Preserved in Portico This version is not peer-reviewed
Shugoshin: From a Perspective of Clinical Disorders
: Received: 24 March 2021 / Approved: 25 March 2021 / Online: 25 March 2021 (15:31:59 CET)
A peer-reviewed article of this Preprint also exists.
Journal reference: BioChem 2021
Proper and timely segregation of cellular genome is an important and a prime requirement of all cell division programmes. Mis-segregation of chromosomes and resulting aneuploidy leads to several clinical consequences. Over the years, shugoshin emerges as a key protein factor involved in the segregation of genetic material in dividing cells. Deletion or altered level of shugoshin is reported in several human malignancies, as a result, shugoshin now emerges as an important tumour associated gene and a possible target for cancer therapy. Apart from the role in cancer, recent studies also showed the involvement of shugoshin in several other clinical disorders. Through this review, we tried to highlight the clinical relevance of shugoshin.
Shugoshin; tumor suppressor; cancer; oncogene; tumour associated gene
LIFE SCIENCES, Biochemistry
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