Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Improved Cognitive Performances in Trace Amine-Associated Receptor 5 (TAAR5) Knock-out Mice

Version 1 : Received: 24 January 2022 / Approved: 25 January 2022 / Online: 25 January 2022 (14:49:51 CET)

How to cite: Maggi, S.; Bon, C.; Gustincich, S.; Tucci, V.; Gainetdinov, R.R.; Espinoza, S. Improved Cognitive Performances in Trace Amine-Associated Receptor 5 (TAAR5) Knock-out Mice. Preprints 2022, 2022010385 (doi: 10.20944/preprints202201.0385.v1). Maggi, S.; Bon, C.; Gustincich, S.; Tucci, V.; Gainetdinov, R.R.; Espinoza, S. Improved Cognitive Performances in Trace Amine-Associated Receptor 5 (TAAR5) Knock-out Mice. Preprints 2022, 2022010385 (doi: 10.20944/preprints202201.0385.v1).

Abstract

Trace amine-associated receptors (TAARs) are a family of G protein-coupled receptors present in mammals in the brain and in several peripheral organs. Apart from its olfactory role, TAAR5 is expressed in the major limbic brain areas and regulates brain serotonin functions and emotional behaviors. However, most of its functions remain undiscovered. Given the role of serotonin and limbic regions in some aspects of cognition, we used a temporal decision-making task to unveil a possible role of TAAR5 in cognitive processes. We found that TAAR5 knock-out (KO) mice showed a generally better performance due to a reduced number of errors and displayed a greater rate of improvement at the task than WT littermates. However, task-related parameters, such as time accuracy and uncertainty have not changed significantly. Overall, we show that TAAR5 modulates specific domains of cognition, highlighting a new role in brain physiology.

Keywords

Trace amine-associated receptor 5; cognition; decision-making; switch task

Subject

BEHAVIORAL SCIENCES, Behavioral Neuroscience

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.