Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Oroxylum indicum Seed Extract as a Potential Antidepressant in Chronic Stress Mouse Model of Depression

Chorpeth Chalermwongkul
,
Charinya Khamphukdee
ORCID logo ,
Supawadee Daodee
ORCID logo ,
Orawan Monthakantirat
,
Chantana Boonyarat
ORCID logo ,
Yutthana Chotritthirong
ORCID logo ,
Juthamart Maneenet
ORCID logo ,
Suresh Awale
ORCID logo ,
Anake Kijjoa
ORCID logo ,
Yaowared Chulikhit
*
Version 1 : Received: 24 August 2023 / Approved: 24 August 2023 / Online: 28 August 2023 (03:35:17 CEST)

How to cite: Chalermwongkul, C.; Khamphukdee, C.; Daodee, S.; Monthakantirat, O.; Boonyarat, C.; Chotritthirong, Y.; Maneenet, J.; Awale, S.; Kijjoa, A.; Chulikhit, Y. Oroxylum indicum Seed Extract as a Potential Antidepressant in Chronic Stress Mouse Model of Depression. Preprints 2023, 2023081808. https://doi.org/10.20944/preprints202308.1808.v1 Chalermwongkul, C.; Khamphukdee, C.; Daodee, S.; Monthakantirat, O.; Boonyarat, C.; Chotritthirong, Y.; Maneenet, J.; Awale, S.; Kijjoa, A.; Chulikhit, Y. Oroxylum indicum Seed Extract as a Potential Antidepressant in Chronic Stress Mouse Model of Depression. Preprints 2023, 2023081808. https://doi.org/10.20944/preprints202308.1808.v1

Abstract

Major depressive disorder (MDD) is one of life-threatening disorders that is prevalent worldwide. The evident etiology of this disease is still poorly understood. Therefore, a possible mechanism is used to evaluate the antidepressant effect. Nowadays, herbal medicine is gaining more interest as an alternative antidepressant. Oroxylum indicum, which is used in traditional medicine and contains a potential antidepressive compound, baicalein, has an antidepressive property. In vitro inhibitory effect on monoamine oxidase-A (MAO-A) enzyme was used to preliminarily screen the antidepressant effect of the O. indicum seed (OIS) extract. Mice were subjected to unpredictable chronic mild stress (UCMS) for 6 weeks and daily administration of the OIS extract started from week 4. The mechanisms involved in antidepressive activity were investigated. The OIS extract significantly alleviated anhedonia and despair behaviors in UCMS-induced mouse model via two possible pathways: (i) normalize the HPA-axis function by restoration of negative feedback (decreased FKBP5 and increased GR expressions) and reduction of glucocorticoid-related negative gene (SGK-1), (ii) improve neurogenesis by escalation of BDNF and CREB expression in the hippocampus and the frontal cortex. HPLC analysis of the extract showed the presence of All the results obtained from this study emphasize its potential as an effective and novel alternative treatment for MDD.

Keywords

Oroxylum indicum, baicalein, unpredictable chronic mild stress, HPA-axis, depression

Subject

Medicine and Pharmacology, Complementary and Alternative Medicine

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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