Preprint Review Version 1 This version is not peer-reviewed

DPP-4/GLP-1 Axis as a Potential Therapeutic Target in Chronic Stress-related Vascular Aging and Atherosclerosis

Version 1 : Received: 8 January 2020 / Approved: 9 January 2020 / Online: 9 January 2020 (13:05:26 CET)

How to cite: Wan, Y.; Piao, L.; Nan, Y.; Cehng, X. DPP-4/GLP-1 Axis as a Potential Therapeutic Target in Chronic Stress-related Vascular Aging and Atherosclerosis. Preprints 2020, 2020010087 (doi: 10.20944/preprints202001.0087.v1). Wan, Y.; Piao, L.; Nan, Y.; Cehng, X. DPP-4/GLP-1 Axis as a Potential Therapeutic Target in Chronic Stress-related Vascular Aging and Atherosclerosis. Preprints 2020, 2020010087 (doi: 10.20944/preprints202001.0087.v1).

Abstract

Exposure to psychosocial stress is a risk factor for cardiovascular disease, including vascular aging, angiogenesis, and atherosclerosis-based cardiovascular disease (ACVD). Dipeptidyl peptidase-4 (DPP-4) is a complex enzyme (also called CD26) that acts as a membrane-anchored cell surface exopeptidase. DPP4 is upregulated in metabolic and inflammatory cardiovascular disorders. The widespread expression of DPP4 macrophages and immune cells and the noncatalytic function of DPP4 (also called CD26) as a signaling and binding protein across a wide range of species suggest a teleological role for DPP4 in inflammation and immune response. DPP-4 exhibits many physiological and pharmacological functions by regulating its extremely abundant substrates [e.g., stromal cell-derived factor-1α/ C-X-C chemokine receptor type-4, glucagon-like peptide-1 (GLP-1), etc.]. Over last ten year, emerging data demonstrated unexpected roles for GLP-1 and DPP-4 in extracellular and intracellular signaling, immune activation, inflammation, oxidative stress production, cell apoptosis, insulin resistance, and lipid metabolism,. This mini review has focuses on recent novel findings in this field, highlighting an imbalance between GLP-1 and DPP4 as a potential therapeutic molecular target in treatments of chronic psychological stress-related atherosclerotic cardiovascular disease in humans and animals.

Subject Areas

Chronic stress; Vascular senescence; inflamamtion; atherosclerosis; dipeptidyl peptidase-4

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