Hepatitis E Virus Seroprevalence and Associated Risk Factors in Pregnant Women Attending Antenatal Consultations in Senegal

How to cite: Diouara, A.A.M.; Lo, S.; Nguer, C.M.; Senghor, A.; Diop Ndiaye, H.; Manga, N.M.; Danfakha, F.; Diallo, S.; Faye Dieme, M.E.; Thiam, O.; Biaye, B.; Manga, N.M.P.; Thiam, F.; Sarr, H.; Lo, G.; Ndour, M.; Manga, S.P.; Diaby, N.; Dieng, M.; Diop, I.; Dieye, Y.; Toure Kane, C.; Peeters, M.; Ayouba, A. Hepatitis E Virus Seroprevalence and Associated Risk Factors in Pregnant Women Attending Antenatal Consultations in Senegal. Preprints 2022, 2022060096. https://doi.org/10.20944/preprints202206.0096.v1 Diouara, A.A.M.; Lo, S.; Nguer, C.M.; Senghor, A.; Diop Ndiaye, H.; Manga, N.M.; Danfakha, F.; Diallo, S.; Faye Dieme, M.E.; Thiam, O.; Biaye, B.; Manga, N.M.P.; Thiam, F.; Sarr, H.; Lo, G.; Ndour, M.; Manga, S.P.; Diaby, N.; Dieng, M.; Diop, I.; Dieye, Y.; Toure Kane, C.; Peeters, M.; Ayouba, A. Hepatitis E Virus Seroprevalence and Associated Risk Factors in Pregnant Women Attending Antenatal Consultations in Senegal. Preprints 2022, 2022060096. https://doi.org/10.20944/preprints202206.0096.v1

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MDPI and ACS Style

Diouara, A.A.M.; Lo, S.; Nguer, C.M.; Senghor, A.; Diop Ndiaye, H.; Manga, N.M.; Danfakha, F.; Diallo, S.; Faye Dieme, M.E.; Thiam, O.; Biaye, B.; Manga, N.M.P.; Thiam, F.; Sarr, H.; Lo, G.; Ndour, M.; Manga, S.P.; Diaby, N.; Dieng, M.; Diop, I.; Dieye, Y.; Toure Kane, C.; Peeters, M.; Ayouba, A. Hepatitis E Virus Seroprevalence and Associated Risk Factors in Pregnant Women Attending Antenatal Consultations in Senegal. Preprints 2022, 2022060096. https://doi.org/10.20944/preprints202206.0096.v1

APA Style

Diouara, A.A.M., Lo, S., Nguer, C.M., Senghor, A., Diop Ndiaye, H., Manga, N.M., Danfakha, F., Diallo, S., Faye Dieme, M.E., Thiam, O., Biaye, B., Manga, N.M.P., Thiam, F., Sarr, H., Lo, G., Ndour, M., Manga, S.P., Diaby, N., Dieng, M., Diop, I., Dieye, Y., Toure Kane, C., Peeters, M., & Ayouba, A. (2022). Hepatitis E Virus Seroprevalence and Associated Risk Factors in Pregnant Women Attending Antenatal Consultations in Senegal. Preprints. https://doi.org/10.20944/preprints202206.0096.v1

Chicago/Turabian Style

Diouara, A.A.M., Martine Peeters and Ahidjo Ayouba. 2022 "Hepatitis E Virus Seroprevalence and Associated Risk Factors in Pregnant Women Attending Antenatal Consultations in Senegal" Preprints. https://doi.org/10.20944/preprints202206.0096.v1

Abstract

In West Africa, research on the hepatitis E virus (HEV) is barely covered despite the recorded outbreaks. The still low level of access to safe water and adequate sanitation is one of the main factors of HEV spread in developing countries. HEV infection induces acute or sub-clinical liver diseases with a mortality rate ranging from 0.5 to 4%. The mortality rate is more alarming (15 to 25%) among pregnant women, especially in the last trimester of pregnancy. Here, we conducted a multicentric socio-demographic and seroepidemiological survey of HEV in Senegal among pregnant women. A total of 1,227 consenting participants attending antenatal clinics responded to our questionnaire. Plasma samples were collected and tested for anti-HEV IgM and IgG by using the WANTAI HEV-IgM and IgG ELISA assay. HEV global seroprevalence was 7.9% with 0.5% and 7.4% for HEV IgM and HEV IgG, respectively. One participant's sample was IgM/IgG positive, while four were declared indeterminate to anti-HEV IgM as per the manufacturer's instructions. From one locality to another, the seroprevalence of HEV antibodies varied from 0 to 1% for HEV IgM and from 1.5 to 10.5% for HEV IgG. The data also showed that seroprevalence varied significantly by marital status (p<0.0001), by the regularity of income (p=0.0043) and by access to sanitation services (p=0.0006). These data could serve as a basis to setup national prevention strategies focused on socio-cultural, environmental and behavioral aspects for a better management of HEV infection in Senegal.

Keywords

Hepatitis E; Associated risk factors; Pregnant women; Environment; Prevention; Senegal

Subject

Biology and Life Sciences, Virology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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