Version 1
: Received: 28 November 2022 / Approved: 30 November 2022 / Online: 30 November 2022 (04:23:43 CET)
How to cite:
Faggioli, F.; Velarde, M.; Wiley, C.D. Cellular Senescence, a Novel Area of Investigation for Metastatic Diseases. Preprints2022, 2022110564. https://doi.org/10.20944/preprints202211.0564.v1
Faggioli, F.; Velarde, M.; Wiley, C.D. Cellular Senescence, a Novel Area of Investigation for Metastatic Diseases. Preprints 2022, 2022110564. https://doi.org/10.20944/preprints202211.0564.v1
Faggioli, F.; Velarde, M.; Wiley, C.D. Cellular Senescence, a Novel Area of Investigation for Metastatic Diseases. Preprints2022, 2022110564. https://doi.org/10.20944/preprints202211.0564.v1
APA Style
Faggioli, F., Velarde, M., & Wiley, C.D. (2022). Cellular Senescence, a Novel Area of Investigation for Metastatic Diseases. Preprints. https://doi.org/10.20944/preprints202211.0564.v1
Chicago/Turabian Style
Faggioli, F., Micheal Velarde and Christopher D. Wiley. 2022 "Cellular Senescence, a Novel Area of Investigation for Metastatic Diseases" Preprints. https://doi.org/10.20944/preprints202211.0564.v1
Abstract
Metastasis is a systemic condition and the major challenge among cancer types, as it can lead to multiorgan vulnerability. Recently, attention has been drawn to cellular senescence, a complex stress response condition, as a factor implicated in metastatic dissemination and outgrowth. Here, we examine the current knowledge of the features required for cells to invade and colonize secondary organs and how senescent cells can contribute to this process. First, we described the role of senescence in placentation, itself an invasive process which has been linked to higher rates of invasive cancers. Second, we describe how senescent cells can contribute to metastatic dissemination and colonization. Third, we discuss several metabolic adaptations by which senescent cells could promote cancer survival along the metastatic journey. In conclusion, we posit that targeting cellular senescence may have a potential therapeutic efficacy to limit metastasis formation.
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
