Version 1
: Received: 22 January 2020 / Approved: 27 January 2020 / Online: 27 January 2020 (09:18:05 CET)
How to cite:
Alessio, N.; Acar, M.; Demirsoy, I.; Squillaro, T.; Siniscalco, D.; Di Bernardo, G.; Peluso, G.; Ozcan, S.; Galderisi, U. Obesity Negatively Affects the Biological Functions of Mesenchymal Stromal Cells Derived from Bone Marrow, Subcutaneous and Visceral Fat of Young Mice. Preprints2020, 2020010323
Alessio, N.; Acar, M.; Demirsoy, I.; Squillaro, T.; Siniscalco, D.; Di Bernardo, G.; Peluso, G.; Ozcan, S.; Galderisi, U. Obesity Negatively Affects the Biological Functions of Mesenchymal Stromal Cells Derived from Bone Marrow, Subcutaneous and Visceral Fat of Young Mice. Preprints 2020, 2020010323
Alessio, N.; Acar, M.; Demirsoy, I.; Squillaro, T.; Siniscalco, D.; Di Bernardo, G.; Peluso, G.; Ozcan, S.; Galderisi, U. Obesity Negatively Affects the Biological Functions of Mesenchymal Stromal Cells Derived from Bone Marrow, Subcutaneous and Visceral Fat of Young Mice. Preprints2020, 2020010323
APA Style
Alessio, N., Acar, M., Demirsoy, I., Squillaro, T., Siniscalco, D., Di Bernardo, G., Peluso, G., Ozcan, S., & Galderisi, U. (2020). Obesity Negatively Affects the Biological Functions of Mesenchymal Stromal Cells Derived from Bone Marrow, Subcutaneous and Visceral Fat of Young Mice. Preprints. https://doi.org/
Chicago/Turabian Style
Alessio, N., Servet Ozcan and Umberto Galderisi. 2020 "Obesity Negatively Affects the Biological Functions of Mesenchymal Stromal Cells Derived from Bone Marrow, Subcutaneous and Visceral Fat of Young Mice" Preprints. https://doi.org/
Abstract
White adipose tissue (WAT) is distributed in several depots that have distinct metabolic and inflammatory functions. In our body there are subcutaneous (sWAT), visceral (vWAT) and bone marrow fat depots (BFAT). Obesity affects size, function and inflammatory state of WATs. This process can alter the stem cell niches present in these tissues and affect the functions of stem cells residing within. In particular, obesity may affect the activity of mesenchymal stromal cells (MSCs) present in WAT. MSCs are an heterogenous population containing stromal cells, progenitor cells, fibroblasts and stem cells that are able to differentiate in adipocytes, chondrocytes, osteocytes and other mesodermal derivatives. We performed a comparison of the effects of obesity on MSCs obtained from sWAT, vWAT and BFAT. Our study evidenced that obesity affected mainly the biological functions of MSCs obtained from bone marrow and vWAT with a decrease in proliferation rate, reduced percentage of cells in S phase and trigger of senescence. The onset of senescence was confirmed by expression of genes belonging to RB and P53 pathways. Our study evidenced that negative consequences of obesity on body physiology may be related also to impairment in the functions of stromal compartment present in the several adipose tissues. This finding provides new insights on the targets that should be considered for an effective treatment of obesity-related diseases.
Biology and Life Sciences, Biology and Biotechnology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
