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Preprint ARTICLE | doi:10.20944/preprints202309.0538.v1

Prognostic Significance of Amino Acid and Biogenic Amines Profiling in Chronic Kidney Disease

Guillermo Gervasini, Zoraida Verde, Luz María González, Celia Chicharro, Laura González-Rodríguez, Ana Fernández-Araque, Sonia Mota-Zamorano, Alberto Pérez-Hernández, Virginio García-López, Fernando Bandrés, Nicolás Roberto Robles

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Chronic kidney disease; End-stage kidney disease; amino acids; metabolites

Online: 7 September 2023 (11:24:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0472.v1

Tratment With Folic Acid Increases Paraoxonase 1 Activity Thereby Improving Chronic Kidney Disease

Andressa Matsumoto, Michael Maes, Ana Paula Michelin, Kamila Bonifácio, Laura Semeão, Rafael Martins, João Pedrão, Estefânia Moreira, Vinicius Delfino, Décio Barbosa

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: chronic kidney disease; folic acid; inflammation; oxidative stress; antioxidants; biomarkers

Online: 31 March 2020 (23:32:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201809.0253.v1

Chronic Unpredictable Environmental Stress Impair Biochemical and Physiological Homeostatsis: Role in Diabetes Mellitus

Alok Raghav, Jamal Ahmad, Imrana Naseem

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: diabetes mellitus; ROS; carbohydrate metabolism; antioxidants; chronic unpredictable environmental stress

Online: 14 September 2018 (05:20:37 CEST)

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Preprint REVIEW | doi:10.20944/preprints202401.0307.v1

Sleep Patterns of Children and Adolescents with Chronic Conditions and Their Families: An Integrative Literature Review

Welker da Silva Xavier, Madalena Paulos Abreu, Michelle Darezzo Rodrigues Nunes, Fernanda Machado Silva-Rodrigues, Liliane Faria Da Silva, Barbara Bertolossi Marta De Araújo, Paula Saud De Bortoli, Lucila Castanheira Nascimento

Subject: Public Health And Healthcare, Nursing Keywords: child; adolescent; family; chronic disease; sleep-wake disorders

Online: 4 January 2024 (15:17:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.1434.v1

Exploring Chronic Patients' Views and Perceptions on Life Constraints and Self- Management Strategies. A Qualitative Study

Michael Rovithis, Sofia Koukouli, Alexios Dimitropoulos, Argyroula Kalaitzaki, Nikos Rikos, George Vasilopoulos, Aikaterini Papachristou, George Tsolas, Alexandra Tamiolaki, Eleni Tsapnidou, Anastasia Dimitrantzou, Dimitrios Katsiris, Elli Katsiri, Areti Stavropoulou

Subject: Public Health And Healthcare, Other Keywords: chronic disease; self-management; elder patients; qualitative study

Online: 21 June 2023 (08:52:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.0048.v1

Sa-β-Gal in Kidney Tubules as a Predictor of Renal Outcome in Patients with Chronic Kidney Disease

Pasquale Esposito, Daniela Picciotto, Daniela Verzola, Giacomo Garibotto, Emanuele Luigi Parodi, Antonella Sofia, Francesca Costigliolo, Gabriele Gaggero, Valentina Zanetti, Michela Saio, Francesca Viazzi

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: senescence; cell; chronic kidney disease; kidney tubules

Online: 1 December 2023 (05:32:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0577.v1

Association of Edentulism With Various Chronic Diseases in Mexican Elders 60+ Years: Results of a Population-Based Survey

Alejandro José Casanova-Rosado, Juan Fernando Casanova-Rosado, Mirna Minaya-Sánchez, José Luís Robles-Minaya, Juan Alejandro Casanova-Sarmiento, María de Lourdes Márquez-Corona, América Patricia Pontigo-Loyola, Horacio Isla-Granillo, Mariana Mora-Acosta, Sonia Márquez-Rodríguez, Carlo Eduardo Medina-Solís, Gerardo Maupomé

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Oral health; edentulism; chronic diseases; elders; Mexico

Online: 24 March 2021 (11:38:36 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.1007.v1

What’s in a Name? Chronic Vestibular Migraine or Persistent Postural Perceptual Dizziness?

Alexander Andrea Tarnutzer, Diego Kaski

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: chronic vestibular syndrome; dizziness; headache; vertigo; somatoform; migraine; mal de débarquement

Online: 15 November 2023 (14:28:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0812.v1

A Comprehensive Study of Renal Angiography in Dogs with Chronic Kidney Disease

Kishorekumar Arumugam, Chandrasekar M, Baranidharan G R, Giridharan S, Pushkin Raj H, Kavitha S

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Renal angiogram; chronic kidney disease; IRIS staging and contrast agent complications.

Online: 13 November 2023 (11:52:05 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202305.0560.v1

Effects of Whole-Body Cryostimulation on pain management and disease activity in active Rheumatic Polymyalgia: a Case-Report

Federica Verme, Alessandra Scarpa, Giorgia Varallo, Paolo Piterà, Paolo Capodaglio, Jacopo Maria Fontana

Subject: Public Health And Healthcare, Physical Therapy, Sports Therapy And Rehabilitation Keywords: Polymyalgia Rheumatica; Whole-Body Cryostimulation; Chronic Pain; Disease Activity; Rehabilitation

Online: 9 May 2023 (04:17:24 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1869.v1

The Roles of MicroRNAs in Obesity: Emphasizing Links with Chronic Kidney Disease and Cardiovascular Disorders

Valérie Metzinger-Le Meuth, Laurent Metzinger

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: RNA; obesity; chronic kidney disease; cardiovascular disorder; gene regulation

Online: 27 June 2023 (10:45:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0902.v1

Mucosal Metabolomic Signatures in Chronic Colitis: Novel Insights into the Pathophysiology of Inflammatory Bowel Disease

Nathan Calzadilla, Aisha Qazi, Anchal Sharma, Kai Mongan, Shane Comiskey, Jahnavi Manne, Alvin G. Youkhana, Sonam Khanna, Seema Saksena, Pradeep K. Dudeja, Waddah A. Alrefai, Ravinder K. Gill

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: chronic colitis; mucosal inflammation; host-microbe interactions; mucosal metabolomics

Online: 13 June 2023 (08:39:45 CEST)

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Preprint REVIEW | doi:10.20944/preprints202106.0233.v1

Chronic Kidney Disease: Role of Diet for a Reduction in the Severity of the Disease

Tania Naber, Sharad Purohit

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Diabetes; Chronic Kidney Disease; Proteinuria; Dialysis; Inflammation; Diet; Nutrition

Online: 8 June 2021 (13:33:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1517.v2

Thiourea Derivatives Rejuvenate Dysfunctional Mitochondria in Chronic Hepatitis B Infection

Jitendra Kumar, Purnima Tyagi, Akhilesh Kumar Saini, Deepti Sharma, Jaswinder Singh Maras, Vijay Kumar

Subject: Biology And Life Sciences, Virology Keywords: Antiviral; Thiourea derivatives; Hepatitis B Virus; Chronic hepatitis B infection; Mitochondria dysfunction; Exhausted hepatocytes

Online: 29 May 2023 (14:29:16 CEST)

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Preprint REVIEW | doi:10.20944/preprints202009.0706.v1

A New Endemic of Concomitant Nonalcoholic Fatty Liver Disease and Chronic Hepatitis B

Hira Hanif, Muzammil Khan, Mukarram Ali, Pir Shah, Jinendra Satiya, Daryl Lau, Aysha Aslam

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Chronic hepatitis B; NAFLD; NASH; biomarkers; magnetic resonance technology; NAFLD therapy

Online: 29 September 2020 (10:40:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202111.0420.v1

Differential Effects of Exercise on fMRI of the Midbrain Ascending Arousal Network Nuclei in Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) and Gulf War Illness (GWI) in a Model of Postexertional Malaise (PEM)

James N Baraniuk, Alison Amar, Haris Pepermintwala, Stuart D Washington

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Midbrain; postexertional malaise; PEM, arousal; exercise; fMRI; autonomic; postural tachycardia; Myalgic Encephalomyelitis / Chronic Fatigue Syndrome; ME/CFS; Gulf War Illness; GWI

Online: 23 November 2021 (10:53:55 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.1436.v1

Cognitive Impairment and Brain Atrophy in Patients with Non-Dialysis and Dialysis Dependent Chronic Kidney Disease

Kazuhiko Tsuruya, Hisako Yoshida

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: brain atrophy; cognitive impairment; chronic kidney disease; dialysis; exercise

Online: 18 January 2024 (15:58:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.0102.v1

Comparison of Surgical Risk Scores in a European Cohort of Patients with Advanced Chronic Liver Disease

Lidia Canillas, Amalia Pelegrina, Elena Colominas-González, Aina Salis, Cesar J. Enríquez-Rodríguez, Xavier Duran, Antonia Caro, Juan Álvarez, Jose A Carrión

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Cirrhosis; Advanced Chronic Liver Disease; Surgery; Postoperative risk; Mortality

Online: 4 September 2023 (07:24:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1646.v1

Predicting Cognitive Impairment in Patients with Chronic Traumatic Encephalopathy: A Single-Center Prospective Cohort Study

Khrystyna Duve, Pavlo Petakh, Valentyn Oksenych, Oleksandr Kamyshnyi

Subject: Neuroscience And Neurology, Medicine And Pharmacology Keywords: chronic traumatic encephalopathy; traumatic brain injury; cognitive impairment; logistic regression

Online: 25 April 2024 (08:45:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1808.v1

Oroxylum indicum Seed Extract as a Potential Antidepressant in Chronic Stress Mouse Model of Depression

Chorpeth Chalermwongkul, Charinya Khamphukdee, Supawadee Daodee, Orawan Monthakantirat, Chantana Boonyarat, Yutthana Chotritthirong, Juthamart Maneenet, Suresh Awale, Anake Kijjoa, Yaowared Chulikhit

Subject: Medicine And Pharmacology, Complementary And Alternative Medicine Keywords: Oroxylum indicum, baicalein, unpredictable chronic mild stress, HPA-axis, depression

Online: 28 August 2023 (03:35:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1518.v1

Changes of Periodontal Parameters and Microbiome Composition of Tooth Pocket in Patients with Chronic Inflammatory Diseases Receiving Targeted Anti-Cytokine Therapy

Juliane Wagner, Luisa Haker, Louisa Mewes, Corinna Bang, Malte Rühlemann, Hendrik Naujokat, Johannes Heinrich Spille, Wolfgang Lieb, André Franke, Stefan Schreiber, Matthias Laudes, Christof Dörfer, Jörg Wiltfang, Christian Graetz, Dominik Maria Schulte

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: chronic inflammation; periodontitis; microbiome; anti-cytokine therapy

Online: 26 March 2024 (11:03:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0342.v1

Factors Associated With Chronic Kidney Disease in Patients With Type 2 Diabetes in Bangladesh

Sheikh Mohammed Shariful Islam, Masudus Salehin, Sojib Bin Zaman, Tania Tansi, Rajat Das Gupta, Lingkan Barua, Palash C Banik, Riaz Uddin

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Type 2 Diabetes Mellitus; Chronic Kidney Diseases; Hypertension; Risk Factors; Bangladesh

Online: 19 November 2021 (09:26:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202104.0205.v1

Different Lower Extremity Arterial Calcification Patterns in Patients with Chronic Limb-Threatening Ischemia Compared with Asymptomatic Controls

Louise CD Konijn, Richard AP Takx, Willem PThM Mali, Hugo TC Veger, Hendrik van Overhagen

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: chronic limb-threatening ischemia; peripheral arterial disease; calcification pattern

Online: 7 April 2021 (14:45:17 CEST)

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Objectives The most severe type of peripheral arterial disease (PAD) is critical limb ischaemia (CLI). In CLI, calcification of the vessel wall plays an important role in symptoms, amputation rate and mortality. However, calcified arteries are also found in asymptomatic persons (non-PAD patients). We investigated whether the calcification pattern in CLI patients and non- PAD patients are different and could possibly explain the symptoms in CLI patients. Materials and Methods 130 CLI and 204 non-PAD patients underwent a CT of the lower extremities. This resulted in 118 CLI patients (mean age 72±12, 70.3% male) that were age-matched with 118 non-PAD patients (mean age 71±11, 51.7% male). The characteristics severity, annularity, thickness and continuity were assessed in the femoral and crural arteries and analysed by binary multiple logistic regression. Results Nearly all CLI patients have calcifications and these are equally frequent in the femoropopliteal (98.3%) and crural arteries (97.5%), while the non-PAD patients had in just 67% any calcifications with more calcifications in the femoropopliteal (70.3%) than in the crural arteries (55.9%, p<0.005). The crural arteries of the CLI patients had significantly more complete annular calcifications (OR 2.92, p=0.001.) while in the non-PAD patients dot-like calcifications dominated. In CLI patients, the femoropopliteal arteries had more severe, irregular / patchy and thick calcifications (OR 2.40, 3.27, 1.81, p≤0.05, respectively) while in non-PAD patients, thin continuous calcifications prevailed. Conclusions Compared with non-PAD patients CLI patients are more frequently and extensively calcified. Annular calcifications were found in the crural arteries of CLI patients while dot-like calcifications were mostly present in the non-PAD patients. These different patterns of calcifications in CLI point at different etiology and can have prognostic and eventually therapeutic consequences.

Preprint ARTICLE | doi:10.20944/preprints202401.0145.v1

Associations between Physical Disability and Chronic Diseases with Depressive Symptoms in Vietnamese-Origin Older Adults in the United States

Christina E Miyawaki, Joshua M Garcia, Luis D Medina, Kim N Nguyen, Oanh L Meyer, Kyriakos S Markides

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: chronic diseases; depressive symptoms; disability; older adults; Vietnamese

Online: 3 January 2024 (08:39:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0925.v1

Middle Meningeal Artery Embolization Reduces the Recurrence Rate of Chronic Subdural Hematoma

Ying Wang, Anwen Shao, Wei Wang, Qinghua Huang, Wei Yan, Meijuan Lan

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: chronic subdural hematoma; middle meningeal artery embolization; propensity score matching; burr hole craniostomy

Online: 15 November 2023 (02:06:16 CET)

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Preprint REVIEW | doi:10.20944/preprints202310.0551.v1

Chronic Kidney Disease in the Elderly Patient with Diabetes

Raja Ravender, Maria-Eleni Roumelioti, Darren W Schmidt, Mark L Unruh, Christos Argyropoulos

Subject: Medicine And Pharmacology, Other Keywords: Diabetes; Chronic Kidney Disease; Treatment; Elderly; Geriatric; Dialysis; SGLT2 inhibitors; GLP1 Receptor Agonists; Non-steroidal Mineralocorticoid Antagonists

Online: 9 October 2023 (16:56:30 CEST)

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Preprint REVIEW | doi:10.20944/preprints202001.0087.v1

DPP-4/GLP-1 Axis as a Potential Therapeutic Target in Chronic Stress-related Vascular Aging and Atherosclerosis

Ying Wan, Limei Piao, Yongshan Nan, Xian-Wu Cehng

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Chronic stress; Vascular senescence; inflamamtion; atherosclerosis; dipeptidyl peptidase-4

Online: 9 January 2020 (13:05:26 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.0686.v1

Is Chronic Kidney Disease due to Cadmium Exposure Inevitable and Can it be Reversed?

Soisungwan Satarug

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: albuminuria; β2-microglobulin; cadmium; chronic kidney disease; GFR; proteinuria; receptor-mediated endocytosis

Online: 12 February 2024 (13:51:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.1193.v1

The Influence of Emotional Intelligence in Quality of Life in Patients Undergoing Chronic Hemodialysis

Afra Masià-Plana, Miquel Sitjar-Suñer, Susana Mantas-Jiménez, Rosa Suñer-Soler

Subject: Public Health And Healthcare, Nursing Keywords: Chronic Kidney Disease; Hemodialysis; Emotional Intelligence; Quality of life; Sex differences; Nursing

Online: 16 January 2024 (06:22:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1228.v1

Varvara Aleksandrovna Ryabkova, Artemiy Vladimirovich Rubinskiy, Valeriy Nikolaevich Marchenko, Vasiliy Ivanovich Trofimov, Leonid Pavlovich Churilov

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: chronic fatigue syndrome; COVID-19; Post-COVID; heart rate variability; autonomic dysfunction

Online: 20 November 2023 (07:51:21 CET)

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Background There is a considerable overlap between clinical presentation of post-COVID-19 condition (PCC) and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) . Many of their common symptoms can be linked to dysregulation of the autonomic nervous system (dysautonomia). This study aimed to objectively assess autonomic function in patients with PCC and in patients with ME/CFS whose disease was not related to COVID-19. Methods Synchronous recordings of an electrocardiogram, continuous dynamics of blood pressure in the digital artery using the Penaz method and ultrasound pneumotachography with the spirography function were obtained with spiroarteriocardiorhythmography method in 34 patients diagnosed with ME/CFS, in whom the onset of the disease was not associated with COVID-19, 29 patients meeting PCC definition and 32 healthy controls. Heart rate variability (HRV), systolic and diastolic blood pressure variability (RV), respiration variability were assessed at rest and in tests with fixed respiratory rates. At rest, indicators of baroreflex regulation were additionally determined (baroreflex effectiveness index and baroreflex sensitivity). Results The total power, power of very low frequency, low-frequency and high-frequency of RR interval variability at rest as well as baroreflex effectiveness index in up-ramps of arterial blood pressure and baroreflex sensitivity were significantly lower both in PCC and ME/CFS patients compared to HC. Several diagnostic prediction models for ME/CFS were developed based on HRV parameters. During slow breathing HRV parameters return to normal in PCC, but not in ME/CFS. Correlation analysis revealed a close relationship of HRV, RV parameters and baroreflex sensitivity with fatigue, but not with HADS depressive/anxiety symptoms in ME/CFS and PCC. Conclusion A similar pattern of HRV and baroreflex failure with signs of a pathological acceleration of age-dependant dysautonomia was identified in ME/CFS and PCC. The clinical, diagnostic and therapeutic implications of these findings are discussed, in light of previously described relationship between inflammation, vascular pathology, atherosclerotic cardiovascular disease and autonomic dysfunction.

Preprint REVIEW | doi:10.20944/preprints202312.1841.v1

A Possible Therapeutic Application of The Selective Inhibitor of Urate Transporter 1, Dotinurad, for Metabolic Syndrome, Chronic Kidney Disease, and Cardiovascular Disease: A Significance of Inhibition of Urate Transporter 1 and Non-inhibition of Other Urate Transporters for Such Diseases

Hidekatsu Yanai, Hiroki Adachi, Mariko Hakoshima, Sakura Iida, Hisayuki Katsuyama

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: ATP-binding cassette transporter G2; chronic kidney disease; dotinurad; hyperuricemia; organic anion transporter1/3; urate transporter 1

Online: 26 December 2023 (03:03:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints201907.0064.v1

Microcystins and Daily Sunlight: Predictors of Chronic Liver Disease and Cirrhosis Mortality

Rajesh Melaram

Subject: Environmental And Earth Sciences, Environmental Science Keywords: microcystins; climatic factors; chronic liver disease and cirrhosis; daily sunlight; enzyme-linked immunosorbent assay

Online: 3 July 2019 (11:46:09 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.1522.v1

A Review and Meta-Analysis of the Effect of Atenolol on All-Cause Mortality Risk among Asians With Chronic Progressive Diseases

Abdullah Alkattan, Eman Alsalameen, Alaa Harmoush, Mhd Nour Farawati, Hind Alsharif, Nagla Mahmoud, Mhd Ali Farawati, Amjad Alfaleh, Mahmoud Kandeel, Nashwa Radwan

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Atenolol; mortality; Asians; chronic progressive disease; cardiovascular disease

Online: 22 September 2023 (04:36:12 CEST)

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Working Paper ARTICLE

Effects of Chronic Lithium Treatment on Anxious Behaviors and Serotonergic Genes Expression in the Midbrain Raphe Nuclei of Defeated Male Mice

Dmitriy A. Smagin, Irina L Kovalenko, Anna G. Galyamina, Irina V Belozertseva, Nikolay V Tamkovich, Konstantin O Baranov, Natalia N. Kudryavtseva

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: chronic social defeat stress; anxiety; lithium chloride; mice

Online: 3 June 2021 (11:41:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.1348.v1

Examining the Impact of Infection Reactivation on Extracellular Vesicles purified from Patients with Chronic Chagas Disease

Rafael Pedro Madeira, Paula Meneghetti, Nicholy Lozano, Gislene M. Namiyama, Vera Lucia Pereira-Chioccola, Ana Claudia Torrecilhas

Subject: Biology And Life Sciences, Parasitology Keywords: Trypanosoma cruzi; extracellular vesicles; chronic Chagas Disease patients; immunosuppression; infection reactivation.

Online: 18 December 2023 (15:17:58 CET)

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Preprint SHORT NOTE | doi:10.20944/preprints202005.0035.v1

When Chronic Diseases Meet Infectious Diseases: A Proposal Toward Healthy Aging: Lessons from COVID-19 Outbreak

Juan Carlos Gómez-Verjan, Carmen García-Peña, Nadia A. Rivero-Segura

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: COVID-19; Chronic diseases; Aging; Immune response; Public health; Healthy Aging

Online: 3 May 2020 (08:15:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0198.v1

Association of Serum and Urinary Magnesium Levels With Body Composition and Inflammatory Markers in Patients With Non-dialysis Chronic Kidney Disease: A Longitudinal Approach

Raimunda Sheyla Carneiro Dias, Dyego José de Araújo Brito, Cleodice Alves Martins, Elton Jonh Freitas Santos, Erika Cristina Ribeiro de Lima Carneiro, Elisangela Milhomen dos Santos, Denizar Vianna Araújo, Natalino Salgado Filho, Mario Bernardo Filho

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Magnesium deficiency; Body composition; Chronic kidney failure.

Online: 13 July 2022 (09:27:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0143.v1

Income Levels and Mortality Rates in Patients with Chronic Kidney Disease in South Korea: a Population-Based Cohort Study Using National Health Insurance Data

Young Choi

Subject: Public Health And Healthcare, Health Policy And Services Keywords: chronic kidney disease; low socioeconomic status; mortality

Online: 6 August 2020 (09:46:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.2098.v1

Frailty in Older Patients with End-Stage Renal Disease and Undergoing Chronic Dialysis in Vietnam

Tan Van Nguyen, Thu Thi Xuan Pham, Mason Jenner Burns, Tu Ngoc Nguyen

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: chronic kidney disease; end-stage renal disease; dialysis; diabetes; frailty; elderly; Vietnam

Online: 29 June 2023 (10:16:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.0053.v1

Machine Learning Driven Dashboard for Chronic Myeloid Leukemia Prediction using Protein Sequences

Waqar Ahmad, Mudasar Iqbal, Muhammad Awais Amin, Waqas Haider Bangyal, Abdul Raheem Shahzad

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Protein Sequences; Pseudo-AAC; AAC; Dipeptide-C; Machine Learning Classifiers; Chronic Myeloid Leukemia; Blood Cancer

Online: 1 December 2023 (05:39:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0645.v1

Best Administration Schedule for Optimal Efficacy and Safety of Arsenic Trioxide Treatment in Chronic Graft versus Host Disease

Dominique Rongvaux-Gaïda, Lieven Huysse, François Rieger, Carole Nicco

Subject: Medicine And Pharmacology, Hematology Keywords: Arsenic trioxide; Chronic Graft-versus-Host Disease; cGvHD; Corticosteroid; autoimmunity

Online: 11 March 2024 (15:18:01 CET)

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Chronic graft-versus-host disease (cGvHD) occurs in 20-50% of recipients following allogeneic haematopoietic stem cell transplantation (allo-HSCT). Corticosteroids (CS) remain the first line treatment but have suboptimal efficacy and carry the risk of long-term side effects. New agents with a better safety profile and higher efficacy, ideally combining immunomodulatory and antifibrotic properties, are urgently needed. From 2016 to 2020, we conducted a phase 2 clinical trial with ATO in chronic GvHD (ClinicalTrials.gov ID NCT02966301 - GMED16-001). This study aimed to evaluate the efficacy and safety of a first-line combination of arsenic trioxide (ATO) and CS in adult patients with cGvHD who require systemic therapy after a first allo-HSCT for a haematological disease. In this prospective, national, multicenter, single-arm, open-label phase II study, conducted in 5 university hospital centers in France, ATO was initiated within 10 days of starting CS at 1 mg/kg/day. Patients received 11 infusions of ATO per 4-week cycle, at a dose of 0.15 mg/kg per infusion. Patients received 1 or 2 cycles of treatment depending on the clinical response and the assessment of the treating physician. The results were published in July 2022 in a paper entitled "High Response Rate and Corticosteroid Sparing with ATO-Based First-Line Therapy in Chronic Graft-versus-Host Disease after Allogeneic Hematopoietic Stem Cell Transplantation". The GMED16-001 study demonstrated convincing efficacy and safety characteristics of the intravenous drug (Trisenox^®/Arscimed^®): the first-line use of ATO in addition to corticosteroids was associated with a high clinical response rate and correlated with rapid corticosteroid (CS) sparing in moderate to severe cGvHD after allo-HSCT. We performed a post-hoc analysis of the data to determine the best schedule for treating cGvHD patients with ATO. Our post-hoc analysis leads us to the conclusion that two cycles of ATO, at 0.15 mg/kg/day, 5 days per week for 4 weeks each, separated by a 4-week therapy-free interval, appears to be the most promising treatment schedule.

Preprint ARTICLE | doi:10.20944/preprints202005.0101.v1

Developing and Validating an Algorithm to Identify Incident Chronic Dialysis Patients Using Administrative Data

Dino Gibertoni, Claudio Voci, Marica Iommi, Benedetta D'Ercole, Marcora Mandreoli, Antonio Santoro, Elena Mancini

Subject: Computer Science And Mathematics, Information Systems Keywords: chronic dialysis; administrative data; hospital discharge records; ambulatory specialty visits; case definition; algorithm

Online: 6 May 2020 (15:26:06 CEST)

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Background: Administrative healthcare databases are widespread and are often standardized with regard to their content and data coding, thus they can be used also as data sources for surveillance and epidemiological research. Chronic dialysis requires patients to frequently access hospital and clinic services, causing a heavy burden to healthcare providers. This also means that these patients are routinely tracked on administrative databases, yet very few case definitions for their identification are currently available. The aim of this study was to develop two algorithms derived from administrative data for identifying incident chronic dialysis patients and test their validity compared to the reference standard of the regional dialysis registry. Methods: The algorithms are based on data retrieved from hospital discharge records (HDR) and ambulatory specialty visits (ASV) to identify incident chronic dialysis patients in an Italian region. Subjects are included if they have at least one event in the HDR or ASV databases based on the ICD9-CM dialysis-related diagnosis or procedure codes in the study period. Exclusion criteria comprise non-residents, prevalent cases, or patients undergoing temporary dialysis, and are evaluated only on ASV data by the first algorithm, on both ASV and HDR data by the second algorithm. We validated the algorithms against the Emilia-Romagna regional dialysis registry by searching for incident patients in 2014. Results: Algorithm 1 identified 680 patients and algorithm 2 identified 676 initiating dialysis in 2014, compared to 625 patients included in the regional dialysis registry. Sensitivity for the two algorithms was respectively 90.8% and 88.4%, positive predictive value 84.0% and 82.0%, and percentage agreement was 77.4% and 74.1%. Conclusions: These results suggest that administrative data have high sensitivity and positive predictive value for the identification of incident chronic dialysis patients. Algorithm 1, which showed the higher accuracy and has a simpler case definition, can be used in place of regional dialysis registries when they are not present or sufficiently developed in a region, or to improve the accuracy and timeliness of existing registries.

Preprint ARTICLE | doi:10.20944/preprints202312.1769.v1

Investigating the Efficacy of Kidney-Protective Lactobacillus Mixture-Containing pet Treats in Feline Chronic Kidney Disease and Its Possible Mechanism

Ching-Wen Tsai, Hsiao-Wen Huang, Ya-Jane Lee, Tsu-Cheng Hsu, Ming-Ju Chen

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: chronic kidney disease; gut microbiota; Lm pet treats; feline

Online: 25 December 2023 (11:19:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202206.0168.v1

The Impact of Spiritual-Based Care Interventions on the Quality of Life of Children with Chronic Diseases: a Philosophical Perspective

Idyatul Hasanah, Moses Glorino Rumambo Pandin, Tita Rohita

Subject: Public Health And Healthcare, Nursing Keywords: Nursing; Spiritual care; Quality of life; Chronic disease; Children

Online: 13 June 2022 (05:17:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201908.0303.v1

Analysis of the Dimensions of Physiotherapy Index of Ventilatory Workload in People with Chronic Obstructive Pulmonary Disease During Stability and Exacerbation in An Outpatient Setting

Rodrigo Muñoz Cofré, Mariano del Sol, Paul Medina González, Jorge Valenzuela Vásquez, Gerardo Molina Vergara, Ramón Pinochet Urzúa, Pablo A. Lizana, Máximo Escobar Cabello

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: ventilatory assessment; physiotherapy; chronic obstructive pulmonary disease

Online: 29 August 2019 (04:52:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.0595.v1

Safety and Efficacy of TKIs in Very Elderly Patients (≥75 Years) with Chronic Myeloid Leukemia

Alessandro Costa, Elisabetta Abruzzese, Roberto Latagliata, Olga Mulas, Ida Carmosino, Emilia Scalzulli, Maria Laura Bisegna, Claudia Ielo, Maurizio Martelli, Giovanni Caocci, Massimo Breccia

Subject: Medicine And Pharmacology, Hematology Keywords: chronic myeloid leukemia; tyrosine kinase inhibitor; very elderly; safety; efficacy; outcome; dose optimization

Online: 8 December 2023 (10:26:16 CET)

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Background: While outcomes of chronic phase chronic myeloid leukemia (CP-CML) patients aged over 65 years have been extensively evaluated in real-life experiences, limited data exist for the very elderly population (i.e., aged ≥ 75 years), especially for next-generation tyrosine kinase inhibitors (TKIs). In this retrospective study, we sought to evaluate the safety and efficacy of TKIs in this particular setting of patients. Methods: We conducted a retrospective analysis of a multicenter cohort of 123 newly diagnosed CP-CML very elderly patients. Results: The median age at diagnosis was 80 years (range: 75-96). In the first-line, 86.1% of patients received imatinib, 7.1% dasatinib, 5.6% nilotinib, and 0.81% received bosutinib. A total of 31 patients (25.2%) switched to second-line therapy, nine patients to a third-line and one patient to a fourth line of therapy. Resistance to treatment was the primary reason for switching therapy in both the first (64.5%) and second lines (77.7%). At diagnosis, reduced doses were administered in 36.5% of patients, in 61.2% in the second line, and in all patients in subsequent lines of therapy. In first-line setting, 71.9% of patients achieved an early molecular response (EMR, i.e. 3-month BCR::ABL1 IS <10%); at 6, 12, and 24 months, MR3 was reached by 35.7%, 55.7%, and 75.0% of patients, with 16.6%, 35.7%, and 51.7% achieving DMR at the same timepoints. Treatment-free remission (TFR) was successfully attempted in 11 patients. During the follow-up period, adverse events (AEs) were observed in 78.8% of patients, including 22 cases of cardiovascular AEs. Toxicity grade ≥ 3 was more commonly observed in patients treated with standard doses of TKIs compared to reduced doses (p=0.033). Overall, median follow-up was 46.62 months (range: 1.8-206.2), and 43 patients died due to non CML related causes. Three patients died due to disease progression to advanced (n=1) and blastic (n=2) phases. The 5-year overall survival (OS) for the entire cohort was 71.9% (95% CI: 0.63-0.81), with no significant difference between patients treated with standard doses of TKI compared to those treated with reduced doses (p=0.35). Conclusions: TKIs appear to be safe and effective even in very elderly CML patients, and dose optimization strategies yield satisfactory molecular responses for adequate disease control with an improved safety profile.

Preprint CASE REPORT | doi:10.20944/preprints202306.1128.v1

Myeloid Sarcoma as an Unusual Presentation of Acute and Chronic Myeloid Leukemia: A Case Series

Ugo Giordano, Mateusz Sawicki, Justyna Pilch, Jakub Mizera, Artur Borkowski, Krzysztof Zduniak, Jarosław Dybko

Subject: Medicine And Pharmacology, Hematology Keywords: myeloid sarcoma; acute myeloid leukemia; chronic myeloid leukemia; chloroma; granulocytic sarcoma; case report

Online: 16 June 2023 (07:15:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0569.v1

Effects of Clinical Characteristics on Sleep Quality in Patients with Chronic Temporomandibular Disorders

Yeon-Hee Lee, Q-Schick Auh, Jung-Sub An, Tae Kim

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Sleep quality; Chronic pain; Temporomandibular disorder; Pittsburgh Sleep Quality Index; STOP-Bang; Epworth Sleepiness Scale

Online: 23 June 2021 (11:11:14 CEST)

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Objectives: This study aimed to investigate and compare sleep quality between patients with chronic temporomandibular disorder and healthy controls, and to analyze the association of sleep quality with disease characteristics, obstructive sleep apnea risk factors, and excessive daytime sleepiness. Methods: Chronic temporomandibular disorder patients (n=503) and 180 age- and sex-matched healthy controls were included, who completed well-organized clinical report and answered questions on sleep quality (Pittsburgh Sleep Quality Index), sleep apnea risk factors (STOP-Bang questionnaire), and excessive daytime sleepiness (Epworth sleepiness scale). Results: Mean global Pittsburgh Sleep Quality Index scores were significantly higher in the patients (6.25±2.77) than in healthy controls (6.25±2.77) (p<0.001). Poor sleep was significantly more prevalent in the patient group (56.9%) than in healthy controls (22.2%) (p<0.001). Compared with healthy controls, chronic temporomandibular disorder patients had a higher likelihood of obstructive sleep apnea. (STOP-Bang total score ≥3; 7.2% vs. 16.1%; p<0.01) and higher excessive daytime sleepiness (Epworth sleepiness scale score ≥10; 12.8% vs. 19.7%; p<0.05). Age (odds ratio=2.551; p<0.001), female sex (odds ratio=1.885; p=0.007), total Epworth sleepiness scale score (odds ratio=1.839; p=0.014), and headache attributed to temporomandibular disorder (odds ratio=1.519; p=0.049) were the most powerful predictors of poor sleep (global Pittsburgh Sleep Quality Index score ≥5) in chronic temporomandibular disorder patients. Conclusion: Chronic temporomandibular disorder patients had sleep quality impairment. Various factors, including peripheral and central factors, affect the patient's sleep quality. Therefore, in addition to sleep quality and sleep-related problems, the underlying central mechanism for poor sleep quality should be assessed when treating chronic temporomandibular disorder patients.

Preprint ARTICLE | doi:10.20944/preprints202305.1254.v1

The Association of Oxidative Stress-Related Gene Polymorphisms with Pain-Related Temporomandibular Disorders and Oral Behavioural Habits

Ema Vrbanović, Marko Zlendić, Koraljka Gall Trošelj, Marko Tomljanović, Kristina Vuković Đerfi, Iva Zilic-Alajbeg

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: antioxidants; chronic orofacial pain; oxidative-stress related genes; temporomandibular disorders; oral behavioural habits; single nucleotide polymorphism

Online: 17 May 2023 (14:15:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0392.v1

Amani Zidan, Ahmed Awaisu, Maguy El-Hajj, Samya Al-Abdulla, Dianne Figueroa, Nadir Kheir

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Medication-related burden; Questionnaire; chronic disease conditions; adherence

Online: 25 June 2018 (14:35:31 CEST)

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Preprint REVIEW | doi:10.20944/preprints202210.0142.v1

Employ of Anthocyanins in nanocarriers for Nano Delivery: In Vitro and In Vivo Experimental Approaches for Chronic Diseases

Ana C. Gonçalves, Amícal Falcão, Gilberto Alves, João A. Lopes, Luís R. Silva

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: bioactive compounds; anthocyanins; drug delivery system; nanoparticles; chronic diseases; health benefits

Online: 11 October 2022 (05:04:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0371.v2

Observational Pilot Study: A comparison of Amino Acids and Derangement of Intestinal Function between Healthy Ageing Subjects and Patients Affected by Chronic Kidney Disease in Conservative Management

Piergiorgio Bolasco, Roberto Aquilani, Roberto Maestri, Maria Paola Esposito, Maria Luisa Deiana, Mariella Cadeddu, Romina Secci, Barbara Casu, Antonella Serra, Paolo Iadarola, Maura D'Amato, Stefano Murtas

Subject: Biology And Life Sciences, Food Science And Technology Keywords: Chronic Kidney Disease; aminoacids; Dysbiosis; metabolic disorders

Online: 27 January 2022 (15:48:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints201907.0262.v1

Chronic Fatigue and Fibromyalgia Symptoms are Key Components of Deficit Schizophrenia and are Strongly Associated with Activated Immune-Inflammatory Pathways

Abbas Almulla, Hussein Al-Hakeim, Mokhlad Abed, André Carvalho, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Chronic fatigue syndrome, inflammation, neuro-immune, physio-somatic, schizophrenia, cytokines

Online: 23 July 2019 (11:49:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0980.v1

Does the Metabolic Syndrome and Its Components Have Prognostic Significance for Renal and Cardiovascular Outcomes in IgA Nephropathy?

Balázs Sági, Tibor Vas, Botond Csiky, Judit Nagy, Tibor József Kovács

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Chronic kidney disease; IgA nephropathy; Renal function; Metabolic syndrome; Arterial stiffness

Online: 15 April 2024 (14:53:42 CEST)

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Background: Cardiovascular (CV) morbidity and mortality are many times higher in chronic kidney disease (CKD), as well as IgA nephropathy (IgAN), than in the general population. The occurrence of metabolic syndrome (MetS) and metabolic risk factors are independent risk factors for CV disease and renal progression. The study aimed to determine the prognostic role of metabolic profiles in a homogenous group of CKD patients. Methods: One hundred and forty-five IgA nephropathy patients (92 male, 53 female, age 54.7 ± 13 years) with CKD stage 1-4 were investigated and followed for a median of 190 months. The composite (CV and renal) endpoints included all-cause mortality and any CV event such as stroke, myocardial infarction, revascularization (CV), end-stage renal disease, and renal replacement therapy (renal). Results: Patients with MetS had significantly more endpoint events (16/27 patients vs. 15/98 patients, p = 0.001) compared to the nonMetS group. Of the secondary endpoints (CV or renal separately), the rate of the renal and CV endpoints was significantly higher in the MetS group (p = 0.001 and p = 0.029). The primary endpoint independent predictors of survival were dyslipidemia, eGFR, hemoglobin, urine albuminuria, and diabetes mellitus, as determined by Cox regression analysis. Independent predictors of secondary renal endpoint were dyslipidemia, hemoglobin, urine albumin, and eGFR. Predictors of secondary cardiovascular endpoints were gender, BMI, and diabetes. Kaplan-Meier curves showed significant differences in MetS and non-MetS when examined at the combined endpoints (CV and renal) or at each endpoint separately. The primary endpoint rate increased significantly with the increased number of MetS components (MetS comp. 0 vs. MetS comp. 2+, primary endpoints, p = 0.012). Conclusion: Our results showed that the metabolic profile has a prognostic role not only for renal endpoints but also for CV endpoints in IgAN. BMI, hyperuricemia, hypertension, and diabetes have a predictive value for the prognosis of IgA nephropathy.

Preprint REVIEW | doi:10.20944/preprints202401.1747.v1

Chronic Lymphocytic Leukemia: Prognostic/Predictive Factors in the Era of Novel Drugs

Antonio Urso, Enrica Antonia Martino, Antonio Cuneo, Massimo Gentile, Gian Matteo Rigolin

Subject: Medicine And Pharmacology, Hematology Keywords: chronic lymphocytic leukemia; BTK inhibitors; BCL-2 inhibitors; prognostic scores; predictive factors; TP53 abnormalities; IGHV; complex karyotype

Online: 24 January 2024 (13:39:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.0934.v1

Exploration of Potential Breath Biomarkers of Chronic Kidney Disease through Thermal Desorption Gas Chromatography Mass Spectrometry

Si-Hyun Seong, Hyun Sik Kim, Yong-Moon Lee, Jae-Seok Kim, Sangwoo Park, Jieun Oh

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: Chronic kidney disease; Hemodialysis; Uremic toxins; Breath markers; Volatile organic compounds; Mass spectrometry

Online: 13 June 2023 (11:40:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202211.0410.v1

Selenylated imidazo[1,2-a]pyridine induces cell senescence and oxidative stress in chronic myeloid leukemia cells

Gabriella Teles Burkner, Dhébora Albuquerque Dias, Kamylla Fernanda Souza de Souza, Anna Júlia Papa de Araújo, Denise Caroline Luiz Soares Basilio, Fernanda Tondello Jacobsen, Ana Carolina Rabello de Moraes, Saulo Euclides Silva-Filho, Marcos Filipe de Oliveira Cavalcante, Cassio Augusto de Oliveira Moraes, Sumbal Saba, Maria Lígia Rodrigues Macedo, Edgar Julian Paredes-Gamero1, Jamal Rafique, Eduardo Benedetti Parisotto

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: Leukemia; imidazo[1,2-a]pyridines; selenide; oxidative stress; senescence; chronic myeloid leu-kemia.

Online: 22 November 2022 (07:49:44 CET)

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Preprint REVIEW | doi:10.20944/preprints202209.0123.v1

Falls Incidence and Associated Risk Factors among People with Chronic Obstructive Pulmonary Disease (COPD)

Mehrdad Davoudi, Seyyed Mohammadreza Shokouhyan, Mohsen Abedi, Mehdi Rezaei, Mohamad Parnianpour, Kinda Khalaf, Masood Mazaheri

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: chronic obstructive pulmonary disease; COPD; fall risk factor; gait; balance; cognition; daily activity; muscle dysfunction

Online: 8 September 2022 (10:35:01 CEST)

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Chronic obstructive pulmonary disease (COPD) is increasingly being recognized as a systemic disease rather than a mere disorder of the lungs. Central (respiratory) and peripheral (limb) muscle weakness are among the main pronounced systemic effects of COPD. While the disease primarily affects the lower limb muscles and contributes to gait impairment, COPD is also associated with an increasing risk of falls in patients (COPDp). Previous studies have reported higher rates of falls among COPDp (1.17 to 1.20 falls/person-year), amounting to four times higher than an age-matched healthy group. Potential fall risk factors include muscle weakness, impaired daily activities, cognitive dysfunction, and gait and balance impairment. Although COPDp often manifest many of these risk factors, there remains a gap in literature regarding falls during walking in this population. This study aimed to 1. analyze the literature to identify the risk factors of falling in COPDp, and 2. investigate the underlying mechanisms by which these risk factors can lead to increased prevalence of falling. The results suggest that in addition to the known risk factors of falling, low back pain and mental fatigue should also be considered as relevant risk factors in the treatment process of these patients. Moreover, respiratory problems, which are common in this population, have demonstrated pronounced effects on energy expenditure, gait, and other types of activities of daily living (ADLs), leading to reduced intensity, disrupted coordination of the trunk-pelvic structure with the lower limbs during gait, and altered motor control performance due to activation of muscles in an inefficient synergic manner. These problems potentially lead to the increased vulnerability of these patients to external disturbances and higher incidence risk of falls and injuries. Cognitive problems, which are typically due to reduced oxygen received by the brain, as well as general inflammation caused by COPD, also play a significant role in gait disruption and balance. Future research is warranted to determine the prevalence of falls in COPDp by examining the response of these patients to Medio-Lateral (ML) and Anterior-Posterior (AP) disturbances during gait in association with traditional and recommended fall risk factors.

Preprint REVIEW | doi:10.20944/preprints202310.0145.v1

Omega-3 Lipid Mediators: Modulation of the M1/M2 Macrophage Phenotype and its Protective Role in Chronic Liver Diseases

Luis A Videla, Rodrigo Valenzuela, Andrea Del Campo, Jessica Zuñiga-Hernandez

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: chronic liver disease; specialized pro-resolving mediators; inflammation; macrophage polarization; inmunometabolism

Online: 3 October 2023 (11:11:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0173.v1

Association of Calcitriol Supplementation with Reduced COVID-19 Mortality in Patients with Chronic Kidney Disease: A Population-based Study

Joaquim Oristrell, Joan C. Oliva, Isaac Subirana, Enrique Casado, Didier Dominguez, Andrea Toloba, Patricia Aguilera, Joan Esplugues, Pilar Fafian, Maria Grau

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: calcitriol; vitamin D; COVID-19; SARS-CoV2 infection; chronic kidney disease

Online: 6 April 2021 (11:50:28 CEST)

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Preprint REVIEW | doi:10.20944/preprints202310.1240.v1

Advancements in Treatment Strategies for Chronic Mesenteric Ischemia: A Comprehensive Review

Genti Xhepa, Andrea Vanzulli, Lucilla Violetta Sciacqua, Agostino Inzerillo, Pierre Faerber, Anna Maria Ierardi, Gianpaolo Carrafiello, Filippo Del Grande, Alexis Ricoeur

Subject: Medicine And Pharmacology, Surgery Keywords: review; chronic mesenteric ischemia; superior mesenteric artery; revascularization; treatment; endovascular revascularization (ER); percutaneous transluminal angioplasty (PTA); primary stenting (PMAS)

Online: 19 October 2023 (10:14:50 CEST)

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Preprint REVIEW | doi:10.20944/preprints202311.1554.v1

Mitochondrial Dysfunction and Coenzyme Q10 Supplementation in Post-Viral Fatigue Syndrome: An Overview

David Mantle, Iain Parry Hargreaves, Joan Carles Domingo, Jesus Castro-Marrero

Subject: Biology And Life Sciences, Life Sciences Keywords: chronic fatigue syndrome; coenzyme Q10; fibromyalgia; Long COVID; mitochondrial dysfunction; myalgic encephalomyelitis; post-viral fatigue syndrome

Online: 24 November 2023 (11:27:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.1870.v1

Polish Adaptation and Psychometric Validation of the PREM-C9 Questionnaire Dedicated for Patients with Chronic Obstructive Pulmonary Disease

Iwona Damps-Konstańska, Weronika Ciećko, Ewa Jassem, Tomasz Bandurski, Dominika Bosek, Marzena Olszewska-Karaban, Ewa Bandurska

Subject: Public Health And Healthcare, Health Policy And Services Keywords: chronic obstructive pulmonary disease (COPD); Patient Reported Outcome Measures; Health Care Surveys

Online: 29 August 2023 (03:31:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.2147.v1

Effects of Chronic Heat Stress on Lung and Growth Performance in Cherry-Valley Ducks under Different Ambient Temperatures

Min Tang, Yi Liu, Dongyue Sun, Congcong Xu, Kongdong Li, Hantao Zhang, Jie Gu, Chaofan Shan, Shijia Ying

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: chronic heat stress; duck rearing; environmental temperature; next-generation sequencing; carcass traits

Online: 1 August 2023 (05:35:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.1483.v1

Comparison of Disease Severity Classifications of Chronic Obstructive Pulmonary Disease: Gold vs. Star in Clinical Practice

Koichi Nishimura, Masaaki Kusunose, Ayumi Shibayama, Kazuhito Nakayasu

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: chronic obstructive pulmonary disease (COPD); disease severity; Global Initiative for Chronic Obstructive Lung Disease (GOLD); STaging of Airflow obstruction by Ratio (STAR); St. George’s Respiratory Questionnaire (SGRQ); COPD assessment test (CAT)

Online: 19 January 2024 (09:47:54 CET)

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Preprint CASE REPORT | doi:10.20944/preprints201808.0143.v1

Classic Hodgkin Lymphoproliferative Diseases Clonally Unrelated to B-Chronic Lymphocytic Leukemia Successfully Treated with Bendamustine Plus Rituximab

Shinya Rai, Hirokazu Tanaka, Ko Fujimoto, Takahiro Kumode, Hiroaki Inoue, Yasuhiro Taniguchi, Luis Espinoza, Yasuyoshi Morita, Yoichi Tatsumi, Takashi Ashida, Ryota Matsuoka, Yukie Kikuti, Naoya Nakamura, Itaru Matsumura

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Lymphoproliferative diseases, Hodgkin lymphoma, Chronic Lymphocytic Leukemia, clonality, Hodgkin/Reed–Sternberg cell, Bendamustine

Online: 7 August 2018 (12:02:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0152.v1

Eugenio Martelli, Matilde Zamboni, Giovanni Sotgiu, Laura Saderi, Massimo Federici, Giuseppe Massimo Sangiorgi, Mariangela Valentina Puci, Allegra Rosa Martelli, Teresa Messina, Paolo Frigatti, Maria Pia Borrelli, Carlo Ruotolo, Ilaria Ficarelli, Paolo Rubino, Francesco Pezzo, Luciano Carbonari, Andrea Angelini, Edoardo Galeazzi, Luca Calia Di Pinto, Franco Michelino Fiore, Armado Palmieri, Giorgio Ventoruzzo, Giulia Mazzitelli, Franco Ragni, Antonio Bozzani, Enzo Forliti, Claudio Castagno, Pietro Volpe, Mafalda Massara, Diego Moniaci, Elisa Pagliasso, Tania Peretti, Mauro Ferrari, Nicola Troisi, Pietro Modugno, Maurizio Maiorano, Umberto Marcello Bracale, Marco Panagrosso, Mario Monaco, Giovanni Giordano, Giuseppe Natalicchio, Antonella Biello, Giovanni Maria Celoria, Alessio Amico, Mauro Di Bartolo, Massimiliano Martelli, Roberta Munaó, Davide Razzano, Giovanni Colacchio, Francesco Bussetti, Gaetano Lanza, Antonio Cardini, Bartolomeo Di Benedetto, Mario De Laurentis, Maurizio Taurino, Pasqualino Sirignano, Pierluigi Cappiello, Andrea Esposito, Santi Trimarchi, Silvia Romagnoli, Andrea Padricelli, Giorgio Giudice, Adolfo Crinisio, Giovanni Di Nardo, Giuseppe Battaglia, Rosario Tringale, Salvatore De Vivo, Rita Compagna, Valerio Stefano Tolva, Ilenia D'Alessio, Ruggiero Curci, Simona Giovannetti, Giuseppe D'Arrigo, Giusi Basile, Dalmazio Frigerio, Gian Franco Veraldi, Luca Mezzetto, Arnaldo Ippoliti, Fabio Massimo Oddi, Alberto Maria Settembrini

Subject: Medicine And Pharmacology, Hematology Keywords: chronic limb-threatening ischemia; outcome; sex; age; limb salvage

Online: 8 December 2022 (09:39:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0488.v1

Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension: Insights from a Low-Volume Centre and Comparative Analysis with Other Centres

Taida Ivanauskiene, Sigitas Cesna, Egle Grigoniene, Lina Gumbienė, Aurelija Daubaraite, Kaste Ivanauskaite

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: balloon pulmonary angioplasty; chronic thromboembolic pulmonary hypertension; treatment of inoperable CTEPH

Online: 8 February 2024 (10:21:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints201810.0254.v1

Solanum Fruit Juice as a Natural and Sustainable Source of Antioxidants for Patients with Chronic Hepatitis C under Antiviral Therapy

Chidiebere Uchenna Iheka, Justice Obinna Osuoha, Idongesit Ekong Archibong, Peter Uchenna Amadi, Oluwatoyin Taiwo Adeoti

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: Solanum fruit juice; biochemical markers; chronic hepatitis C; oxidative stress; antioxidants

Online: 12 October 2018 (04:55:44 CEST)

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Working Paper HYPOTHESIS

The Central Nervous System’s Adaptive Changes Make Chronic Diseases Incurable

Jianqing Wu, Ping Zha

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: incurable disease; chronic disease; cancer theory; central nervous system; state memory; mutation; tissue ecosystem; emotion; stress; exercise; baseline biochemical and cellular processes

Online: 24 November 2019 (14:50:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0978.v1

Oncostatin M’s Involvement in the Pathogenesis of Chronic Rhinosinusitis: Focus on Type 1 and 2 Inflammation

Chie Ishikawa, Sachio Takeno, Yukako Okamoto, Tomohiro Kawasumi, Takashi Kakimoto, Kota Takemoto, Manabu Nishida, Takashi Ishino, Takao Hamamoto, Tsutomu Ueda, Akio Tanaka

Subject: Medicine And Pharmacology, Otolaryngology Keywords: paranasal sinus; chronic rhinosinusitis; CRS; epithelial cell; eosinophil; oncostatin M; OSM; OSM receptor; OSMR

Online: 17 October 2023 (08:05:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.2135.v1

Vaccination against Influenza: Clinical and Cytokine Profile of Patients with Asthma and Chronic Obstructive Pulmonary Disease

Мikhail Petrovich Kostinov, Alexander Chuchalin, Anna Chebykina, Nelli Kimovna Akhmatova, Valentina Borisovna Polishchuk, Nadezhda Kryukova, Aristitsa M. Kostinova, Anna E Vlasenko, Alexander Petrovich Cherdantsev, Irina Leonidovna Solovieva, Marina Loktionova, Anna Dmitrievna Shmitko, Lilya Solomonovna Gladkova, Yvette Albahansa Mana

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Influenza vaccine; Grippol® Plus; asthma; chronic obstructive pulmonary disease; vaccine efficacy; cytokines; CRP

Online: 30 September 2023 (08:27:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0233.v1

Relationship Between ACE I/D Polymorphism and Cardiovascular Mortality Risk in Non-Hemodialyzed Chronic Kidney Disease

Hendri Susilo, Budi Susetyo Pikir, Mochammad Thaha, Mochamad Yusuf Alsagaff, Satriyo Dwi Suryantoro, Citrawati Dyah Kencono Wungu, Ifan Ali Wafa, Cennikon Pakpahan, Delvac Oceandy

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: chronic kidney disease; gene polymorphism; angiotensin-converting enzyme; cardiovascular disease; cardiovascular mortality risk; genotype

Online: 26 April 2022 (10:05:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201803.0018.v2

Effects of Excitatory Repetitive Transcranial Magnetic Stimulation of the P3 Point in Chronic Stroke Patients – Case Reports

Ronaldo Luis da Silva, Angela Maria Costa de Souza, Francielly Ferreira Santos, Sueli Toshie Inoue, Johanne Higgins , Victor Frak

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: intraparietal sulcus; stroke; rTMS; Fugl-Meyer Assessment; fast frequency TMS; motricity; sensibility; chronic patients

Online: 17 April 2018 (08:35:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1792.v1

Characterization of Three Somatic Mutations in the 3'UTR of RRAS2 and Their Clinical Implications in Chronic Lymphocytic Leukemia

Marta Lacuna, Alejandro M. Hortal, Claudia Cifuentes, Tania Gonzalo, Miguel Alcoceba, Miguel Bastos, Xose R Bustelo, Marcos González, Balbino Alarcón

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: RRAS2; Somatic mutations; 3'-untranslated region; Chronic Lymphocytic Leukemia (CLL); Clinical implications

Online: 27 October 2023 (12:17:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1294.v1

The Mediating Effects of Social Networks and Wisdom on the Relationship between Lifestyle Habits and Healthy Aging in Older Adults with Chronic Diseases

Hee-Kyung Kim, Hye-Suk Oh, Cheol-Hee Park

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: elderly; healthy aging; lifestyle habits; social networks; wisdom; chronic disease

Online: 19 July 2023 (09:53:15 CEST)

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Preprint REVIEW | doi:10.20944/preprints202301.0447.v1

Still Finding Ways to Augment the Existing Management of Acute and Chronic Kidney Diseases with Targeted Gene and Cell Therapies: Opportunities and Hurdles

Peter Corridon

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: acute kidney disease; chronic kidney disease; gene therapy; cell therapy

Online: 25 January 2023 (04:29:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0675.v1

Prevalence of Fetal Inflammatory Response Syndrome and Villitis of Unknown Etiology in the Placenta of Saudi Women and Their Association with Baby Gender

Waleed Mohammed Aldahmash, Khaldoon Aljerian, Saleh Hamed Alwasel

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Inflammatory Response Syndrome; VUE; chronic deciduitis; CD8; CD68; Placenta; gender

Online: 10 November 2023 (07:29:45 CET)

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Long-term health consequences are influenced by circumstances that occur during pregnancy. The confluence of the maternal and fetal circulations occurs at the placenta, which is the first or-gan to develop. Placental pathology can provide an accurate diagnosis of inflammation inside the amniotic sac. The pathological alterations of preterm placentas provide evidence for the causes of numerous perinatal pathologies, including spontaneous preterm births. This retrospec-tive study aimed to re-examine placentas regarded as normal by the Obstetrics and Gynecology Department in our institution so that grading and staging of any evident inflammatory response could be evaluated and associated with baby gender. Eighty-four full-term placentas were col-lected after delivery. Placentas that were considered normal and were not sent to the histo-pathology department were taken. Morphological examination of fresh placenta was conducted. Full thicknesses of placenta samples were taken from central and marginal regions of placental disc. Fetal and maternal inflammatory responses syndrome were assessed. Villitis of unknown etiology (VUE) and chronic deciduitis also were evaluated in the placenta. Immunohistochemis-try (IHC) was also performed to evaluate patterns of inflammation in the placenta using an-ti-CD8 and anti-CD68 antibodies. The correlation between the silent pathologies and clinical complications or involvement of developing fetal inflammatory response syndrome was meas-ured. In this study, seventeen (20%) maternal inflammatory samples and ten (12%) fetal inflam-matory samples showed inflammatory responses. The frequency of chronic deciduitis and villi-tis of unknown etiology was more remarkable among Saudi pregnant women than the previ-ously reported findings in the literature of placental pathology. The prevalence of fetal and ma-ternal inflammatory response was greater in the placentas of mothers of males than in placentas of female mothers. Grading placental inflammation usually predict the degree of maternal an-ti-fetal cellular rejection. Fetal inflammatory response syndrome usually goes unnoticed in Sau-di Arabia. There are differences in the inflammatory response in the placenta based on the sex of the newborn. Increasing the number of placental samples that must be sent for microscopic in-spection may be preferable due to their significance in identifying the causes of chronic disor-ders.

Preprint REVIEW | doi:10.20944/preprints202308.1664.v1

Limb Salvage and Survival in Chronic Limb-Threatening Ischemia: The Need for Fast-Track Team-Based Approach

Giorgio Ventoruzzo, Giulia Mazzitelli, Umberto Ruzzi, Francesco Liistro, Alessia Scatena, Eugenio Martelli

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: peripheral arterial disease; critical limb ischemia; chronic limb-threatening ischemia; survival; mortality; limb salvage

Online: 25 August 2023 (02:41:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0458.v2

Cost-sensitive Ensemble Feature Ranking and Automatic Threshold Selection for Chronic Kidney Disease Diagnosis

Syed Imran Ali, Bilal Ali, Jamil Hussain, Musarrat Hussain, Fahad Ahmed Satti, Gwang Hoon Park, Sungyoung Lee

Subject: Computer Science And Mathematics, Computer Science Keywords: Cost-sensitive feature selection; ensemble models; decision tree classifiers; chronic kidney disease; random forests; gradient boosted trees

Online: 6 July 2020 (09:56:15 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.1715.v1

Percutaneous Deep Venous Arterialization for Limb Salvage of No Option Patients with Chronic Limb-Threatening Ischemia

Stavros Spiliopoulos, Efstathia Davoutis, Nikolaos-Achilleas Arkoudis, Kaji Sritharan, Symeon Lechareas

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: chronic limb-threatening ischemia; peripheral arterial disease; endovascular treatment; tibial vessels; percutaneous deep venous arterialization

Online: 26 September 2023 (04:44:37 CEST)

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Preprint REVIEW | doi:10.20944/preprints202207.0171.v1

The Effects of Chronic Stress on Neuroanatomy and Cognitive Function

Niki Viradia, Jesica Godinez Paredes, Syed Hassan

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Alzheimer’s; aging; amygdala; brain plasticity; CA1; CA3; chronic stress; cognition; GABA; HIF-1; hippocampus; hypoxia; neurogenesis; Parkinson’s; prefrontal cortex; PSA-NCAM; ROS; spatial learning

Online: 12 July 2022 (04:25:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202302.0207.v1

Mild Chronic Kidney Disease Associated with Low Bone Formation and Decrease in Phosphate Transporters and Signaling Pathways Gene Expression

Evdokia Bogdanova, Airat Sadykov, Galina Ivanova, Irina Zubina, Olga Beresneva, Natalia Semenova, Olga Galkina, Marina Parastaeva, Vladimir Sharoyko, Vladimir Dobronravov

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Chronic kidney disease; bone remodeling; static bone histomorphometry; inorganic phosphate transporters; intracellular signaling

Online: 13 February 2023 (08:46:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints201906.0243.v1

Serum Agrin and Talin, Two Muscular Proteins, are Significantly Increased in Major Depression and Increased Agrin and Lowered Creatine Phosphokinase are Associated with Chronic Fatigue and Fibromyalgia Symptoms in Depression

Hussein Kadhem Al-Hakeim, Ameer Abdul Razzaq Al-Issa, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: major depression; chronic fatigue; fibromyalgia; neuro-immune; inflammation

Online: 24 June 2019 (10:19:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1998.v1

Non-Thyroidal Illness in Chronic Renal Failure: Triiodothyronine Levels and Modulation of Extra-Cellular Superoxide Dismutase (ec-SOD)

Antonio Mancini, Andrea Silvestrini, Fabio Marcheggiani, Emmanuele Capobianco, Sonia Silvestri, Erminia Lembo, Patrick Orlando, Flavia Beccia, Nicola Nicolotti, Nicola Panocchia, Luca Tiano

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Oxidative stress; ec-SOD; Low T3 syndrome; total antioxidant capacity; hemodialysis; chronic kidney diseases

Online: 31 July 2023 (02:49:11 CEST)

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Preprint REVIEW | doi:10.20944/preprints202310.1603.v1

Navigating the Complexities of Traumatic Encephalopathy Syndrome (TES): Current State and Future Challenges

Arman F Fesharaki-Zadeh

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: chronic traumatic encephalopathy (CTE); Alzheimer’s disease (AD); traumatic encephalopathy syndrome (TES); traumatic brain injury (TBI); repetitive head impacts (RHI)

Online: 25 October 2023 (08:57:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202010.0604.v1

People-Centeredness, Chronic Conditions and Diversity Sensitive eHealth: Exploring Emancipation of the ‘Health Care System’ and the ‘Patient’ in Health Informatics

Lars Botin, Pernille S. Bertelsen, Christian Nøhr

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: eHealth; end-user; chronic disease; participatory design; socio-technical; diversity in care

Online: 29 October 2020 (09:30:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.1984.v1

Urinary L-FABP, a Biomarker for Disease Progression, Dialysis and Overall Mortality in Chronic Kidney Disease

Nicos Mitsides, Vikram Mitra, Ananya Saha, Shelley Harris, Philip A. Kalra, Sandip Mitra

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: chronic kidney disease; biomarkers; urinary liver type fatty acid binding protein; urinary protein to creatinine ratio

Online: 28 September 2023 (10:17:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202001.0236.v1

A Mathematical Model of the Transition from the Normal Hematopoiesis to the Chronic and Accelerated Acute Stages in Myeloid Leukemia

Lorand Gabriel Parajdi, Radu Precup, Eduard Alexandru Bonci, Ciprian Tomuleasa

Subject: Computer Science And Mathematics, Applied Mathematics Keywords: mathematical modeling; dynamic system; steady state; stability; hematopoiesis; chronic myeloid leukemia; stem cells

Online: 21 January 2020 (10:16:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202305.2023.v1

Inhaled Corticosteroids and the Risk of Nontuberculous Mycobacterial Pulmonary Disease in Chronic Obstructive Pulmonary Disease: Findings from a Nationwide Population-Based Study

Iseul Yu, Se Hwa Hong, Min-Seok Chang, Seok Jeong Lee, Suk Joong Yong, Won-Yeon Lee, Sang-Ha Kim, Ji-Ho Lee

Subject: Medicine And Pharmacology, Pulmonary And Respiratory Medicine Keywords: nontuberculous mycobacterial pulmonary disease; inhaled corticosteroid; chronic obstructive pulmonary disease; fluticasone; budesonide

Online: 30 May 2023 (02:34:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1234.v1

Perception of Complementary Medicine and Treatment Adherence as Predictors of Self-Efficacy in Individuals with Chronic Conditions in Mexico

Karina Isabel Casco-Gallardo, Nissa Yaing Torres-Soto, Claudia Nelly Orozco-González, Nancy Griselda Pérez-Briones, José Antonio Guerrero-Solano, Gabriela Maldonado-Muñiz, Claudia Atala Trejo-García, Benjamín López-Nolasco

Subject: Public Health And Healthcare, Nursing Keywords: Complementary therapies; treatment adherence; self-efficacy; chronic diseases; Diabetes Mellitus, Type 2; hypertension; obesity.

Online: 18 April 2024 (09:16:33 CEST)

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Chronic conditions like type 2 diabetes mellitus (T2DM), arterial hypertension (HTN), and obesity are major global health issues, causing significant morbidity and mortality. In Latin America, these conditions contribute to millions of premature deaths annually, posing challenges exacerbated by limited healthcare access and poor primary care quality, particularly in Mexico. Complementary medicine presents a potential solution, offering minimally invasive techniques to improve physical, mental, and spiritual well-being. Effective treatment adherence, crucial for positive outcomes, is influenced by self-efficacy, the ability to manage one's behavior in response to medical conditions. However, treatment adherence rates remain low, indicating a pressing public health concern. This study aimed to explore how perception of complementary medicine and treatment adherence predict self-efficacy among individuals with chronic conditions in Mexico. Analyzing data from 113 participants revealed significant correlations between variables, with treatment adherence positively associated with self-efficacy and perception of holistic medicine negatively correlated with self-efficacy. Regression analysis showed that incorporating perception of complementary medicine and treatment adherence significantly explained self-efficacy levels, suggesting the potential of complementary therapies in holistic healthcare approaches. However, collinearity between variables highlights the need for further research to better understand these relationships and their implications for improving healthcare outcomes in Mexico. Integrating complementary therapies with conventional treatments could enhance overall well-being and treatment adherence, offering promising avenues for addressing chronic conditions in the region. These findings underscore the importance of comprehensive healthcare approaches that integrate both conventional and complementary modalities to optimize health outcomes and quality of life for individuals with chronic conditions in Mexico and beyond.

Preprint ARTICLE | doi:10.20944/preprints202309.1417.v1

Mice Overexpressing Wild Type RRAS2: A Novel Preclinical Model for Testing Anti-Chronic Lymphocytic Leukemia Therapies

Balbino Alarcón, Alejandro M. Hortal, Ana Villanueva, Irene Arellano, Cristina Prieto, Pilar Mendoza, Xose R Bustelo

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: R-RAS2; RAS; GTPases; chronic lymphocytic leukemia; B-CLL; mouse model; ibrutinib; venetoclax; new therapies; cancer treatment

Online: 21 September 2023 (12:04:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1021.v1

Precise Filtration of Chronic Myeloid Leukemia Cells by an Ultrathin Microporous Membrane with Backflushing to Minimize Fouling

Jaehyuk Lee, Jeongpyo Hong, Jungwon Lee, Changgyu Lee, Tony Kim, Young Jeong, Kwanghee Kim, Inhwa Jung

Subject: Engineering, Bioengineering Keywords: ultra-thin porous membrane; pumping head for backflush; chronic myeloid leukemia cell; fouling; blocking filtration model

Online: 14 July 2023 (15:23:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202111.0484.v1

Disinhibited-Like Behavior Correlates With Frontal Cortex Damage in Alcohol-Induced Wernicke-Korsakoff Syndrome

Marta Moya, Leticia López-Valencia, Borja García-Bueno, Laura Orio

Subject: Social Sciences, Behavior Sciences Keywords: Chronic alcohol; Thiamine Deficiency; Disinhibition; Wernicke´s Encephalopathy; Recognition memory; Nitrosative stress; Lipid peroxidation; Apoptosis; Cell damage; Nutritional deficit

Online: 25 November 2021 (16:03:13 CET)

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Preprint BRIEF REPORT | doi:10.20944/preprints202401.1407.v1

B Cell Subsets and Immune Checkpoint Expression in Patients With Chronic Lymphocytic Leukaemia

Aviwe Ntsethe, Zekhethelo Alondwe Mkhwanazi, Phiwayinkosi Vusi Dludla, Bongani Brian Nkambule

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Chronic lymphocytic leukaemia; immune checkpoints; B cell subsets; beta-2 microglobulin; programmed death protein 1; cytotoxic T-lymphocyte associated protein 4

Online: 19 January 2024 (04:36:13 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.0804.v1

Metabolic Dysfunction-Associated Fatty Liver Disease and Chronic Viral Hepatitis: The Interlink

Cornelius J Fernandez, Mohammed Alkhalifah, Hafsa Afzar, Joseph M Pappachan

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: metabolic dysfunction-associated fatty liver disease (MAFLD); chronic viral hepatitis; Hepatitis B virus (HBV); Hepatitis C virus; Hepatic Fibrosis; Cirrhosis; and Hepatocellular carcinoma

Online: 14 November 2023 (05:28:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.1756.v1

Designing Nerve Growth Factor Analogues to Suppress Pain Signal Transduction Mediated by the p75NTR-NGF-TrkA Complex: A Structural and Biophysical Perspective

Wei Li

Subject: Biology And Life Sciences, Biophysics Keywords: Nerve growth factor (NGF); NGF analogues; anti-NGF antibodies; chronic pain signal transduction; p75NTR-NGF-TrkA complex

Online: 28 March 2024 (13:39:38 CET)

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As a key mediator of chronic pain, neurotrophin nerve growth factor (NGF) binds to two neurotrophin receptors: p75 neurotrophin receptor (p75NTR) and tyrosine kinase receptor A (TrkA). The formation of the p75NTR-NGF-TrkA complex is implicated in the potentiation of chronic pain signals, making it an attractive target for therapeutic explorations. NGF analogues and monoclonal antibodies (mAbs) targeting NGF represent two distinct approaches in modulating the intricate signaling pathways involved in pain transduction mediated by the p75NTR-NGF-TrkA complex. While NGF analogues offer the advantage of tailored design to fine-tune neurotrophic responses, monoclonal antibodies provide a more systemic and comprehensive blockade of NGF, inhibiting its interactions with both p75NTR and TrkA receptors. However, the use of mAbs may pose challenges related to potential side effects and interference with the physiological functions of NGF. As a result, balancing the benefits and drawbacks of the two approaches is critical for advancing therapeutic strategies towards the alleviation of p75NTR-NGF-TrkA-mediated pain. In this study, therefore, a novel structural and biophysical approach was employed for the design of NGF analogues to suppress p75NTR-NGF-TrkA-related chronic pain signaling. Employing high-throughput structural modeling and biophysics-based intermolecular binding affinity calculations, this article for the first time puts forward a set of NGF analogues, including in particular NGF analogues with four site-specific mutations, for whose dimerizations the K d at 37 ^◦C were reduced by three orders of magnitude (from 10^-9 M to 10^-6 M) compared to the K d at 37 ^◦C for the dimerization of native NGFs. Overall, the integration of structural and biophysical perspectives enhances our understanding of the rational design of NGF analogues as promising candidates for the development of NGF-targeted analgesic therapies, which balances the benefits and drawbacks of anti-NGF antibodies and NGF analogues for advancing therapeutic strategies towards the alleviation of p75NTR-NGF-TrkA-mediated pain.

Preprint ARTICLE | doi:10.20944/preprints202309.1998.v1

Low Post-treatment Quality of Life and the High Incidence of Pain are Common and Significantly Exacerbated in Depressed Head and Neck Patients Treated with Definitive Accelerated Radiotherapy

Alicja Heyda, Dorota Księżniak-Baran, Andrzej Wygoda, Krzysztof Składowski

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: definitive accelerated radiotherapy; depression; chronic pain; head and neck cancer; quality of life

Online: 28 September 2023 (10:41:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202102.0488.v1

Machine Learning Model for Diagnosing the Stage of Liver Fibrosis in Patients With Chronic Viral Hepatitis C

Valeriy Tsvetkov, Ivan Tokin, Dmitriy Lioznov

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Hepatitis C virus; Chronic viral hepatitis C; Liver fibrosis; Liver cirrhosis; Diagnosis of liver fibrosis; Machine learning

Online: 22 February 2021 (15:31:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.0311.v1

Retrospective Cross-Sectional Study on Chronic Hepatitis C in Estonia, Latvia, Lithuania, and Ukraine: Virus, Patient, and Disease Characteristics in Patients under Care (RESPOND-C Study)

Ligita Jančorienė, Baiba Rozentāle, Ieva Tolmane, Agita Jēruma, Riina Salupere, Arida Buivydienė, Jonas Valantinas, Limas Kupčinskas, Jolanta Šumskienė, Eglė Čiupkevičienė, Arvydas Ambrozaitis, Olga Golubovska, Larysa Moroz, Robert Flisiak, Borys Bondar

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Baltic states; chronic hepatitis C; epidemiology; hepatitis C virus; genotype; Ukraine

Online: 5 July 2023 (12:30:04 CEST)

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Background and objectives: Since 2013, highly effective direct-acting (DAA) chronic hepatitis C (CHC) antiviral therapy became available, which has cure rates of over 95%. For choice of optimal CHC treatment, assessment of hepatitis C virus (HCV) genotype (GT) and liver fibrosis stage are necessary. Information about distribution of these parameters among CHC patients in Baltic states and especially in Ukraine is scarce. This study was performed to obtain epidemiological data regarding CHC GT and fibrosis stage distribution for better planning of resources and prioritization of patients for DAA drug treatment according to disease severity in high-income (Baltic states) and lower-middle income (Ukraine) countries. Materials and Methods: This was an epidemiological, retrospective, cross-sectional study that included 1451 CHC patients. Demographic and disease information from medical charts was collected for each patient during a single visit. Results: Most frequent suspected mode of viral transmission was blood transfusions (17.8%), followed by injection drug use (15.7%); however, in 50.9% of patients exact mode of transmission was not clarified. In Ukraine (18.4%) and Estonia (26%) transmission by the injection drug use was higher than in Lithuania (5%) and Latvia (5.3%). Distribution of HCV GT among patients with CHC was as follows: GT1 - 66.4%; GT3 - 28.1; and GT2 - 4.1%. The prevalence of GT1 was the highest in Latvia (84%), and the lowest in Ukraine (63%, p<0.001). Liver fibrosis stages were distributed as follows: F0 - 12.2%, F1 - 26.3%, F2 - 23.5%, F3 – 17.1% and F4 - 20.9%. Cirrhosis (F4) was more prevalent in Lithuanian patients (30.1%) than in Estonians (8.1%, p <0.001). Conclusions: This study contributes to the knowledge of epidemiological characteristics of HCV infection in the Baltic states and Ukraine. The data regarding the patterns of HCV GT and fibrosis stage distribution will be helpful for the development of national strategies to control HCV infection in the era of DAA therapy.

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