Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Machine Learning Model for Diagnosing the Stage of Liver Fibrosis in Patients With Chronic Viral Hepatitis C

Version 1 : Received: 19 February 2021 / Approved: 22 February 2021 / Online: 22 February 2021 (15:31:11 CET)

How to cite: Tsvetkov, V.; Tokin, I.; Lioznov, D. Machine Learning Model for Diagnosing the Stage of Liver Fibrosis in Patients With Chronic Viral Hepatitis C. Preprints 2021, 2021020488 (doi: 10.20944/preprints202102.0488.v1). Tsvetkov, V.; Tokin, I.; Lioznov, D. Machine Learning Model for Diagnosing the Stage of Liver Fibrosis in Patients With Chronic Viral Hepatitis C. Preprints 2021, 2021020488 (doi: 10.20944/preprints202102.0488.v1).

Abstract

Aim. The purpose of the work was the development of a machine learning model for diagnosing the stage of liver fibrosis in patients with chronic viral hepatitis C according to the data of routine clinical examination. Materials and methods. A total of 1240 patients with chronic viral hepatitis C was examined. A set of data obtained from 689 patients balancing by the stage of liver fibrosis was used for developing and testing machine learning models. 9 routine clinical parameters were selected as the most important predictors for determining the likelihood of liver fibrosis the 3–4 stages presence: age, height, weight and body mass index of the patient, the number of platelets in the clinical blood test, levels of alanine transaminase, aspartate transaminase, gamma-glutamyltransferase, and total bilirubin in a biochemical blood test. Results. The accuracy of the developed method for determining the 3–4 stages of liver fibrosis in patients with chronic viral hepatitis C in comparison with the «gold standard» of diagnosis (liver biopsy) was 80.56% (95% CI: 69.53–88.94%), sensitivity — 66.67%, specificity — 94.44%. Conclusion. The developed method is an alternative to more expensive and geographically inaccessible studies. The method does not require the purchase of additional equipment or software, as well as additional laboratory tests, when used in real clinical practice. The introduction of the method into clinical practice can help to solve the problem of low material and territorial availability of diagnostic tests and allow determining the stage of liver fibrosis in patients with chronic viral hepatitis C.

Supplementary and Associated Material

https://ai.influenza.spb.ru/en/fptest: The interface for informational use is presented on the official website.

Keywords

Hepatitis C virus; Chronic viral hepatitis C; Liver fibrosis; Liver cirrhosis; Diagnosis of liver fibrosis; Machine learning

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