NIH SenNet Consortium: Mapping Senescent Cells in the Human Body to Understand Health and Disease

Patty J Lee; Philip Blood; Katy Börner; Judith Campisi; Feng Chen; Heike Daldrup-Link; Phil De Jager; Li Ding; Francesca E. Duncan; Oliver Eickelberg; Rong Fan; Toren Finkel; Vesna Garovic; Nils Gehlenborg; Carolyn Glass; Ziv Bar-Joseph; Pragati Katiyar; So-Jin Kim; Melanie Königshoff; George Kuchel; Haesung Lee; Jun H. Lee; Jian Ma; Qin Ma; Simon Melov; Kay Metis; Ana L. Mora; Nicolas Musi; Nicola Neretti; João F. Passos; Irfan Rahman; Juan Carlos Rivera-Mulia; Paul Robson; Mauricio Rojas; Ananda L. Roy; Birgit Schilling; Pixu Shi; Jonathan Silverstein; Vidyani Suryadevera; Jichun Xie; Jinhua Wang; An-Kwok Ian Wong; Laura Niedernhofer

doi:10.20944/preprints202207.0160.v2

How to cite: Lee, P. J.; Blood, P.; Börner, K.; Campisi, J.; Chen, F.; Daldrup-Link, H.; De Jager, P.; Ding, L.; Duncan, F. E.; Eickelberg, O.; Fan, R.; Finkel, T.; Garovic, V.; Gehlenborg, N.; Glass, C.; Bar-Joseph, Z.; Katiyar, P.; Kim, S.-J.; Königshoff, M.; Kuchel, G.; Lee, H.; Lee, J. H.; Ma, J.; Ma, Q.; Melov, S.; Metis, K.; Mora, A. L.; Musi, N.; Neretti, N.; Passos, J. F.; Rahman, I.; Rivera-Mulia, J. C.; Robson, P.; Rojas, M.; Roy, A. L.; Schilling, B.; Shi, P.; Silverstein, J.; Suryadevera, V.; Xie, J.; Wang, J.; Wong, A.-K. I.; Niedernhofer, L. NIH SenNet Consortium: Mapping Senescent Cells in the Human Body to Understand Health and Disease. Preprints 2022, 2022070160. https://doi.org/10.20944/preprints202207.0160.v2 Lee, P. J.; Blood, P.; Börner, K.; Campisi, J.; Chen, F.; Daldrup-Link, H.; De Jager, P.; Ding, L.; Duncan, F. E.; Eickelberg, O.; Fan, R.; Finkel, T.; Garovic, V.; Gehlenborg, N.; Glass, C.; Bar-Joseph, Z.; Katiyar, P.; Kim, S.-J.; Königshoff, M.; Kuchel, G.; Lee, H.; Lee, J. H.; Ma, J.; Ma, Q.; Melov, S.; Metis, K.; Mora, A. L.; Musi, N.; Neretti, N.; Passos, J. F.; Rahman, I.; Rivera-Mulia, J. C.; Robson, P.; Rojas, M.; Roy, A. L.; Schilling, B.; Shi, P.; Silverstein, J.; Suryadevera, V.; Xie, J.; Wang, J.; Wong, A.-K. I.; Niedernhofer, L. NIH SenNet Consortium: Mapping Senescent Cells in the Human Body to Understand Health and Disease. Preprints 2022, 2022070160. https://doi.org/10.20944/preprints202207.0160.v2

Abstract

Cells respond to a myriad of stressors by senescing, acquiring stable growth arrest, morphologic and metabolic changes, and a senescence-associated-secretory-phenotype (SASP). The heterogeneity of senescent cells (SnCs) and their SASP is vast, yet poorly characterized. SnCs have diverse roles in health and disease and are therapeutically targetable, making characterization of SnCs and harmonization of their nomenclature a priority. The Cellular Senescence Network (SenNet), a NIH Common Fund initiative, will leverage emerging single cell and spatial-omics to identify and map SnCs in numerous organs across the lifespan of humans and mice. A common coordinate framework will integrate the data, using validated, standardized methods, creating public 4-dimensional SnC atlases. Key SenNet deliverables include development of innovative tools/technologies to detect SnCs, biomarker discovery, common annotations to describe SnCs and extensive public data sets. The goal is to comprehensively understand and map SnCs for diagnostic and therapeutic purposes to improve human health.

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Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Comment 1

Received: 15 September 2022
Commenter: Patty Lee
Commenter's Conflict of Interests: Author

Comment: Author name correction

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NIH SenNet Consortium: Mapping Senescent Cells in the Human Body to Understand Health and Disease

Abstract

Keywords

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