Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Network Protein Interaction in Parkinson's Disease and Periodontitis Interplay: A Bioinformatic Analysis

Version 1 : Received: 2 September 2020 / Approved: 3 September 2020 / Online: 3 September 2020 (04:13:12 CEST)

How to cite: Botelho, J.; Mascarenhas, P.; Mendes, J.J.; Machado, V. Network Protein Interaction in Parkinson's Disease and Periodontitis Interplay: A Bioinformatic Analysis. Preprints 2020, 2020090050 (doi: 10.20944/preprints202009.0050.v1). Botelho, J.; Mascarenhas, P.; Mendes, J.J.; Machado, V. Network Protein Interaction in Parkinson's Disease and Periodontitis Interplay: A Bioinformatic Analysis. Preprints 2020, 2020090050 (doi: 10.20944/preprints202009.0050.v1).

Abstract

Recent studies supported a clinical association between Parkinson’s Disease (PD) and periodontitis. Hence, investigating possible protein interactions between these two conditions is of interest. In this study, we conducted a protein-protein network interaction analysis with recognized genes encoding proteins for PD and periodontitis. Genes of interest were collected via GWAS database. Then, we conducted a protein interaction analysis using STRING database, with a highest confidence cut-off of 0.9. Our protein network casted a comprehensive analysis of potential protein-protein interactions between PD and periodontitis. This analysis may underpin valuable information for new candidate molecular mechanisms between PD and periodontitis and may serve new potential targets for research purposes. These results should be carefully interpreted giving the limitations of this approach.

Subject Areas

Parkinson’s disease; Periodontitis; Periodontal disease; protein-protein network interaction; Bioinformatics

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