Working Paper Review Version 1 This version is not peer-reviewed

Role of Nucleoid Associated Protein HU in the Intercellular and Extracellular Milieu

Version 1 : Received: 5 June 2020 / Approved: 7 June 2020 / Online: 7 June 2020 (09:07:56 CEST)

How to cite: Dey, D. Role of Nucleoid Associated Protein HU in the Intercellular and Extracellular Milieu . Preprints 2020, 2020060070 Dey, D. Role of Nucleoid Associated Protein HU in the Intercellular and Extracellular Milieu . Preprints 2020, 2020060070

Abstract

Nucleoid-associated proteins (NAPs) play an architectural role by bending, bridging, and wrapping the DNA along with a regulatory role of controlling various transcriptional units in the cell. Previews reviews have highlighted the role of HU and its paralog IHF plays in intracellular function as a transcriptional regulator, nucleoid bending protein and sometimes also moonlights in other functions. This review highlights along with the canonical functions of HU and IHF which affects genes responsible for translational machineries, cell wall biosynthesis, aerobic respiration and virulence ; other non-canonical roles which HU plays outside the cellular milieu, notably in acting as an adhesin and playing role in host-cell adhesion, its role in biofilm architecture and its association with cationic low complexity region, resembling histone like H1 proteins. HU and IHF thus has evolved as a hub protein performing a vast type of functions which makes it a important drug target for antibacterial therapy.

Subject Areas

nucleoid-associated proteins (NAPs); moonlighting proteins; drug target; biofilm; specificity determination; phylogenetic analysis

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