Changes of Periodontal Parameters and Microbiome Composition of Tooth Pocket in Patients with Chronic Inflammatory Diseases Receiving Targeted Anti-Cytokine Therapy

How to cite: Wagner, J.; Haker, L.; Mewes, L.; Bang, C.; Rühlemann, M.; Naujokat, H.; Spille, J.H.; Lieb, W.; Franke, A.; Schreiber, S.; Laudes, M.; Dörfer, C.; Wiltfang, J.; Graetz, C.; Schulte, D.M. Changes of Periodontal Parameters and Microbiome Composition of Tooth Pocket in Patients with Chronic Inflammatory Diseases Receiving Targeted Anti-Cytokine Therapy. Preprints 2024, 2024031518. https://doi.org/10.20944/preprints202403.1518.v1 Wagner, J.; Haker, L.; Mewes, L.; Bang, C.; Rühlemann, M.; Naujokat, H.; Spille, J.H.; Lieb, W.; Franke, A.; Schreiber, S.; Laudes, M.; Dörfer, C.; Wiltfang, J.; Graetz, C.; Schulte, D.M. Changes of Periodontal Parameters and Microbiome Composition of Tooth Pocket in Patients with Chronic Inflammatory Diseases Receiving Targeted Anti-Cytokine Therapy. Preprints 2024, 2024031518. https://doi.org/10.20944/preprints202403.1518.v1

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MDPI and ACS Style

Wagner, J.; Haker, L.; Mewes, L.; Bang, C.; Rühlemann, M.; Naujokat, H.; Spille, J.H.; Lieb, W.; Franke, A.; Schreiber, S.; Laudes, M.; Dörfer, C.; Wiltfang, J.; Graetz, C.; Schulte, D.M. Changes of Periodontal Parameters and Microbiome Composition of Tooth Pocket in Patients with Chronic Inflammatory Diseases Receiving Targeted Anti-Cytokine Therapy. Preprints 2024, 2024031518. https://doi.org/10.20944/preprints202403.1518.v1

APA Style

Wagner, J., Haker, L., Mewes, L., Bang, C., Rühlemann, M., Naujokat, H., Spille, J.H., Lieb, W., Franke, A., Schreiber, S., Laudes, M., Dörfer, C., Wiltfang, J., Graetz, C., & Schulte, D.M. (2024). Changes of Periodontal Parameters and Microbiome Composition of Tooth Pocket in Patients with Chronic Inflammatory Diseases Receiving Targeted Anti-Cytokine Therapy. Preprints. https://doi.org/10.20944/preprints202403.1518.v1

Chicago/Turabian Style

Wagner, J., Christian Graetz and Dominik Maria Schulte. 2024 "Changes of Periodontal Parameters and Microbiome Composition of Tooth Pocket in Patients with Chronic Inflammatory Diseases Receiving Targeted Anti-Cytokine Therapy" Preprints. https://doi.org/10.20944/preprints202403.1518.v1

Abstract

Abstract Background: Periodontitis is associated with systemic chronic inflammatory diseases. There is limited evidence on the influence of anti-cytokine therapies on the periodontal condition and microbiome in the tooth pocket of such patients, so the aim of this study was to elucidate this issue. Methods: In this observational trial, the periodontal status and the gingival crevicular fluid of 13 patients with different chronic inflammatory diseases were obtained before initiation of anti-cytokine treatment and 14 weeks after. Gingival crevicular fluid was collected for 16S rRNA gene sequencing from a clinically healthy tooth and the deepest measured pocket. Results: In participants with advanced attachment loss at baseline, the clinical attachment level significantly decreased from 2.9 (2.3-3.4) to 2.4 (1.3-3.0) mm (p = 0.04), and the bleeding- on-probing index dropped from 19.4 (10.0-21.0) to 7.3 (6.9-9.9) mm (p = 0.02) without any further periodontal treatment. Shannon’s diversity index significantly increased in the deepest pockets of patients (p = 0.039). Conclusion: The data showed alterations in diversity of the subgingival microbiome and improvement of periodontal parameters over the course of the study, implying a shift towards a healthier condition after starting anti-cytokine therapy. Additional investigations are needed to analyze whether the administration of selective biologicals can improve periodontal conditions in patients with or without chronic inflammatory diseases.

Keywords

chronic inflammation; periodontitis; microbiome; anti-cytokine therapy

Subject

Medicine and Pharmacology, Dentistry and Oral Surgery

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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