacology, Pharmacy Keywords: Computational Pharmaceutics, AI, multi-scale modeling, quantum computing, drug
discovery, blockchain frameworks ;

Online: 16 April 2024 (10:32:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0994.v1

The Curious Role of PAI‐1 in Severe OSA

Tea Friščić, Edvard Galić, Domagoj Vidović, Petrana Brečić, Igor Alfirević

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: plasminogen activator inhibitor-1; obstructive sleep apnea; continuous positive airway pressure; atherogenesis; fibrinolytic capacity

Online: 16 April 2024 (07:41:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1003.v1

Ending an Odyssey? The Psychosocial Experiences of Parents after the Genetic Diagnosis of a Mitochondrial Disease in Children

Oliver Heath, Emma Hammerl, Anna Spitzinger, Saskia B. Wortmann

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Mitochondrial diseases; genetic diagnosis; value of a diagnosis; diagnostic odyssey; parental attitudes

Online: 16 April 2024 (03:41:30 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0944.v1

Immune Checkpoint Inhibitors: Fundamental Mechanisms, Current Status And Future Directions

Abdullah Younis

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Immune checkpoint inhibitor; ipilimumab; pembrolizumab ;

Online: 16 April 2024 (03:30:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0980.v1

Does the Metabolic Syndrome and Its Components Have Prognostic Significance for Renal and Cardiovascular Outcomes in IgA Nephropathy?

Balázs Sági, Tibor Vas, Botond Csiky, Judit Nagy, Tibor József Kovács

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Chronic kidney disease; IgA nephropathy; Renal function; Metabolic syndrome; Arterial stiffness

Online: 15 April 2024 (14:53:42 CEST)

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Background: Cardiovascular (CV) morbidity and mortality are many times higher in chronic kidney disease (CKD), as well as IgA nephropathy (IgAN), than in the general population. The occurrence of metabolic syndrome (MetS) and metabolic risk factors are independent risk factors for CV disease and renal progression. The study aimed to determine the prognostic role of metabolic profiles in a homogenous group of CKD patients. Methods: One hundred and forty-five IgA nephropathy patients (92 male, 53 female, age 54.7 ± 13 years) with CKD stage 1-4 were investigated and followed for a median of 190 months. The composite (CV and renal) endpoints included all-cause mortality and any CV event such as stroke, myocardial infarction, revascularization (CV), end-stage renal disease, and renal replacement therapy (renal). Results: Patients with MetS had significantly more endpoint events (16/27 patients vs. 15/98 patients, p = 0.001) compared to the nonMetS group. Of the secondary endpoints (CV or renal separately), the rate of the renal and CV endpoints was significantly higher in the MetS group (p = 0.001 and p = 0.029). The primary endpoint independent predictors of survival were dyslipidemia, eGFR, hemoglobin, urine albuminuria, and diabetes mellitus, as determined by Cox regression analysis. Independent predictors of secondary renal endpoint were dyslipidemia, hemoglobin, urine albumin, and eGFR. Predictors of secondary cardiovascular endpoints were gender, BMI, and diabetes. Kaplan-Meier curves showed significant differences in MetS and non-MetS when examined at the combined endpoints (CV and renal) or at each endpoint separately. The primary endpoint rate increased significantly with the increased number of MetS components (MetS comp. 0 vs. MetS comp. 2+, primary endpoints, p = 0.012). Conclusion: Our results showed that the metabolic profile has a prognostic role not only for renal endpoints but also for CV endpoints in IgAN. BMI, hyperuricemia, hypertension, and diabetes have a predictive value for the prognosis of IgA nephropathy.

Preprint REVIEW | doi:10.20944/preprints202404.0971.v1

The New Horizon of Antipsychotics beyond the Classic Dopaminergic Hypothesis—The Case of the Xanomeline-Trospium Combination: A Systematic Review

Octavian Vasiliu, Beatrice Budeanu, Mihai Stefan Catanescu

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: xanomeline; trospium; schizophrenia; Alzheimer’s disorder; psychoses; acetylcholine; muscarinic receptors; antipsychotics; dopaminergic hypothesis

Online: 15 April 2024 (14:36:30 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202404.0976.v1

A Novel Presentation: Epsilon Waves in the Electrocardiogram of a Patient with Dravet Syndrome Without Structural Heart Disease

Alejandro Jesús Bermejo Valdés, Jessica Archer Jiménez

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Dravet syndrome; epsilon waves; arrhythmogenic right ventricular dysplasia; sudden unexpected death in epilepsy; SCN1A gene

Online: 15 April 2024 (14:22:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0978.v1

The Increasing Role of the Allergist in the Management of Infusion Reactions at the Oncology Day Hospital

Julian Borrás Cuartero, Maria Cruz Torres Gorriz, Cristina Isabel Stein Coronado, Adrian Germán Sánchez, Cristina Giovanna Pesántez Méndez, Maria Dolores Latorre Ibáñez, Ernesto Enrique

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: drug allergy; rapid drug desensitization; same‐day desensitization; chemotherapy allergy; personalized &; precision medicine

Online: 15 April 2024 (14:17:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0982.v1

MiR-449a: A Potential Biomarker for Vocal Function Preservation in Combination Therapy for Laryngeal Cancer

Amal F. Gharib, Abdulraheem Almalki, Amani A. Alrehaili, Afaf Awwadh Alharthi, Ohud Alsalmi, Rasha L. Etewa, Mutaib M. Mashraqi, Shaimaa A Alharthi, Wael H Elsawy

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: laryngeal squamous cell carcinoma (lscc); chemotherapy; radiation therapy; mir-449a; biomarker

Online: 15 April 2024 (14:07:49 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0968.v1

Peritoneum Adhesion Genetic Determinism

Mirela Lungu, Iuliana-Laura Candussi, Claudiu N Lungu, Mihaela C Mehedinti

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: peritoneum, adhesion , adhesion genes, peritonitis, reintervention.

Online: 15 April 2024 (13:49:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0901.v1

Impact of Withdrawal of SGLT2 Inhibitors on Clinical Outcomes in Patients with Heart Failure

Masaki Nakagaito, Teruhiko Imamura, Ryuichi Ushijima, Makiko Nakamura, Koichiro Kinugawa

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: heart failure; SGLT2 inhibitor; hospitalization; medical cost

Online: 15 April 2024 (11:36:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0961.v1

The Preventive Potential of the Mycelial Submerged Culture of Ophiocordyceps sinensis against Neurodegenerative Diseases and Its Possible Active Compounds

Hsien-Chi Huang, Yu-Juan Shi, Thuy-Lan-Thi Vo, Tai-Hao Hsu, Tuzz-Ying Song

Subject: Medicine And Pharmacology, Complementary And Alternative Medicine Keywords: Ophiocordyceps sinensis; neurodegenerative disease; microglial; anti-inflammatory; cytokines; submerged culture

Online: 15 April 2024 (11:29:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0942.v1

Evaluation of Effect of Different Insertion Speeds and Torques on Implant Placement Status and Removal Torque in Polyurethane Dense D1 Bone Model

Zeynep Dilan Orhan, Levent Ciğerim

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: polyurethane modal; polyurethane foam; polyurethane plate; dental implant; insertion torque; removal torque; implant placement status

Online: 15 April 2024 (10:51:10 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0950.v1

Bridging the Divide – a Review on the Implementation of Personalized Cancer Medicine

Michele Masucci, Ingemar Ernberg, Claes Karlsson, Lennart Blomqvist Blomqvist

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: individualised medicine; precision medicine; personalized medicine; stratified medicine; translational cancer research; cancer care; oncology; evidence based medicine; team science; management; scientific leadership; organization

Online: 15 April 2024 (10:45:33 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202404.0934.v1

Pentoxifylline and Norcantharidin Modify p62 Expression in 2D and 3D Cultures of B16F1 Cells

José Luis González-Quiroz, Juan Moisés Ocampo-Godínez, Victoria Noemi Hernández-González, Ruth Angélica Lezama, Elba Reyes-Maldonado, Armando Vega-López, María Lilia Domínguez-López

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Melanoma; 3D cultures; autophagy; p62; spheroids

Online: 15 April 2024 (10:20:48 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0951.v1

CXCR4: From Signaling to Clinical Applications in Neuroendocrine Neoplasms

David Sanchis-Pascual, María Isabel Del Olmo-García, Stefan Prado-Wohlwend, Carlos Zac, Ángel Segura Huerta, Javier Hernández-Gil, Luis Martí-Bonmatí, Juan F. Merino-Torres

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: CXCR4; CXCL12; cancer; neuroendocrine neoplasm; radiotracer

Online: 15 April 2024 (10:16:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0937.v1

Incidence of Thyroid Cancer in Bethesda III Thyroid Nodules: A Retrospective Analysis at a Single Endocrine Surgery Center

Iyad Hassan, Lina Hassan, Nahed Balalaa, Mohammad Askar, Hussa Alshehhi, Mohamed Almarzooqi

Subject: Medicine And Pharmacology, Surgery Keywords: FNAC, Bethesda classification, thyroid cancer; indeterminate nodules, thyroid nodules; ultrasound guided biopsy, thyroidectomy; 0

Online: 15 April 2024 (10:08:52 CEST)

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Background: Fine-needle aspiration cytology (FNAC) is widely used to diagnose and monitor thyroid nodules. The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) is the standard for interpreting FNAC specimens. The risk of malignancy in Bethesda III nodules also known as Atypia of Undetermined Significance (AUS) varies significantly throughout several studies published worldwide. This retrospective study examines the risk of cancer in thyroid FNAC categorized as Bethesda III, as identified in the final histopathology of thyroidectomy specimens at a single endocrine surgery center. Methods: This retrospective cohort analysis included 1038 consecutive patients who underwent elective thyroid surgery with complete follow up data between January 2020 and March 2024. Preoperative data on clinical and pathological characteristics have been collected. The final histopathology report from the thyroidectomy specimen was compared to the results of the preoperative FNAC on nodules that were judged to be Bethesda category III. Statistical methods were performed using SPSS version 29. Results: A total of 670 ultrasound-guided FNACs (64.5%) performed during the study period were included in the final analysis. The study population was predominantly female, represented by 79.6% of patients with a mean age of 42.5 (SD 12.1), while 20.4% were male and significantly older with mean age 45.13 years (p = 0.02). The FNAC inadequacy rate was 5.1%, which was associated with a high risk of malignancy (6 out of 34, 17.6%). Out of the total sample size of 170 patients classified as group III, 57 were found to have malignancies in final surgical histopathology, representing 33.5% of the cases within this category. The secondary gender-related outcome analysis showed that female patients classified under the Bethesda II category had a significantly higher risk of malignancy, with a rate of 21.2%, compared to males who had a malignancy rate of 3.4% in the same Bethesda category (p = 0.001, chi square test). However, female had more better prognostic non-invasive tumors than male (p = 0.02, chi square test). Conclusion: The study's results indicate that Bethesda categories II and III are associated with a higher risk of malignancy in comparison to the reports of the000 first and third editions of the TBSRTC, particularly for female patients classified under category II.

Preprint ARTICLE | doi:10.20944/preprints202404.0919.v1

Bacterial Thrombolytic Enzyme Synthesis and Screening from Several Egyptian Soil Conditions

Mohammed Kassab

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: fibrinolytic; enzyme; thrombosis; screening; myocardial infarction

Online: 15 April 2024 (10:03:01 CEST)

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Thromboembolic conditions, such as stroke and myocardial infarction [MI], are the primary causes of mortality globally. High efficiency was demonstrated by fibrinolytic enzymes isolated from microbial sources in dissolving various blood clots. The study aimed to investigate and produce bacterial fibrinolytic enzymes from various Egyptian soil conditions using recombinant DNA technology. Fifty soil samples were examined to determine the production of fibrinolytic enzymes. The plasmin plate technique assessed the thrombolytic activities of the strong fibrinolytic enzyme-producing bacterial isolates. In addition to determining the molecular mass using a mass spectrometer and the western blot method, the activity and thermostability of the enzymes were characterized. An affinity chromatography approach was used to purify the fibrinolytic enzymes. However, bacterial recombinant DNA technology produced the pure bacterial fibrinolytic enzyme. Several dosage formulations for the formulation of fibrinolytic enzymes were tested. By using affinity chromatography and the SDS-PAGE test, the isolated bacterial fibrinolytic enzyme in this investigation was almost 83% pure. Bacillus cereus ATCC 4342 was identified as the predominant bacterial isolate secreting fibrinolytic enzymes. It was discovered that the fibrinolytic enzyme activity of fifty soil samples ranged from 0.167 U/ml to 1.853 U/ml. The extracellular enzyme extracted from Bacillus cereus culture supernatant demonstrated a relatively stable fibrinolytic activity over 18 hours at a pH range of 7.4–10, as well as stability with maximum productivity at 43℃ for over 60 minutes. In this investigation, the enzyme was referred to as Fibrin-proteinase[ FP]. The fibrin clots were directly thrombolyzed by the FP. The calculated values for the specific activity and molecular mass of the FP were approximately 40.71 units/mg of protein and approximately 30 KDa, respectively. It was observed that the presence of Fe+3 marginally boosted protease activity, but the presence of EDTA decreased it. On the other hand, adding monovalent cations like K+1 and Na+1 significantly increased the fibrinolytic activity of FP. The enzyme exhibited activity throughout the temperature range of 20 to 65℃, peaking at 55℃. The ideal range for the generation of protease was 35–43℃ and 8.0–10. The thermostable fibrinolytic enzyme FP, which was isolated from Bacillus cereus ATCC 4342 in various soil environments in Egypt during the current study, was a promising fibrinolytic enzyme because it demonstrated a more extensive and effective fibrinolytic activity and fewer side effects than the fibrinolytic enzymes that are currently available worldwide. It is advised that further research be done on optimizing the right formulation of bacterial fibrinolytic enzymes in the future to help dissolve different types of blood clots and, as a result, lower the high death rate that exists worldwide.

Preprint ARTICLE | doi:10.20944/preprints202404.0938.v1

Zingiber Officinale and Azadirachta Indica Partially Ameliorates Paracetamol Induced Liver Damage: Rodent Modeling Study

Shafaq Sana, Muhammad Tauseef Sultan, Ahmad Mujtaba Noman, Muhammad Israr, Rizwan Azhar, Codrut Ciurea, Marius Irimie, Radu Necula

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: acetaminophen; liver damage; ginger; neem; Medicinal Plants; liver function test

Online: 15 April 2024 (09:51:31 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0907.v1

Emerging Roles of Exosomes in Stroke Therapy

Anthony Larson, Dilmareth N. Rodriguez, Andrew Crane, Dana Larocca, Walter C. Low, Andrew W. Grande, Jieun Lee

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: stroke; exosomes; stem cells; stroke therapy

Online: 15 April 2024 (09:46:38 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202404.0887.v1

Saving High-Risk Patients from COVID-19 Severity and Death Mainly with Plant-Based Diets and Supplements

Dasaad Mulijono

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: plant-based diet; supplement; COVID-19; inflammation; cardiometabolic; antioxidant; anti-viral; anti-thrombotic

Online: 15 April 2024 (09:33:38 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202404.0868.v1

IgA Nephropathy with Hepatitis B Infection: A Rare Case of Infection and Autoimmunity

Simoni Shah, Heer Shah, Anushree Doshi, Vismit Gami, Dev Desai

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: IgA nephropathy; Hepatitis B Infection; Autoimmune; Hematuria

Online: 15 April 2024 (09:05:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0899.v1

Totally Endoscopic Replacement of the Ascending Aorta and the Aortic Root including the Aortic Valve via Right Mini-Thoracotomy: A Multicenter Study

Marwan Hamiko, Saad Salamate, Maedeh Ayay Nassari, Andre Spaeth, Sami Sirat, Mirko Doss, Mohamed Amer, Miriam Silaschi, Ali El-Sayed Ahmad, Farhad Bakhtiary

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: right minithoracotomy; endoscopic surgery; minimally invasive aortic replacement; minimally invasive aortic root replacement

Online: 15 April 2024 (09:00:07 CEST)

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Background: Recently, minimally invasive access via right-anterolateral mini-thoracotomy (RAMT) has been gaining popularity in cardiac surgery. This approach is also an option for sur-geons performing aortic surgery. Aim of the study is to present our surgical method highlighting the total endoscopic minimally invasive approach via RAMT for replacement of the ascending aorta (AAR) with or without involvement of the aortic root and the aortic valve. Methods: Clini-cal data of 44 patients from three participating institutions with AAR with or without involving the aortic valve or aortic root via RAMT between April 2017 and February 2024 were retrospec-tively analyzed. According to surgical procedure patients were divided in group A with only AAR and group B with concomitant valve or root replacement. Operative time, length of ventila-tion, perioperative outcome, length of intensive care unit (ICU) as well as postoperative hospital stay, and mid- and long-term results were retrospectively analyzed. Results: Mean age was 61.4 ± 10.7 years old with a frequency of male gender (63.6%). Mean cardiopulmonary bypass (CBP) time and aortic cross-clamping time was 94.9 ± 32.5 min. and 63.8 ± 25.9 min., respectively. CPB and aortic clamp time were significantly lower in group A. In the first 24 hours the mean drain-age volume was 790.3 ± 423.6 ml. Re-thoracotomy due to bleeding was zero. Sternotomy could be avoided in all patients. Patients stayed 35.9 ± 23.5 hrs at ICU and were discharged 7.8 ± 3.0 days following surgery from hospital. Mean ventilation time was 5.8 ± 7.6 hrs. All patients survived and 30-day mortality was 0.0%. At a median follow-up time of 18.2 months, all patients were alive. The results were similar in both groups. Conclusions: The full endoscopic RAMT approach with 3D visualization is a safe and feasible technique which can be transferred in the field of aor-tic surgery without compromising surgical quality, postoperative outcomes, or patient safety when performed by an experienced team in a high-volume center.

Preprint ARTICLE | doi:10.20944/preprints202404.0892.v1

Predictive Score for Advanced Colorectal Neoplasia Based on Cardiovascular and Colorectal Cancer Risk Factors

Lara M. Ruiz Belmonte, Patricia Carrera-Lasfuentes, Alberto Cebollada-Solanas, Carmelo Scarpignato, Angel Lanas, Carla J. Gargallo-Puyuelo

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: colorectal neoplasia; cardiovascular risk; risk factors; predictive score

Online: 15 April 2024 (08:56:05 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0905.v1

Particles in Exhaled Air (PExA): Clinical Uses and Future Implications

Thomas Roe, Siona Silveira, Zixing (Hings) Luo, Eleanor L. Osborne, Ganapathy Senthil Murugan, Michael P. W. Grocott, Anthony Postle, Ahilanandan Dushianthan

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: PExA; particles in exhaled air; asthma; acute respiratory distress syndrome

Online: 15 April 2024 (08:51:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0927.v1

Manufacture of Corallopyronin B Antibiotic from Heterogeneous Soil Environments in Egypt

Mohammed Mahmoud Shawky Kassab

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Corallopyronin B; Infection; Antimicrobial; Resistance; Myxobacteria

Online: 15 April 2024 (08:49:18 CEST)

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Background: Antibiotic resistance is an urgent issue everywhere in the globe. It is necessary to look into new sources of antibiotics to address this issue. Aim of the study: studying the purification of Corallopyronin B from various soil conditions in Egypt, as well as the antibacterial effectiveness of Corallopyronin B in preclinical animal testing and randomized human clinical trials phases 1/2. Type of the study: Screening experimental study. Methodology: Several soil conditions in Egypt were examined to create bacterial isolates that generated the antibiotic chemical Corallopyronin B. Using reversed-phase HPLC, Myxopyronin B was purified. The test antibiotic's minimum inhibitory concentration( MIC) and in vitro antibacterial activity were ascertained using the paper disc diffusion assay and the broth microdilution technique. Furthermore, in stages 1/2 of randomized clinical trials including human and animal models, pharmacokinetics, adverse drug reactions, and the in vivo antibacterial spectrum were discovered. Results: The soil bacterial isolate Corallococcus coralloides DSM 2259, which was grown on a Casein yeast peptone( CYP) plate, produced Corallopyronin B from its culture supernatant. At MICs more than 100 mcg/ml, the test antibiotic inhibited the growth of many Gram -ve bacteria, including Escherichia coli, while also preventing the growth of numerous Gram +ve bacteria, with MICs ranging from 1 to 10 mcg/ml. Eukaryotic cells, on the other hand, including those in humans and fungi, were unharmed. The test antibiotic was shown to have a bactericidal effect by inhibiting bacterial DNA-dependent RNA polymerase( RNLP). In phases 1/2 of randomized human clinical trials, when 600 mg of the dose per 70 kg of body weight was administered SC, the Cmax was 8.6 mcg/ml at Tmax 1 hour; T1/2 reached 136 min following first-order kinetics of elimination. It stopped acting around 6-7 hours after SC was administered. In the preclinical and randomized human clinical trial phases 1/2, less than 6 percent of experimental candidates had uncommon toxicity, which showed up as reduced bile flow. Protein binding with plasma albumin was detected which reached about 83%. Conclusion: The current work was noteworthy since it involved the production of the bactericidal antibiotic Corallopyronin B from Corallococcus coralloides DSM 2259 which was isolated from several soil environments in Egypt.

Preprint ARTICLE | doi:10.20944/preprints202404.0869.v1

Nutritional Trends in Cystic Fibrosis: Insights from the Italian Cystic Fibrosis Patient Registry

Donatello Salvatore, Rita Padoan, Annalisa Amato, Marco Salvatore, Giuseppe Campagna

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: cystic fibrosis, nutrition, obesity

Online: 15 April 2024 (08:07:15 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202404.0866.v1

First Clinical Experience with a New Device for the Removal of Cochlear Schwannoma

Christoph J. Pfeiffer, Conrad Riemann, Rayoung Kim, Lars Uwe Scholtz, Mathias Schuermann, Ingo Todt

Subject: Medicine And Pharmacology, Otolaryngology Keywords: cochlear implant; intra-cochlear intra-labyrinthine schwannoma; tissue removal device

Online: 15 April 2024 (08:00:52 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0913.v1

Statins for Heart Failure with Preserved Ejection Fraction: Current Evidence and Perspectives

Artem Ovchinnikov, Alexandra Potekhina, Tatiana Arefieva, Anastasiia Filatova, Fail Ageev, and Evgeny Belyavskiy

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: statins; heart failure with preserved ejection fraction; inflammation; diastolic dysfunction; prognosis

Online: 15 April 2024 (07:25:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0903.v1

Retrospective Analysis of Clostridioides difficile Infection Rates in Hospitalized Patients during COVID-19 Pandemic. A Unicenter Study in Reus, Spain

Simona Iftimie, Ana F. López-Azcona, Mireia Corchero-Valverde, Antonio Peralta-Vázquez, Laia Revuelta López-Cordón, Carles García-Cervera, Luís Manuel Fernández-Domínguez, Jordi Camps, Jorge Joven, Antoni Castro

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Cancer; Clostridioides difficile; COVID-19; Infectious diseases; Pandemic; Risk factors

Online: 15 April 2024 (05:37:35 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0900.v1

Human Placental Schistosomiasis – a Review of the Literature

Jacob Gerstenberg, Sasmita Mishra, Martha Holtfreter, Joachim Richter, Saskia Dede Davi, Dearie G. Okwu, Michael Ramharter, Johannes Mischlinger, Benjamin T. Schleenvoigt, For TropNet

Subject: Medicine And Pharmacology, Tropical Medicine Keywords: Schistosomiasis; Placenta; Adverse Birth Outcomes; Pregnancy; Praziquantel

Online: 15 April 2024 (05:32:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0893.v1

Landmark Evaluation of Transferrin Glycoforms: Pioneering Congenital Glycosylation Disorder Diagnosis in Cuba

Alejandro Jesús Bermejo Valdés, Jessica Archer Jiménez

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Congenital disorders of glycosylation; CDG; N-glycosylation; serum transferrin isoelectric focusing

Online: 15 April 2024 (05:14:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0882.v1

Acute Kidney Disease following Acute Kidney Injury in Children—A Retrospective Observational Cohort Study on Risk Factors and Outcomes

Flavia Chisavu, Lazar Chisavu, Viviana Ivan, Adalbert Schiller, Adelina Mihaescu, Luciana Marc, Ramona Stroescu, Ruxandra Maria Steflea, Mihai Gafencu

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: acute kidney disease; children; mortality; chronic kidney disease

Online: 15 April 2024 (04:46:15 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202404.0878.v1

How to Regress or Reverse Coronary Artery Disease

Dasaad Mulijono, Albert Manggading Hutapea, I Nyoman Ehrich Lister

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: plant-based diet; atherosclerotic; vulnerable plaque; supplements

Online: 15 April 2024 (04:12:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0867.v1

Stratification of Homologous Recombination Deficiency-Negative High-Grade Ovarian Cancer by the Type of Peritoneal Spread into Two Groups with Distinct Survival Outcome

Simon Schnaiter, Esther Schamschula, Juliane Laschtowiczka, Heidelinde Fiegl, Johannes Zschocke, Alain Zeimet, Katharina Wimmer, Daniel Reimer

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Personalized medicine; genomic instability; Miliary disease; epithelial ovarian cancer; PARP inhibitor; staging

Online: 12 April 2024 (21:20:09 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints202404.0855.v1

A Hypothesis: Covid-Induced Micro-clots Are Formed Only during Sero-Conversion

R Anthony Vere Hodge

Subject: Medicine And Pharmacology, Other Keywords: Long-covid; Micro-clots; Sero-conversion; Aspirin; Platelets; Spike protein; Vaccine

Online: 12 April 2024 (14:36:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1140.v2

The Surprises of Molecular Testing in Neurofibromatosis Type 1: Rare Association between Two Mutational Variants

Aurora Jurca, Codruta Diana Petchesi, Maria Claudia Jurca, Diter Atasie, Dan Bembea, Alexandru Daniel Jurca

Subject: Medicine And Pharmacology, Other Keywords: neurofibromatosis type 1; cone-rod dystrophy; molecular diagnosis; rare association

Online: 12 April 2024 (14:32:30 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202404.0825.v1

Iron Supplementation in the Treatment of Cocaine Use Disorder

Sarah Hughes, Olivia Hill, Raja Mogallapu

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Iron Deficiency; Cocaine; Substance Use Disorder

Online: 12 April 2024 (13:33:57 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0852.v1

Ginkgo biloba: A Leaf of Hope in the Fight Against Alzheimer’s Dementia: Clinical Trial Systematic Review

Guilherme Lopes de Oliveira Pagotto, Livia Maria Oliveira dos Santos, Najwa Osman, Caroline Barbalho Lamas, Lucas Fornari Laurindo, Karina Torres Pomini, Leila M. Guissoni, Enzo Pereira de Lima, Ricardo de Alvares Goulart, Virginia M. C. Strozze Catharin, Rosa Direito, Masaru Tanaka, Sandra Maria Barbalho

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Alzheimer disease; cognitive dysfunction; Gingko biloba; EGb 761; terpenoids; flavonoids

Online: 12 April 2024 (12:37:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0842.v1

Prognostic Value and Limits of Heart Rate and QT-Corrected in A Large Population

Paolo Giovanardi, Cecilia Vernia, Sara Roversi, Enrico Tincani, Giuseppe Spadafora, Federico Silipo, Claudio Giberti

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: electrocardiogram; QT corrected; Bazett; heart rate; all-cause death; mortality

Online: 12 April 2024 (09:54:01 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202404.0822.v1

Synovial Sarcoma of the Ethmoid Sinus with Extension to the Cavernous Sinus: A Case Report and Literature Review

Haneen Hisham Sharabati, Laila Riyad Innab, Saja Shawki Hussein, Ayman Ahmad Salman, Anis Munir Naser, Izzeddin Abdulsamee' Bakri

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Ethmoid sinus; Synovial sarcoma; Stroke; Cavernous sinus; Surgery

Online: 12 April 2024 (04:54:00 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202404.0817.v1

Primary Sjogren’s Syndrome: A Rare Case of Hypokalemic Periodic Paralysis

Simoni Shah, Zeal Soni, Nilay Suthar, Dev Desai

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Sjogren syndrome; periodic paralysis; Hypokalemia; autoimmine

Online: 12 April 2024 (04:51:02 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0819.v1

Understanding Macrophage Complexity in Metabolic Dysfunction-associated Steatotic Liver Disease: Transitioning from the M1/M2 Paradigm to Spatial Dynamics

Forkan Ahamed, Natalie Eppler, Elizabeth Jones, Yuxia Zhang

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: macrophages; diversity; Kupffer cell; monocyte-derived macrophage; spatial dynamics; metabolic dysfunction-associated steatotic liver disease (MASLD)

Online: 12 April 2024 (04:44:38 CEST)

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Preprint INTERESTING IMAGES | doi:10.20944/preprints202404.0815.v1

Magnetic Resonance Imagining Presentation of the Achilles Tendon Injuries – Examples from Our Practice

Stefan Stankov, Vladimir Živković, Dušan Stanković, Saša Bubanj, Šćepan Sinanović, Bojan Bjelica, Nikola Aksović, Emir Bilalović, Tatiana Dobrescu, Adina-Camelia Şlicaru

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: Achilles Tendon Injuries, Screening Techniques, Interesting Images, athletes and non-athletes, case reports

Online: 12 April 2024 (04:41:58 CEST)

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Medicine and Pharmacology