Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Clinical and Structural Biological Studies of Central Nervous System Inflammatory Demyelinating Diseases Related to COVID-19 Vaccines

Mei-Yun Cheng
ORCID logo ,
Hsuan-Chen Ho
ORCID logo ,
Jung-Lung Hsu
,
Yi Wang
,
Lin-Yi Chen
ORCID logo ,
Ming-Feng Liao
ORCID logo ,
Long-Sun Ro
*
Version 1 : Received: 8 February 2024 / Approved: 8 February 2024 / Online: 8 February 2024 (08:43:50 CET)

A peer-reviewed article of this Preprint also exists.

Cheng, M.-Y.; Ho, H.-C.; Hsu, J.-L.; Wang, Y.; Chen, L.; Lim, S.-N.; Liao, M.-F.; Ro, L.-S. Clinical Research into Central Nervous System Inflammatory Demyelinating Diseases Related to COVID-19 Vaccines. Diseases 2024, 12, 60. Cheng, M.-Y.; Ho, H.-C.; Hsu, J.-L.; Wang, Y.; Chen, L.; Lim, S.-N.; Liao, M.-F.; Ro, L.-S. Clinical Research into Central Nervous System Inflammatory Demyelinating Diseases Related to COVID-19 Vaccines. Diseases 2024, 12, 60.

Abstract

Various vaccines have been developed in response to the SARS-CoV-2 pandemic, and the safety of vaccines has become an important issue. COVID-19 vaccines-related central nervous system inflammatory demyelinating diseases (CNS IDDs) have been reported recently. We present one case of AstraZeneca vaccine-related myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease and literature review another 78 patients published from January 2020 to October 2022. Patients were divided into three vaccine groups (viral vector, mRNA and inactivated vaccines) for further analyses. Among 79 patients with COVID-19 vaccines-related CNS IDDs, 49 (62%) cases received viral vector vaccines, 20 (25.3%) received mRNA vaccines and 10 (12.7%) received inactivated vaccines. Twenty-seven cases (34.2%) were confirmed with autoantibodies, including 15 patients (19%) with anti-MOG, 11 (13.9%) with anti-aquaporin 4 (AQP4), and one (1.3%) with both antibodies. Significantly, more males developed CNS IDDs post viral vector vaccines compared to mRNA and inactivated vaccines. Patients receiving mRNA vaccines were older than other groups. Furthermore, mRNA and inactivated vaccines correlated more with anti-AQP4 antibodies, while viral vector vaccines showed higher MOG positivity. The research suggests potential associations between COVID-19 vaccines-related CNS IDDs and gender, age, and autoantibodies, contingent on vaccine types. Protein sequence analysis implies similarities between the S protein and AQP4/MOG. Further studies may elucidate the mechanisms of CNS IDDs, aiding vaccine selection for specific groups.

Keywords

Acute disseminated encephalomyelitis; Central nervous system inflammatory demyelinating diseases; COVID-19 vaccines; Myelin oligodendrocyte glycoprotein antibody-associated disease; Neuromyelitis optica spectrum disorders; Transverse myelitis

Subject

Medicine and Pharmacology, Clinical Medicine

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0
Get PDF Cite Share 0
Bookmark BibSonomy Mendeley Reddit Delicious
×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.