Review
Version 1
Preserved in Portico This version is not peer-reviewed
Potential Role of Cellular Senescence on Coronavirus Infections
Version 1
: Received: 28 April 2020 / Approved: 30 April 2020 / Online: 30 April 2020 (13:58:41 CEST)
How to cite: Chapagain, P. Potential Role of Cellular Senescence on Coronavirus Infections. Preprints 2020, 2020040532. https://doi.org/10.20944/preprints202004.0532.v1 Chapagain, P. Potential Role of Cellular Senescence on Coronavirus Infections. Preprints 2020, 2020040532. https://doi.org/10.20944/preprints202004.0532.v1
Abstract
The disproportionate incidences of COVID-19-related hospitalization and mortality for different age groups and various underlying health conditions is a result of a complex social predisposition to the exposure, resistance, and tolerance for the infection. Based on the observed data as well as the molecular mechanisms for viral entry and replication, cellular senescence related to aging, obesity, hypertension, and diabetes appears to be strongly correlated with the SARS-CoV-2 infections resulting in higher COVID-19 related complications and mortality. Establishing such a correlation may allow us to better explain the pathobiology as well as the differential nature of the SARS-CoV-2 infections and consider targeted control and therapeutic strategies to combat the disease.
Keywords
cellular senescence; SARS-CoV-2; coronavirus; aging
Subject
Biology and Life Sciences, Anatomy and Physiology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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