Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Renal Disease in Patients with Crohn's Disease

Version 1 : Received: 21 July 2020 / Approved: 23 July 2020 / Online: 23 July 2020 (07:50:19 CEST)

How to cite: Atencio Ibarra, L.; Navarro Quiroz, R.; Aroca Martinez, G.; Sarmiento Gutierrez, J.; Cadena Bonfanti, A.; Sierra Carrero, L.; Gomez Escorcia, L.; Garcia Alzate, R.; Ospino Rodriguez, M.; Lozano Arias, D.; Gonzales Torres, H.; Carrero Gonzalez, C.; Fernandez-Ponce, C.; Navarro Quiroz, E. Renal Disease in Patients with Crohn's Disease. Preprints 2020, 2020070534 (doi: 10.20944/preprints202007.0534.v1). Atencio Ibarra, L.; Navarro Quiroz, R.; Aroca Martinez, G.; Sarmiento Gutierrez, J.; Cadena Bonfanti, A.; Sierra Carrero, L.; Gomez Escorcia, L.; Garcia Alzate, R.; Ospino Rodriguez, M.; Lozano Arias, D.; Gonzales Torres, H.; Carrero Gonzalez, C.; Fernandez-Ponce, C.; Navarro Quiroz, E. Renal Disease in Patients with Crohn's Disease. Preprints 2020, 2020070534 (doi: 10.20944/preprints202007.0534.v1).

Abstract

Crohn's disease (CD) results from an aberrant immune response against the commensal microbiota in genetically susceptible hosts. However, the nature of the immune defects, the microflora involved and the genetic susceptibility remain incompletely defined and controversial. Extraintestinal manifestations occur in up to 25-35% of patients and generally precede the onset of gastrointestinal symptoms, which are often of a colonic nature and are influenced by disease activity. Renal manifestations can be considered dependent on the same immune mechanism that determines inflammatory bowel disease in CD. This review seeks to describe the current state of association between CD and kidney disease.

Subject Areas

Crohn's disease; renal disease; amyloidosis

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