Version 1
: Received: 23 May 2020 / Approved: 24 May 2020 / Online: 24 May 2020 (16:53:56 CEST)
How to cite:
Kanwore, K.; Guo, X.; Abiola, A.A.; Kambey, P.A.; Oluwafemi, A.A.; Gao, D. Gene Mutation and Epigenetic Modification Origin in Glioma Initiation: Are the GDNF and SOX1 Overexpression the Causes of Its Initiation?. Preprints2020, 2020050388. https://doi.org/10.20944/preprints202005.0388.v1
Kanwore, K.; Guo, X.; Abiola, A.A.; Kambey, P.A.; Oluwafemi, A.A.; Gao, D. Gene Mutation and Epigenetic Modification Origin in Glioma Initiation: Are the GDNF and SOX1 Overexpression the Causes of Its Initiation?. Preprints 2020, 2020050388. https://doi.org/10.20944/preprints202005.0388.v1
Kanwore, K.; Guo, X.; Abiola, A.A.; Kambey, P.A.; Oluwafemi, A.A.; Gao, D. Gene Mutation and Epigenetic Modification Origin in Glioma Initiation: Are the GDNF and SOX1 Overexpression the Causes of Its Initiation?. Preprints2020, 2020050388. https://doi.org/10.20944/preprints202005.0388.v1
APA Style
Kanwore, K., Guo, X., Abiola, A.A., Kambey, P.A., Oluwafemi, A.A., & Gao, D. (2020). Gene Mutation and Epigenetic Modification Origin in Glioma Initiation: Are the GDNF and SOX1 Overexpression the Causes of Its Initiation?. Preprints. https://doi.org/10.20944/preprints202005.0388.v1
Chicago/Turabian Style
Kanwore, K., Adekunle Adebayo Oluwafemi and Dianshuai Gao. 2020 "Gene Mutation and Epigenetic Modification Origin in Glioma Initiation: Are the GDNF and SOX1 Overexpression the Causes of Its Initiation?" Preprints. https://doi.org/10.20944/preprints202005.0388.v1
Abstract
The extrinsic and intrinsic factors are essential in glioma initiation. Many extrinsic factors (UV, radiation, food, etc.) and intrinsic factors (proteins, hormones, ageing, DNA and RNA damages, etc.) was reported to being responsible for glioma initiation and progression. However, the cell responsible for glioma origin is still unknown. Many research papers have reported that glioma stem cells, senescent cells, injured cells, and death neurons are the cells of glioma origin. However, gene mutation and oncogene protein overexpression doesn’t occur only in cancer but during life evolution. The source of genetic mutations has become a fundamental issue in understanding its role in the initiation of glioma. The glioma is the precise coordination of several distant factors that work together in the initiation and development of glioma. However, the role and effects of the genes (GDNF and SOX1) on cancer cells are well known, but their gene mutation origin is controversial. Several models and theories have been proposed to explain the origins of GDNF and SOX1 genetic mutations and epigenetic modification related to cancer. Our aim in this review is to clear that incertitude about glioma origin (gene mutation and epigenetic modifications) and those factors involved in glioma initiation and recurrence.
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
