Preprint Case Report Version 1 Preserved in Portico This version is not peer-reviewed

Granulomatosis with Polyangiitis Restricted to The Back Muscle: The First Case Report

Version 1 : Received: 29 July 2020 / Approved: 13 August 2020 / Online: 13 August 2020 (06:59:27 CEST)

A peer-reviewed article of this Preprint also exists.

Lee, Y.-M.; Chung, S.W. Granulomatosis with Polyangiitis Restricted to the Back Muscle: The First Case Report. Medicina 2020, 56, 431. Lee, Y.-M.; Chung, S.W. Granulomatosis with Polyangiitis Restricted to the Back Muscle: The First Case Report. Medicina 2020, 56, 431.

Journal reference: Medicina 2020, 56, 431
DOI: 10.3390/medicina56090431

Abstract

Granulomatosis with polyangiitis (GPA) is an autoimmune disease which is a type of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis that frequently affects the lungs and kidneys. However, GPA limited to a single organ has also been reported. A 73-year-old man was admitted for back pain and fever. We detected elevated levels of inflammatory markers and myeloperoxidase-ANCA. Magnetic resonance imaging indicated diffuse inflammation of the back and psoas muscles. Histology showed degenerated muscle fibers and granulomatosis vasculitis with mixed lymphoplasma cell infiltration. High-dose methylprednisolone therapy improved his symptoms. A final diagnosis of GPA limited to the muscles was made.

Subject Areas

ANCA-associated vasculitis; organ limited vasculitis; GPA

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