Working Paper Hypothesis Version 1 This version is not peer-reviewed

The Central Nervous System’s Adaptive Changes Make Chronic Diseases Incurable

Version 1 : Received: 23 November 2019 / Approved: 24 November 2019 / Online: 24 November 2019 (14:50:49 CET)

How to cite: Wu, J.; Zha, P. The Central Nervous System’s Adaptive Changes Make Chronic Diseases Incurable. Preprints 2019, 2019110287 Wu, J.; Zha, P. The Central Nervous System’s Adaptive Changes Make Chronic Diseases Incurable. Preprints 2019, 2019110287

Abstract

We examined special roles of the Central Nervous System (CNS) in an attempt to resolve the puzzle that chronic diseases cannot be cured by medicine. By exploring a skill-learning model, we found that the CNS is able to remember certain information reflecting biochemical and cellular (B&C) processes in the body. From the skill using ability, we found that the CNS is able to control basic B&C processes that drive and power the skill. From the ability to adjust forces and force direction of a physical act, we found that the CNS is able to adjust B&C processes that drive the physical act. From this adjustment capability, we further inferred that the CNS must also store information on the baseline B&C processes. As a whole, we found that the CNS can maintain information on baseline B&C processes, up-regulate or down-regulate the processes, and make comparisons in performing its regulatory functions. We found that chronic diseases are the results of deviated baseline B&C processes. Per the proved hypothesis, the CNS maintains deviated baseline B&C processes, and thus protects the body states of fully developed diseases. We then used the three CNS roles to explain that cancer progresses with increasing malignancy, cancer quickly returns after a surgery, cancer cells repopulate after chemotherapy and radiotherapy, cancer develops drug resistance inevitably, immune cells rebound after suppression, generally poor benefits of cancer drugs such as beta-blockers, etc. We further showed that long-term exercises generally push most, if not all, baseline B&C processes in diametrical opposing directions against the diseased B&C processes, implying that exercises play unique roles in reversing chronic diseases. Finally, we proposed several strategical approaches to resetting the CNS’ state memory as the essential condition for curing chronic diseases.

Subject Areas

incurable disease; chronic disease; cancer theory; central nervous system; state memory; mutation; tissue ecosystem; emotion; stress; exercise; baseline biochemical and cellular processes

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