Preprint Review Version 1 This version is not peer-reviewed

Jumonji C Demethylases in Cellular Senescence

Version 1 : Received: 13 November 2018 / Approved: 16 November 2018 / Online: 16 November 2018 (07:21:53 CET)

A peer-reviewed article of this Preprint also exists.

Leon, K.E.; Aird, K.M. Jumonji C Demethylases in Cellular Senescence. Genes 2019, 10, 33. Leon, K.E.; Aird, K.M. Jumonji C Demethylases in Cellular Senescence. Genes 2019, 10, 33.

Journal reference: Genes 2019, 10, 33
DOI: 10.3390/genes10010033

Abstract

Senescence is a stable cell cycle arrest that is either tumor suppressive or tumor promoting depending on context. Epigenetic changes such as histone methylation are known to affect both induction and suppression of senescence by altering expression of genes that regulate the cell cycle and the senescence-associated secretory phenotype. A conserved group of proteins containing a Jumonji C (JmjC) domain alter chromatin state, and therefore gene expression, by demethylating histones. Here, we will discuss what is currently known about JmjC demethylases in induction of senescence and how these enzymes suppress senescence to contribute to tumorigenesis.

Subject Areas

senescence; demethylases; epigenetics; histones; cancer

Readers' Comments and Ratings (0)

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.