Nadeem, J.; Parveen, A.; Kim, S.Y. DNA damage response & senescence-associated secretory phenotype pathway: Emerging targets for anti-aging. Preprints2023, 2023091932. https://doi.org/10.20944/preprints202309.1932.v1
APA Style
Nadeem, J., Parveen, A., & Kim, S.Y. (2023). DNA damage response & senescence-associated secretory phenotype pathway: Emerging targets for anti-aging. Preprints. https://doi.org/10.20944/preprints202309.1932.v1
Chicago/Turabian Style
Nadeem, J., Amna Parveen and Sun Yeou Kim. 2023 "DNA damage response & senescence-associated secretory phenotype pathway: Emerging targets for anti-aging" Preprints. https://doi.org/10.20944/preprints202309.1932.v1
Abstract
Cellular aging has drawn the attention of researchers, scientists, and biotech businesses for the treatment of a number of medical conditions. Cellular aging is primarily defined by consistent cessation of proliferative development in response to internal and external stressors, including DNA damage, telomere shortening, mitochondrial dysfunction, and regulation of the senescence-associated secretory phenotype (SASP). Disturbances involving these factors may contribute to age-related disease development. Therefore, the current review aims to explore anti-aging factors targeting DNA damage response and SASP regulation and their detailed signaling networks. In addition, it provides an opportunity for researchers to identify not only anti-aging targets, but also anti-aging therapeutic strategies based on identified and non-identified targets.
Keywords
Anti-aging, DNA damage response, senescence-associated secretory phenotype
Subject
Medicine and Pharmacology, Medicine and Pharmacology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
