Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Gut Microbiome and Cellular Senescence in the Context of Aging and Disease: An Emerging Frontier

Version 1 : Received: 14 May 2021 / Approved: 17 May 2021 / Online: 17 May 2021 (08:51:53 CEST)

How to cite: Sharma, R. Gut Microbiome and Cellular Senescence in the Context of Aging and Disease: An Emerging Frontier. Preprints 2021, 2021050372 (doi: 10.20944/preprints202105.0372.v1). Sharma, R. Gut Microbiome and Cellular Senescence in the Context of Aging and Disease: An Emerging Frontier. Preprints 2021, 2021050372 (doi: 10.20944/preprints202105.0372.v1).

Abstract

The significance of diversity, composition, and functional attributes of the gut microbiota is recognized in human health and disease. Studies have also shown that the gut microbiota is related to human aging, and a causal relationship between gut microflora dysbiosis and chronic age-related disorders is also becoming apparent. Further, emerging evidence indicates that age-associated changes in the gut microbiome are predictors of human survival and longevity. Recent advances in our understanding of the cellular and molecular aspects of biological aging have revealed a cellular senescence-centric view of the aging process. However, the association between gut microbiome and cellular senescence is only beginning to be understood. The present review provides an integrative view of the emerging relationship between the gut microbiome and cellular senescence in aging and disease. Evidence relating to microbiome-mediated modulation of senescent cells, as well as senescent cells-mediated changes in intestinal homeostasis have been discussed. Unanswered questions and future research directions have also been deliberated to truly ascertain the relationship of the gut microbiome and cellular senescence for developing microbiome-based age-delaying and longevity promoting therapies.

Subject Areas

Aging; Microbiome; Probiotics; Cellular senescence; SASP; Stress; Immunity

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.