Version 1
: Received: 2 February 2021 / Approved: 3 February 2021 / Online: 3 February 2021 (17:00:00 CET)
How to cite:
Chandra, A.; Rajawat, J. Skeletal Aging and Osteoporosis: Cellular Senescence and Beyond. Preprints2021, 2021020127. https://doi.org/10.20944/preprints202102.0127.v1
Chandra, A.; Rajawat, J. Skeletal Aging and Osteoporosis: Cellular Senescence and Beyond. Preprints 2021, 2021020127. https://doi.org/10.20944/preprints202102.0127.v1
Chandra, A.; Rajawat, J. Skeletal Aging and Osteoporosis: Cellular Senescence and Beyond. Preprints2021, 2021020127. https://doi.org/10.20944/preprints202102.0127.v1
APA Style
Chandra, A., & Rajawat, J. (2021). Skeletal Aging and Osteoporosis: Cellular Senescence and Beyond. Preprints. https://doi.org/10.20944/preprints202102.0127.v1
Chicago/Turabian Style
Chandra, A. and Jyotika Rajawat. 2021 "Skeletal Aging and Osteoporosis: Cellular Senescence and Beyond" Preprints. https://doi.org/10.20944/preprints202102.0127.v1
Abstract
Bone is a dynamic organ maintained by tightly regulated mechanisms. With old age, bone homeostasis which is maintained by an intricate balance between bone formation and bone resorption, undergoes deregulation. Oxidative stress-induced DNA damage, cellular apoptosis, and cellular senescence are all responsible for this tissue dysfunction and the imbalance in bone homeostasis. These cellular mechanisms have become a target for therapeutics to treat age-related osteoporosis. Pharmacological and genetic mouse models have shown the importance of senescent cell clearance in alleviating age-related osteoporosis. Senescent cells have an altered secretome, which may have an autocrine, paracrine, or endocrine function. The current review discusses the current and potential pathways which lead to a senescence profile in an aged skeleton. The review was written following an extensive literature survey of published studies, mostly excluding articles published on pre-print servers. The review discusses potential therapeutics targeting cellular senescence and the senescent secretome as underlying pathogenesis of an aging bone.
Biology and Life Sciences, Biochemistry and Molecular Biology
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
