Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Chronic Kidney Disease: Role of Diet for a Reduction in the Severity of the Disease

Version 1 : Received: 7 June 2021 / Approved: 8 June 2021 / Online: 8 June 2021 (13:33:23 CEST)

A peer-reviewed article of this Preprint also exists.

Naber, T.; Purohit, S. Chronic Kidney Disease: Role of Diet for a Reduction in the Severity of the Disease. Nutrients 2021, 13, 3277. https://doi.org/10.3390/nu13093277 Naber, T.; Purohit, S. Chronic Kidney Disease: Role of Diet for a Reduction in the Severity of the Disease. Nutrients 2021, 13, 3277. https://doi.org/10.3390/nu13093277

Journal reference: Nutrients 2021, 13, 3277
DOI: 10.3390/nu13093277

Abstract

Chronic kidney disease is a critical health crisis in the US, affecting about 37 million adults. Known as "the silent killer" because it is often undiagnosed until it has reached a stage of progression. Renal dysfunction causes many adverse effects to the body's biological mechanisms, such as fluid electrolyte and pH balance, blood pressure regulation, excretion of toxins and waste, vitamin D metabolism, and hormonal regulation. Many CKD patients experience hyperkalemia, hyperphosphatemia, chronic metabolic acidosis, bone deterioration, blood pressure abnormalities, and edema. Symptoms experienced may be minimized, and the disease's progression may be slowed through an appropriate diet, which is why medical nutrition therapy is a critical aspect of the medical intervention for CKD. The current KDOQI recommendations are proposed as well as the physiological mechanisms behind the recommendations. Current biological explanations of the effects of a whole foods plant-based diet are included for possible contrast with the current renal diet. Strong evidence continues to support the importance of proper nutrition in the prevention and progression of kidney disease.

Keywords

Diabetes; Chronic Kidney Disease; Proteinuria; Dialysis; Inflammation; Diet; Nutrition

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