Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Mathematical Connection Between Short Telomere Induced Senescence Calculation and Mortality Rate Data

Version 1 : Received: 27 July 2020 / Approved: 28 July 2020 / Online: 28 July 2020 (10:07:22 CEST)

A peer-reviewed article of this Preprint also exists.

Torrance, J.B.; Goldband, S. Mathematical Connection between Short Telomere Induced Senescence Calculation and Mortality Rate Data. Int. J. Mol. Sci. 2020, 21, 7959. Torrance, J.B.; Goldband, S. Mathematical Connection between Short Telomere Induced Senescence Calculation and Mortality Rate Data. Int. J. Mol. Sci. 2020, 21, 7959.

Journal reference: Int. J. Mol. Sci. 2020, 21, 7959
DOI: 10.3390/ijms21217959

Abstract

The last 20 years have seen a surge in scientific activity and promising results in the study of aging and longevity. Many researchers have focused on telomeres, which are composed of a series of TTAGGG repeat nucleotide sequences at the ends of each chromosome. Measurements of the length of these telomere strands show that they decrease in length with increasing age, leading many authors to propose that when the length of these telomere strands decreases sufficiently, the cells enter into a state of replicative senescence, eventually leading to disease and death. These ideas are supported by evidence that short telomere length is correlated with increased mortality. In this paper, we extend this idea to make an actual calculation of the predicted mortality rate caused by short telomere length induced senescence (STLIS). We derive a simple equation for the mathematical relationship between telomere length and mortality rate. Using only 3 parameters based on telomere length measurement data of Canadians, we have calculated both the magnitude and the age dependence of the mortality rate, for both men and women. We show that these calculated data are in good quantitative agreement with the actual number of Canadians that die. This agreement provides strong evidence (but not proof) that the mechanism of STLIS plays an important role in the major diseases of aging (e.g., cardiovascular disease, many cancers, and diabetes mellitus) which dominate human mortality. This result represents significant progress in our understanding the factors behind the cause of aging.

Subject Areas

aging; telomeres; senescence; mortality; disease

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.