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Preprint REVIEW | doi:10.20944/preprints202401.2238.v1

N-glycosylation as a Modulator of Protein Conformation and Assembly in Disease

Chiranjeevi Pasala, Tanaya Roychowdhury, Sahil Sharma, Elisabetta Moroni, Giorgio Colombo, Gabriela Chiosis

Subject: Biology And Life Sciences, Other Keywords: N-glycosylation; disease; conformational mutant; aberrant protein assembly; energy landscape; SARS-CoV-2 spike protein; glucose regulated protein 94 (GRP94); prion protein; disease-associated protein conformation; protein dynamics; protein assembly mutation; gain-of-function conformational change

Online: 31 January 2024 (14:12:55 CET)

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Preprint REVIEW | doi:10.20944/preprints202308.0733.v1

Protein-Bound Uremic Toxins in Senescence and Kidney Fibrosis

Yi Yang, Milos Mihajlovic, Rosalinde Masereeuw

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: chronic kidney disease; uremic toxins; renal tubular transport; extracellular matrix remodeling; apoptosis resistance; inflammatory response; senescence-associated secretory phenotype factors

Online: 9 August 2023 (10:49:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0220.v1

Beyond Quiescent and Active: Intermediate Microglial Transcriptomic States in a Mouse Model of Down Syndrome

Álvaro Fernández-Blanco, Cèsar Sierra, Clara Tejido, Mara Dierssen

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Down syndrome; microglia; disease-associated microglia

Online: 5 February 2024 (05:38:38 CET)

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Preprint REVIEW | doi:10.20944/preprints202306.1245.v1

Significance of Diabetic Kidney Disease Biomarkers in Predicting Metabolic-Associated Fatty Liver Disease

Jaehyun Bae, Byung-Wan Lee

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: diabetic kidney disease; metabolic-associated fatty liver disease; biomarker

Online: 16 June 2023 (13:36:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.1669.v1

Effects of Probiotics in Elderly Hospitalized Tube-Fed Patients with Antibiotic Use

Chu-Hsuan Hsia, Hsiu-Yueh Su, Yue-Hwa Chen, Han-Chuan Chuang, Yi-wen Chien

Subject: Biology And Life Sciences, Aging Keywords: Antibiotic-associated diarrhea (AAD); Clostridium difficile-associated diarrhea (CDAD); Probiotic; Tube-fed elderly; Infectious disease

Online: 27 November 2023 (10:22:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202002.0234.v1

Sequence Properties of the MAAP Protein and of the VP1 Capsid Protein of Adeno-Associated Viruses

David G. Karlin

Subject: Biology And Life Sciences, Virology Keywords: adeno-associated virus; protein sequence analysis; overlapping genes; amino acid depletion; cysteine depletion; tyrosine depletion; capsid design; membrane-binding amphipathic helix

Online: 17 February 2020 (02:42:39 CET)

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Working Paper REVIEW

Role of Nucleoid Associated Protein HU in the Intercellular and Extracellular Milieu

Debayan Dey

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: nucleoid-associated proteins (NAPs); moonlighting proteins; drug target; biofilm; specificity determination; phylogenetic analysis

Online: 7 June 2020 (09:07:56 CEST)

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Preprint REVIEW | doi:10.20944/preprints201810.0023.v1

Unfolded Protein Response-Dependent Communication and Contact among Endoplasmic Reticulum, Mitochondria and Plasma Membrane.

Atsushi Saito, Kazunori Imaizumi

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Unfolded protein response; ER morphology; Mitochondria-associated ER membrane; ER-PM contact sites

Online: 2 October 2018 (13:41:17 CEST)

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Preprint REVIEW | doi:10.20944/preprints201809.0521.v1

Unfolded Protein Response-Dependent Communication and Contact among Endoplasmic Reticulum, Mitochondria and Plasma Membrane.

Atsushi Saito, Kazunori Imaizumi

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Unfolded protein response; ER morphology; Mitochondria-associated ER membrane; ER-PM contact sites

Online: 26 September 2018 (15:44:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0050.v1

Network Protein Interaction in Parkinson's Disease and Periodontitis Interplay: A Bioinformatic Analysis

João Botelho, Paulo Mascarenhas, José João Mendes, Vanessa Machado

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Parkinson’s disease; Periodontitis; Periodontal disease; protein-protein network interaction; Bioinformatics

Online: 3 September 2020 (04:13:12 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.1062.v1

Metabolic-Dysfunction Associated Steatotic Liver Disease -Its Pathophysiology, Association with Atherosclerosis and Cardiovascular Disease, and Ideal Treatments

Hidekatsu Yanai, Hiroki Adachi, Mariko Hakoshima, Sakura Iida, Hisayuki Katsuyama

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: cardiovascular disease; fatty acids; insulin resistance; metabolic-dysfunction associated steatotic liver disease; pemafibrate; triglyceride

Online: 18 September 2023 (08:37:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0151.v1

The Surgical, Histopathological Characteristics, and Survival Outcome of Ovarian Clear Cell Carcinoma: A Retrospective Case Series Sharing the Experience of a Tertiary Cancer Centre over 10 Years

Sally EL Tawab, Sabina Nistor, Rene Roux, Sanjiv Manek, Kezia Geitskell, Ahmed Ahmed, Sean Kehoe, Hooman Soleymani majd

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Ovarian clear cell carcinoma; residual disease; recurrence; survival; endometriosis- associated

Online: 10 April 2023 (05:14:42 CEST)

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Preprint REVIEW | doi:10.20944/preprints201912.0040.v1

Herpesviruses and the Unfolded Protein Response

Benjamin P. Johnston, Craig McCormick

Subject: Biology And Life Sciences, Virology Keywords: unfolded protein response (UPR); integrated stress response (ISR); ATF6; IRE1; XBP1; PERK; ATF4; GADD34; herpesvirus; Kaposi’s sarcoma-associated herpesvirus (KSHV); cytomegalovirus (CMV); herpes simplex virus (HSV)

Online: 4 December 2019 (04:38:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202202.0017.v1

Novel Protein-Protein Interactions Highlighting the Crosstalk between Hypoplastic Left-Heart Syndrome, Ciliopathies and Neurodevelopmental Delays

Kalyani B Karunakaran, George C Gabriel, N Balakrishnan, Cecilia W Lo, Madhavi K Ganapathiraju

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: protein-protein interactions; interactome; congenital heart disease; developmental disorder; hypoplastic left heart syndrome; web application

Online: 1 February 2022 (16:00:59 CET)

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Preprint REVIEW | doi:10.20944/preprints202302.0054.v1

The Elusive Trypanosoma cruzi Disperse Gene Protein Family (DGF-1)

Jose Luis Ramirez

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Chagas Disease; surface proteins; disperse protein family; Trypanosoma cruzi

Online: 3 February 2023 (03:11:08 CET)

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Preprint REVIEW | doi:10.20944/preprints201807.0481.v2

A Closer Look into the Role of Protein Tau in the Identification of Promising Therapeutic Targets for Alzheimer’s Disease

Rubayat Islam Khan, Saif Shahriar Rahman Nirzhor, Barnaly Rashid

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: protein tau; Alzheimer’s disease; neurodegenerative disease; synaptic dysfunction; Aβ-peptides; tau-imaging

Online: 27 August 2018 (11:25:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0460.v1

Proof-of-Concept of a Novel Multiepitope Recombinant Protein for the Serodiagnosis of Patients with Chagas Disease

Juliana Martins Machado, Isabela Amorim Gonçalves Pereira, Ana Clara Gontijo Maia, Mariana Ferraz Chaves Francisco, Lais Moreira Nogueira, Isadora Braga Gandra, Anna Julia Ribeiro, Kamila Alves Silva, Carlos Ananias Aparecido Resende, Jonatas Oliveira da Silva, Michelli dos Santos, Ana Alice Maia Gonçalves, Grasiele de Sousa Vieira Tavares, Miguel Angel Chávez-Fumagalli, Mariana Campos da Paz da Paz, Rodolfo Cordeiro Giunchetti, Manoel Otávio C. Rocha, Ana Thereza Chaves, Eduardo Antônio Ferraz Coelho, Alexsandro S. Galdino

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: multiepitope; recombinant protein; immunodiagnosis; Chagas disease

Online: 26 December 2022 (02:17:58 CET)

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Preprint REVIEW | doi:10.20944/preprints202306.1209.v1

Medication Review With Follow-up for End-stage Renal Disease: Drug-Related Problems and Negative Outcomes Associated With Medication. A Systematic Review

Alfonso Pereira-Céspedes, Alberto Jiménez-Morales, Magdalena Palomares-Bayo, Fernando Martínez-Martínez, Miguel Ángel Calleja-Hernández

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: End-stage renal disease; medication review; drug-related problems; negative outcomes associated with medication.

Online: 16 June 2023 (10:13:13 CEST)

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Preprint REVIEW | doi:10.20944/preprints202109.0359.v1

Post-translational Modifications of the p53 Protein and the Impact in Alzheimer’s Disease: A Review of the Literature

James Clark, Simona Piccirella, Rakez Kayed, Giulia Abate, Daniela Uberti, Paul Kinnon

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: p53; post-translational modifications; alzheimer's disease

Online: 21 September 2021 (12:01:29 CEST)

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Preprint REVIEW | doi:10.20944/preprints202307.1599.v1

The Role of Pregnancy Associated Plasma Protein-A in Triple Negative Breast Cancer: A Promising Target for Achieving Clinical Benefits

Arpita Poddar, Farah Ahmady, Sushma R. Rao, Revati Sharma, George Kannourakis, Prashanth Prithviraj, Aparna Jayachandran

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: pregnancy associated plasma protein-A; breast cancer; triple negative breast cancer; epithelial-mesenchymal transition; cancer therapy; cancer biomarker; immunotherapy

Online: 24 July 2023 (10:35:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201907.0043.v1

Construction and Comprehensive Analysis of a Molecular Associations Network via lncRNA-miRNA -disease-drug-protein Graph

Zhen-Hao Guo, Hai-Cheng Yi, Zhu-Hong You

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: Network biology; LINE; lncRNA; protein; miRNA; Drug; disease

Online: 2 July 2019 (11:42:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202102.0062.v1

Network Protein Interaction in the Link between Stroke and Periodontitis Interplay: A Pilot Bioinformatic Analysis

Yago Leira, Paulo Mascarenhas, Juan Blanco, Tomás Sobrino, José João Mendes, Vanessa Machado, João Botelho

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Stroke; Periodontitis; Periodontal disease; protein-protein network interaction; Bioinformatics

Online: 1 February 2021 (16:45:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.0918.v1

Inhibition of Drp1-Filamin Protein Complex Prevents Hepatic Lipid Droplet Accumulation by Increasing Mitochondria-Lipid Droplet Contacts

Kohei Ariyoshi, Kazuhiro Nishiyama, Yuri Kato, Xinya Mi, Tomoya Ito, Yasu-Taka Azuma, Akiyuki Nishimura, Motohiro Nishida

Subject: Biology And Life Sciences, Life Sciences Keywords: lipid droplet; mitochondria fission; fatty liver disease; cilnidipine

Online: 15 April 2024 (08:02:27 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202402.0232.v1

Exploring Natural Compounds for Alzheimer's Disease: Virtual Screening and Docking Study with KIBRA Protein

Ivan Vito Ferrari

Subject: Public Health And Healthcare, Other Keywords: Hypericin,Autodock Vina,Alzheimer's Disease,KIBRA Protein

Online: 5 February 2024 (07:46:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202203.0267.v1

Bacteria-Derived Protein Aggregates Contribute to the Disruption of Host Proteostasis

Alyssa C. Walker, Rohan Bhargava, Autumn S. Dove, Amanda S. Brust, Ali A. Owji, Daniel M. Czyz

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Caenorhabditis elegans; proteostasis; bacteria; neurodegenerative diseases; protein aggregates; protein conformational disease; butyrate; aminoglycoside; Pseudomonas aeruginosa

Online: 18 March 2022 (09:21:45 CET)

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Preprint REVIEW | doi:10.20944/preprints202404.0819.v1

Understanding Macrophage Complexity in Metabolic Dysfunction-associated Steatotic Liver Disease: Transitioning from the M1/M2 Paradigm to Spatial Dynamics

Forkan Ahamed, Natalie Eppler, Elizabeth Jones, Yuxia Zhang

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: macrophages; diversity; Kupffer cell; monocyte-derived macrophage; spatial dynamics; metabolic dysfunction-associated steatotic liver disease (MASLD)

Online: 12 April 2024 (04:44:38 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202401.1652.v1

Exploring the Interaction of E3 Ubiquitin-Protein Ligase Parkin with Natural Compound Amentoflavone: Implications for Parkinson’s Disease Therapy

Ivan Vito Ferrari

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: docking studies; amentoflavone; Parkinson's disease; pyrx program

Online: 23 January 2024 (07:47:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202105.0032.v1

Cellular Prion Protein and Amyloid – β Oligomers in Alzheimer's Disease – There Are Connections?

Naomi Hachiya, Michał Fułek, Katarzyna Zajączkowska, Donata Kurpas, Elżbieta Trypka, Jerzy Leszek

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Alzheimer’s disease; cellular prion protein; amyloid β and PrP interaction in Alzheimer’s; BACE1; Aβ

Online: 5 May 2021 (10:45:04 CEST)

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Preprint REVIEW | doi:10.20944/preprints202210.0056.v1

Structural Determinant of β-Amyloid Formation: From Transmembrane Protein Dimerization to β-Amyloid Aggregates

Nicolas Papadopoulos, Nuria Suelves, Florian Perrin, Devkee M. Vadukul, Céline Vrancx, Stefan N. Constantinescu, Pascal Kienlen-Campard

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Alzheimer’s disease; Amyloid Precursor Protein; Amyloid beta; APP-C99; dimerization; Orientations; Aggregation; Oligomerization

Online: 6 October 2022 (08:41:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0277.v1

Pan-Neuronal Expression of Human Mutant Huntingtin Protein in Drosophila Impairs Immune Response of Hemocytes

Jyoti Dhankhar, Namita Agrawal, Anju Shrivastava

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Huntington’s disease; transgenic Drosophila; immune response; phenoloxidase activity; phagocytosis; reactive oxygen species

Online: 16 September 2021 (11:05:34 CEST)

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Huntington’s disease (HD) is a late-onset; progressive, dominantly inherited neurological disorder marked by an abnormal expansion of polyglutamine (poly Q) repeats in Huntingtin (HTT) protein. The pathological effects of mutant Huntingtin (mHTT) are not restricted to the nervous system but systemic abnormalities including immune dysregulation have been evidenced in clinical and experimental settings of HD. Indeed, mutant huntingtin (mHTT) is ubiquitously expressed and could induce cellular toxicity by directly acting on immune cells. However, it is still unclear if selective expression ofmHTT exon1 in neurons could induce immune responses and hemocyte function. In the present study, we intended to monitor perturbations in the hemocytes population and their physiological functions in Drosophila, caused by pan-neuronal expression of mHTT protein. We found that pan-neuronal expression of mHtt significantly alters crystal cells and plasmatocyte count in larvae and adults with disease progression. Interestingly, plasmatocytes isolated from diseased conditions exhibit a gradual decline in phagocytic activity ex vivo at progressive stages of the disease as compared to age-matched control groups. We also observed an increased production of reactive oxygen species (ROS) in plasmatocytes at advanced stages of the disease. In addition, diseased flies displayed elevated reactive oxygen species (ROS) in circulating plasmatocytes at the larval stage and in sessile plasmatocytes of hematopoietic pockets at of disease. All the parameters were monitored progressively, targeting the circulation at larvae stage and hematopoietic pockets in adults at different disease stages, and many alterations were documented in the early stage itself. These findings strongly implicate that neuronal expression of mHtt alone is sufficient to induce non-cell-autonomous immune dysregulation in vivo. Based on these findings, we propose that further insight into the mechanisms through which neuronal expression of mHtt might be inflicting the innate immune responses would facilitate therapeutic inventions aimed at amelioration of HD pathology and improving the quality of life of the patients.

Preprint ARTICLE | doi:10.20944/preprints202403.0717.v1

Potential Inhibitors of Lumpy Skin Disease’s Viral Protein (DNA Polymerase): A Combination of Bioinformatics Approaches

Sabbir Zia, Md-Mehedi Sumon, Md-Ashikur Ashik, Abul Basar, Sangjin Lim, Yeonsu Oh, Yungchul Park, Md Mafizur Rahman

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Lumpy skin disease; DNA polymerase; potential inhibitors; phytocompounds; antiviral drug compounds; molecular docking

Online: 13 March 2024 (07:58:39 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.1776.v1

Potential Rheumatoid Arthritis-Associated Interstitial Lung Disease Treatment and Computational Approach for Future Drug Development

Eun Ji Jeong, Hyunseok Hong, Kyoung-Soo Kim

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: rheumatoid arthritis-associated interstitial lung disease (RA-ILD); pulmonary fibrosis; antifibrotics; computational drug repositioning; drug–target interaction

Online: 24 January 2024 (21:08:58 CET)

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Working Paper ARTICLE

Paraoxonase-1 and -3 Protein Expression in Brain of the tg2576 Mouse Model of Alzheimer’s Disease

Jose Gregorio Salazar, Judit Marsillach, Ingrid Reverte, Bharti Mackness, Michael Mackness, Jorge Joven, Jordi Camps, María Teresa Colomina

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: paraoxonases; oxidative stress; Alzheimer’s disease; brain; Tg2576 mice; astrocytes; hippocampus; amyloid-β; microglia; neurons

Online: 18 December 2020 (11:53:45 CET)

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Preprint REVIEW | doi:10.20944/preprints201802.0047.v1

Aptamers Selected for Recognizing Amyloid β-protein—A Case for Cautious Optimism

Farid Rahimi

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Alzheimer disease; Amyloid β-protein; Antibodies; Cross-reactions; Nucleotide aptamers; Oligonucleotide ligands; Systematic evolution of ligands by exponential enrichment; Specificity; Therapeutics

Online: 5 February 2018 (22:37:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202305.0276.v1

Synthesis and Preclinical Evaluation of Novel 68Ga-labeled (R)-Pyrrolidin-2-yl-boronic acid-based PET Tracers for Fibroblast Activation Protein-targeted Cancer Imaging

Shreya Bendre, Hsiou-Ting Kuo, Helen Merkens, Zhengxing Zhang, Antonio A. W. L. Wong, François Bénard, Kuo-Shyan Lin

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: fibroblast activation protein α (FAP-α); cancer-associated fibroblasts (CAFs); FAP inhibitors (FAPIs); PET imaging; gallium-68; (R)-pyrrolidin-2-yl-boronic acid-based radiopharmaceuticals

Online: 5 May 2023 (02:40:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0564.v1

In vivo Neuropharmacological Potential of Gomphandra tetrandra (Wall.) Sleumer and in-silico Study against β-Amyloid Precursor Protein

Md Saidur Rahman, Md Nazmul Hasan Zilani, Md. Aminul Islam, Md Munaib Hasan, Md. Muzahidul Islam, Farzana Yasmin, Partha Biswas, Akinori Hirashima, Md. Ataur Rahman, Md. Nazmul Hasan, Bonglee Kim

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Neurological activity; GC-MS; ADMET profile; Molecular Docking; Beta-amyloid precursor protein; Alzheimer’s disease

Online: 26 July 2021 (10:27:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2168.v1

Alterations in the amyloid protein precursor, α-secretase, β-secretase, presenilins and tau protein Genes in the CA3 Area of the Hippocampus in a 2-Year Ischemic Model of Alzheimer’s Disease

Stanisław Czuczwar, Janusz Kocki, Barbara Miziak, Jacek Bogucki, Anna Bogucka-Kocka, Ryszard Pluta

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: brain ischemia; Alzheimer’s disease; CA3 area; amyloid protein precursor; amyloid; α-secretase; β-secretase; presenilin 1 and 2; tau protein; genes

Online: 30 September 2023 (08:01:45 CEST)

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Understanding the phenomena underlying the non-selective susceptibility to ischemia of py-ramidal neurons in the CA3 area of the hippocampus is important from the point of view of elu-cidating the mechanisms of memory loss and the development of post-ischemic dementia. We used an ischemic model of Alzheimer's disease to study changes in amyloid protein precursor gene expression, its cleavage enzymes and tau protein in the CA3 area of the hippocampus af-ter a 10-minute brain ischemia with 12, 18, and 24-month survival. Quantitative reverse tran-scriptase PCR assay showed that the expression of all the genes that contribute to amyloid pro-duction was dysregulated within 2 years in the CA3 area of the hippocampus after ischemia. The expression of the amyloid protein precursor gene was above the control values at all times of the study. The expression of the α-secretase gene also exceeded the control values throughout the study. In contrast, the expression of the β-secretase gene reaching its maximum increase 12 months after ischemia, was below control values after 18 months and again above control values after 24 months of survival. Presenilin 1 and 2 gene expression was significantly elevated throughout the follow-up period, with peak expression of both genes occurring 12 months after ischemia. This suggests that the genes studied are involved in the non-amyloidogenic processing of amyloid protein precursor. Also, tau protein gene expression was significantly elevated throughout the observation period, and peak gene expression was present 12 months after is-chemia. Data indicate that an episode of brain ischemia with long-term survival causes damage and death of pyramidal neurons in the CA3 area of the hippocampus in a manner dependent on modified tau protein. Thus defining a new and important mechanism of pyramidal neuronal death in the CA3 area after ischemia. In addition tau protein gene modification after brain is-chemia is useful in identifying ischemic mechanisms occurring in Alzheimer's disease.

Preprint ARTICLE | doi:10.20944/preprints202211.0135.v1

Rare Amyloid Precursor Protein Point Mutations Recapitulate Worldwide Migration and Admixture in Healthy Individuals: Implications For the Study of Neurodegeneration

Paolo Abondio, Francesco Bruno, Amalia Cecilia Bruni, Donata Luiselli

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: amyloid; Alzheimer’s disease; neurodegenerative diseases; neurodegeneration; dementia; population genomics; migration; admixture; APP; neuropathology

Online: 8 November 2022 (02:10:21 CET)

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Preprint REVIEW | doi:10.20944/preprints202012.0578.v2

Unfolded Protein Response and Crohn’s Diseases: A Molecular Mechanism of Wound Healing in the Gut

Chao Li

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Unfolded protein response; Endoplasmic reticulum stress; Glucose-regulated protein 78 kD; Inflammatory Bowel Diseases; Crohn’s disease; Fibrosis; Wound healing

Online: 12 January 2021 (17:03:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1264.v1

Prevalence of Condom Use and Associated Factors among Undergraduate Students of Gulu University.

Brian Otim, Jerom Okot, Ritah Nantale, Winnie Kibone, Grace Madraa, Christopher Okot, Felix Bongomin

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Undergraduates; condom use; associated factors; Uganda

Online: 21 March 2024 (08:55:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1831.v1

COVID-19 Vaccine Coverage and Factors Associated with Vaccine Hesitancy: A Cross-Sectional Survey in the City of Kinshasa, Democratic Republic of Congo

Pierre Z Akilimali, Landry Egbende, Dynah M Kayembe, Francis Kabasubabo, Benito Kazenza, Steve Botomba, Nguyen Toan Tran, Désiré Kulimba Mashinda

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: COVID-19; vaccine hesitancy; associated factors

Online: 26 January 2024 (02:07:33 CET)

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: Background: Vaccination against COVID-19 has been the main strategy used by most countries to limit the spread of the virus. However, vaccine uptake has been low in Africa, leading to the implementation of several interventions in order to improve vaccine coverage. This study was conducted due to the lack of information about COVID-19 vaccine coverage and the factors associated with vaccine hesitancy. Methods: This cross-sectional study was carried out in Kinshasa city using multi-stage random sampling. A total of 2160 households were included in the study. The data were analyzed using Stata 15 software. The means and standard deviations were calculated for normally distributed continuous variables, while proportions with their 95% confidence intervals (CIs) were calculated for categorical variables. Pearson’s chi-square test or Fisher’s exact test was used to test the associations between dependent variables and each independent variable. Logistic regression was used to identify the factors associated with hesitancy receiving the COVID-19 vaccination. Results: The majority of respondents were aged between 25 and 34 and 35 and 49 (28.9%). During this study, 15% (95% CI [13.25–17.9]) of respondents had received at least one dose of the COVID-19 vaccine. Among the reasons given for refusing to be vaccinated, most respondents cited concerns about the vaccine being unsafe or causing adverse reactions (45%). Among the reasons given for accepting the vaccine, 26% thought that the vaccine prevented superinfection. The factors associated with hesitancy toward the COVID-19 vaccine were female gender, an age of less than 35 years, and living in non-slum households. Conclusions: Despite the interventions implemented across the country, the reluctance to be vaccinated remains a problem; this could lead to poor health outcomes, especially among the elderly and those with pre-existing conditions. It is important to step up awareness-raising campaigns in the community in order to increase the uptake of vaccination.

Preprint ARTICLE | doi:10.20944/preprints202309.1004.v1

MicroRNAs Signature Set Identifies Heavy Drinkers with Alcohol-associated Cirrhosis from those Without Liver Injury

Fathima Shihana, Mugdha V. V Joglekar, Tae Hwi Linus Schwantes-An, Anandwardhan Hardikar, Devanshi Seth

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: alcohol-associated liver cirrhosis; microRNAs; biomarker

Online: 15 September 2023 (03:31:18 CEST)

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Background: Alcohol-associated Liver Disease (ALD) is the most common disorder of prolonged drinking. Mechanisms underlying cirrhosis in such patients remain unclear. MicroRNAs play regulatory role in several diseases, are affected by alcohol and may be important players in alcohol use disorders, such as cirrhosis. Methods: We investigated serum samples from heavy chronic alcohol users (80g/d (M) and 50g/d (F) for ≥10 years) that were available from our previously reported GenomALC study. A subset of drinkers with liver cirrhosis (cases, n=24) and those without significant liver disease (controls, n=23) were included. Healthy controls (HC, n=5) were volunteers in the study. Global microRNA profiling was performed using high-throughput real-time quantitative PCR to identify the microRNA signatures. Ingenuity Pathway Analysis software (IPA) was utilized to identify target mRNAs of significantly altered microRNAs and molecular pathways were analysed. Identified microRNAs were analysed for correlation with traditional liver disease biomarkers and risk gene variants previously reported from GenomALC genome-wide association study. Results: The expression of 81 and 21 microRNAs was significantly downregulated in cases compared to HC and controls, respectively (p<0.05, Ct >1.5-fold). Most microRNAs showed lower abundance in alcohol users compared with HC. Seven microRNAs (miR-16, miR-19a, miR-27a, miR-29b, miR-101, miR-130a, & miR-191) had a highly significant correlation (p<0.001) with INR, bilirubin and MELD score. Three microRNAs (miR-27a, miR-130a and miR-191) significantly predicted cases with AUC-ROC 0.8, 0.78 and 0.85, respectively (P<0.020), however, INR performed best (0.97, p<0.001). A different set of 6 microRNAs (miR-19a, miR-26a, miR-101, miR-151-3p, miR-221, & miR-301) showed positive correlation (ranging 0.32-0.51, p<0.05) with rs10433937:HSD17B13 gene variant, associated with risk of cirrhosis. IPA analysis revealed mRNA targets of the significantly altered microRNAs associated with cell death/necrosis, fibrosis and increased steatosis, particularly triglyceride metabolism related mRNA targets. Conclusions: MicroRNA signatures in drinkers distinguished those with liver cirrhosis from those without liver disease. We identified mRNA targets in liver functions that were enriched for disease pathogenesis pathways.

Preprint CASE REPORT | doi:10.20944/preprints202306.2102.v1

Gordonia sputi as an Arising Causative Agent of Bacteremia in Immunocompromised Comorbid Dialysis Patients—A Case Report

Bozhidar Vergov, Andreana Angelova, Alexandra Baldzhieva, Yordan Kalchev, Georgi Tsochev, Marianna Murdjeva

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Gordonia sputi; Dialysis; Catheter-associated infection

Online: 29 June 2023 (11:35:49 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202112.0492.v1

Secondary Structure and X-Ray Crystallographic Analysis of the Glideosome-Associated Connector (GAC) from Toxoplasma gondii

Amit Kumar, Xu Zhang, Oscar Vadas, Fisentzos Stylianou, Nicolas Dos Santos Pacheco, Sarah Rouse, Marc Morgan, Dominique Soldati-Favre, Stephen Matthews

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: glideosome-associated connector; protein; crystallography; structure

Online: 30 December 2021 (17:13:26 CET)

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Preprint BRIEF REPORT | doi:10.20944/preprints202310.1087.v1

Anti-IL1 Therapy Does Not Affect the Response to SARS-COV-2 Vaccination and Infection in Patients with Systemic Autoinflammatory Diseases

Leonie Geck, Koray Tascilar, David Simon, Arnd Kleyer, Georg Schett, Juergen Rech

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: autoinflammatory diseases; SARS-CoV-2; vaccination; familial Mediterranean fever Adult-onset Still's disease; cryopyrin-associated periodic syndrome; systemic autoinflammatory diseases

Online: 17 October 2023 (11:54:44 CEST)

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Preprint REVIEW | doi:10.20944/preprints202202.0013.v1

P53 Protein Modulates Muscle Metabolism and Generates a Non-Genetic Risk Environment that Contributes to Triggering Amyotrophic Lateral Sclerosis

Águeda Gema Espina-Zambrano

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: ALS; motor neuron disease (MND); metabolism; muscle; TP53; TDP43; immunomodulatory therapies; neuromuscular junction; mitochondria; epigenetic regulation

Online: 1 February 2022 (12:49:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.1729.v1

The Calculation and Evaluation of an Ultrasound-Estimated Fat Fraction in Non-alcoholic Fatty Liver Disease and Metabolic-Associated Fatty Liver Disease.

Pál Novák Kaposi, Zita Zsombor, Aladár Dávid Rónaszéki, Bettina Katalin Budai, Barbara Csongrády, Róbert Stollmayer, Ildikó Kalina, Gabriella Győri, Viktor Bérczi, Klára Werling, Pál Maurovich-Horvát, Anikó Folhoffer, Krisztina Hagymási

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: quantiative ultrasound; attenuation coefficient; backscatter-distribution coefficient; liver stiffness; non-alcoholic fatty liver disease; metabolic-associated fatty liver disease; hepatic steatosis; ultrasound-estimated fat fraction; proton density fat fraction

Online: 26 September 2023 (05:36:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0427.v1

Hepatotoxicity of Two Progoitrin-Derived Nitriles in New Zealand White Rabbits

Mark Grey Collett, Zoe Maree Matthews, Kathleen Henry Parton

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: brassica-associated liver disease; BALD; progoitrin; 1-cyano-2-hydroxy-3-butene; 1-cyano-2-hydroxy-3,4-epithiobutane; nitrile; toxicity; rabbits

Online: 18 September 2020 (10:07:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202102.0069.v1

Could Protein Content of Urinary Extracellular Vesicles be Useful to Detect Alcoholic Liver Disease and Assess Hepatocarcinoma Risk?

Gonzalez E., Azkargorta M., Garcia-Vallicrosa C., Prieto-Elordui J., Elortza F., Blanco-Sampascual S., Falcon-Perez JM

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: extracellular vesicles (EVs); urinary extracellular vesicles (uEVs); exosomes; biomarkers; liquid biopsy; cirrhosis; fibrosis; hepatocarcinoma (HCC); alcoholic liver disease (ALD).

Online: 1 February 2021 (18:15:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202207.0175.v1

Orthogonal Frames in Krein Spaces

Osmin Oberto Ferrer Villar, Arley Yessit Sierra Acosta, Osvaldo De Jesus Polo Flórez

Subject: Computer Science And Mathematics, Analysis Keywords: Krein space; fundamental symmetry; Hilbert associated; frames

Online: 12 July 2022 (08:10:52 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202109.0015.v1

HIV Prevalence and Risk Factors for Infants Born to Mothers on Arv Treatment at CHUB/Rwanda

Bernard Nsengimana, Francois Nkurunziza, Wivine Mudahigwa Ntaganira, Ruth Uzayisenga, Gad Rutayisire

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Rwanda; Risk associated MTCT; HIV-exposed infants

Online: 1 September 2021 (12:18:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0453.v1

How Well do European Patients Understand Cancer-Associated Thrombosis? A Patient Survey

Ismail Elalamy, Anna Falanga, Charis Girvalaki, Manuel Monreal, Jacob C. Easaw, Annie Young

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Cancer-associated thrombosis; survey; anticoagulant; cancer patients

Online: 17 June 2021 (09:17:59 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202008.0292.v1

Granulomatosis with Polyangiitis Restricted to The Back Muscle: The First Case Report

Yu-Mi Lee, Sang Wan Chung

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: ANCA-associated vasculitis; organ limited vasculitis; GPA

Online: 13 August 2020 (06:59:27 CEST)

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Preprint REVIEW | doi:10.20944/preprints202104.0379.v1

Involvement of the Protein Ras Homolog Enriched in the Striatum, Rhes, in Dopaminergic Neurons Degeneration: Link to Parkison’s Disease

Marcello Serra, Annalisa Pinna, Giulia Costa, Alessandro Usiello, Massimo Pasqualetti, Luigi Avallone, Micaela Morelli, Francesco Napolitano

Subject: Social Sciences, Psychology Keywords: Substantia nigra; mTOR; SUMO E3 ligase; Huntington’s disease; 3,4-methylenedioxymethamphetamine (MDMA); autophagy; L-Dopa-induced dyskinesia (LID); mitophagy

Online: 14 April 2021 (13:41:05 CEST)

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Working Paper REVIEW

Microbiota-Immune Interactions in Ulcerative Colitis and Colitis-Associated Cancer, and Emerging Microbiota-Based Therapies

Jelena Popov, Valentina Caputi, Nandini Nandeesha, David Avelar Rodriguez, Nikhil Pai

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: ulcerative colitis; inflammatory bowel disease; pediatrics; FMT; probiotics; synbiotics; antibiotics; prebiotics; fecal microbiota transplant; colitis-associated cancer; colorectal cancer; CAC; CRC; dysbiosis

Online: 20 September 2021 (14:20:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0475.v1

A Retrospective, Observational Study of Catheter-associated Urinary Tract Infection Events Post-implementation of a Novel Urinary Catheter System with Active Drain Line Clearance and Automated Intra-abdominal Pressure Monitoring

Patrick Brockway, David M. Hill, Vanessa Moll, Kelly Stanton, Manu L.N.G. Malbrain, Sai R. Velamuri

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: catheter-associated infection; CAUTI; urinary tract infection; healthcare-associated infection; active drain line clearance; burns; intra-abdominal pressure; measurement

Online: 30 September 2022 (04:13:24 CEST)

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Preprint REVIEW | doi:10.20944/preprints202311.0804.v1

Metabolic Dysfunction-Associated Fatty Liver Disease and Chronic Viral Hepatitis: The Interlink

Cornelius J Fernandez, Mohammed Alkhalifah, Hafsa Afzar, Joseph M Pappachan

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: metabolic dysfunction-associated fatty liver disease (MAFLD); chronic viral hepatitis; Hepatitis B virus (HBV); Hepatitis C virus; Hepatic Fibrosis; Cirrhosis; and Hepatocellular carcinoma

Online: 14 November 2023 (05:28:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1721.v1

Inflammation and Iron Profile in Children with Sickle Cell Disease in Cameroon: Frequency and Associated Factors

Romaric Tuono De Manfouo, Josué Simo Louokdom, Bernard Claude Chetcha, Prosper Cabral Biapa Nya, Claude Tayou Tagny, Constant Anatole Pieme

Subject: Biology And Life Sciences, Other Keywords: sickle cell anemia; iron profile; inflammation; associated factors

Online: 28 March 2024 (04:15:25 CET)

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Background and objectives: sickle cell disease is the most common hemoglobinopathy in the world. It is considered to be a real public health problem. Sickle cell patients are subjected to several factors causing inflammation such as iron metabolism. The study aimed to look for inflammation in children with sickle cell disease in Cameroon, identify the factors associated with inflammation, and raise the consequences for the patient including the iron profile and the profile of the hemogram. Materials and methods: We conducted an analytical cross-sectional study for 03 months. The sickle cell disease patients coming and/or followed at the Hematology Department of the Regional Hospital of Bafoussam and the Central Hospital of Yaoundé have been recruited. The exploration of inflammation was made by determining CRP, IL6, and ferritin concentrations. The hematological parameters and iron profile were evaluated using standard methods. Statistical analysis of the data was performed; Univariate and multivariate logistic regression analyses allowed to identification of factors associated with inflammation in patients, using the statistical tool R version 4.1.1.. The proportions were compared with the chi-square test when the expected numbers were greater than 5 and the Fisher test when not. Results: The frequency of inflammation in the population was 42.3%. Hyperferritinemia was significantly greater (p<0.001) in patients with inflammation compared to the non-inflammatory patients (96.8% and 76.7% respectively). Patients with inflammation showed a significant elevation of iron parameters (p<0.05). In addition, ferritin and IL6 elevation were associated with inflammation during sickle cell disease respectively (Or = 4.96; 95% CI [1.15-36.42]; p=0.056) and (Or =6.23; 95% CI [1.43-45.96]; p=0.030). Conclusions: The elevated iron in plasma is an effect of inflammation in sickle cell patients. Hence the need of controlling inflammation and iron in the latter is necessary.

Preprint ARTICLE | doi:10.20944/preprints202202.0082.v1

Discovery of Novel Trace Amine-Associated Receptor 5 (TAAR5) Antagonists Using a Deep Convolutional Neural Network

Carlotta Bon, Ting-Rong Chern, Elena Cichero, Terrence O'Brien, Stefano Gustincich, Raul R Gainetdinov, Stefano Espinoza

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Trace amine-associated receptor 5; antagonist; AtomNet; BRET.

Online: 7 February 2022 (11:57:16 CET)

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Preprint REVIEW | doi:10.20944/preprints202103.0638.v1

Shugoshin: From a Perspective of Clinical Disorders

Ravinder Kumar, Meenakshi Agarwal

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Shugoshin; tumor suppressor; cancer; oncogene; tumour associated gene

Online: 25 March 2021 (15:31:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1145.v1

Combined Prognostic Value of Pre-procedural Protein-Energy Wasting and Inflammation Status for Amputation and/or Mortality After Lower Extremity Revascularization in Hemodialysis Patients With Peripheral Arterial Disease

Yoshitaka Kumada, Norikazu Kawai, Narihiro Ishida, Yasuhito Nakamura, Hiroshi Takahashi, Satoru Ohshima, Ryuta Ito, Hideo Izawa, Toyoaki Murohara, Hideki Ishii

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: lower extremity revascularization; peripheral artery disease; hemodialysis; geriatric nutritional risk index; C-reactive protein

Online: 17 November 2023 (07:43:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0297.v1

The Autophagy-Related Musa acuminata Protein MaATG8F Interacts with MaATG4B, Regulating Banana Disease Resistance to Fusarium oxysporum f. sp. cubense Tropical Race 4

Huoqing Huang, Yuzhen Tian, Yile Huo, Yushan Liu, Wenlong Yang, Yuqing Li, Mengxia Zhuo, Dandan Xiang, Chunyu Li, Ganjun Yi, Siwen Liu

Subject: Biology And Life Sciences, Horticulture Keywords: ATG8; ATG4; autophagy; Fusarium oxysporum f. sp. cubense tropical race 4; plant disease resistance

Online: 6 December 2023 (03:17:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0500.v1

Clinical and Structural Biological Studies of Central Nervous System Inflammatory Demyelinating Diseases Related to COVID-19 Vaccines

Mei-Yun Cheng, Hsuan-Chen Ho, Jung-Lung Hsu, Yi Wang, Lin-Yi Chen, Ming-Feng Liao, Long-Sun Ro

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Acute disseminated encephalomyelitis; Central nervous system inflammatory demyelinating diseases; COVID-19 vaccines; Myelin oligodendrocyte glycoprotein antibody-associated disease; Neuromyelitis optica spectrum disorders; Transverse myelitis

Online: 8 February 2024 (08:43:50 CET)

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Preprint REVIEW | doi:10.20944/preprints202404.1713.v1

A Comprehensive Review of Fragile X Syndrome and Fragile X Premutation Associated Conditions in Africa

Chioma N.P. Mbachu, Ikechukwu Mbachu, Randi Hagerman

Subject: Clinical Medicine, Medicine And Pharmacology Keywords: Fragile X syndrome; Fragile X premutation associated conditions; Africa

Online: 26 April 2024 (08:15:57 CEST)

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Preprint REVIEW | doi:10.20944/preprints202401.1401.v1

NF-κB: Governing Innate Immunity in Cancer

Jessica Cornice, Daniela Verzella, Paola Arboretto, Davide Vecchiotti, Daria Capece, Francesca Zazzeroni, Guido Franzoso

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: NF-κB; Tumor-associated macrophages (TAMs); Tumor microenvironment (TME)

Online: 18 January 2024 (14:05:44 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.2013.v1

Modified Crosstalk between Phytohormones in Arabidopsis Mutants for PEP-Associated Proteins

Ivan A. Bychkov, Aleksandra A. Andreeva, Radomira Vankova, Jozef Lacek, Natalia V. Kudryakova, Victor V. Kusnetsov

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Arabidopsis thaliana; phytohormones; gene expression; PEP-associated proteins; mutants

Online: 26 December 2023 (14:09:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0861.v1

Antineutrophil Cytoplasmic Antibody-associated Vasculitis and the Risk of Developing Incidental Tuberculosis: A Population-based Cohort Study

Shan-Ho Chan, Ming-Feng Li, Shih-Hsiang Ou, Mei-Chen Lin, Jen-Hung Wang, Po-Tsang Lee, Hsin-Yu Chen

Subject: Medicine And Pharmacology, Internal Medicine Keywords: antineutrophil cytoplasmic antibody-associated vasculitis; tuberculosis; population-based study

Online: 13 October 2023 (08:10:55 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.1932.v1

DNA damage response & senescence-associated secretory phenotype pathway: Emerging targets for anti-aging

Jawad Nadeem, Amna Parveen, Sun Yeou Kim

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Anti-aging, DNA damage response, senescence-associated secretory phenotype

Online: 28 September 2023 (04:56:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1409.v1

Early and Late Complications after Cataract Surgery in Patients with Uveitis

Gentian Bajraktari, Tomislav Jukić, Miro Kalauz, Martin Oroz, Andrea Radolović Bertetić, Nenad Vukojević

Subject: Medicine And Pharmacology, Ophthalmology Keywords: uveitis-associated cataract; postoperative complications; phacoemulsification; uveitis; visual prognosis

Online: 21 September 2023 (04:56:43 CEST)

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Background and Objectives: Uveitis, a prevalent eye disorder characterized by inflammatory processes, often leads to cataract formation and significant visual impairment. This study aimed to evaluate preoperative conditions and postoperative outcomes following cataract surgery in uveitis patients. Materials and Methods: A retrospective study was conducted at the University Hospital Center Rebro Zagreb, Croatia, involving uveitis patients who underwent cataract surgery between 2013 and 2022. Eligible patients had uveitic cataracts affecting visual acuity or posterior segment visualization in a "quiet eye" and were disease-inactive for at least three months. Patients with certain preexisting ocular conditions were excluded. Data collected included patient demographics, uveitis type, preoperative therapy, preexisting lesions, and postoperative outcomes such as visual acuity, intraocular pressure, central macular thickness, and complications. Statistical analysis was performed to identify risk factors associated with complications. Results: The study included 105 patients. After cataract surgery, there was a significant improvement in visual acuity at various time points, with 90% of eyes showing improvement. Intraocular pressure decreased over time. Central macular thickness increased at three months post-surgery but remained stable thereafter. Early and late complications were observed in 52.4% and 63.8% of eyes, respectively. The most common complications were posterior capsular opacification, macular edema, and epiretinal membrane. Factors associated with complications varied between early and late stages but included age, age at onset of uveitis, and uveitis type. Conclusion: Cataract surgery in uveitis patients presents challenges but can lead to significant visual improvement. This study highlights the importance of careful patient selection, preoperative and postoperative inflammation management, and precise surgical techniques. Although complications were common, they were manageable, and most patients experienced improved vision, emphasizing the benefits of cataract surgery in this population. However, future investigations should address the study's limitations and further refine perioperative strategies.

Preprint ARTICLE | doi:10.20944/preprints202307.1717.v1

Indoor Air Contamination by Yeasts in Healthcare Facilities: Risks of Invasive Fungal Infection

Jean Phellipe Marques do Nascimento, Raniele dos Santos, Mirna Samile dos Santos Silva, Mykaella Andrade de Araújo, Lucas Anhezini, Daniela Évelin dos Santos, Eurípedes Alves da Silva-Filho

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: Healthcare-associated infections; indoor air quality; infection control; Candida

Online: 25 July 2023 (11:50:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0482.v1

A Ketogenic Diet in Combination With Gemcitabine Mitigates Pancreatic Cancer Associated Cachexia in Male and Female KPC Mice

Natalia E Cortez, Suraj Pathak, Cecilia Rodriguez Lanzi, Brian Hong, Rasheed O Sule, Ryman Crone, Fangyi Wang, Shuai Chen, Aldrin Gomes, Keith Baar, Gerardo Guillermo Mackenzie

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: cachexia; pancreatic cancer; ketogenic diet; gemcitabine; cancer-associated cachexia

Online: 7 June 2023 (03:53:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1641.v1

Extensive Drug Resistance of Strong Biofilm-Producing Acinetobacter baumannii Strains Isolated from Infections and Colonization Hospitalized Patients in Southern Poland

Tomasz Kasperski, Dorota Romaniszyn, Estera Jachowicz-Matczak, Monika Pomorska-Wesołowska, Jadwiga Wójkowska-Mach, Agnieszka Chmielarczyk

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: Acinetobacter baumannii; biofilm; extensively drug resistance; biofilm associated genes

Online: 23 May 2023 (10:33:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202301.0471.v1

Risk Factors of Cannula-associated Arterial Thrombosis following Extracorporeal Membrane Oxygenation support: A Retrospective Study

Ngan Hoang Kim Trieu, Xuan Thi Phan, Linh Thanh Tran, Huy Minh Pham, Dai Quang Huynh, Tuan Manh Nguyen, Anh Tuan Mai, Quan Quoc Minh Du, Bach Xuan Nguyen, Thao Thi Ngoc Pham

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: extracorporeal membrane oxygenation; cannula-associated arterial thrombosis; flow rate

Online: 26 January 2023 (08:33:01 CET)

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Preprint REVIEW | doi:10.20944/preprints202208.0316.v1

Type of ANCA may be Superior to Clinical Phenotype in Distinguishing Different Clinical Entities in ANCA-associated Vasculitis

Afroditi Maria Konstantouli, Georgios Lioulios, Asimina Fylaktou, Maria Stangou

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: ANCA-associated vasculitis; Proteinase 3; Myeloperoxidase; Clinical Phenotype; Outcome

Online: 17 August 2022 (09:58:51 CEST)

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Preprint REVIEW | doi:10.20944/preprints201904.0209.v1

The Immunosuppressive Microenvironment of Classic Hodgkin Lymphoma and Therapeutic Approaches to Counter It

Donatella Aldinucci, Cinzia Borghese, Naike Casagrande

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Hodgkin lymphoma; tumor microenvironment; immune escape; tumor-associated macrophages

Online: 18 April 2019 (08:14:50 CEST)

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Preprint REVIEW | doi:10.20944/preprints201702.0098.v1

MicroRNAs in the Communication between Cancer Associated Fibroblasts (CAF) and Cancer Cells

Maren Schoepp, Anda Jana Stroese, Joerg Haier

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: MicroRNA; cancer associated fibroblasts; cell-cell communication; transformation; epigenetic

Online: 28 February 2017 (10:29:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints202110.0178.v1

Assessment of the Contribution of a Thermodynamic and Mechanical Destabilization of Myosin–Binding Protein C Domain C2 to the Pathomechanism of Hypertrophic Cardiomyopathy–causing Double Mutation MYBPC3Δ25bp/D389V

Frederic V. Schwäbe, Emanuel K. Peter, Manuel H. Taft, Dietmar J. Manstein

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: cardiac muscle; cardiac contractility; force generation; enhanced molecular dynamics simulations; allostery; protein folding; disease; hypertrophic cardiomyopathy

Online: 12 October 2021 (12:20:26 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202401.0567.v1

Bromelain: Unveiling its Potential as a Natural Anti-Inflammatory Agent through Effective Binding to Apoptosis-associated Speck-like Containing CARD (ASC)

Ivan Vito Ferrari

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Apoptosis-associated speck-like containing; Bromelain; HDOCK SERVER

Online: 8 January 2024 (06:53:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1967.v1

Oncogenic Human Papillomavirus Infection (HPV 16/18) and Associated Factors among Women in East Gojjam Zone, Northwest Ethiopia 2021

mamaru getinet

Subject: Medicine And Pharmacology, Anatomy And Physiology Keywords: OncoE6TM cervical test; HPV; East Gojjam zone; prevalence; associated factors

Online: 26 December 2023 (10:14:26 CET)

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Background: Human papillomavirus is a common pathogen that infects the skin and mucosal epithelium, is transmitted sexually; causes condylomas or squamous cell carcinomas. Two (16 and 18) of the 150 HPV serotypes are oncogenic types. Studies have been done on the infection by oncogenic human papillomavirus 16/18 and associated factors are found to be very limited in Ethiopia. Objective: This study aimed to assess the prevalence of oncogenic human papillomavirus infection (HPV 16/18) and associated factors among women. Methods: An institutional-based cross-sectional study was conducted among 337 women screened for cervical cancer in two hospitals in East Gojjam Zone from February to April 2021 G.C. Four BSc-qualified nurses who worked in the chosen hospitals collected the data using pretested questionnaire and an HPV test (OncoE6TM Cervical Test) specific to HPV16/18 in cervical swabs. Descriptive analysis was performed to determine the prevalence and a multivariate logistic regression model was used to identify the associated factors of HPV16/18 infection. Finally, statistical significance was declared at P < 0.05.Results: The prevalence of HPV infection was 14.2% (95% CI: 10.7% -18.1%). The mean age of the respondents was 36.7±9.1 years. Women with the age group of 55-65 years (AOR = 7.91, 95% CI: 1.95-32.09), early initiation of sexual intercourse (AOR = 5.36, 95% CI: 1.58-18.13), history of sexually transmitted infection (STI) (AOR = 3.52, 95% CI: 1.27-9.72), human immunodeficiency virus (HIV) positive status (AOR = 6.8, 95% CI: 1.99-23.54), and number of lifetime sexual partners (AOR = 4.37, 95% CI: 1.15-17.3) were important independent factors associated with the presence of oncogenic HPV infection. Conclusion and Recommendation: We found a relatively low prevalence of high-risk HPV infection. Age, early initiation of sexual intercourse at less than 18 years, STI of women, being HIV seropositive, and a number of sexual partners were important factors for high-risk HPV infection. Women aged > 46 years, women with early initiation of sex, a history of STI, being HIV positive, and a history of multiple sexual partners should be encouraged to be screened and vaccinated for HPV infection. Wider-ranging studies are also needed in HPV-infected women in association with the cervical lesion.

Preprint ARTICLE | doi:10.20944/preprints202311.1256.v1

TitleBiological Effects of “Inflammageing” on Human Oral Cells: Insights into a Potential Confounder of Age-Related Diseases

Elli Alexakou, Athina Bakopoulou, Danae A Apatzidou, Aristeidis Kritis, Andigoni Malousi, Vassiliki Anastassiadou

Subject: Biology And Life Sciences, Life Sciences Keywords: inflammageing; senescence; pro-inflammatory stimulus; Senescence Associated Secretory Phenotype (SASP)

Online: 20 November 2023 (16:15:05 CET)

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Objectives: The term "inflammageing” describes the process of inflammation-induced aging that leads living cells to a state of permanent cell cycle arrest due to chronic antigenic irritation. This in vitro study aimed to shed light on the mechanisms of “inflammageing” on human oral cells. Methods: Primary cultures of human gingival fibroblasts (hGFs) were exposed to variable pro-inflammatory stimuli, including lipopolysaccharide (LPS), Tumor Necrosis Factor-alpha (TNFa), and gingival crevicular fluid (GCF) collected from active periodontal pockets of systemically healthy patients. Inflammageing was studied through two experimental models, employing either late-passage (“aged”) cells (p.10) that were exposed to the pro-inflammatory stimuli or early-passage (“young”) cells (p.1) continuously exposed during a period of several passages (up to p.10) to the above-mentioned stimuli. Cells were evaluated for the expression of beta-galactosidase activity (histochemical staining), senescence-associated genes (qPCR analysis), and biomarkers related to a Senescence Associated Secretory Phenotype (SASP), through proteome profile analysis and bioinformatics. Results: A significant increase (p<0.05) of beta-galactosidase-positive cells was observed after exposure to each pro-inflammatory stimulus. The senescence-associated gene expression included upregulation for CCND1 and downregulation for SUSD6, and STAG1, a profile typical for cellular senescence. Overall, pro-inflammatory priming of late-passage cells caused more pronounced effects in terms of senescence, than long-term exposure of early-passage cells to these stimuli. Proteomic analysis showed induction of SASP, evidenced by upregulation of several pro-inflammatory proteins (IL-6, IL-10, IL-16, IP-10, MCP-1, MCP-2, M-CSF, MIP-1a, MIP-1b, TNFb, sTNF-RI, sTNF-RII, TIMP-2) implicated in cellular aging and immune responses. The least potent impact on the induction of SASP was provoked by LPS and the most pronounced by GCF. Conclusion: This study demonstrates that long-term exposure of hGFs to various pro-inflammatory signals induced or accelerated cellular senescence with the most pronounced impact noted for the late-passage cells. The outcome of this analyses provides insights into oral chronic inflammation, as a potential confounder of age-related diseases.

Preprint REVIEW | doi:10.20944/preprints202207.0078.v2

Mitochondrial Damage-Associated Molecular Patterns Content in Extracellular Vesicles Promotes Early Inflammation in Neurodegenerative Disorders

Claudia Deus, Henrique Tavares, Margarida Beatriz, Sandra Mota, Carla Lopes

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Extracellular vesicles; neurodegenerative disorders; mitochondrial damage-associated molecular patterns; inflammation

Online: 6 July 2022 (09:16:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0096.v1

Hepatitis E Virus Seroprevalence and Associated Risk Factors in Pregnant Women Attending Antenatal Consultations in Senegal

Abou Abdallah Malick Diouara, Seynabou Lo, Cheikh Momar Nguer, Assane Senghor, Halimatou Diop Ndiaye, Noël Magloire Manga, Fodé Danfakha, Sidy Diallo, Marie Edouard Faye Dieme, Ousmane Thiam, Babacar Biaye, Ndèye Marie Pascaline Manga, Fatou Thiam, Habibou Sarr, Gora Lo, Momar Ndour, Sébastien Paterne Manga, Nouhou Diaby, Modou Dieng, Idy Diop, Yakhya Dieye, Coumba Toure Kane, Martine Peeters, Ahidjo Ayouba

Subject: Biology And Life Sciences, Virology Keywords: Hepatitis E; Associated risk factors; Pregnant women; Environment; Prevention; Senegal

Online: 7 June 2022 (08:06:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0385.v1

Improved Cognitive Performances in Trace Amine-Associated Receptor 5 (TAAR5) Knock-out Mice

Silvia Maggi, Carlotta Bon, Stefano Gustincich, Valter Tucci, Raul R Gainetdinov, Stefano Espinoza

Subject: Social Sciences, Behavior Sciences Keywords: Trace amine-associated receptor 5; cognition; decision-making; switch task

Online: 25 January 2022 (14:49:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202101.0320.v2

Phylogenetic and Expression Analysis of CENH3 and APOLLO Genes in Sexual and Apomictic Boechera Species

Evgeny Bakin, Fatih Sezer, Aslıhan Özbilen, Irem Kilic, Buket Uner, Mike Rayko, Kemal Melih Taskin, Vladimir Brukhin

Subject: Biology And Life Sciences, Plant Sciences Keywords: Boechera; Brassicaceae; CENH3; APOLLO; apomixis associated genes; cell division; apomeiosis

Online: 20 December 2021 (10:40:57 CET)

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Apomictic plants (reproducing via asexual seeds), unlike sexual individuals, avoid meiosis and egg cell fertilization. Consequently, apomixis is very important for fixing maternal genotypes in the next plant generations. Despite the progress in the study of apomixis, molecular and genetic regulation of the latter remains poorly understood. So far APOLLO (Aspartate Glutamate Aspartate Aspartate histidine exonuclease) is one of the very few described genes associated with apomixis in Boechera species. The centromere-specific histone H3 variant encoded by CENH3 gene is essential for cell division. Mutations in CENH3 disrupt chromosome segregation during mitosis and meiosis since the attachment of spindle microtubules to a mutated form of the CENH3 histone fails. This paper presents in silico characteristic of APOLLO and CENH3 genes, which may affect apomixis. Also, we characterize the structure of CENH3, study expression levels of APOLLO and CENH3 in gynoecium/siliques of the natural diploid apomictic and sexual Boechera species at the stages of before and after fertilization. While CENH3 was a single copy gene in all Boechera species, the APOLLO gene have several polymorphic alleles associated with sexual and apomictic reproduction in the Boechera genera. Expression of the APOLLO apo-allele during meiosis was upregulated in gynoecium of apomict B. divaricarpa downregulating after meiosis until 4th day after pollination (DAP). On the 5th DAP, expression in apomictic siliques increased again. In sexual B. stricta gynoecium and siliques APOLLO apo-allele did not express. Expression of the APOLLO sex-allele during and after meiosis in gynoecium of sexual plants was several times higher than that in apomictic gynoecium. However, after pollination the sex-allele was downregulated in sexual siliques to the level of apomicts and increased sharply on the 5th DAP, while in apomictic siliques it almost did not express. At the meiotic stage, the expression level of CENH3 in the gynoecium of apomicts was two times lower than that of the sexual Boechera, decreasing in both species after meiosis and keep remaining very low in siliques of both species for several days after artificial pollination until the 4th DAP, when the expression level raised in sexual B. stricta siliques exceeding 5 times the level in apomictic B. divaricarpa siliques. We also discuss polymorphism and phylogeny of the APOLLO and CENH3 genes.

Preprint REVIEW | doi:10.20944/preprints202004.0331.v1

Coronavirus 2019 Infection in People with Associated Co-Morbidities: Case Fatality and ACE2 Inhibitors Treatment Concerns

Maryam Honardoost, Rokhsareh Aghili, Mohammad E. Khamseh

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: COVID-19; associated comorbidities; treatment; ACE2 inhibitors; Type 2 diabetes

Online: 19 April 2020 (05:42:22 CEST)

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Preprint REVIEW | doi:10.20944/preprints202005.0340.v1

Roles of Cannabidiol in Reversing Proteinopathies

Raju Dash, Md. Chayan Ali, Israt Jahan, Yeasmin Akter Munni, Sarmistha Mitra, Md. Abdul Hannan, Binod Timalsina, Diyah Fatimah Oktaviani, Ho Jin Choi, Il Soo Moon

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: Cannabidiol; Alzheimer's disease; Huntington's disease; Multiple sclerosis; Parkinson’s disease; Prion disease; Proteinopathies

Online: 21 May 2020 (09:43:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0338.v1

Emergent Viral Disease in Alfalfa (Medicago sativa L.) Plots in Cochabamba, Bolivia, a Preliminary Evaluation

Mario Coca Morante, Nilo Acha Molina, Arnold Calani Lucas, Ruddy Meneses Arce

Subject: Biology And Life Sciences, Virology Keywords: disease incidence; emerging disease; Cultivated forage crops; plant pathology; disease incidence; emerging disease

Online: 24 January 2022 (09:57:58 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.0263.v1

Cancer‐Associated Fibroblast Heterogeneity in Oral Cancer

Julia Arebro, Che-Min Lee, Kevin L Bennewith, Cathie Garnis

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Cancer‐associated fibroblast, CAF subtype, oral squamous cell carcinoma, tumor microenvironment

Online: 5 December 2023 (11:11:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1202.v1

The Risk of Death among Patients with Healthcare-Associated Infections and Cardiovascular Diseases Admitted in Intensive Care Unit in Romania

Mihaela Alexandra Budianu, Liviu Moraru, Bogdan Mihai Budianu, Judit Kovacs, Septimiu Voidăzan

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: healthcare-associated infections; Intensive Care Unit; cardiovascular diseases, multidrug resistant bacteria

Online: 18 October 2023 (18:26:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1121.v1

Knowledge and Visual Differentiation Ability of the Pressure Injury Classification System and Incontinence-Associated Dermatitis among Hospital Nurses: A Descriptive Study

Seungmi Park, Eun Jung Kim, Son Ja Lee, Eun Jeong Kim, Ji Yeon Lee, Jung Eun Hong

Subject: Public Health And Healthcare, Nursing Keywords: clinical nurses; visual differentiation; diagnostic ability; pressure injury; incontinence-associated dermatitis

Online: 18 October 2023 (10:00:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1794.v1

DNA Promoter Methylation of the ATM, APC, CDO1, RB1, TP53, WIF1 Genes in Patients with Head and Neck Squamous Cell Carcinoma

Segey Kurevlev, Anna Aghjanayan, Leyla Tskhovrebova, Konstantin Gordon, Andrey Polyakov, Mikhail Ratushnyy, Timur Fatkhudinov

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: DNA methylation; cancer associated genes; head and neck squamous cell carcinoma

Online: 25 August 2023 (08:33:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0307.v1

The Consistency of the Distribution Function Conditional Estimate and Application on the Consistency and Asymptotic Normality of the Conditional Hazard Function Estimate for High Dimensional Quasi-Associated Data

Hamza Daoudi, Zouaoui Chikr Elmezouar, Fatimah Alshahrani

Subject: Computer Science And Mathematics, Mathematics Keywords: conditional distribution function; asymptotic normality, conditionalhazard function; quasi-associated; functional data

Online: 3 August 2023 (10:53:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0751.v1

Identification of EGF Receptor and Thrombospondin-1 As En-Dogenous Targets of ER-Associated Degradation Enhancer EDEM1 in HeLa Cells

Kohta Miura, Riko Katsuki, Shusei Yoshida, Ren Ohta, Taku Tamura

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Endoplasmic reticulum-associated degradation (ERAD); EDEM1; ER chaperone; EGF receptor; TSP1

Online: 12 June 2023 (03:58:21 CEST)

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Preprint REVIEW | doi:10.20944/preprints202207.0160.v2

NIH SenNet Consortium: Mapping Senescent Cells in the Human Body to Understand Health and Disease

Patty J Lee, Philip Blood, Katy Börner, Judith Campisi, Feng Chen, Heike Daldrup-Link, Phil De Jager, Li Ding, Francesca E. Duncan, Oliver Eickelberg, Rong Fan, Toren Finkel, Vesna Garovic, Nils Gehlenborg, Carolyn Glass, Ziv Bar-Joseph, Pragati Katiyar, So-Jin Kim, Melanie Königshoff, George Kuchel, Haesung Lee, Jun H. Lee, Jian Ma, Qin Ma, Simon Melov, Kay Metis, Ana L. Mora, Nicolas Musi, Nicola Neretti, João F. Passos, Irfan Rahman, Juan Carlos Rivera-Mulia, Paul Robson, Mauricio Rojas, Ananda L. Roy, Birgit Schilling, Pixu Shi, Jonathan Silverstein, Vidyani Suryadevera, Jichun Xie, Jinhua Wang, An-Kwok Ian Wong, Laura Niedernhofer

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Cellular Senescence Network; Normal Aging; Senescence; Senescence-associated secretory phenotype; SenNet

Online: 15 September 2022 (12:52:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202202.0232.v1

The microRNAs in the Antennae of Apolygus lucorum (Hemiptera: Miridae): Expression Properties and Targets Prediction

Adel Khashaveh, Xingkui An, Shuang Shan, Xiaoqian Pang, Yan Li, Xiaowei Fu, Yongjun Zhang

Subject: Biology And Life Sciences, Insect Science Keywords: Small RNA sequencing; miRNAs; Target prediction; Chemosensory-associated genes; Apolygus lucorum

Online: 18 February 2022 (10:01:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints202009.0573.v1

Epidemiological and Microbiological Aspects of Health Care-associated Infections in Ukraine During the 2009–2019 Period

Yulian Konechnyi, Marta Panas, Iryna Tymchuk, Roksolana Konechna, Olena Borysiuk, Iryna Hubytska, Lesya Zhurakhivska, Olena Korniychuk

Subject: Medicine And Pharmacology, Epidemiology And Infectious Diseases Keywords: healthcare-associated infections; HCAIs; hospital acquired infections; nosocomial infections; statistical analysis

Online: 24 September 2020 (08:19:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201607.0003.v6

Farey Sequences and the Riemann Hypothesis

Darrell Cox

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Riemann hypothesis, Farey sequence, Gauss sum associated with a Dirichlet character

Online: 10 August 2016 (11:35:25 CEST)

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Preprint REVIEW | doi:10.20944/preprints202010.0510.v1

The Participation of the Intrinsically Disordered Regions of the bHLH-PAS Transcription Factors in Disease Development

Beata Greb-Markiewicz, Marta Kolonko-Adamska

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: disease-associated mutation; IDR; intrinsically disordered region; LLPS; phase separation; PTM; Ahr; AhRR; SIM1; SIM2; Hif-2α; NPAS4; ARNT2; BMAL1; disorder prediction; LLPS prediction; cancer; HuVarBase; catGranule prediction

Online: 26 October 2020 (10:30:47 CET)

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Preprint REVIEW | doi:10.20944/preprints202007.0534.v1

Renal Disease in Patients with Crohn's Disease

Linda Atencio Ibarra, Roberto Navarro Quiroz, Gustavo Aroca Martinez, Joany Sarmiento Gutierrez, Andres Cadena Bonfanti, Leandro Sierra Carrero, Lorena Gomez Escorcia, Roberto Garcia Alzate, Maria Ospino Rodriguez, Daisy Lozano Arias, Henry Gonzales Torres, Carmen Carrero Gonzalez, Cecilia Fernandez-Ponce, Elkin Navarro Quiroz

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Crohn's disease; renal disease; amyloidosis

Online: 23 July 2020 (07:50:19 CEST)

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Preprint REVIEW | doi:10.20944/preprints202002.0036.v1

Amyloidosis and Renal Disease in Patients with Crohn's Disease

Roberto Navarro Quiroz, Gustavo Aroca Martinez, Linda Atencio Ibarra, Maria Ospino Rodriguez, Joany Sarmiento Gutierrez, Andres Cadena Bonfanti, Esperanza Diaz Arroyo, Lorena Gomez Escorcia, Jose Luis Villarreal, Roberto Garcia Alzate, Henry Gonzales Torres, Daisy Lozano Arias, Carmen Carrero Gonzalez, Elkin Navarro Quiroz

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Crohn's disease; renal disease; amyloidosis

Online: 4 February 2020 (04:51:50 CET)

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