Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Non-Thyroidal Illness in Chronic Renal Failure: Triiodothyronine Levels and Modulation of Extra-Cellular Superoxide Dismutase (ec-SOD)

Antonio Mancini
*,† ,
Andrea Silvestrini
*,† ORCID logo ,
Fabio Marcheggiani
,
Emmanuele Capobianco
,
Sonia Silvestri
,
Erminia Lembo
,
Patrick Orlando
,
Flavia Beccia
,
Nicola Nicolotti
ORCID logo ,
Nicola Panocchia
,
Luca Tiano
ORCID logo
†
These authors contributed equally to the work.
Version 1 : Received: 28 July 2023 / Approved: 28 July 2023 / Online: 31 July 2023 (02:49:11 CEST)

A peer-reviewed article of this Preprint also exists.

Mancini, A.; Silvestrini, A.; Marcheggiani, F.; Capobianco, E.; Silvestri, S.; Lembo, E.; Orlando, P.; Beccia, F.; Nicolotti, N.; Panocchia, N.; et al. Non-Thyroidal Illness in Chronic Renal Failure: Triiodothyronine Levels and Modulation of Extra-Cellular Superoxide Dismutase (Ec-SOD). Antioxidants 2024, 13, 126, doi:10.3390/antiox13010126. Mancini, A.; Silvestrini, A.; Marcheggiani, F.; Capobianco, E.; Silvestri, S.; Lembo, E.; Orlando, P.; Beccia, F.; Nicolotti, N.; Panocchia, N.; et al. Non-Thyroidal Illness in Chronic Renal Failure: Triiodothyronine Levels and Modulation of Extra-Cellular Superoxide Dismutase (Ec-SOD). Antioxidants 2024, 13, 126, doi:10.3390/antiox13010126.

Abstract

Oxidative stress (OS) is reported in several chronic diseases. Extra-cellular superoxide dismutase (ec-SOD) catalyzes the dismutation of superoxide anion with a protective role on endothelial cells. In chronic kidney diseases (CKD), OS and thyroid dysfunction (low T3 syndrome) are fre-quently present, but their relationship has not been investigated. This cohort study evaluated ec-SOD activity in CKD patients during haemodialysis, divided into: “acute hemodialytic pa-tients” (AH, 1-3 months of treatment) and “chronic hemodialytic patients” (CH, treated for a longer period). We also evaluated plasmatic total antioxidant capacity (TAC) and the relation-ships with thyroid hormones. Two basal samples (“basal 1”, 3 days after the last dialysis and “basal 2”, 2 days after the last dialysis) were collected. On the same day of basal 2, a sample was collected 5 and 10 min after the standard heparin dose and at the end of the procedure. The ec-SOD values were significantly higher in CH vs AH in all determinations. Moreover, they pre-sented lower TAC values. Dividing CH patients into two subgroups according to fT3 levels (nor-mal or low) we found significantly lower ec-SOD values in the group with low fT3 at basal, 5 and 10 min samples. Finally, a significant correlation was observed between fT3 and ec-SOD in the basal 1 samples. These data, confirming OS and low T3 syndrome in CKD, suggest that low fT3 concentrations can influence ec-SOD activity and therefore contribute to possible endothelial oxi-dative damage in such a situation.

Keywords

Oxidative stress; ec-SOD; Low T3 syndrome; total antioxidant capacity; hemodialysis; chronic kidney diseases

Subject

Medicine and Pharmacology, Endocrinology and Metabolism

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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