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Jumonji C Demethylases in Cellular Senescence
Version 1
: Received: 13 November 2018 / Approved: 16 November 2018 / Online: 16 November 2018 (07:21:53 CET)
A peer-reviewed article of this Preprint also exists.
Leon, K.E.; Aird, K.M. Jumonji C Demethylases in Cellular Senescence. Genes 2019, 10, 33. Leon, K.E.; Aird, K.M. Jumonji C Demethylases in Cellular Senescence. Genes 2019, 10, 33.
Abstract
Senescence is a stable cell cycle arrest that is either tumor suppressive or tumor promoting depending on context. Epigenetic changes such as histone methylation are known to affect both induction and suppression of senescence by altering expression of genes that regulate the cell cycle and the senescence-associated secretory phenotype. A conserved group of proteins containing a Jumonji C (JmjC) domain alter chromatin state, and therefore gene expression, by demethylating histones. Here, we will discuss what is currently known about JmjC demethylases in induction of senescence and how these enzymes suppress senescence to contribute to tumorigenesis.
Keywords
senescence; demethylases; epigenetics; histones; cancer
Subject
Biology and Life Sciences, Cell and Developmental Biology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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