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Preprint ARTICLE | doi:10.20944/preprints202404.0892.v1

Predictive Score for Advanced Colorectal Neoplasia Based on Cardiovascular and Colorectal Cancer Risk Factors

Lara M. Ruiz Belmonte, Patricia Carrera-Lasfuentes, Alberto Cebollada-Solanas, Carmelo Scarpignato, Angel Lanas, Carla J. Gargallo-Puyuelo

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: colorectal neoplasia; cardiovascular risk; risk factors; predictive score

Online: 15 April 2024 (08:56:05 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0819.v1

Understanding Macrophage Complexity in Metabolic Dysfunction-associated Steatotic Liver Disease: Transitioning from the M1/M2 Paradigm to Spatial Dynamics

Forkan Ahamed, Natalie Eppler, Elizabeth Jones, Yuxia Zhang

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: macrophages; diversity; Kupffer cell; monocyte-derived macrophage; spatial dynamics; metabolic dysfunction-associated steatotic liver disease (MASLD)

Online: 12 April 2024 (04:44:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0812.v1

Genetic Markers of Helicobacter pylori Antibiotic Resistance in Moscow

Natalia Bodunova, Larisa Tsapkova, Vera Polyakova, Irina Baratova, Konstantin Rumyantsev, Natalia Dekhnich, Karina Nikolskaya, Margarita Chebotareva, Irina Voynovan, Elena Parfenchikova, Galina Pronina, Ekaterina Chernikova, Dmitry Bordin

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Helicobacter pylori; antibiotic resistance; methods for determining H. pylori resistance; molecular genetic diagnostics; phenotypic methods for determining antibiotic resistance; geographical distribution of H. ; pylori antibiotic resistance

Online: 12 April 2024 (03:53:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0776.v1

Prior Appendicectomy and Gut Microbiota Reestablishment in Adults After Bowel Preparation and Colonoscopy

Amelia J McGuinness, Martin O'Hely, Douglas Stupart, David Watters, Samantha L Dawson, Christopher Hair, Michael Berk, Mohammadreza Mohebbi, Amy Loughman, Glenn Guest, Felice N Jacka

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Bowel preparation; gut microbiota; colonoscopy; appendix; appendicectomy; appendectomy.

Online: 11 April 2024 (10:10:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1832.v1

Development and Validation of a Machine Learning Model for Predicting Endoscopic Intervention in Upper Gastrointestinal Bleeding

Omran A. Abu-Dhaim, Abdel-Latif Mughrabi Sabbagh, Yaman B. Ahmed, Daoud O. Al Aruri, Owais Ghammaz, Yaser M. Rayyan, Omar Alqudah, Mu'taz M Massad, Karam I. Khraim, Mustafa Q. Khasawneh, Laith F. Alquran, Batool N. AlQadri, Qasim N. Mhaidat, Hamza Alhawamleh, Own M. Al-Ajlouni, Khalil I. Hamarneh, Mohammad A. Hussein, Lina N. Mustafa, Basel E. Al-Bkoor, Amro Alkhatib, Layla Abu Joudeh, Osama Alghafri, Niazy Abu Farsakh

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: upper gastrointestinal bleeding; machine learning; endoscopic intervention; gradient boosting classifier; Glasgow Blatchford Score; Rockall Score

Online: 29 March 2024 (11:53:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1795.v1

Differential Diagnosis of Solid Pancreatic Lesions Using Detective Flow Imaging Endoscopic Ultrasonography

Haruo Miwa, Kazuya Sugimori, Shoichiro Yonei, Hayato Yoshimura, Kazuki Endo, Ritsuko Oishi, Akihiro Funaoka, Hiromi Tsuchiya, Takashi Kaneko, Kazushi Numata, Shin Maeda

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Detective Flow Imaging; Pancreatic Cancer; Endoscopic Ultrasonography

Online: 29 March 2024 (05:17:37 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202403.1602.v1

Rhodotorula mucilaginosa Fungaemia in an Infected Biloma Patient Following a Traumatic Liver Injury

Mohammad Nizam Mokhtar, Raha Abdul Rahman, Farah Hanim Abdullah, Izzuddin Azaharuddin, Azarinah Izaham, Chuan Hun Ding

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Biloma; Rhodotorula mucilaginosa; Fungaemia; Liver; Trauma

Online: 26 March 2024 (14:35:36 CET)

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Preprint REVIEW | doi:10.20944/preprints202403.0945.v1

Exploring Advanced Therapies for Primary Biliary Cholangitis: Insights from the Gut Microbiota-Bile Acid-Immunity Network

Ziqi Guo, Kun He, Ke Pang, Daiyu Yang, Chengzhen Lyu, Haifeng Xu, Dong Wu

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: primary biliary cholangitis; gut microbiota; bile acid

Online: 15 March 2024 (16:01:10 CET)

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Preprint REVIEW | doi:10.20944/preprints202403.0935.v1

Advancing Hepatitis C Elimination in Africa: Insights from Egypt

IZERE Salomon, Sibomana Olivier, Ndayambaje Egide

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Hepatitis C; Elimination; Africa; Egypt; Direct-acting antivirals; Policy insights; Hepatitis virus

Online: 15 March 2024 (14:40:24 CET)

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Preprint REVIEW | doi:10.20944/preprints202403.0720.v1

Early Onset Gastrointestinal Malignancies: An Investigation into a Rising Concern

Aayush Vishwanath, Shreyas Krishna, Albert P Manudhane, Phil A Hart, Somashekar G Krishna

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: early onset gastrointestinal malignancies; young adult cancer; early onset colorectal cancer; early onset esophageal cancer; esophageal adenocarcinoma; esophageal squamous cell carcinoma; early onset gastric cancer; early onset pancreatic cancer; early onset liver cancer; gastrointestinal malignancy; hepatocellular carcinoma; BRCA mutation; ATM mutation; MLH1; MSH2; MSH6; PRSS1; early onset biliary malignancy

Online: 12 March 2024 (14:33:15 CET)

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Preprint REVIEW | doi:10.20944/preprints202403.0587.v1

The Many Faces of Metabolic Dysfunction-Associated Fatty Liver Disease Treatment: From the Mediterranean Diet to Fecal Microbiota Transplantation

Ludovico Abenavoli, Maria Luisa Gambardella, Giuseppe Guido Maria Scarlata, Ilaria Lenci, Leonardo Baiocchi, Francesco Luzza

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Steatosis; Probiotics; Gut-liver axis; Leaky gut

Online: 11 March 2024 (09:46:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0396.v1

Food Beliefs and Risk of Orthorexia in Patients with Inflammatory Bowel Disease

Francesca Maria Di Giorgio, Stefania Pia Modica, Marica Saladino, Stefano Muscarella, Stefania Ciminnisi, Piero Luigi Almasio, Salvatore Petta, Maria Cappello

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: inflammatory bowel disease; orthorexia nervosa; eating disorders

Online: 8 March 2024 (01:55:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0332.v1

Differential protective effect of zinc and magnesium for the hepatic and renal toxicity induced by acetaminophen and potentiated with ciprofloxacin in rats

Alexandra Moraru (Ciocan), Diana C. Ciubotariu, Cristina Mihaela Ghiciuc, Catalina Elena Lupusoru, Mihnea Eudoxiu Hurmuzache, Radu Crișan-Dabija

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: magnesium chloride (MgCl2); zinc gluconate (ZnG); liver diseases; kidney diseases

Online: 6 March 2024 (13:55:48 CET)

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Background: The purpuse was to investigate the influence induced by magnesium chloride (MgCl2) and zinc gluconate (ZnG) supplementation on liver and kidney injuries experimentally-induced with acetaminophen (AAPh) and potentiated by ciprofloxacin addition in rats. Material and methods: The experiment was performed on 5 animals groups: group 1 – control, treated for 6 weeks with normal saline, 1mL/kg; group 2 – AAPh, treated for 6 weeks with AAPh, 100 mg/ kg/day; group 3 – AAPh+C, treated AAPh 100 mg/kg/ day for 6 weeks and ciprofloxacin, 50mg /kg/day, only in the last 14 days of the experiment; group 4 – AAPh+C+Mg, with the same treatment as group 3, but, and in the last 14 days, MgCl2 10 mg/ kg/day was added; group 5 – AAPh+C+Zn, with the same treatment as group 3, but, and in the last 14 days, zinc gluconate (ZnG),10 mg/kg/day was added. All administrations were performed by oral gavage. At the end of the experiment, the animals were sacrificed and blood samples were collected for biochemistry examinations. Results: Treatment with AAPh for 6 weeks determined an alteration of the liver function (increases in alanine aminotransferase, aspartate aminotransferase, lactic dehydrogenase and, and gamma-glutamyl transferase) and of renal function (increases in serum urea and creatinine) (P < 0.001 group 2 vs. group 1 for all mentioned parameters). Also, the antioxidant defense capacity was impaired in group 2 vs. group 1 (superoxide dismutase and glutathione peroxidase activity decreased in group 2 vs. group 1, 0.001 < P < 0.01, respectively 0.01 < P < 0.05). The addition of ciprofloxacin, 50 mg/kg/day during the last 14 days resulted in further increases in alkaline phosphatase, alanine aminotransferase, aspartate aminotransferase, urea and creatinine (0.01 < P < 0.05, group 3 vs. group 2). MgCl2 provided a slight protection against liver enzymes increase and a more pronounced protection against the increase in serum urea and creatinine (0.001 < P < 0.01 group 4 vs. group 3). MgCl2 provided a slight protection against the decrease in superoxide dismutase (0.01 < P < 0.05 group 4 vs. group 3), but not against decrease of glutathione peroxidase. The improvement of mentioned parameters could also be seen in case of ZnG, to a higher extent especially in the case of alanine aminotransferase and lactic dehydrogenase (0.01 < P < 0.05 group 5 vs. group 4). Conclusions: This study represents a furthermore proof for beneficial effect of magnesium and zinc salts against toxicity induced by different agents, including antibacterials added to the analgesic and antipyretic acetaminophen; the protection is proven on the liver and kidney’s function; the antioxidant profile improvement has a key role, especially in case of zinc gluconate.

Preprint REVIEW | doi:10.20944/preprints202403.0312.v1

Probiotics in the Treatment of Irritable Bowel Syndrome in General Practice: A Real-World Narrative Review

Franco Ferrarini, Giuseppe Milazzo

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Irritable Bowel Syndrome; Probiotics; General Practice

Online: 6 March 2024 (04:45:49 CET)

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Preprint REVIEW | doi:10.20944/preprints202403.0139.v1

Cross Talk between Gut Microbiota and Immune System: From Pathophysiology to Potential Therapeutic Interventions in Inflammatory Bowel Disease

Elisabetta Bretto, Gian Paolo Caviglia, Giorgio Maria Saracco, Elisabetta Bugianesi, Davide Giuseppe Ribaldone

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: IBD; Crohn’s disease; ulcerative colitis; immunological modulation; microbiota; micobiome; inflammation; pathogenesis; flare immunity

Online: 4 March 2024 (11:13:50 CET)

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Preprint REVIEW | doi:10.20944/preprints202403.0114.v1

The current and prospective adjuvant therapies for hepatocel-lular carcinoma

Jeng-Shiun Du, Shih-Hsien Hsu, Shen-Nien Wang

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Hepatocellular carcinoma (HCC); adjuvant therapy; recurrence; improvement

Online: 4 March 2024 (10:36:35 CET)

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Preprint REVIEW | doi:10.20944/preprints202403.0030.v1

The Role of Cytokines in the Pathogenesis and Treatment of Alcoholic Liver Disease

Giuseppe Guido Maria Scarlata, Carmen Colaci, Marialaura Scarcella, Marcello Dallio, Alessandro Federico, Luigi Boccuto, Ludovico Abenavoli

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: alcohol; oxidative stress; inflammation; gut dysbiosis; biological drugs; probiotics

Online: 4 March 2024 (06:18:36 CET)

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Preprint REVIEW | doi:10.20944/preprints202403.0006.v1

Platelet, Antiplatelet Therapy and Masld: A Narrative Review

Andrea Boccatonda, Lorenza Del Cane, Lara Marola, Damiano D’Ardes, Gianfranco Lessiani, Nicoletta Di Gregorio, Claudio Ferri, Francesco Cipollone, Carla Serra, Francesca Santilli, Fabio Piscaglia

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: cancer; NAFLD; MASLD; aspirin; thromboxane

Online: 1 March 2024 (07:42:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1735.v1

Onion Polyphenols as Multi-Target-Directed Ligands in MASLD – a Preliminary Molecular Docking Study

Maria Rosaria Paravati, Anna Caterina Procopio, Maja Milanović, Giuseppe Guido Maria Scarlata, Nataša Milošević, Maja Ružić, Nataša Milić, Ludovico Abenavoli

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: MASLD; liver; onion; nutraceutics; in silico research; molecular docking.

Online: 29 February 2024 (12:02:44 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.1627.v1

Recently updated role of Chitinase 3-like 1 on various cell types as a major infuencer of chronic inflammation

Emiko Mizoguchi, Takayuki Sadanaga, Linda Nanni, Siyuan Wang, Atsushi Mizoguchi

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: inflammation, pathogenesis, inflammatory bowel disease, asthma, dysbiosis

Online: 28 February 2024 (12:49:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1587.v1

Endoscopic Papillary Balloon Dilation for Children with Common Bile Duct Stones, Especially for Infants: A Literature Review

Katsunori Kouchi, Ayako Takenouchi, Aki Matsuoka, Kiyoaki Yabe, Hiroko Yoshizawa, Chikako Nakata, Jun Fujishiro, Harutoshi Sugiyama

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: endoscopic papillary balloon dilation, common bile duct stone, choledocholithiasis, children, endoscopic retrograde cholangiopancreatography

Online: 28 February 2024 (08:48:37 CET)

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Background: Endoscopic sphincterotomy (EST) has been employed for the endoscopic treatment of common bile duct stones (CBDSs), and a high success rate of stone removal has been reported. However, EST is associated with the risk of bleeding, perforation, and sphincter of Oddi function disruption. To avoid these risks, endoscopic papillary balloon dilation (EPBD) is an option for CBDS. Sphincter of Oddi function preservation decreases long-term biliary infection and gallstone recurrence. EPBD may have advantages in children who require a long follow-up. However, there have been few reports on pediatric cases, particularly in infants. Methods: From September 2017 to December 2023, we performed EPBD for four pediatric CBDSs. The patients were aged from 5 months to 8 years; including two infants aged 5 and 6 months. Furthermore, we reviewed the stone removal rate and complications of 545 ESTs performed at high-volume centers and 13 EPBD-reported cases in children with CBDSs. Results: CBDSs of all patients who underwent EPBD in our institution were successfully removed. No bleeding or perforation was noted, and pancreatitis was observed in three patients. In an analysis of 545 ESTs in children, the stone removal rate was high, ranging from 83% to 100% (mean, 96%). The incidence of pancreatitis was 0%–9.6% (mean, 4.4%), and the grade of pancreatitis was almost mild. The bleeding frequency was 1.3%–5.4% (mean, 2.7%). According to the grade of bleeding, seven and four cases were mild (64%) and moderate (36%), respectively, Compared with adult cases who underwent EST, the frequency of pancreatitis and bleeding was almost similar in children.; however once bleeding occur, it has a higher risk of leading to blood transfusion in children. Stone removal by EPBD in children was 100% successful. All complications were pancreatitis, and its frequency was 46% (6/13 patients, including five mild cases and one moderate case), which is higher than that of EST and adult cases who underwent EPBD. In most children with pancreatitis, pancreatic enzyme levels returned to normal within 2–3 days following EPBD, and no severe cases caused by EPBD were reported. Conclusions: CBDS removal by EPBD in children has a high success rate with very low risk of bleeding and perforation. Although pancreatitis frequently occurs, most cases are mild. Sphincter of Oddi function preservation by EPBD is expected to prevent long-term stone recurrence and biliary tract infection, and EPBD is considered an effective method for CBDS removal in children.

Preprint ARTICLE | doi:10.20944/preprints202402.1605.v1

Autoprobiotics in the treatment of patients with colorectal cancer in the early postoperative period

Elena I Ermolenko, Natalia V Baryshnikova, Galina Alekhina, Alexander Zakharenko, Oleg Ten, Victor A Kashchenko, Nadezhda Lavrenova, Olga Gushchina, Timofey Ovchinnikov, Anastasia Morozova, Anastasia Ilina, Alena B. Karaseva, Anna Tsapieva, Nikita Gladyshev, Alexander V. Dmitriev, Alexander Suvorov

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: microbiome, autoprobiotics, Enterococcus spp., Parvomonas micra, alpha diversity, gut dysbiosis, interleukins

Online: 28 February 2024 (08:05:17 CET)

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Introduction: Despite great advances in the treatment of oncological diseases, the development of medical technologies to prevent or reduce complications of therapy, in particular, those associated with surgery and the introduction of antibiotics remains relevant. The aim of the study: to evaluate the effectiveness of the use of autoprobiotics based on indigenous non-pathogenic strains of Enterococcus faecium and Enterococcus hirae in the complex therapy of colorectal cancer (CRC) in the early postoperative period. Materials and methods: A total of 36 patients diagnosed with CRC were enrolled in the study. The study group (Group A) comprised 24 CRC patients who received autoprobiotic therapy in the early postoperative period, while the control group (Group C) included 12 CRC patients without autoprobiotic therapy.Prior to surgery and between days 14-16 post-surgery, comprehensive evaluations were conducted on all patients, encompassing the following: stool and gastroenterological complains analysis. examination of the gut microbiota (bacteriological study, quantitative polymerase chain reaction, metagenome analysis), analysis of interleukins in serum. Results: The use of autoprobiotics led to decrease dyspeptic complaints after surgery, was associated with absence of postoperative complications, did not cause side effects, led to a decrease in the level of pro-inflammatory cytokines (IL-6 and IL-18) in the blood serum. The use of autoprobiotics led to positive changes in the structure of escherichia and enterococci populations, the elimination of Parvomonas micra, Fusobacterium nucleatum, decrease in the quantitative content of Clostridium perfringens, Akkermansia muciniphila. Metagenomic analysis (16S rRNA) revealed an increase in alpha diversity. Conclusion: The administration of autoprobiotics in the postoperative period is highly effective and safe in the comprehensive treatment of colorectal cancer patients. Future studies will allow the discovery of additional fine mechanisms of autoprobiotic therapy and its impact on the digestive, immune, endocrine and neural systems.

Preprint ARTICLE | doi:10.20944/preprints202402.1509.v1

Insulin-Like Growth Factor Binding Proteins and Cellular Senescence Are Involved in the Progression of Non-alcoholic Fatty Liver Disease and Fibrosis in a Mouse Model

Carolina Guzmán, Miriam G Bautista-Ubaldo, Adriana Campos Espinosa, Ivette I Romero-Bello, Angel Daniel Santana-Vargas, Gabriela Gutierrez-Reyes

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Insulin-like growth factor binding proteins; liver fibrosis; cellular senescence; steatohepatitis; steatosis.

Online: 27 February 2024 (10:06:34 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.1362.v1

Hereditary Hemochromatosis – How Not to Overlook and Properly Manage “Iron People”- a Critical Overview

Agnieszka Szczerbinska, Beata Kasztelan-Szczerbinska, Anna Rycyk-Bojarzynska, Halina Cichoz-Lach

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: hereditary hemochromatosis; iron overload; HFE gene mutation; non-HFE gene mutation; phlebotomy

Online: 25 February 2024 (23:35:08 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.1385.v1

Recent Advancement in Diagnosis of Biliary Tract Cancer through Pathological and Molecular Classifications

Sang-Hoon Lee, Si Young Song

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Biliary tract cancer; cholangiocarcinoma; gallbladder cancer; diagnosis; precision medicine

Online: 23 February 2024 (14:58:36 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202402.1237.v1

Beyond Tumors: Gastric Syphilis Imitating a Gastric Cancer

Claudia Guerrero Muñoz, Andres Castañeda Agredo, Maria Jose Romero Valle, Andrés Mauricio Silva Silva, Marta León del Campo, Claudia Azpirtarte Sanchez, Marta Domínguez Fraga, Manuel Vicente Milán Pilo, Benjamin Arturo Polo Lorduy, Agustina Gonzalez Guirado, Maria Jesus Martin Relloso, Paloma Sanchez-Fayos Calabuig, Orencio Bosch

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Endoscopy; gastric cancer; syphilis

Online: 21 February 2024 (15:33:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0942.v1

ARFI of the Liver and of the Spleen, Combined with Spleen Dimension and Platelet Count in New Ratio Scores, Identifies Cirrhotic Patients with High-Risk Oesophageal Varices

Antonio F.M. Vainieri, Elisa Brando, Antonio De Vincentis, Giulia Di Pasquale, Valentina Flagiello, Paolo Gallo, Francesca Barone, Teresa Massaro Cenere, Evelyn Di Matteo, Antonio Picardi, Giovanni Galati, Claudia Altamura, Carlo Altomare, Paola Balestrieri, Myriam Carpenito, Livio Cortese, Fabio Costa, Alessandro Ferrini, Daria Maggi, Diana Lelli, Antonella Grasso, Simona Mega, Giuseppina Pacella, Andrea Palermo, Claudia L. Piccolo, Simone Scarlata, Lorenzo Schiavoni, Serena Stigliano

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: ARFI; acoustic radiation forced impulse; platelet count; spleen; oesophageal varices

Online: 19 February 2024 (14:51:45 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.0955.v1

A Quest for Survival: a Review of Early Biomarkers for Pancreatic Cancer and the Most Effective Approaches at Present

Muhammad Begawan Bestari, Ignatius Ronaldi Joewono, Ari Fahrial Syam

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: pancreatic cancer; early biomarker; early diagnosis

Online: 19 February 2024 (14:51:22 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.0861.v1

Guidelines on Management of Hereditary Polyposis Syndromes in Pediatric Patients: Agreement, Disagreement and Where it Matters

Taina Hudson, Claudia Phen, Isabel Rojas, Shlomi Cohen, Warren Hyer, Thomas Attard

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: hereditary; pediatric polyp; polyposis; cancer; syndromes

Online: 16 February 2024 (01:54:32 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.0759.v1

Clinical Significance and Remaining Issues of Anti‐ HBc Antibody and HBV Core‐Related Antigen

Yoshihiko Yano, Itsuko Sato, Takamitsu Imanishi, Ryutaro Yoshida, Takanori Matsuura, Yoshihide Ueda, Yuzo Kodama

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: anti-HBc antibody; HBV core-related antigen; HBV

Online: 14 February 2024 (09:11:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0622.v1

High Prevalence and Risk Factors of Significant Hepatic Fibrosis in Omani Hepatitis B Inactive Carriers: A Retrospective Study

Halima H. Al Shuaili, Bushra Awadh Al Mashikhi, Ahmed Al Sinani, Said A. Al-Busafi

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Hepatitis B Inactive Carriers; Hepatic Fibrosis; Prevalence; Risk Factors; Oman

Online: 12 February 2024 (08:53:17 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.0606.v1

Advanced Diagnostic and Therapeutic Endoscopy for Early Gastric Cancer

Mitsuhiro Fujishiro

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: early gastric cancer; gastric cancer screening; endoscopic diagnosis; endoscopic mucosal resection; endoscopic submucosal dissection

Online: 12 February 2024 (08:10:42 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.0493.v1

Global Perspectives on Hepatitis B Vaccination: Challenges, Achievements, and the Road to Elimination by 2030

Said A. Al-Busafi, Ahmed Alwassief

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Hepatitis B; liver disease; WHO; vaccination; elimination; barriers

Online: 8 February 2024 (06:33:33 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202402.0438.v1

A Successful Approach in Diagnosing Shiga - Toxin Producing Escherichia coli -Induced Colitis

Violeta Melinte, Cristina Maria Văcăroiu, Adelina Maria Radu, Miriana Ioana Cismaru, Amalia Loredana Călinoiu, Adina Rusu, Anca Monica Oprescu Macovei, Mihai Ciocîrlan, Elena Cristina Tianu, Luminița Mîrzan, Daniela Elena Mihăilă, Ioana Veronica Trandafir, Claudia Sorina Bugeac Mitacu, Valeriu Gheorghiță

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: STEC, bloody diarrhoea, ischemic colitis, E coli

Online: 7 February 2024 (11:54:06 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.0273.v1

Endoscopic Diagnosis of Small Bowel Tumor

Tomonori Yano, Hironori Yamamoto

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: balloon-assisted enteroscopy; capsule endoscopy; CT enterography

Online: 5 February 2024 (10:54:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0190.v1

Effect of a Gluten Free Diet in Whole Gut Transit Time in Celiac Disease (CD) and Non-gluten Celiac Sensitivity (NGCS) Patients. A Study Using the Wireless Motility Capsule (WMC)

Orestes Cobos-Quevedo, Gildardo Alfonso Hernandez, Xaira Jimena Rivera-Gutiérrez, Peter Grube-Pagola, Jose Maria Remes-Troche

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: celiac disease; gluten; diet; non-celiac sensitivity; wheat

Online: 5 February 2024 (06:59:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0113.v1

Pharmacological Activation of TRPC6 Channel Prevents Colitis Progression.

Kazuhiro Nishiyama, Yuri Kato, Akiyuki Nishimura, Xinya Mi, Ryu Nagata, Yasuo Mori, Yasu-Taka Azuma, Motohiro Nishida

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Canonical transient receptor potential 6; Colitis; Stress resistance; Gut microbiota

Online: 2 February 2024 (06:39:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.2207.v1

The Impact of Phenotype of Inflammatory Bowel Diseases, Inflammation Activity and Therapy on Mucosal Mature Cd83⁺ Dendritic Cell

Bruna Rosic Despalatovic, Marija Babić, Andre Bratanić, Ante Tonkić, Žarko Ardalić, Katarina Vilović

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: CD83+dendritic cell; ulcerative colitis; Crohn’ s disease

Online: 31 January 2024 (13:05:40 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.2153.v1

Telemedicine as an Option of Healthcare Services in monitoring Non Alcoholic Fatty Liver Disease (NAFLD) Patients Facing COVID-19 Pandemic

Femmy Nurul Akbar, Safira Rosiana Choirida, Ahmad Zaqi Muttaqin, Fika Ekayanti, Hari Hendarto

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: non-alcoholic fatty liver disease; telemedicine; monitor; body weight; body mass index

Online: 31 January 2024 (07:08:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1871.v1

Comparison between the Regenerative and Therapeutic Impact of BM-MSCs and AD-MSCs Pre-treated with Melatonin on Liver Fibrosis

Ahmed Elzainy, Abir El Sadik

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Proliferation; inflammation; apoptosis; regeneration; therapy; liver

Online: 26 January 2024 (09:01:25 CET)

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Background The distinctive feature of liver fibrosis is the progressive replacement of healthy hepatic cells by extracellular matrix protein, which is abundant in collagen I and III with impaired matrix remodelling. The activation of myofibroblastic cells enhances a fibrogenic response of complex interactions of hepatic stellate cells, fibroblasts and inflammatory cells to produce excessive deposition of extracellular protein matrix. This process is activated by multiple fibrogenic mediators and cytokines such as TNF-α and IL-1ß with decrease in the anti-fibrogenic factor NF-ҡß. Mesenchymal stem cells (MSCs) represent a promising therapy for liver fibrosis giving more advanced regenerative influence when cultured with extrinsic or intrinsic proliferative factors, cytokines, anti-oxidants, growth factors, and hormones such as Melatonin (MT). However, previous studies showed conflicted findings concerning the therapeutic effects of adipose (AD) and bone marrow (BM)-MSCs, therefore, the present work aimed to accomplish a comparative and comprehensive study investigating the impact of MT pre-treatment on the immunomodulatory, anti-inflammatory and anti-apoptotic effects of AD and BM-MSCs and to critically analyse whether MT pre-treated both AD-MSCs and BM-MSCs reveal equal or different therapeutic and regenerative potentials in CCl4-injured liver of experimental rat models. Materials and methods Six groups of experimental rats were used with ten rats in each group; group I (control group), group II (CCl4-treated group), group III (CCl4 and BM-MSCs treated group), group IV (CCl4 and MT pre-treated BM-MSCs group), group V (CCl4 and AD-MSCs treated group) and group VI (CCl4 and MT pre-treated AD-MSCs group). Liver function tests, gene expression of inflammatory, fibrogenic, apoptotic and proliferative factors were analysed. Histological and immunohistochemical changes were assessed. Results The present study compared the capability of AD and BM-MSCs, with and without the pre-treatment of MT, to reduce hepatic fibrosis. Both types of MSCs improved hepatocyte function by reducing the serum levels of (ALT), aspartate aminotransferase (AST), alkaline phosphatase (AKP), and total bilirubin (TBIL). In addition, the changes in the hepatocellular architecture including the hepatocytes, liver sinusoids, central veins, portal veins, biliary ducts and hepatic arteries showed decrease hepatocyte injury and cholestasis with reduction of inflammation, apoptosis and necrosis of the hepatic cells together with inhibition of liver tissue fibrosis. These results were augmented by the analysis of the expression of the anti-inflammatory cytokines TNFα and IL-1β, the anti-fibrogenic factor NF-ҡß, the apoptotic factor caspase-3 and the proliferative indicators antigen Ki-67 and proliferating cell nuclear antigen (PCNA). These findings were found statistically significant, with the best results in the rats received AD-MSCs pre-treated with MT, denoting better regenerative and therapeutic effects. Conclusion AD-MSCs, pre-treated with MT, are superior to BM-MSCs due to their better efficacy in improving hepatic fibrosis and promoting the therapeutic and regenerative capability of liver tissue. They represent a very significant tool for future stem cell use in tissue regeneration strategy for the treatment of liver diseases.

Preprint REVIEW | doi:10.20944/preprints202401.1510.v1

Ustekinumab in the Treatment of Inflammatory Bowel Diseases: Evolving Paradigms

Giammarco Mocci, Antonio Tursi, Francesca Maria Onidi, Paolo Usai-Satta, Giovanni Mario Pes, Maria Pina Dore

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: crohn’ s disease; inflammatory bowel diseases; mucosal healing; safety; remission; ulcerative colitis; ustekinumab

Online: 19 January 2024 (14:43:02 CET)

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Preprint BRIEF REPORT | doi:10.20944/preprints202401.1491.v1

Comparison of LIRADS 5 Image Guided Core Biopsy Derived From Formalin Fixed and Frozen Tissue Cores for Radiogenomics and Radioproteomics Analysis in Well, Moderate and Poorly Differentiated Hepatocellular Carcinoma

Margaret Simonian, David sk Lu, Julian P Whitelegge, Whitaker Cohn, Preeti Ahuja, William Hsu, Steven Raman

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Liver HCC, radioproteomics, radiogenomics

Online: 19 January 2024 (10:51:19 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.1270.v1

Role of EUS in Early Chronic Pancreatitis

Jimil Shah, Abhirup Chatterjee, Truptesh H Kothari

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: chronic pancreatitis; alcohol; SPINK1; Abdominal pain

Online: 17 January 2024 (05:55:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0886.v1

Treatment of Initially Unresectable Local Advanced Pancreatic Adenocarcinoma with Folfirinox: A Prospective Study YCOG1403 (C-flap Study)

Noritoshi Kobayashi, Yasuhiro Yabushita, Ryutaro Mori, Tomoaki Takahashi, Kentaro Miyake, Yu Sawada, Yuki Homma, Ryusei Matsuyama, Naoki Okubo, Eriko Katsuta, Kensuke Kubota, Shoji Yamanaka, Yasushi Ichikawa, Itaru Endo

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: unresectable locally advanced pancreatic cancer; FOLFIRINOX; R0 resection

Online: 11 January 2024 (07:41:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0794.v1

A New Organ: The Mesentery and Non-Vascular Mesenteric Diseases

Monjur Ahmed

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: mesentery; mesenteropathy; mesenteric adenitis; mesenteric panniculitis; mesenteric adiposity; mesenteric neoplasms

Online: 10 January 2024 (08:23:44 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0766.v1

Identification of Dhx15 as a Major Regulator of Liver Development, Regeneration and Tumor Growth in Zebrafish and Mice

Irene Portolés, Jordi Ribera, Esther Fernandez-Galán, Elena Lecue, Gregori Casals, Pedro Melgar-Lesmes, Guillermo Fernández-Varo, Loreto Boix, Marco Sanduzzi, Veenu Aishwarya, Maria Reig, Wladimiro Jiménez, Manuel Morales-Ruiz

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: RNA helicase; hepatocellular carcinoma; liver regeneration; liver organogenesis; glucose metabolism

Online: 10 January 2024 (08:16:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0726.v1

Features of Appendix Development in Children with COVID-19

Grigory Demyashkin, Konstantin Gorokhov, Vladimir Shchekin, Matvey Vadyukhin, Artem Matevosyan, Arina Rudavina, Anna Pilipchuk, Alina Pilipchuk, Petr Shegay, Andrey Kaprin

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: acute appendicitis, COVID-19, children, immunohistochemistry, CD

Online: 10 January 2024 (03:58:07 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.0725.v1

Antibiotic Therapy for Active Crohn’s Disease Targeting Pathogens: An Overview and Update

Gaetano Iaquinto, Giuseppe Mazzarella, Carmine Sellitto, Angela Lucariello, Raffaele Melina, Salvatore Iaquinto, Antonio De Luca, Vera Rotondi Aufiero

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Crohn’ s disease, Escherichia coli species, Mycobacterium avium paratuberculosis, antibiotic therapy.

Online: 9 January 2024 (14:05:02 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.0605.v1

Superior Mesenteric Artery Syndrome Results From Hypersecretion of Hydrochloric Acid

Michael Levin

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Duodenal physiology; superior mesenteric artery syndrome; Ochsner's sphincter dyskinesia; hydrochloric acid hypersecretion; pathophysiology

Online: 8 January 2024 (09:41:28 CET)

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It is currently believed that the cause of superior mesenteric artery syndrome (SMAS) is compression of the duodenum in the angle between the aorta and superior mesenteric artery (SMA). It is recognized that a decrease in aortomesenteric angle (AMA) <25° and intervascular distance < 8 mm, caused by fat loss, is characteristic of SMAS. Based on these statements, surgeons operate on patients with symptoms of dyspepsia only based on a reduction of AMA. This study is devoted to the analysis of the literature, including four own studies on this issue. Results: Measurement of the length of the constriction in the third part of the duodenum on radiograms from available sources showed that its true length ranged from 2.5 to 4.2 (3.30±0.15) cm and began a few centimeters cranial to the AMA. Therefore, it could not have been caused by compression in the AMA. In terms of length (3.20±0.15 cm) and location, this constriction corresponded to Ochsner’s sphincter, which normally short-term contracts to prevent the penetration of an acid bolus into the jejunum. Conscientious studies have shown that AMA is proportional to BMI, i.e., a decrease in AMA is observed in all thin people. An analysis of 211 cases of SMAS made it possible to differentiate two types of diseases. In 101 patients, the disease occurred acutely 1–53 (8.2 ± 1.9) days after stressful situations, accompanied by a catabolic reaction and hypersecretion of hydrochloric acid. In 110 patients, SMAS developed 3-72 (17.2±3.2) months after the diagnosis of acid-dependent diseases. Conclusion: The analysis of the literature led to the conclusion that hypersecretion of hydrochloric acid causes damage to the upper level of the digestive system, including duodenal dyskinesia. One of the manifestations of duodenal dyskinesia is an increase in tone and hypertrophy of the Ochsner’s sphincter. The clinic of the disease depends on the varying degree of Ochsner’s sphincter dyskinesia. In severe cases, partial or complete intestinal obstruction. New ideas about the etiology and pathogenesis of the so-called SMAS have made it possible to propose a tactic for the diagnosis and treatment of Ochsner’s sphincter dyskinesia, where there is no place for surgical treatment.

Preprint ARTICLE | doi:10.20944/preprints202401.0240.v1

Fibrosis Progression in Patients with Budd-Chiari Syndrome and Transjugular Shunt (TIPS): A Long-Term Study Using Transient Elastography

Martin Rössle, Dominik Bettinger, Lukas Sturm, Marlene Reincke, Robert Thimme, Michael Schultheiss

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Budd-Chiari syndrome; Cirrhosis; Fibrosis; transient elastography; Fibroscan

Online: 3 January 2024 (10:36:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0014.v1

scRNA-Seq and Network Pharmacology Analysis Reveal SCF/C-kit as the Targeting Mechanism of Qi Lang Formula Relieving Constipation

Jiacheng Li, Yugang Fu, Yanping Wang, Yiyuan Zheng, Yong Li

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Qi Lang Formula; Constipation; Interstitial cells of Cajal; SCF/c-Kit; proliferation

Online: 3 January 2024 (03:37:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.2320.v1

Prediction of Colorectal Cancer Liver Metastasis through an MRI Radiomic Model

Yaokun Wu, Ning Liu, Yunyun Tao, Jing Zheng, Xiaohua Huang, Lin Yang, Xiaoming Zhang

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Radiomics; MRI; Colorectal cancer; Liver Metastasis

Online: 29 December 2023 (14:27:23 CET)

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Objective: To investigate the efficacy of a magnetic resonance imaging (MRI) radiomics model in predicting colorectal cancer liver metastasis (CRLM). Methods: A total of 120 patients who underwent baseline MRI examination at the Affiliated Hospital of North Sichuan Medical College from June 2016 to August 2022 and were pathologically confirmed to have colorectal cancer (CRC) were randomly divided into a training group and a validation group. The clinical risk factors and MRI data of all patients were collected. Univariate and multivariate analysis were used to screen the clinically independent risk factors for CRLM. The radiomic features of each sequence were extracted from oblique axial or axial fat-free T2-weighted imaging (T2WI) and diffusion-weighted imaging (DWI) sequences. Least absolute shrinkage and selection operator (LASSO) regression was used to screen the optimal radiomic features of each sequence. Logistic regression was used to establish a prediction model of each sequence (T2WI and DWI models), a combined radiomics model (M) integrating the features of T2WI and DWI sequences, and a combined imaging-clinical model (U) combining the radiomic features of each sequence with clinically independent risk factors. The area under the receiver operating characteristic curve (AUC) was calculated to evaluate the predictive performance of each model. Results: Among the 120 CRC patients enrolled, 57 had liver metastasis, and 63 did not. The tumor markers carcinoembryonic antigen and carbohydrate antigen 19-9 were clinically independent risk factors for CRLM. Three optimal radiomic features were screened from T2WI and DWI sequences through LASSO regression analysis, respectively. The AUC values of the T2WI, DWI, M, and U models were 0.811, 0.803, 0.824, and 0.899 in the training group and 0.795, 0.798, 0.813, and 0.889 in the validation group, respectively. The predictive performance of the combined models was better than that of the single-sequence models. The U model performed best at predicting CRLM. Conclusion: An MRI radiomics model based on CRC primary lesions can predict CRLM well. Our combined model integrating the radiomic features of each sequence and clinically independent risk factors had the best predictive performance.

Preprint REVIEW | doi:10.20944/preprints202312.2276.v1

Early Biomarkers for Pancreatic Cancer: A Quest for Survival, Review on the Most Effective Approaches at Present

Muhammad Begawan Bestari, Ignatius Ronaldi Joewono, Ari Fahrial Syam

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: pancreatic cancer; early biomarker; early diagnosis

Online: 29 December 2023 (10:35:47 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.2070.v1

Recent Treatment Strategies for Acute Pancreatitis

Yong Cook Song, Sang Hoon Lee

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: acute pancreatitis; fluid resuscitation; initial management

Online: 28 December 2023 (04:26:02 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.2003.v1

Gastrointestinal Motility and Law of the Intestine

Michael Levin

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: gastroenterology; gastroesophageal reflux disease; x-ray diagnosis; pH monitoring; physiology; hypothesis

Online: 26 December 2023 (14:21:30 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.1921.v1

Nevin Varghese, Amry Majeed, Suraj Nyalakonda, Tina Boortalary, Dina Halegoua-DeMarzio, Hie-Won Hann

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Hepatitis B virus, Hepatocellular Carcinoma, nucleoside analog, antiviral therapy, hepatitis cure, cccDNA

Online: 26 December 2023 (09:49:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1657.v1

Involvement of Liver Redox State in the Zi-Dovudine-Induced Hepatic Steatosis and Its Partial Prevention by Adenosine

Martha Lucinda Contreras-Zentella, Armando Butanda-Ochoa, Lourdes Sánchez-Sevilla, Rodolfo Díaz-Paredes, Rolando Hernández-Muñoz

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Liver redox state, Fatty liver, Hepatotoxicity, Insulin, Glucagon, Lactic acidosis, Cetosis

Online: 21 December 2023 (12:13:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1508.v1

Imaging Characteristics of Hypervascular Focal Nodular Hyperplasia-Like Lesions in Patients with Chronic Alcoholic Liver Disease

Atsushi Urase, Masakatsu Tsurusaki, Ryohei Kozuki, Atsushi Kono, Keitaro Sofue, Kazunari Ishii

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: focal nodular hyperplasia; alcoholic liver disease; hepatocellular carcinoma; magnetic resonance imaging

Online: 20 December 2023 (08:37:17 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.1367.v1

EUS-GE in Gastric Outlet Obstruction Management: Current Methods and Comparisons

Dimitrios Ziogas, Thomas Vasilakis, Christina Kapizioni, Eleni Koukoulioti, Georgios Tziatzios, Paraskevas Gkolfakis, Antonio Facciorusso, Ioannis S. Papanikolaou

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Endoscopic ultrasound-guided gastroenterostomy; Gastric outlet obstruction; Endosonography; Self expandable metal stent; Gastroenterostomy

Online: 19 December 2023 (10:46:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1225.v1

Serum Amyloid A as a biomarker in Inflammatory Bowel Diseases

Marie Stute, Martin Kreysing, Markus Zorn, Patrick Michl, Annika Gauss

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Serum Amyloid A; SAA; Inflammatory Bowel Disease; biomarker; Crohn’s disease; Ulcerative Colitis

Online: 18 December 2023 (09:07:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1198.v1

Regeneration of Non-Alcoholic Fatty Liver Cells Using Chimeric FGF21/HGFR: A Novel Therapeutic Approach

Sung-Jun Kim, So-Jung Kim, Jeongeun Hyun, Hae-Won Kim, Jun-Hyeog Jang

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: keyword 1 alpha mouse liver 12(AML12), fibroblast growth factor 21 (FGF21), Hepatocyte Growth Factor Receptor (HGFR), chimeric FGF21/HGFR, liver regeneration

Online: 15 December 2023 (14:38:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1162.v1

Impact of Statins on the Survival of Patients with Advanced Hepatocellular Carcinoma Treated with Sorafenib or Lenvatinib

Hyo Jung Cho, Ji Eun Han, Jisu Kim, Jae Youn Cheong, Soon Sun Kim, Sun Gyo Lim, Min Jae Yang, Choong-Kyun Noh, Gil Ho Lee, Jung Woo Eun, Bumhee Park

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: statin; multityrosine kinase inhibitor; sorafenib resistance; hepatocellular carcinoma; lipophilic statin; hydrophilic statin

Online: 15 December 2023 (12:14:20 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.0922.v1

Coffee and Microbiota: A Narrative Review

Federico Rosa, Benedetta Marigliano, Sergio Mannucci, Marcello Candelli, Gabriele Savioli, Giuseppe Merra, Christian Zanza, Antonio Gasbarrini, Francesco Franceschi, Andrea Piccioni

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Coffee; Coffee consumption; Microbiota; Gut microbiota; Microbiome

Online: 13 December 2023 (10:47:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0836.v1

Efficacy and Safety of Postbiotic (Metabiotic) Contained Inactivated Lactobacillus reuteri (Limosilactobacillus Reuteri) DSM 17648 as Adjuvant Therapy in the Eradication of Helicobacter pylori in Adults with Functional Dyspepsia: A Randomized Double-

Vladimir Ivashkin, Igor Maev, Elena Poluektova, Alexander Sinitsa, Elena Avalueva, Marina Mnatsakanyan, Vladimir Simanenkov, Julia Karpeeva, Daria Kopylova, Irina Kuprina, Yury Kucheryavyy, Tatiana Lapina, Olga Solovyeva, Malle Soom, Natalia Cheremushkina, Evgeniya Maevskaya, Caterina Holz, Roman Maslennikov

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: postbiotics; metabiotics; eradication; functional digestive disease; probiotics; microbiota.

Online: 12 December 2023 (08:26:54 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.1932.v1

The Management of Hepatic Encephalopathy from Ward to Domiciliary Care: Current Evidence and Grey Areas

Daniele Bellafante, Stefania Gioia, Jessica Faccioli, Oliviero Riggio, Lorenzo Ridola, Silvia Nardelli

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: overt hepatic encephalopathy; minimal hepatic encephalopathy; portosystemic shunts; ammonia; liver cirrhosis

Online: 30 November 2023 (04:17:20 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.1525.v1

Current Status and New Developments in the Ultrasonography Diagnosis of Gallbladder Diseases

Lara Mencarini, Amanda Vestito, Rocco Maurizio Zagari, Marco Montagnani

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: adenomyomatosis; gallbladder cancer; gallbladder perforation; gallbladder polyps; multiparametric US; MVFI; POCUS; porcelain gallbladder; veno-occlusive disease; xanthogranulomatous cholecystitis

Online: 23 November 2023 (11:14:31 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.1517.v1

Benign Recurrent Intrahepatic Cholestasis: Where are we now?

Eleni V Geladari, Natalia G Vallianou, Evangelia Margellou, Dimitris Kounatidis, Vassilios Sevastianos, Alexandra Alexopoulou

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Benign recurrent intrahepatic cholestasis; mutations; elevated conjugated bilirubin; normal gamma-glutamyl transferase

Online: 23 November 2023 (11:12:32 CET)

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Preprint BRIEF REPORT | doi:10.20944/preprints202311.1365.v1

Bowel Cleansing Preparations are Associated with Gastroduodenal Lesions

Anas Khouri, Cesar G Moreno, Jack A A Di Palma

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: owel preparation; Duodenal lesions; Gastric lesions; Oral sulfate solution (OSS); polyethylene glycol (PEG) ;

Online: 22 November 2023 (03:39:59 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202311.1336.v1

Pneumatosis Intestinalis Concurrent with Superior Mesenteric Artery Thrombosis: A Case Report

Parihar Doshi, Tushar Teraiya, Vismit Gami, Sahil Shah, Dev Desai

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Pneumatosis intestinalis; Thrombosis; CT Scan; Atherosclerosis; Ischemia

Online: 21 November 2023 (13:43:57 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.0651.v1

Interpreting Rectal MRI Post-Neoadjuvant Therapy

Joao Miranda, Pamela Causa Andrieu, Josip Nincevic, Lucas de Padua Gomes de farias, Hala Khasawneh, Yuki Arita, Nir Stanietzky, Maria Clara Fernandes, Tiago Biachi De Castria, Natally Horvat

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: rectal cancer; neoadjuvant therapy; magnetic resonance imaging; treatment response

Online: 9 November 2023 (14:38:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0389.v1

High Mobility Group Box-1 as a Candidate Biomarker of Portal Vein Thrombosis in Patients with Hepatocellular Carcinoma

Mattia Perazzi, Roberto Piffero, Rosalba Minisini, Silvia Gaia, Emanuela Rolle, Gian Paolo Caviglia, Michela Emma Burlone, Giulia Francesca Manfredi, Stelvio Tonello, Mattia Bellan, Patrizia Carucci, Mario Pirisi

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: High Mobility Group Box-1 (HMGB-1); portal vein thrombosis (PVT); hepatocellular carcinoma (HCC)

Online: 7 November 2023 (10:36:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0394.v1

Complications and Retrieval of Forgotten Biliary Stents: A Clinical Insight

Sreedevi Sunkara, Manoj Kumar Katragadda, Pandu Ranga Kumari Motepalli, Harinath Reddy Naru, Suresh Babu Sayana, Ramesh Kandimalla

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Endobiliary Stenting, Forgotten Biliary Stents, Cholangitis, Choledocholithiasis, Interventional Gastroenterology

Online: 7 November 2023 (06:42:39 CET)

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Introduction: Endoscopic biliary stenting is a widely utilized procedure in the realm of interventional gastroenterology, primarily employing plastic stents for short-term biliary drainage. This case series endeavours to investigate the occurrence and ensuing clinical ramifications of forgotten or retained biliary stents. Methods: Carried out over an 8-month duration at King George Hospital in Visakhapatnam, this case series encompasses 12 patients diagnosed with forgotten biliary stents. Diagnostic confirmation was established through a combination of X-ray, abdominal ultrasound, and magnetic resonance cholangiopancreatography (MRCP). Four patients experienced complications such as fractured distal pigtails and obstructed stents, thwarting retrieval efforts via endoscopic retrograde cholangiopancreatography (ERCP) and cholangioscopy. Results: This case series featured 12 patients with a median age of 48 years (range: 18-76), comprising 7 females (58.3%) and 5 males (41.7%). The primary indication for initial stent placement was choledocholithiasis in 10 instances (83.3%), while benign biliary strictures accounted for 3 cases (25%). On average, patients presented 31.3 months post-initial stenting, primarily manifesting cholangitis symptoms (83.3%). ERCP succeeded in stent removal in 8 cases (66.6%), while the remaining cases necessitated advanced procedures such as cholangioscopy, with two patients being referred for surgical intervention. It is noteworthy that there were no instances of mortality. Conclusion: This case series, conducted against the backdrop of the COVID-19 pandemic, highlights an increased prevalence of neglected plastic biliary stents. The principal complication encountered was cholangitis, often coexisting with common bile duct (CBD) stones. Standard ERCP techniques demonstrated reduced efficacy in instances characterized by fractured, obstructed, or displaced stents, necessitating the exploration of alternative strategies like cholangioscopy or surgical intervention. This compilation of cases underscores the pressing imperative for prompt stent retrieval and the enhancement of management protocols to proactively mitigate the potential for complications.

Preprint REVIEW | doi:10.20944/preprints202311.0285.v1

Emerging Pharmaceutical Therapies to Address the Inadequacy of Gluten-Free Diet for Celiac Disease

Martina Crepaldi, Michela Palo, Daria Maniero, Luisa Bertin, Edoardo Vincenzo Savarino, Robert Paul Anderson, Fabiana Zingone

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: celiac disease (CeD); gluten-free diet (GFD); novel treatment; non-dietary treatment

Online: 6 November 2023 (13:44:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.2088.v2

Immune Responses of Anti-HCV Antibody after Direct-Acting Antiviral Therapy Associated Allograft Injury with Acute Jaundice in Patients underwent Liver Transplantation

Shu-Hsien Lin, Kun-Ta Wu, Chih-Chi Wang, Kuang-Tzu Huang, Li-Wen Hsu, Hock-Liew Eng, King-Wah Chiu

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: acute cellular rejection; anti-HCV antibody; biliary complications; direct-acting antivirals; hepatitis C virus; liver transplantation

Online: 3 November 2023 (14:38:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0166.v1

Association of Periodontal Disease with Activity of Crohn's Disease

Miloš Živić, Nebojsa Zdravkovic, Bojan Stojanovic, Bojan Milosevic, Zeljko Todorovic, Miljan Adamović, Natasa Zdravkovic

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Crohn’s disease; periodontal disease; Crohn’s disease activity indexes; periodontal indexes

Online: 2 November 2023 (10:51:54 CET)

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Preprint BRIEF REPORT | doi:10.20944/preprints202311.0119.v1

Dynamics of Serologic Change to Gluten in Celiac Disease Patients

Jack Syage, Ana Ramos, Vasiliy Loskutov, Anna Norum, Adam C Bledsoe, Rok Seon Seon Choung, Matthew Dickason, Jennifer Sealey-Voyksner, Joseph Murray

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: celiac disease; serology; gluten; gluten-free diet (GFD); tTG-IgA

Online: 2 November 2023 (07:56:27 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202311.0083.v1

Collision Tumors of the Colon and Peritoneum: Signet-Ring Carcinoma and Granular Cell Tumor

Dorela-Codruta Lazureanu, Denisa Anderco, Sorin Dema, Aura Jurescu, Remus Cornea, Octavia Vita, Bogdan Tunescu, Sorina Taban

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: abdominal collision tumors; colon signet-ring carcinoma; peritoneal granular cell tumor

Online: 2 November 2023 (06:51:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0030.v1

Impacts and Prevalence of Sarcopenia in Patients with MASLD: A Cross-Sectional Study

Kally Janaina Berleze, Luis Fernando Ferreira, André Ferreira D'Ávila, Caroline Buss, Cristiane Valle Tovo, Luis Henrique Telles da Rosa

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Sarcopenia; MASLD; Liver Disease; Aging.; Steatotic liver disease

Online: 1 November 2023 (07:06:18 CET)

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Introduction: Sarcopenia, muscle loss, often coexists with MASLD, a common liver disorder, which is more prevalent in those with sarcopenia. Sarcopenia also increases the risk of liver conditions like steatosis and fibrosis. Studies on sarcopenia in MASLD are common in developed countries, but fewer follow the EWGSOP2 guidelines in Brazil. Aim: to assess sarcopenia prevalence in MASLD patients. Methods: Cross-sectional study conducted at the Gastroen-terology/Hepatology Service of ISCMPA with patients diagnosed with MASLD. The EWGSOP2 criteria were used to evaluate sarcopenia. Categorical data presented as absolute and relative frequency; parametric continuous data ex-pressed as mean±standard deviation; non-parametric continuous data as me-dian and IQR. Gender differences in were analyzed using Fisher's Exact Test or Chi-squared tests, and for continuous variables, T Student tests (parametric) and Mann-Whitney U tests for independent samples (non-parametric). The significance level was set at 5% (p<0.05). Results: The study involved 103 MASLD patients with an average age of 60.39 years, comprising 48 (46.60%) adults and 55 (53.40%) older individuals. Concerning sarcopenia diagnosis, four individuals exhibited decreased muscle strength; two had reduced MME (sarcopenia); and one showed decreased walking speed (severe sarcopenia). Among the participants, 63 (60.6%) were physically active. 35 (62.5%) had mild to moderate steatosis, while 21 (37.5%) had severe steatosis. In terms of EHNA, 13 subjects (24.08%) had moderate to severe EHNA. Regarding fibrosis classi-fication, 68 (72.34%) individuals had undetermined or high probability based on the NAFLD score, with higher prevalence in males (n=23; 88.5%). Fibrosis assessment via liver biopsy revealed 27 (28.72%) in F1 and F2 and 15 (16.96%) in F3 and F4. Stratification of fibrosis into F3 and F4 was more com-mon among men (n=9; 47.4%). Conclusion: Most of the population was physi-cally active. The parameters indicating sarcopenia exceeded the thresholds recommended by EWGSOP2. The prevalence of sarcopenia was low in individuals with MASLD.

Preprint ARTICLE | doi:10.20944/preprints202310.1682.v1

Atezolizumab plus Bevacizumab Treatment Worsens Liver Reserve in Patients with Nafld/Nash-Associated Liver Cancer More than in Those with Non-nafld/Non-Nash-Associated Liver Cancer

Rie Sugimoto, Kenta Motomura, Takeaki Satoh, Yuki Tanaka, Shinsaku Yamashita, Nobito Higuchi, Toshimasa Koyanagi, Tsukasa Nakamura, Masatake Tanaka, Yuuki Azuma, Takeshi Goya, Akifumi Kuwano, Aritsune Ooho, Mari Ooe, Taiji Mutsuki, Masami Kuniyoshi, Kazuki Kurosaka, Yusuke Morita, Seiya Tada, Yoshifusa Aratake, Tsuyoshi Yoshimoto, Takeshi Senju, Tomoyuki Kurashige, Shigeru Harada, Akihiro Ueda, Masayuki Miyazaki, Makoto Nakamuta, Motoyuki Kohjima

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Atezolizumab; bevacizumab; non-alcoholic fatty liver disease; non-alcoholic steato hepatitis; albumin-bilirubin (ALBI) score

Online: 26 October 2023 (09:01:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1656.v1

Clinical Outcomes of Next-Generation Microwave Thermosphere Ablation for Hepatocellular Carcinoma with Primarily Hepatitis-Related Etiology

Shinichiro Nakamura, Toshifumi Tada, Masahiko Sue, Yu Matsuo, Shiho Murakami, Toshiro Muramatsu, Kazuhiko Morii, Hiroyuki Okada

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: microwave thermosphere ablation; hepatocellular carcinoma; recurrence; safety

Online: 26 October 2023 (03:59:34 CEST)

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Preprint REVIEW | doi:10.20944/preprints202310.1615.v1

Thyroid Hormone and Mitochondrial Dysfunction: Therapeutic Implications for Metabolic Dysfunction-Associated Steatotic Liver Disease (Masld)

Raghu Ramanathan, Sohum A Patwa, Ahmad Hassan Ali, Jamal A Ibdah

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Liver; Mitochondrial dysfunction; FAO; MASLD; Thyroid

Online: 26 October 2023 (03:17:06 CEST)

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Preprint REVIEW | doi:10.20944/preprints202310.1620.v1

Endoscopic Management of Gastric Disruptions

Veeral M Oza, Truptesh H Kothari

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: gastric perforation; leak; suturing; clips; sponge; endovacuum

Online: 25 October 2023 (10:13:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1627.v1

Neutrophil-Creatinine Index: A New Prognostic Factor for Severity of Acute Pancreatitis

Abdurrahman Sahin

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: acute pancreatitis; neutrophil-creatinine index; neutrophil-to-lymphocyte ratio; prognosis; severity

Online: 25 October 2023 (10:06:31 CEST)

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Background and Objectives: The severity of acute pancreatitis (AP) is graded as mild (MAP), moderately severe (MSAP), and severe (SAP) according to the revised Atlanta Classification. Determining the severity of AP is the main goal in the early time of AP. The aim of this study was to compare laboratory parameters or indices including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and neutrophil-creatinine index (NCI) at admission for predicting severity of AP. Materials and Methods: In this retrospective study, the data from patients who admitted with diagnosis of AP between January 2018 and December 2021 were collected. Laboratory parameters and indices including NLR, PLR and NCI were compared in the discrimination of AP severity groups. Results: A total of 421 patients [MAP group (n=213), MSAP group (n=158) and SAP group (n=50)] were included. WBC count, neutrophil count, hematocrit, CRP, BUN, creatinine, NLR and NCI were significant parameters to discriminate AP subgroups. The AUROC analysis for discriminating MSAP from MAP showed that WBC (AUC: 0.723, 95% CI: 0.674-0.768, p<0.001), hematocrit (AUC: 0.566, 95% CI: 0.514-0.607, p=0.032), NLR (AUC: 0.649, 95% CI: 0.598-0.698, p< 0.001) and NCI (AUC: 0.749, 95% CI: 0.701-0.792, p<0.001) were statistically significant parameters. Similarly, AUCs to discriminate SAP from MSAP were (AUC: 0.649, 95% CI: 0.579-0.713, p < 0.001) for WBC, (AUC: 0.703, 95% CI: 0.621-0.785, p< 0.001) for BUN, (AUC: 0.602, 95% CI: 0.532-0.669, p=0.029) for CRP and (AUC: 0.742, 95% CI: 0.676-0.800, p<0.001) for NCI. Logistic regression analyses indicated that NCI was the only parameter to discriminate MSAP form MAP (OR: 1.119, 95% CI: 1.015-1.235, p=0.023) and SAP from MSAP (OR: 1.113, 95% CI: 1.042-1.888, p = 0.001). Conclusions: The present study enabled the identification of neutrophil-creatinine index as a new prognostic tool for the assessment AP severity at hospital admission.

Preprint ARTICLE | doi:10.20944/preprints202310.1619.v1

Early Initiation of Adalimumab Significantly Diminishes Post-operative Crohn’s Disease Endoscopic Recurrence and Is Superior to 6-Mercaptopurine Therapy. An Open Label Randomized Controlled Study

Ayal Hirsch, Erez Scapa, Naomi Fliss Isakov, Hagit Tulchinsky, Eran Itzkowitz, Yehuda Kariv, Yulia Ron, Henit Yanai, Ian White, Sharif Yassin, Nathaniel Aviv Cohen, Eli Brazovski, Iris Dotan, Nitsan Maharshak

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: clinical trial; crohn; surgery; 6-mercaptopurine; adalimumab

Online: 25 October 2023 (10:04:57 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202310.1524.v1

Gastrointestinal Granular Cell Tumor: The First Report of a Multifocal and Potentially Hereditary Case

Riccardo Sigon, Lisa Fusaro, Fabio Monica, Michele Campigotto

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: granular cell tumor; Abrikossoff tumor; multifocal tumor; gastrointestinal tract; inherited tumor

Online: 24 October 2023 (10:32:40 CEST)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202302.0297.v2

“Peptic Ulcers are an Infectious Disease Caused By Helicobacter Pylori” is an Illusion in Medical Research

Simon Xin Min Dong

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: peptic ulcers, pathogenesis, etiology, Helicobacter pylori, illusion, African enigma, psychosomatic disease, psychological stress

Online: 23 October 2023 (12:01:11 CEST)

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Currently, peptic ulcers are widely studied as an infectious disease caused by Helicobacter pylori primarily due to 3 supporting evidences, and this etiology may explain the other 3 observations, but cannot confront the challenges of the 15 major characteristics and the other 75 observations/phenomena of peptic ulcers. To address the challenges, a recently published Complex Causal Relationship with its accompanying methodologies was applied to analyze existing data. Peptic ulcers are identified as a psychosomatic disease triggered by psychological stress, where Helicobacter pylori plays a secondary role in only the late phase of ulceration. This new etiology elucidated all the 15 major characteristics and 81 observations/phenomena of peptic ulcers in a series of 6 articles. This sixth article focuses exclusively on the controversies surrounding the role of Helicobacter pylori in peptic ulcers. In-depth analyses find that all the 3 evidences supporting “peptic ulcers are an infectious disease caused by Helicobacter pylori” are deceiving, and 2 of the 3 explainable observations may have been misinterpreted. Meanwhile, the definitions of ‘etiological factor’ and ‘causality’ do not support ‘H. pylori infection is an etiological factor of peptic ulcers’, and existing literatures have presented a controversial view on the role of Helicobacter pylori in peptic ulcers. Interestingly, if “peptic ulcers are an infectious disease caused by Helicobacter pylori” is considered an illusion, all the characteristics of the disease, along with all the clinical, epidemiological, and laboratory observations/phenomena, can be fully understood. This illusion has misguided peptic ulcer research over the past 36 years with little progress in the field, and that may represent a widespread situation in modern medical research, resulting in a direct interference with the true understanding of disease. Evidently, keeping the concept “illusion” in mind may help remove a huge obstacle that impedes medical advance, thereby facilitating the in-depth study of disease.

Preprint REVIEW | doi:10.20944/preprints202201.0226.v4

Laboratory Techniques for Hepatic Diseases Diagnosis

Antonella Elisa Chesca, Aigul Medetova, Galiya Abdulina, Berik Kouchebekov, Saule Ahmetova, Tim Sandle

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Hepatitis C virus (HCV); liver; blood; electrochemiluminescence (ECL); ELISA method (Enzyme-Linked Immunosorbent Assay)

Online: 19 October 2023 (10:53:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1209.v1

Risk factors for developing metachronous superficial gastric epithelial neoplasms after endoscopic submucosal dissection

Tsunehiro Suzuki, Kenichi Goda, Manabu Ishikawa, Shintaro Yamaguchi, Tomonori Yoshinaga, Masayuki Kondo, Mimari Kanazawa, Yasuhito Kunogi, Takanao Tanaka, Akira Kanamori, Keiichiro Abe, Akira Yamamiya, Takeshi Sugaya, Keiichi Tominaga, Hidetsugu Yamagishi, Hironori Masuyama, Atsushi Irisawa

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: stomach; early gastric cancer; gastric adenoma; metachronous cancer; cumulative incidence; en-doscopic resection; endoscopic submucosal dissection; Helicobacter pylori; spontaneous eradica-tion; intestinal metaplasia

Online: 19 October 2023 (10:45:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1059.v1

The Effect of Propofol Combined with Psychological Intervention on Pain and Emotional Evaluation in Painless Colonoscopic Colonic Polypectomy Patients

Xiao- Mei Zhang, Lu Yu, Jia-Wei Zhang, Ya-Feng Yuan

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Propofol; Psychological intervention; Painless colonoscopic colonic polypectomy EMR; Pain

Online: 18 October 2023 (03:10:38 CEST)

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Preprint REVIEW | doi:10.20944/preprints202310.0849.v1

Role of Transjugular Intrahepatic Portosystemic Shunt in the Liver Transplant Setting

Simone Di Cola, Lucia Lapenna, Jakub Gazda, Stefano Fonte, Giulia Cusi, Samuele Esposito, Marco Mattana, Manuela Merli

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Transjugular Intrahepatic Portosystemic Shunt; TIPS; liver transplantation; bridge to transplant; timing

Online: 13 October 2023 (08:00:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0836.v1

Therapeutic Efficacy and Safety of Lenvatinib after Atezolizumab Plus Bevacizumab for Unresectable Hepatocellular Carcinoma

Shigeki Yano, Tomokazu Kawaoka, Shintaro Yamasaki, Yusuke Johira, Masanari Kosaka, Yuki Shirane, Ryoichi Miura, Kei Amioka, Kensuke Naruto, Kenji Yamaoka, Yasutoshi Fujii, Shinsuke Uchikawa, Hatsue Fujino, Atsushi Ono, Takashi Nakahara, Eisuke Murakami, Daiki Miki, Masataka Tsuge, Yuji Teraoka, Hirotaka Kouno, Shintaro Takaki, Nami Mori, Keiji Tsuji, Shiro Oka

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: hepatocellular carcinoma; unresectable; atezolizumab plus bevacizumab; lenvatinib

Online: 12 October 2023 (15:36:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0666.v1

A Multiparametric Method Improves the Serological Characterization of Inflammatory Bowel Diseases: Preliminary Results from a Multicenter Eastern Europe Study

Nikola Panic, Marco Marino, Goran Hauser, Silvia Jacobsen, Francesco Curcio, Francesco Meroi, Adriana Cifù, Eleonora Castagnaviz, Cinzia Pistis, Giovanni Terrosu, Milutin Bulajic, Salvatore Francesco Vadalà Di Prampero, Dino Tarabar, Irena Krznaric-Zrnic, Gordana Kovacevic, Ivan Ranković, Martina Fabris

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: inflammatory bowel disease; anti-pancreatic antibodies; cell based assay; Crohn’s disease; diagnostic biomarker

Online: 11 October 2023 (14:23:46 CEST)

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Introduction: The serological support to early diagnosis and differential diagnosis of inflammatory bowel diseases (IBD) is actually very limited. In this study we evaluated the performance of a promising multiparametric method including either well established and newly developed biomarkers. Methods: This multicenter retrospective observational study finally enrolled 156 patients with IBD, 100 affected by Crohn’s disease (CD) and 56 by ulcerative colitis (UC) recruited at the Gastroenterology Units of Udine (Italy), Rijeka (Croatia) and Belgrade (Serbia). Twently age-sex matched blood donors (BD) were included as controls. Autoantibody profiles were determined using a mosaic cell and tissue-based indirect immunofluorescence (IIF) method simultaneously investigating: anti-saccharomyces cerevisiae antibodies (ASCA), anti-atypical perinuclear neutrophilic antibodies (P-ANCA), anti-pancreatic antigens antibodies (PAB) and anti-goblet cells antibodies (GAB). Results: PAB (anti-CUZD1 and/or anti-GP2 antibodies) were present in 24 CD patients versus none of UC patients or BD (24% sensitivity, 100% specificity). As regards CD patients, combined positivity of PAB and ASCA (sensitivity 84%, specificity 71.4%) performed better than ASCA alone. Colon involvement (87.5% vs. 60.5%; p=0.014), deep mucosal lesions (58.3% vs. 25.0%; p=0.002) and need for biologic therapies (79.2% vs. 46.1%; p=0.005) were significantly more prevalent in PAB-positive than in PAB-negative CD patients. Multivariate analysis identified PAB positivity (OR=3.67; 95%CI=1.29-10.46) and anti-CUZD1 in particular (OR=3.54; 95%CI=1.08-11.63) as significant risk factors for deep mucosal lesions development in CD. Conclusion: A multiparametric diagnostic approach appears very useful to better characterize IBD patients. PAB, isolated or combined with other autoantibodies, may support both differential diagnosis and selection of CD patients at risk for more severe disease.

Preprint REVIEW | doi:10.20944/preprints202310.0727.v1

Involvement of Lipophagy and Chaperone mediated autophagy in the pathogenesis of Non-alcoholic fatty liver disease by regulation of lipid droplets

Eleftheria M Mastoridou, Anna C Goussia, Panagiotis Kanavaros, Antonia V Charchanti

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Non-alcoholic fatty liver disease, lipophagy, chaperone-mediated autophagy, perilipins

Online: 11 October 2023 (12:53:31 CEST)

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Preprint INTERESTING IMAGES | doi:10.20944/preprints202310.0450.v1

SpyGlass Cholangioscopy for Indeterminate Biliary Stricture in a Patient with Primary Sclerosing Cholangitis

Ning-Hsuan Chin, Kuan-Chih Chen, Kuo-Hsin Chen, Tzong-Hsi Lee, Hsiu-Po Wang, Chen-Shuan Chung

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: cholangioscopy; primary sclerosing cholangitis; SpyGlass; biliary stricture

Online: 9 October 2023 (08:51:11 CEST)

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Preprint REVIEW | doi:10.20944/preprints202310.0116.v1

What Should We Know about Drugs Levels and Therapeutic Drug Monitoring during Pregnancy and Breastfeeding in Inflammatory Bowel Disease under Biologic Therapy?

Mathiilde Barrau, Xavier Roblin, Leslie Andromaque, Aurore Rozieres, Mathias Faure, Stephane Paul, Stephane Nancey

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: TDM; prgnancy; chilfborn; lactation; biotherapy; IBD

Online: 3 October 2023 (07:15:39 CEST)

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The real long-term influences of in utero drug exposure in pregnant women on childhood development have yet to be fully determined and depend on the duration of in utero drug exposure and maternal drug levels. Therapeutic drug monitoring (TDM) during pregnancy may help limit fetal drug exposure while maintaining therapeutic drug levels in maternal blood. Most antibody therapies used in patients with Inflammatory Bowel Disease (IBD) are IgG molecules which are actively transported across the placenta, especially during the third trimester of the pregnancy. Here we propose an up to date clinical review to summarize the available findings of serum drug levels in maternal blood during pregnancy, in the blood cord, infants at delivery and in breast milk of patients with IBD treated with biologics. Conversely to adalimumab (ADA) levels, which are relatively stable during pregnancy, infliximab (IFX) drug clearance decreased significantly during the second and third trimesters, leading to increasing maternal IFX concentrations. As most guidelines recommend using live vaccines in infants at the age of one or earlier in case of negative serum drug levels in newborns, statistical models could help clinicians in making a decision to adjust the last dose of the biologic during pregnancy and to determine the optimal date to vaccinate. Altogether, data from the literature offers strong reassurance regarding the safety profile of anti-TNFα therapies during pregnancy not only for IBD patients who intend to conceive, but also for pregnant women and for the physicians taking care of these patients. ADA and IFX levels in breast milk are detectable but very low and therefore it is recommended to pursue breast feeding under anti-TNFα therapy. Our knowledge on ustekinumab or vedolizumab levels in pregnant women remains unclear and scarce. It is currently not recommended in patients with IBD in clinical practice. Therefore, TDM and proactive dose adjustment are not necessary during pregnancy since its impact for making a clinical decision have not yet been clearly demonstrated in routine practice. Overall, drug concentrations in the blood cord, the infant at birth and postpartum serum concentrations in infants, due to active placental drug transfer, may have a greater impact than the limited drug transfer in breast milk during lactation on the risk of infection and developmental outcomes. Ustekinumab and vedolizumab exposure during pregnancy and lactation are both considered low risk by the recent ECCO guidelines despite the limited data currently available.

Preprint ARTICLE | doi:10.20944/preprints202310.0026.v1

Involvement of Heparanase in the Pathogenesis of Acute Pancreatitis: Implication of Novel Therapeutic Approaches

Dalit B Hamo-Giladi, Ahmad Fokra, Edmond Sabo, AVIVA KABALA, Irina Minkov, Salim Hadad, Zaid Abassi, Iyad Khamaysi

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Acute pancreatitis; Heparanase; Lipase; Amylase; Mitochondria; NSAIDs

Online: 2 October 2023 (03:22:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2059.v1

Diagnosing Liver Cirrhosis by Overlooked Tools: A Retrospective Study

Giovanni Tarantino, Vincenzo Citro, Marianna Tarantino, Domenico Capone

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Total serum bile acids; antipyrine clearance; liver-spleen scan; chronic hepatitis; liver cirrhosis; AUROCs

Online: 30 September 2023 (10:08:10 CEST)

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Background Total serum bile acids (TSBA), liver-spleen scan and dynamic liver functional tests, in our case the antipyrine clearance (Ap Cl), have been long adopted. The aim of our study was that of assessing whether some diagnostic tests, scarcely performed due to the novel techniques implementation, were reliable diagnostic tools. Methods Data extracted from records of two well-matched for age and gender populations was retrospectively analysed. Specifically, 17 patients with biopsy-proven chronic hepatitis were confronted with 17 subjects suffering from liver cirrhosis. Clinical, laboratory and instrumental findings, such as the Child-Pugh classification, the number connection test for evaluating hepatic encephalopathy, prothrombin time, serum albumin levels, TSBA concentration, Ap Cl determination, abdominal ultrasound and liver-spleen scan imaging as well as endoscopy features were evaluated. Results Cirrhotics showed a median concentration of TSBA increased respect to that of patients with chronic hepatitis, independently from gender, 20.1 versus 12.24 micromol/L, P= 0.0054. The median AP Cl value of the patients with liver cirrhosis was reduced confronted with that of patients with chronic hepatitis, specifically, 13.92 opposed to 18.3 mcg Ap/dL, P= 0.045. Furthermore, the median liver-spleen scan score was higher in cirrhotics than in chronic hepatitis patients, i.e., 3.47 versus 1.47, P= 0.000. The AUROCs of TSBA levels and of the liver-spleen scan scores for differentiating patients with liver cirrhosis from those with chronic hepatitis were 0.82 and 0.96, respectively. When was applied a new predictive model, combining the previous ones, the AUROC to discriminate patients belonging to the two populations was 0.98. The best cut-off of the new index was 26, with a sensitivity and specificity of 100.00% and 82.35%, respectively, correctly classifying 91.18% of the patients. Discussion Both TSBA and liver-spleen scan were high discriminant as well as their combination, while Ap Cl showed some limitations as reliable diagnostic tool. TSBA and liver-spleen scan have been too soon and unnecessarily overlooked.

Preprint REVIEW | doi:10.20944/preprints202309.2083.v1

A Gastroenterologist’s Guide to Care Transitions in Cystic Fibrosis from Pediatrics to Adult Care

Dhiren Patel, Michelle Baliss, Pavithra Saikumar, Laith Numan, Jeffrey Teckman, Christine Hachem

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Cystic Fibrosis; transition of care; pediatrics; Gastrointestinal care; Pancreatic enzyme; highly effective modulators

Online: 29 September 2023 (10:43:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2096.v1

An Emulsified Liquid Paraffin Formulation for Functional Constipation: Pharmacokinetics of Vitamins K1, D3, A, and E in a Rat Model

Federico Perez Agudo, Janne Mannila, Valtteri Rinne, Elina Kallio, Ville Moilanen

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: constipation; laxatives; liquid paraffin; fat-soluble vitamins; vitamin A; vitamin E; vitamin D3; vitamin K1; pharmacokinetics; experimental model.

Online: 29 September 2023 (09:52:43 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.2077.v1

Illuminating Dersimelagon: A Novel Agent in the Treatment of Erythropoietic Protoporphyria and X-Linked Protoporphyria

Katelyn E Madigan, Sean R Rudnick, Matthew A Agnew, Numra Urooj, Herbert L Bonkovsky

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Erythropoietic Protoporphyria; X-linked protoporphyria, oral, dersimelagon

Online: 29 September 2023 (05:48:07 CEST)

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Medicine and Pharmacology