Preprint Review Version 1 This version is not peer-reviewed

Amyloidosis and Renal Disease in Patients with Crohn's Disease

Version 1 : Received: 2 February 2020 / Approved: 4 February 2020 / Online: 4 February 2020 (04:51:50 CET)

How to cite: Navarro Quiroz, R.; Aroca Martinez, G.; Atencio Ibarra, L.; Ospino Rodriguez, M.; Sarmiento Gutierrez, J.; Cadena Bonfanti, A.; Diaz Arroyo, E.; Gomez Escorcia, L.; Villarreal, J.L.; Garcia Alzate, R.; Gonzales Torres, H.; Lozano Arias, D.; Carrero Gonzalez, C.; Navarro Quiroz, E. Amyloidosis and Renal Disease in Patients with Crohn's Disease. Preprints 2020, 2020020036 (doi: 10.20944/preprints202002.0036.v1). Navarro Quiroz, R.; Aroca Martinez, G.; Atencio Ibarra, L.; Ospino Rodriguez, M.; Sarmiento Gutierrez, J.; Cadena Bonfanti, A.; Diaz Arroyo, E.; Gomez Escorcia, L.; Villarreal, J.L.; Garcia Alzate, R.; Gonzales Torres, H.; Lozano Arias, D.; Carrero Gonzalez, C.; Navarro Quiroz, E. Amyloidosis and Renal Disease in Patients with Crohn's Disease. Preprints 2020, 2020020036 (doi: 10.20944/preprints202002.0036.v1).

Abstract

Crohn's disease (CD) results from an aberrant immune response against commensal microbiota in genetically susceptible hosts. However, the nature of immune defects, the microflora involved, and genetic susceptibility remain incompletely defined and controversial. This review seeks to describe the present state of association between CD and renal disease; moreover, we highlight the convergence of CD with amyloidosis that can trigger sustained inflammation, producing the pathological alteration observed in both diseases. The following MESH terms were searched in PubMed, PubMed Central (PMC), and Web of Science: “Crohn´s disease” and “renal disease.” The R RISmed package was used for PubMed and PMC. The abnormal humoral immune response is described along with alterations in immune cell migration mechanisms in CD during inflammation.

Subject Areas

Crohn's disease; renal disease; amyloidosis

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