Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Potential Role of Cellular Senescence on Coronavirus Infections

Version 1 : Received: 28 April 2020 / Approved: 30 April 2020 / Online: 30 April 2020 (13:58:41 CEST)

How to cite: Chapagain, P. Potential Role of Cellular Senescence on Coronavirus Infections. Preprints 2020, 2020040532 (doi: 10.20944/preprints202004.0532.v1). Chapagain, P. Potential Role of Cellular Senescence on Coronavirus Infections. Preprints 2020, 2020040532 (doi: 10.20944/preprints202004.0532.v1).

Abstract

The disproportionate incidences of COVID-19-related hospitalization and mortality for different age groups and various underlying health conditions is a result of a complex social predisposition to the exposure, resistance, and tolerance for the infection. Based on the observed data as well as the molecular mechanisms for viral entry and replication, cellular senescence related to aging, obesity, hypertension, and diabetes appears to be strongly correlated with the SARS-CoV-2 infections resulting in higher COVID-19 related complications and mortality. Establishing such a correlation may allow us to better explain the pathobiology as well as the differential nature of the SARS-CoV-2 infections and consider targeted control and therapeutic strategies to combat the disease.

Subject Areas

cellular senescence; SARS-CoV-2; coronavirus; aging

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