Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

NF-κB: Governing Innate Immunity in Cancer

Jessica Cornice
,
Daniela Verzella
* ORCID logo ,
Paola Arboretto
,
Davide Vecchiotti
ORCID logo ,
Daria Capece
ORCID logo ,
Francesca Zazzeroni
,
Guido Franzoso
* ORCID logo
Version 1 : Received: 17 January 2024 / Approved: 18 January 2024 / Online: 18 January 2024 (14:05:44 CET)

A peer-reviewed article of this Preprint also exists.

Cornice, J.; Verzella, D.; Arboretto, P.; Vecchiotti, D.; Capece, D.; Zazzeroni, F.; Franzoso, G. NF-κB: Governing Macrophages in Cancer. Genes 2024, 15, 197. Cornice, J.; Verzella, D.; Arboretto, P.; Vecchiotti, D.; Capece, D.; Zazzeroni, F.; Franzoso, G. NF-κB: Governing Macrophages in Cancer. Genes 2024, 15, 197.

Abstract

Tumor-associated macrophages (TAMs) are the major component of the tumor microenvironment (TME), where they sustain tumour progression and anti-tumor immunity. Due to their plasticity, macrophages can exhibit anti- or pro-tumor functions through the expression of different gene sets leading to distinct macrophages phenotypes: M1-like or pro-inflammatory and M2-like or anti-inflammatory. NF-κB transcription factors are central regulators of TAMs in cancers, where they often drive macrophage polarization towards M2-like phenotype. Therefore, the NF-κB pathway is an attractive therapeutic target for cancer immunotherapy in a wide range of human cancers. Hence, targeting NF-κB pathways in the myeloid compartment is a potential clinically strategy to overcome microenvironment-induced immunosuppression and increase anti-tumor immunity. In this review, we discuss the role of NF-κB as key driver of macrophage functions in tumours as well as the principal strategies to overcome tumour immunosuppression by targeting NF-κB pathway.

Keywords

NF-κB; Tumor-associated macrophages (TAMs); Tumor microenvironment (TME)

Subject

Biology and Life Sciences, Biology and Biotechnology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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