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Preprint REVIEW | doi:10.20944/preprints202109.0341.v1

Effect of Anti-cancerous Compounds on Cancer Cells Extracted From Edible Mushrooms: A Review

Kannan Vignesh, Moumita Ghosh

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Edible Mushrooms; anti-cancerous; bioactive compounds; therapeutic; β-glucan

Online: 20 September 2021 (15:33:47 CEST)

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Preprint REVIEW | doi:10.20944/preprints202109.0047.v2

Clinically Translatable Approaches of Inhibiting TGF-β to Target Cancer Stem Cells in TNBC

Andrew Sulaiman, Sarah McGarry, Sai Charan Chilumula, Vishak Vinod, Rohith Kandunuri

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Triple Negative Breast Cancer; Cancer Stem Cell; TGF-β

Online: 8 September 2021 (20:53:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201910.0272.v1

Provitamin A Biofortification of Durum Wheat through a TILLING Approach

Francesco Sestili, Maria Dolores Garcia-Molina, Gianluca Gambacorta, Romina Beleggia, Ermelinda Botticella, Pasquale De Vita, Daniel-Valentin Savatin, Stefania Masci, Domenico Lafiandra

Subject: Biology And Life Sciences, Plant Sciences Keywords: durum wheat; β-carotene; TILLING; biofortification; vitamin A deficiency

Online: 24 October 2019 (05:28:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints201704.0135.v1

Regulation of G Protein-Coupled Receptors by Ubiquitination

Kamila Skieterska, Pieter Rondou, Kathleen Van Craenenbroeck

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: GPCR; ubiquitination; β-arrestin; deubiquitinating enzyme; E3 ubiquitin ligase

Online: 21 April 2017 (06:23:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201609.0037.v1

Antioxidant Activity and Isolation of β-Sitosterol from Ethyl Acetate Extract of Aerial Parts of Consolida orientalis

Abbas Ali Dehpour

Subject: Biology And Life Sciences, Plant Sciences Keywords: Consolida orientalis; ethyl acetate extract; antioxidant activity; β-sitosterol

Online: 9 September 2016 (11:18:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.2245.v1

Correlation of Presynaptic and Postsynaptic Proteins with Pathology in Alzheimer’s Disease

Geidy E. Serrano, Jessica Walker, Courtney Nelson, Michael Glass, Richard Arce, Anthony Intorcia, Madison P. Cline, Natalie Lana Nabaty, Amanda Acuña, Ashton Huppert Steed, Lucia Sue, Christine Belden, Parichita Choudhury, Eric Reiman, Alireza Atri, Thomas G Beach

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: aging; SNAP25; PSD95; neurofibrillary tangles; amyloid plaques; Braak stage; cerebral cortex; PET imaging

Online: 29 December 2023 (11:29:36 CET)

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Synaptic transmission is essential for nervous system function and the loss of synapses is a known major contributor to dementia. Alzheimer’s disease dementia (ADD) is characterized by synaptic loss in the mesial temporal lobe and cerebral neocortex, brain areas associated with memory and cognition. The association of synaptic loss and ADD was established in the late 1980s and it has been estimated that 30-50% of neocortical synaptic protein is lost in ADD, but there has not yet been a quantitative profiling of different synaptic proteins in different brain regions in ADD from the same individuals. Very recently, PET imaging of synapses is being developed, accelerating the focus on the role of synaptic loss in ADD and other conditions. In this study, we quantified densities of two synaptic proteins, the presynaptic protein SNAP25 and the postsynaptic protein PSD95 in human brain using enzyme-linked immunosorbent assays (ELISA). Protein was extracted from the cingulate, hippocampus, frontal, visual, and entorhinal cortex from cognitively unimpaired controls, subjects with mild cognitive impairment (MCI) and demented subjects with different levels of Alzheimer’s pathology. SNAP25 is significantly reduced in ADD when compared to controls in frontal cortex, visual cortex and cingulate; while hippocampus showed a smaller, non-significant reduction and entorhinal cortex concentrations were not different. In contrast, all brain areas showed lower PSD95 concentrations in ADD when compared to non-demented controls, although in hippocampus this failed to reach significance. Interestingly, cognitively unimpaired cases with high levels of AD pathology had higher levels of both synaptic proteins in all brain regions. SNAP25 and PSD95 concentrations significantly correlated with densities of neurofibrillary tangles, amyloid plaques and Mini Mental State Examination scores. Our results suggest that synaptic transmission is affected by ADD in multiple brain regions. Differences were less marked in entorhinal cortex and hippocampus, most likely due to a ceiling effect imposed by the very early development of neurofibrillary tangles in older people in these brain regions.

Preprint ARTICLE | doi:10.20944/preprints202211.0135.v1

Rare Amyloid Precursor Protein Point Mutations Recapitulate Worldwide Migration and Admixture in Healthy Individuals: Implications For the Study of Neurodegeneration

Paolo Abondio, Francesco Bruno, Amalia Cecilia Bruni, Donata Luiselli

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: amyloid; Alzheimer’s disease; neurodegenerative diseases; neurodegeneration; dementia; population genomics; migration; admixture; APP; neuropathology

Online: 8 November 2022 (02:10:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints201806.0463.v1

α-Synuclein Amyloid Fibrils Investigation with the Use of Fluorescent Probe Thioflavin T

Anna I. Sulatskaya, Natalia P. Rodina, Maksim I. Sulatsky, Olga I. Povarova, Iuliia A. Antifeeva, Irina M. Kuznetsova, Konstantin K. Turoverov

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: α-synuclein; amyloid fibrils; fibrillogenesis; thioflavin T; equilibrium microdialysis; binding parameters; structural polymorphism

Online: 28 June 2018 (10:50:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0380.v1

Computational Insight into the Effect of Natural Compounds on the Destabilization of Preformed Amyloid-β(1-40) Fibrils

Francesco Tavanti, Alfonso Pedone, Maria Cristina Menziani

Subject: Chemistry And Materials Science, Theoretical Chemistry Keywords: molecular dynamics simulation; biophenols; natural compounds; amyloid fibrils; Alzheimer’s disease; ligand-protofiber interactions

Online: 27 May 2018 (13:09:22 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202312.1872.v1

Pharmacokinetic and Pharmacodynamic Analysis Using Monte Carlo Simulation of the Oxacephem Antibiotic Flomoxef against Extended-Spectrum β-Lactamase-Producing Enterobacterales from Dogs

Mizuki Kusumoto, Makoto Jitsuiki, Tomoki Motegi, Kazuki Harada

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: pharmacokinetics–pharmacodynamics approach; flomoxef; extended-spectrum β-lactamases; Enterobacterales; Dogs

Online: 26 December 2023 (02:37:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1506.v1

A Comprehensive Strategy for Stepwise Design of a Lab Prototype for the Removal of Emerging Contaminants in Water Using Cyclodextrin Polymers as Adsorbent Material

Antonio Tomás Hernández Cegarra, Teresa Gómez Morte, José Antonio Pellicer, Nuria Vela, María Isabel Rodríguez-López, Estrella Núñez-Delicado, José Antonio Gabaldón Hernández

Subject: Chemistry And Materials Science, Chemical Engineering Keywords: β-Cyclodextrins; porous adsorbent; adsorption kinetics; pilot design; furosemide; hydrochlorothiazide.

Online: 20 December 2023 (08:58:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1423.v1

Antitumor Effect of Novel Berberine Analogues in a Canine Mammary Tumor Cell Line and in Zebrafish Reporters via Wnt/β-Catenin and Hippo Pathways

Alessandro Sammarco, Giorgia Beffagna, Roberta Sacchetto, Andrea Vettori, Federico Bonsembiante, Giulia Scarin, Maria Elena Gelain, Laura Cavicchioli, Silvia Ferro, Cristina Geroni, Paolo Lombardi, Valentina Zappulli

Subject: Medicine And Pharmacology, Veterinary Medicine Keywords: berberine derivates; dog; mammary tumors; zebrafish; Hippo; Wnt; β-catenin

Online: 22 November 2023 (11:45:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0724.v1

Phenotypic Detection of Carbapenemase and AmpC‐β‐Lactamase Production among Extended Spectrum β‐Lactamase (ESBL)‐Producing Escherichia coli and Klebsiella spp., Isolated from Clinical Specimens

Zakaria Garba, Berenger Kaboré, Isidore Bonkoungou, Magloire H. Natama, ROUMBA Toussaint, Kaisa Haukka, Juha P. Kirveskari, Halidou Tinto, Lassana Sangaré, Nicolas Barro, Anu Kantele

Subject: Public Health And Healthcare, Other Keywords: ESBL; carbapenemase; AmpC‐β‐lactamase; E. coli; Klebsiella spp; hospitals

Online: 10 November 2023 (14:42:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1006.v1

β-cyclodextrin Nanophotosensitizers for Redox-Sensitive Delivery of Chlorin e6

Jaewon Jo, Ji Yoon Kim, Je-Jung Yun, Young Ju Lee, Young-IL Jeong

Subject: Chemistry And Materials Science, Biomaterials Keywords: β-Cyclodextrin; redox-sensitive; cancer targeting; photodynamic therapy; chlorin e6

Online: 17 October 2023 (05:12:13 CEST)

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The aim of this study is to prepare redox-sensitive nanophotosensitizers for targeted delivery of chlorin e6 (Ce6) against cervical cancer. For this purpose, Ce6 was conjugated with β-cyclodextrin (bCD) via disulfide bond creating nanophotosensitizers that were fabricated for redox-sensitive delivery of Ce6 against cancer cells. bCD was treated with succinic anhydride to synthesize suc-cinylated bCD (bCDsu). After that, cystamine was attached to the carboxylic end of bCDsu (bCDsu-ss) and the amine end group of bCDsu-ss was conjugated with Ce6 (bCDsu-ss-Ce6). Chemical composition of bCDsu-ss-Ce6 was confirmed with 1H and 13C NMR spectra. bCDsu-ss-Ce6 nanophotosensitizers were fabricated by dialysis procedure. They formed small particles with an average particle size of 152.0±23.2 nm and they showed improved singlet oxygen (SO) generation in the aqueous solution under light irradiation and was significantly higher than that of Ce6 alone. Ce6 release rate from bCDsu-ss-Ce6 nanophotosensitizers was accelerated by addition of glutathione (GSH), indicating that bCDsu-ss-Ce6 nanophotosensitizers have re-dox-sensitive photosensitizer delivery capacity. bCDsu-ss-Ce6 nanophotosensitizers have low in-trinsic cytotoxicity against CCD986Sk human skin fibroblast cells as well as Ce6 alone. However, bCDsu-ss-Ce6 nanophotosensitizers showed improved Ce6 uptake ratio, higher reactive oxygen species (ROS) production and phototoxicity compared to those of Ce6 alone. GSH addition resulted in higher Ce6 uptake ratio, ROS generation and phototoxicity than those of Ce6 alone, indicating that bCDsu-ss-Ce6 nanophotosensitizers have redox-sensitive biological activity in vitro against HeLa human cervical cancer cells. At tumor xenograft model using HeLa cells, bCDsu-ss-Ce6 nanophotosensitizers efficiently accumulated in the tumor rather than normal organs, i.e. fluores-cence intensity in tumor tissues was significantly higher than those of other organs while Ce6 alone did not specifically target tumor tissue. These results indicated higher anticancer activity of bCDsu-ss-Ce6 nanophotosensitizers, by efficiently inhibiting growth of tumor in in vivo animal tumor xenograft study.

Preprint ARTICLE | doi:10.20944/preprints202309.0170.v1

Decrease of α-Globin and Increase of the Autophagy-Activating Kinase ULK1 mRNA in Erythroid Precursors from β-Thalassemia Patients Treated with Sirolimus

Matteo Zurlo, Cristina Zuccato, Lucia Carmela Cosenza, Jessica Gasparello, Maria Rita Gamberini, Alice Stievano, Monica Fortini, Marco Prosdocimi, Alessia Finotti, Roberto Gambari

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: β-thalassemia; autophagy; fetal hemoglobin; α-globin; rapamycin; sirolimus; ULK1

Online: 4 September 2023 (10:43:35 CEST)

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Preprint REVIEW | doi:10.20944/preprints202307.1415.v1

β-Tricalcium Phosphate as Alveolar Bone Grafting in Cleft Lip/Palate: A Systematic Review

Alexander Patera Nugraha, Hui Yang, Junduo Chen, Kunhua Yang, Ploypim Kraisintu, Kyaw Zaww, Aobo Ma, Ruixian Wang, Nada Emad Alshafei Mohamed Alhadi, Juan Ramon Vanegas Sáenz, Guang Hong

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Medicine; β-Tricalcium Phosphate; Bonegraft; CL/P; Dental Material; Bioceramic

Online: 20 July 2023 (10:25:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202301.0540.v1

Antibacterial and Antibiofilm Activities of Β –Lapachone by Modulating the Catalase Enzyme

Mushtaq Ahmad Mir, Sumaya Ahmed Altuhami, Sukanta Mondal, Nasreena Bashir, Ayed Dera

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: β -Lapachone; Bactericidal; Biofilms; Resistant; Zone of inhibition; Antimicrobial activity

Online: 30 January 2023 (06:10:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0350.v1

Diversity and Distribution of β-lactamase Genes Circulating in Indian Isolates of Multi-drug Resistant Klebsiella pneumoniae

Suraj Shukla, Siddhi Desai, Ashutosh Bagchi, Pushpendra Singh, Madhvi Joshi, Chaitanya Joshi, Jyoti Patankar, Geeti Maheshwari, Ekadashi Rajni, Manali Shah, Devarshi Gajjar

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: whole genome sequencing; β-lactamases; MLST; plasmid replicons; Klebsiella pneumoniae

Online: 19 January 2023 (09:06:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0288.v1

Osteoinductive Moldable and Curable Bone Substitutes Based on Collagen, BMP-2 and Highly Porous Polylactide Granules, or a Mix of HAP/β-TCP

Andrey Vasilyev, Valeriya Kuznetsova, Tatyana Bukharova, Egor Osidak, Timofei Grigoriev, Yuriy Zagoskin, Irina Nedorubova, Sergey Domogatsky, Igor Babichenko, Oksana Zorina, Sergey Kutsev, Sergei Chvalun, Anatoly Kulakov, Fedor Losev, Dmitry Goldshtein

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: сollagen; fibronectin; hydrogel; polylactide; HAP/β-TCP; BMP-2; osteoinduction

Online: 16 November 2021 (11:36:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0220.v1

β-Ga₂O₃ Used as a Saturable Absorber to Realize Passively Q-Switched Laser Output

Baizhong Li, Qiudi Chen, Peixiong Zhang, Ruifeng Tian, Lu Zhang, Qinglin Sai, Bin Wang, Mingyan Pan, Youchen Liu, Changtai Xia, Zhenqiang Chen, Hongji Qi

Subject: Chemistry And Materials Science, Chemical Engineering Keywords: β-Ga2O3 crystal; optical floating zone; saturable absorber; Q-switch

Online: 12 November 2021 (12:09:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202110.0196.v1

Folic Acid Decorated β-Cyclodextrin-Based Poly(ε-Caprolactone)/Dextran Star Polymer with Disulﬁde Bond-Linker as Theranostic Nanoparticle for Tumor-Targeted MRI and Chemotherapy

Huikang Yang, Nianhua Wang, Ruimeng Yang, Li-Ming Zhang, Xinqing Jiang

Subject: Chemistry And Materials Science, Biomaterials Keywords: star polymer; β-cyclodextrin; tumor-targeted; disulﬁde bond; theranostic nanoparticles

Online: 13 October 2021 (11:00:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0105.v1

The Role of Wnt/Beta-Catenin Pathway, SATB1 and SATB2 in Endometrial Cancer Patients

Paweł Sadłecki, Magdalena Bodnar, Andrzej Marszalek, Malgorzata Walentowicz-Sadlecka

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: endometrial cancer; tumor microenvironment; Wnt/β-catenin pathway; SATB1; SATB2

Online: 6 September 2021 (14:29:35 CEST)

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Wnt/β-catenin signaling pathway plays an established role in various diseases and is considered a hallmark of endometrial cancer (EC). Special AT-rich sequence-binding protein 1 and 2 (SATB1 and SATB2) are nuclear matrix-associated proteins involved in chromatin remodeling and regulation of gene expression. SATB1 promotes the progression of numerous types of cancers, whereas SATB2 acts as a tumor suppressor. Despite a recent progress in our knowledge about EC, the exact mechanisms that control their proliferation and metastatic potential still remain unknown. The aim of our study was to investigate the association between Wnt3A, β-catenin, SATB1 and SATB2 protein level and the clinicopathological features of EC patients. 92 EC patients, aged 37-84, were enrolled to our study. The immunoexpression of WNT3A was found in specimens from all EC patients, β-catenin was expressed in 97% of the cases, SATB1 in 87%. The significant association between Wnt3a expression and tumor grade was found; moreover mean IRS for Wnt3a turned out to be significantly lower in high-grade tumors than in low-grade malignancies (p=0.038). In turn, immunoexpression of β-catenin varied significantly across FIGO stages and was associated with the presence of lymph node metastases. Mean IRS for β-catenin in patients with lymph node metastases was significantly lower than in those without (p = 0.028). The Kaplan-Meier analyses demonstrated a stepwise impairment of cancer overall survival with increasing SATB1 expression. In conclusion, both Wnt/β-catenin signaling pathway and SATB1 contribute to progression of EC. Downregulation of β-catenin may predispose to lymphatic spread of EC. In turn, downregulation of Wnt3a seems to be characteristic for high-grade tumors, but probably does not play a role in formation of lymph node metastases. The important role of SATB1 as a predictor of poor survival and could be helpful in establishing a more accurate prognosis in endometrial cancer patients.

Preprint REVIEW | doi:10.20944/preprints202103.0444.v1

SMADS-mediate Molecular Mechanisms in Sjӧgren's Syndrome

Margherita Sisto, Domenico Ribatti, Sabrina Lisi

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: SMAD; Sjӧgren’s syndrome; epithelial-mesenchymal transition; fibrosis; TGF-β; inflammation

Online: 17 March 2021 (14:43:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0383.v1

Discovery and Optimization of Selective Inhibitors of Meprin α (Part II)

Chao Wang, Juan Diez, Hajeung Park, Christoph Becker-Pauly, Gregg B. Fields, Timothy P. Spicer, Louis D. Scampavia, Dmitriy Minond, Thomas D. Bannister

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: meprin α; meprin β; zinc metalloproteinase; medicinal chemistry; probe development

Online: 15 December 2020 (12:56:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202010.0572.v1

Effects of Tenascin C on the Integrity of Extracellular Matrix and Skin Aging

Young Eun Choi, Min Ji Song, Mari Hara, Kyoko Imanaka-Yoshida, Dong Hun Lee, Jin Ho Chung, Seung-Taek Lee

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: aging; collagen; extracellular matrix; fibroblast; skin; tenascin C; TGF-β

Online: 28 October 2020 (08:49:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202010.0359.v1

Comparison of the Structural Evolution of β Polypropylene During the Sequential and Simultaneous Biaxial Stretching Process

Daoxin Zhang, Lei Ding, Feng Yang, Fang Lan, Ya Cao, Ming Xiang

Subject: Chemistry And Materials Science, Biomaterials Keywords: β-iPP; simultaneous biaxial stretching; sequential biaxial stretching; structure evolution

Online: 19 October 2020 (08:07:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0585.v1

Kinetic Characterization of β-xylosidase (GbtXyl43A) from Wild-type Geobacillus thermoleovorans IT-08 and The Variant GbtXyl43A-D121N

Ika Fitriani Juli Palupi, Kartika Dwi Asni Putri, Ni Nyoman Purwani, Sri Sumarsih, Ni Nyoman Tri Puspaningsih

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Geobaccilus thermoleovorans IT-08; β-D-xylosidase; GbtXyl43A; kinetic characteristics

Online: 24 September 2020 (14:15:50 CEST)

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Working Paper ARTICLE

COVID-19: Role of the Interferons

Claudio G. Gallo, Sirio Fiorino, Giovanni Posabella, Donato Antonacci, Antonio Tropeano, Emanuele Pausini, Carlotta Pausini, Tommaso Guarniero, Marco Zancanaro

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: COVID-19; SARS CoV-2; IFN-⍺; IFN-β; IFN-λ

Online: 2 August 2020 (11:31:40 CEST)

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COVID-19 disease, caused by the SARS-CoV2 virus, is a potentially fatal disease that represents a serious public health and economic problem worldwide. The SARS-CoV2 virus infects the lower respiratory tract and can cause pneumonia in humans. ARDS is the leading cause of death in COVID-19 disease. One of the main characteristics of ARDS is the cytokine storm, an uncontrolled systemic inflammatory response resulting from the release of pro-inflammatory cytokines and chemokines and growth factors, by immune cells. The other important aspect of the disease is represented by the involvement of the vascular organ that undergoes endothelitis. Hyperinflammation and endothelitis contribute in various ways to trigger coagulation disorders with diffuse micro thrombotic and thromboembolic phenomena. Lastly, multiple organ failure may occur (MOF). Since so far there is no approved treatment, there is an urgent need to reposition known treatments, considered safe, to be included in trials. Naturally produced interferons represent the body's first line of defense against viruses. Pharmacological forms, obtained by means of genetic recombination techniques, have long been approved and used to treat numerous pathologies. Interferons are divided into three families, within which some subfamilies are distinguishable. Only IFN-II comprises a single isoform which has completely different aspects and functions. The IFN I and III, however, each comprise different subfamilies (17 subfamilies the IFN-I and 4 subfamilies the IFN-III), share many aspects, representing the body's first antiviral response, but play different roles. The use of IFNs has been studied in two severe hCoV (Human Coronavirus) diseases, closely related to COVID-19 disease, such as SARS and MERS. Numerous in vitro and in vivo studies have been conducted, often in combination with other antivirals. The results have been controversial. The positive results in vitro and in experimental animals were often not replicable in humans. The possible positioning of these molecules in the right window of therapeutic opportunity requires that the complex dialogue between IFN, inflammasome, cytokines, pro-inflammatory chemokines, growth factors and barrier function be shed light.

Working Paper ARTICLE

Synthesis, Antimicrobial Study and Molecular Docking Simulation of 3,4-Dimethoxy-β-nitrostyrene Derivatives as Candidate of PTP1B Inhibitor

Salman Alfarisi, Mardi Santoso, Alfinda Novi Kristanti, Ni Nyoman Tri Puspaningsih

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: 3,4-dimethoxy-β-nitrostyrene derivatives; antimicrobial agent; PTP1B; molecular docking

Online: 20 July 2020 (11:31:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201905.0290.v1

N-Terminal (1→3)-β-D-glucan Recognition Proteins from Insects Recognize the Difference in ultra-Structures of (1→3)-β-D-glucan

Yoshiyuki Adachi, Masaki Ishii, Takashi Kanno, Junko Tetsui, Ken-ichi Ishibashi, Daisuke Yamanaka, Noriko Miura, Naohito Ohno

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: β-D-glucan; glucan binding protein; host defense; innate immunity

Online: 24 May 2019 (08:56:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201903.0045.v1

The Novel Thienopyrimidine Derivative, RP-010, Produces Its Efficacy in Prostate Cancer Cells by Inducing the Fragmentation of β-catenin

Haneen Amawi, Noor Hussein, Sai HS Boddu, Chandrabose Karthikeyan, Frederick E. Williams, Charles R. Ashby Jr., Raman Dayanidhi, Piyush Trivedi, Amit Tiwari

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Thienopyrimidines, RP-010, Prostate cancer, Metastasis, Wnt/β-catenin, Apoptosis.

Online: 4 March 2019 (13:37:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints201808.0432.v1

Inhibition of Wnt3a/FOXM1/β-Catenin Axis and Activation of GSK 3β and Caspases are Critically Involved in Apoptotic Effect of Moracin D in Breast Cancers

Sung Min Hwang, Hyo-Jung Lee, Ji Hoon Jung, Deok Yong Sim, Jisung Hwang, Ji Eon Park, Sunghoon Kim

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Breast cancer; Moracin D; Apoptosis; FOXM1; β-catenin; GSK 3β

Online: 24 August 2018 (10:58:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201612.0120.v1

β-Glucans and Post Prandial Satiety: The Role of Intestinal Hormones in Healthy Volunteers

Sara Baldassano, Silvio Buscemi, Anna Aiello, Giulia Accardi, Calogero Caruso, Sonya Vasto

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: β-glucans; entero-endocrine system; intestinal hormones; microbiota; nutritional intervention

Online: 23 December 2016 (13:37:44 CET)

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Preprint REVIEW | doi:10.20944/preprints201908.0234.v1

Over-Production of Therapeutic Growth Factors for Cartilage Regeneration by Protein Production Platforms and Protein Packaging Cell Lines: A Narrative Review of the Current State-of-the-Art

Ali Mobasheri, Pablo Martín-Vasallo

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: osteoarthritis; articular cartilage; degeneration; regeneration; therapeutic protein; growth factor; protein production platform; protein packaging cell line; transforming growth factor β (TGF-β); GP2-293 cells

Online: 23 August 2019 (03:33:49 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202109.0133.v1

Fluid and Tissue Biomarkers of Lewy Body Dementia: Report of an LBDA Symposium

Gregory D. Scott, Moriah R. Arnold, Thomas G. Beach, Christopher H. Gibbons, Anumantha G. Kanthasamy, Russell M. Lebovitz, Afina W. Lemstra, Leslie M. Shaw, Charlotte E. Teunissen, Henrik Zetterberg, Angela S. Taylor, Todd C. Graham, Bradley F. Boeve, Stephen N. Gomperts, Neill R. Graff-Radford, Charbel E.-H. Moussa, Kathleen L. Poston, Liana S. Rosenthal, Marwan N. Sabbagh, Ryan R. Walsh, Miriam T. Weber, Melissa J. Armstrong, Jee A. Bang, Andrea C. Bozoki, Kimiko Domoto-Reilly, John E. Duda, Jori E. Fleisher, Douglas R. Galasko, James E. Galvin, Jennifer G. Goldman, Samantha K. Holden, Lawrence S. Honig, Daniel E. Huddleston, James B. Leverenz, Irene Litvan, Carol A. Manning, Karen S. Marder, Alexander Y. Pantelyat, Victoria S. Pelak, Douglas W. Scharre, Sharon J. Sha, Holly A. Shill, Mari Zoltan, Joseph F. Quinn, David J. Irwin

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: cerebrospinal fluid; alpha-synuclein; skin biopsy; seeded aggregation assays; tau, amyloid; Lewy body dementia

Online: 7 September 2021 (16:26:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0564.v1

In vivo Neuropharmacological Potential of Gomphandra tetrandra (Wall.) Sleumer and in-silico Study against β-Amyloid Precursor Protein

Md Saidur Rahman, Md Nazmul Hasan Zilani, Md. Aminul Islam, Md Munaib Hasan, Md. Muzahidul Islam, Farzana Yasmin, Partha Biswas, Akinori Hirashima, Md. Ataur Rahman, Md. Nazmul Hasan, Bonglee Kim

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Neurological activity; GC-MS; ADMET profile; Molecular Docking; Beta-amyloid precursor protein; Alzheimer’s disease

Online: 26 July 2021 (10:27:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201705.0144.v1

Neuroprotective Effect of Anthocyanin Extract from Lycium ruthenicum Murray in Aβ1–42-induced Rat Model of AD

Xueling Wu, Xiaoxiao Li, Shuang Liang, Yanxia Liu, Xueling Dai, Qiusheng Zheng, Yaxuan Sun

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Alzheimer’s disease (AD); amyloid-β1-42(Aβ1–42); Lycium ruthenicum Murray (LRA); neuroprotective effect

Online: 19 May 2017 (06:26:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0789.v1

Decreased Penetration Mechanism of Ranitidine Due to Application of Sodium Sulfobutyl Ether-β-Cyclodextrin

Yang Rui, Zhang Jing, Huang Jia-Qi, Wang Xiao-Feng, Yang Hui-Ying, Jin Qing-Ri

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: sodium sulfobutyl ether-β-cyclodextrin; ranitidine; apparent permeability coefficient; permeability; inhibition

Online: 12 October 2023 (20:13:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1491.v1

Significance of Lipopolysaccharides in Gastric Cancer and their Potential as a Biomarker for Nivolumab Sensitivity

Nobuhiro Nakazawa, Takehiko Yokobori, Makoto Sohda, Nobuhiro Hosoi, Takayoshi Watanabe, Yuki Shimoda, Munenori Ide, Akihiko Sano, Makoto Sakai, Bilguun Erkhem-Ochir, Hiroomi Ogawa, Ken Shirabe, Hiroshi Saeki

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: epithelial–mesenchymal transition (EMT); Gastric cancer; lipopolysaccharides (LPS); Nivolumab; TGF-β

Online: 21 June 2023 (07:28:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1076.v1

Enhancing the Anti-Leukemic Potential of Thymoquinone- SBE-β-CD Inclusion Complex

ELTAYEB E.M. EID, Salah Abdalrazak Alshehade, Amer A. Almiman, Sareh Kamran, Vannajan Sanghiran Lee, Mohammed Abdullah Alshawsh

Subject: Medicine And Pharmacology, Hematology Keywords: Thymoquinone; SBE-β-CD; Leukemia; Drug delivery system; Telomerase inhibition; Apoptosis

Online: 15 June 2023 (05:37:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0547.v1

About the Mechanical Strength of CPC Scaffolds

Elisa Bertrand, Sergej Zankovic, Johannes Vinke, Hagen Schmal, Michael Seidenstuecker

Subject: Engineering, Bioengineering Keywords: Calciumphosphate cement; CPC; β-TCP; 3D printing; mechanical properties; sinter ceramics

Online: 8 May 2023 (15:05:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202302.0284.v1

Cbfβ Is a Novel Modulator Against Osteoarthritis by Maintaining Articular Cartilage Homeostasis Through TGF-Ꞵ Signaling

Xiangguo Che, Xian Jin, Narae Park, Hee-June Kim, Hee-Soo Kyung, Hyun-Ju Kim, Jane B. Lian, Janet L. Stein, And Je-Yong Choi

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: articular cartilage; Runx1/Cbfβ complex; Osteoarthritis; TGF-β signaling; proteasomal degradation

Online: 16 February 2023 (09:40:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0434.v1

Evaluation of Terbutaline Adsorption from Aqueous Medium by Mechanically Generated [Cu (INA)2]-MOF Metal-Organic Framework and its Modified Magnetic Composite ([Cu (INA)2]-MOF@Fe3O4)

Usman Armaya’u, Marinah Mohd Ariffin, Saw Hong Loh, Wan Mohd Afiq Wan Mohd Khalik, Hanis Mohd Yusoff

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Adsorption; β-agonists; Magnetic-composite; Metal-Organic Frameworks; Pollutant; Removal; Terbutaline

Online: 23 December 2022 (01:51:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202206.0328.v1

Assessing the Spatiotemporal Relationship between Coastal Habitats and Fish Assemblages at Two Neotropical Estuaries of the Mexican Pacific

Victor Muro, Felipe Amezcua, Georgina Ramírez-Ortiz, Francisco Flores-de-Santiago, Felipe Amezcua-Linares, Yareli Hernandez

Subject: Biology And Life Sciences, Ecology, Evolution, Behavior And Systematics Keywords: mangrove forests; Marine Protected Areas; α-diversity; β-diversity; multivariate analyses

Online: 24 June 2022 (03:28:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0085.v1

Decrease of Aflatoxin M₁ Concentration in Milk During Cholesterol Removal by Β-Cyclodextrin Application

Peter Šimko, Lukáš Kolarič

Subject: Chemistry And Materials Science, Food Chemistry Keywords: aflatoxin M1; milk; dairy; cholesterol; β-cyclodextrin; food safety; global warming

Online: 11 April 2022 (03:18:05 CEST)

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Preprint REVIEW | doi:10.20944/preprints202001.0063.v1

Stem Cell Therapy for Diabetes: Beta Cells versus Pancreatic Progenitors

Essam Abdelalim, Bushra Memon

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: hPSCs; hyperglycemia; insulin-secreting cells; β-cell precursors; pancreatic islets; transplantation.

Online: 8 January 2020 (05:30:34 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints201909.0313.v1

Structural Flexibility of Peripheral Loops and Extended C-Term Domain of Short Length Substrate Binding Protein from Rhodothermus marinus

Ji-Eun Bae, In Jung Kim, Yongbin Xu, Ki Hyun Nam

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: substrate-binding protein; sbp; abc transport; α/β-domain; rhodothermus arinus

Online: 27 September 2019 (12:16:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201812.0059.v1

Optimization of the Factors Affecting the Absorption of Vardenafil from Oral Disintegrating Tablets: A Clinical Pharmacokinetic Investigation

Hytham Al-Gethmy, Usama Fahmy, Nabil Alhakamy, Osama Ahmed, Khalid El-Say

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: Bioavailability; Box-Behnken design; β-cyclodextrin; erectile dysfunction; taste masking; vardenafil.

Online: 4 December 2018 (16:39:51 CET)

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Preprint REVIEW | doi:10.20944/preprints201805.0355.v1

TGF-β Sustains Tumor Progression through Biochemical and Mechanical Signal Transduction

Robert L. Furler, Douglas F. Nixon, Christine A. Brantner, Anastas Popratiloff, Christel H. Uittenbogaart

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: TGF-β; cancer; immunosuppression; TAK1; mechanobiology; extracellular matrix; tensegrity; DNA damage

Online: 25 May 2018 (08:37:53 CEST)

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Preprint REVIEW | doi:10.20944/preprints201805.0180.v1

Unanswered Questions Regarding Sex and BMP/TGF-β Signaling

Tapan A. Shah, Melissa B. Rogers

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: BMP; TGF-β; signaling; sex; chromosomes; XIST; genomic imprinting; hormones; fibrosis

Online: 11 May 2018 (09:49:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201609.0123.v1

Discovery of Potent Carbonic Anhydrase and Acetylcholinesterase Inhibitors: 2-Aminoindan β-Lactam Derivatives

Hayriye Genç, Ramazan Kalin, Zeynep Köksal, Nastaran Sadeghian, Umit M. Kocyigit, Mustafa Zengin, İlhami Gülçin, Hasan Özdemir

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: carbonic anhydrase; acetylcholinesterase; β-Lactam; 2-Azetidinone; enzyme inhibition; enzyme purification

Online: 30 September 2016 (05:38:45 CEST)

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Preprint REVIEW | doi:10.20944/preprints202007.0674.v1

Over-production of Therapeutic Growth Factors for Articular Cartilage Regeneration by Protein Production Platforms and Protein Packaging Cell Lines

Ali Mobasheri, Heonsik Choi, Pablo Martín-Vasallo

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: osteoarthritis; articular cartilage; degeneration; regeneration; therapeutic protein; growth factor; protein production platform; protein packaging cell line; transforming growth factor β (TGF-β); GP2-293 cells; TissueGene-C

Online: 28 July 2020 (10:16:51 CEST)

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This review article focuses on the current state-of-the-art in the area of cellular and molecular biotechnology for over-production of clinically relevant therapeutic and anabolic growth factors. We discuss how the currently available tools and emerging technologies can be used for the regenerative treatment of osteoarthritis (OA). Transfected protein packaging cell lines such as GP-293 cells may be used as “cellular factories” for large-scale production of therapeutic proteins and pro-anabolic growth factors, particularly in the context of cartilage regeneration. However, when irradiated with gamma or x-rays, these cells lose their capacity for replication, which actually makes them safe for use as a live cell component of intra-articular injections. This innovation is already here, in the form of TissueGene-C, a new biological drug which consists of normal allogeneic primary chondrocytes combined with transduced GP2-293 cells that overexpress the growth factor transforming growth factor β1 (TGF-β1). TissueGene-C has revolutionized the concept of cell therapy, allowing drug companies to develop live cells as biological drug delivery systems for direct intra-articular injection of growth factors whose half-lives are in the order of minutes. Therefore, in this paper, we discuss the potential for new innovations in regenerative medicine for degenerative diseases of synovial joints using mammalian protein production platforms, specifically protein packaging cell lines, for over-producing growth factors for cartilage tissue regeneration and give recent examples. Mammalian protein production platforms that incorporate protein packaging eukaryotic cell lines are superior to prokaryotic bacterial expression systems and are likely to have a significant impact on the development of new humanized biological growth factor therapies for treating focal cartilage defects and more generally for the treatment of degenerative joint diseases such as OA, especially when injected directly into the joint.

Preprint REVIEW | doi:10.20944/preprints201912.0135.v1

Systemically Administered, Target-specific, Multi-functional Therapeutic Recombinant Proteins in Regenerative Medicine

Tero Järvinen, Toini Pemmari

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: vascular homing peptide; cell penetrating peptide; angiogenesis; vascular heterogeneity; fibrosis; targeted delivery; decorin; transforming growth factor-β (tgf-β), bystander effect, cendr peptide; tissue regeneration; regenerative medicine

Online: 10 December 2019 (15:02:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0340.v1

Amyloid-Forming Corpora Amylacea and Spheroid-Type Amyloid Deposition: Comprehensive Analysis Using Immunohistochemistry, Proteomics, and a Literature Review

Shojiro Ichimata, Yukiko Hata, Tsuneaki Yoshinaga, Nagaaki Katoh, Fuyuki Kametani, Masahide Yazaki, Yoshiki Sekijima, Naoki Nishida

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Amyloid; beta-2 micro-globulin; corpora amylacea; functional amyloids; lactoferrin; lysosome; macrophage; pulmonary surfactant protein

Online: 6 March 2024 (14:06:29 CET)

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Preprint HYPOTHESIS | doi:10.20944/preprints202108.0115.v1

Intracellular Ion Changes Induced by the Exposure to Beta-Amyloid Can Be Explained by the Formation of Channels in the Lysosomal Membranes

Dmitry V Zaretsky, Maria V Zaretskaia

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: beta-amyloid toxicity, proteolytic digestion, membrane channel, intracellular ion disturbances, calcium homeostasis, intracellular pH, lysosome

Online: 4 August 2021 (13:19:50 CEST)

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Preprint REVIEW | doi:10.20944/preprints202103.0365.v1

Neurofluids – Deep Inspiration, Cilia and Preloading of the Astrocytic Network

Hans Ludwig, Steffi Dreha-Kulaczewski, Christoph Bock

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Real-time MR imaging; CSF; cilia sensing; aquaporin; nitric oxide; amyloid-ß; glymphatic system; hydrocephalus

Online: 15 March 2021 (10:36:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.1692.v1

β‐Carotene Impacts the Liver microRNA Profile in a Sex‐Specific Manner in Mouse Offspring of Western Diet‐Fed Mothers: Results from Microarray Analysis by Direct Hybridization

Diana Marisol Abrego-Guandique, Sebastià Galmés, Roberto Cannataro, Maria Cristina Caroleo, Joan Ribot, M. Luisa Bonet, Erika Cione

Subject: Biochemistry And Molecular Biology, Biology And Life Sciences Keywords: Carotenoids; β-carotene; Liver; microRNAs; Western Diet; Lactation; Weaning; early-life programming

Online: 25 April 2024 (16:06:08 CEST)

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Preprint REVIEW | doi:10.20944/preprints202307.0979.v1

A New Paradigm in the Relationship between Gut Microbiota and Breast Cancer: ß-Glucuronidase Enzyme Identified as Potential Therapeutic Target

María Leonor Fernández-Murga, Fernando Gil Ortiz, Lucía Serrano García, Antonio Llombart-Cussac

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: breast cancer; microbiota; estrobolome; β-glucuronidase; dysbiosis; inhibitors; metabolomics; personalized medicine; review

Online: 14 July 2023 (07:08:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1910.v1

TAp73 Inhibits EMT and Cell Migration in Pancreatic Cancer Cells Through Promoting SMAD4 Expression and SMAD4 Dependent Inhibition of ERK Activation

Hendrik Ungefroren, Björn Konukiewitz, Rüdiger Braun, Ulrich Friedrich Wellner, Hendrik Lehnert, Jens U. Marquardt

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: TAp73; PDAC; SMAD4; transforming growth factor-β; epithelial-mesenchymal transition; cell migration

Online: 27 June 2023 (12:53:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0532.v1

Yield, Characterization and Possible Exploitation of Cannabis Sativa L. Roots Grown Under Aeroponics Cultivation

Fabio Ferrini, Daniele Fraternale, Sabrina Donati Zeppa, Giancarlo Verardo, Andrea Gorassini, Vittoria Carrabs, Maria Cristina Albertini, Piero Sestili

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Cannabis Sativa L.; Aeroponics; Roots; Campesterol; Stigmasterol; β-Sitosterol; Epi-friedelanol; Friedelin

Online: 22 June 2021 (08:27:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0513.v1

Evolution of the Microstructure and Mechanical Properties of a Ti35Nb2Sn Alloy Post-Processed by Hot Isostatic Pressing for Biomedical Applications

Joan Lario Femenía, Angel Vicente Escuder, Vicente Amigó Borrás

Subject: Chemistry And Materials Science, Biomaterials Keywords: Hot isostatic pressing; β-Type titanium alloy; biomaterial; phase transformation; powder metallurgy

Online: 19 April 2021 (17:16:20 CEST)

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Preprint REVIEW | doi:10.20944/preprints202103.0154.v1

Bioactive Components in Oat and Barley Grain as a Promising Breeding Trend for Functional Food Production

Nataliia Shvachko, Igor Loskutov, Tatyana Semilet, Vitaly Popov, Olga Kovaleva, Alexey Konarev

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: β-glucans; polysaccharides; flavonoids; anthocyanins; antioxidants; biological role of pigments; gene families

Online: 4 March 2021 (11:19:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202006.0093.v1

Thymic Stromal Lymphopoietin promoted CD4⁺CD25^- T cells differentiation isolated from the thymus of patients with Myasthenia Gravis to CD4⁺CD25⁺ Regulatory T Cells In Vitro

Jiang Yuan, Na Wang, Md Rezaul Karim, Lei Zeng, Qiang Sun, Yanpeng Sun, Hong-Yan Zhang, Yun-Fu Wang

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: myasthenia gravis; thymic stromal lymphopoietin; regulatory T cells; TGF- β; IL-10

Online: 7 June 2020 (15:00:37 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.1162.v2

Structural Variations of Prions and Prion-Like Proteins Associated with Neurodegeneration

Carter Sky Christensen, Wenshu Li, Danyang Yu, Henry James Li

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: prions; neurodegeneration; Alzheimer’ s disease; protein homeostasis; aggregation; prion-like proteins; amyloid beta; hyperphosphorylated tau; self replication

Online: 19 December 2023 (09:42:02 CET)

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Preprint REVIEW | doi:10.20944/preprints202301.0239.v1

The Nerve Growth Factor Receptor (NGFR/P75^ntr): A Major Player in Alzheimer’s Disease

Francesco Bruno, Paolo Abondio, Alberto Montesanto, Donata Luiselli, Amalia Cecilia Bruni, Raffaele Maletta

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Alzheimer’s disease; Nerve growth factor receptor; NGFR; p75NTR; amyloid-beta; expression; signaling pathways; neuropathology; diagnosis; treatment.

Online: 13 January 2023 (07:37:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints201811.0142.v1

Simultaneous Occurrence of Bioactive Compounds (Melatonin, Protocatechuic Acid and Hydroxytyrosol) Increases Their Neuroprotective Effects Against Alpha-Synuclein-Induced Proteotoxicity

Marta Gallardo-Fernández, Ruth Hornedo-Ortega, Ana B Cerezo, Ana M Troncoso, Mª Carmen Garcia-Parrilla

Subject: Biology And Life Sciences, Toxicology Keywords: melatonin, protocatechuic acid, hydroxytyrosol, α-synuclein, toxicity, amyloid aggregation, neurodegeneration, Parkinson´s disease, olive oil, wine

Online: 6 November 2018 (13:09:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.0316.v1

Human Serum Albumin Grafted by Monomeric and Polymeric β-Cyclodextrin as Drug Delivery System for Levofloxacin with Improved Pharmacological Properties

Tatiana Yu Kopnova, Linara R. Yakupova, Natalya Georgievna Belogurova, Elena Vadimovna Kudryashova

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: levofloxacin; human serum albumin; hydroxypropyl-β-cyclodextrin; conjugate; drug delivery systems; antibacterial activity

Online: 6 November 2023 (07:51:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.1297.v1

Zanubrutinib Ameliorates Cardiac Fibrosis and Inflammation Induced by Chronic Sympathetic Activation

Wenqi Li, Shuwen Zhu, Jing Liu, Zhigang Liu, Yang Miao, Jianwei Zhang, Shimeng Li, Qianyi Zhang, Zhichao Liu, Yue Yang, Li Chen, Xiaowei Guo, Tiantian Zhang, Lingxin Meng, Dan Chai, Guodong Tang, Xiaohe Li, Honggang Zhou, Cheng Yang

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Heart failure; β-adrenergic receptor; cardiac fibrosis; cardiac inflammation; Bruton’s tyrosine kinase; Zanubrutinib

Online: 19 June 2023 (05:23:12 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0525.v1

Recent Advances for the Synthesis of Dihydroquinolin-2(1H) ‑ones via Catalytic Annulation of α,β-unsaturated N-arylamides

Yan-Ning Niu, Lin-shuang Tian, Huai-Zhong Lv, And Ping-Gui Li

Subject: Chemistry And Materials Science, Organic Chemistry Keywords: 3,4-dihydroquinolin-2(1H)-one; α,β-unsaturated N-arylamides; radical; photochemical; annulation

Online: 7 June 2023 (10:12:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202203.0154.v1

A Destabilizer of Both Wnt/β-Catenin and Ras/ERK Pathways Suppresses Cancer Stem Cell Activation in Colorectal Cancer

Jung Kyu Choi, Ihn-Sil Kwak, Sae-Bom Yoon, Heeyeong Cho, Byoung-San Moon

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: Colorectal cancer; Cancer stem cell; Neural progenitor cell; Wnt/β-catenin; K-Ras

Online: 10 March 2022 (14:26:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202102.0038.v1

Detection of Chymotrypsin by Optical and Acoustic Methods

Ivan Piovarci, Tibor Hianik, Ilia N. Ivanov

Subject: Biology And Life Sciences, Biophysics Keywords: chymotrypsin; β-casein; nanoparticles; UV-Vis spectroscopy; dynamic light scattering; quartz crystal microbalance.

Online: 1 February 2021 (13:59:40 CET)

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Preprint REVIEW | doi:10.20944/preprints202006.0277.v2

NKX6.1 Transcription Factor: A Crucial Regulator of Pancreatic β-Cell Development, Identity, and Proliferation

Idil Aigha, Essam Abdelalim

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Diabetes; transcription factor; β-cell mass; pluripotent stem cells; pancreatic progenitors; cell therapy

Online: 19 October 2020 (16:04:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0618.v1

Training of Primary Chicken Monocytes Results in Enhanced Pro-inflammatory Responses

Michel B. Verwoolde, Robin H.G.A. van den Biggelaar, Jürgen van Baal, Christine A. Jansen, Aart Lammers

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Innate immune memory; inflammatory response; β-glucan; flow cytometry; primary chicken monocytes; macrophages

Online: 25 July 2020 (18:00:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201907.0092.v1

Relationships between Urine Albumin Excretion and Dietary Habits in Patients with Type 2 Diabetes

Sadako Matsui, Yasuhisa Someya, Hiroshi Yoshida

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: Type 2 diabetes; urea albumin excretion; food frequency questionnaire survey; β-cryptoxanthin; fruits

Online: 8 July 2019 (14:44:24 CEST)

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Preprint REVIEW | doi:10.20944/preprints201809.0448.v1

Phenotypic Assays for Detection of Extended Spectrum Β-Lactamases and Carbapenemases: A Laboratory Guide for Microbiologists

Dickson Aruhomukama

Subject: Medicine And Pharmacology, Pharmacy Keywords: Extended spectrum β-lactamases, AmpC Carbapenemases, Carbapenemases, Classification, Phenotypic Detection, Clinically significant bacteria

Online: 24 September 2018 (08:57:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201801.0156.v1

Potential of New Isolates of Dunaliella salina for Natural β-Carotene Production

Yanan Xu, Iskander M. Ibrahim, Chiziezi I. Wosu, Ami Ben-Amotz, Patricia J. Harvey

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Dunaliella salina; new isolates; characterization; light intensity; β-carotene; carotenoids; correlations; lutein; classification

Online: 17 January 2018 (12:04:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.1326.v1

Post-translational Modifications of Beta-Amyloid Alter Its Transport across the Blood-Brain Barrier

Kseniya B. Varshavskaya, Irina Yu. Petrushanko, Vladimir A. Mitkevich, Evgeny P. Barykin, Alexander A. Makarov

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Alzheimer’s disease; blood–brain barrier; beta-amyloid; post-translational modifications; RAGE; caveolin-dependent endocytosis; clathrin-dependent endocytosis

Online: 18 December 2023 (12:49:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1781.v1

Synthesis and PET Imaging Biodistribution Studies of Radiolabeled Iododiflunisal, a Transthyretin Tetramer Stabilizer, Candidate Drug for Alzheimer’s Disease

Sameer M Joshi, Thomas C Wilson, Zibo LI, Sean Preshlock, Vanessa Gómez-Vallejo, Véronique Gouverneur, Jordi Llop, Gemma Arsequell

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Iododiflunisal; transthyretin tetramer stabilizer; small-molecule chaperone; amyloid beta; in vivo imaging; 18F; positron emission tomography (PET).

Online: 29 November 2023 (07:16:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202311.1722.v1

Supercritical Antisolvent Precipitation of Corticosteroids/β‐Cyclodextrin Inclusion Complexes

Stefania Mottola, Iolanda De Marco

Subject: Engineering, Chemical Engineering Keywords: Corticosteroid; inclusion complex; β-cyclodextrin; SAS micronization; controlled release; supercritical carbon dioxide; supercritical antisolvent

Online: 27 November 2023 (16:10:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.0191.v1

Interaction of Thiol Antioxidants with a,β-Unsaturated Ketone Moiety of Curcumin; Its Implication for Stability and Bioactivity of Curcuminoids

Bo Hyun Lee, Eiseul Song, Jungil Hong

Subject: Biology And Life Sciences, Food Science And Technology Keywords: curcumin; curcuminoid; α, β-unsaturated carbonyl group; demethoxycurcumin; bisdemethoxycurcumin; N-acetylcysteine; glutathione; thiol antioxidant

Online: 5 September 2023 (03:06:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1052.v1

The Role of Endogenous Beta-Endorphin and Enkephalins in the Crosstalk between Ethanol and Morphine

Andy Tseng, Abdul Hamid, Kabirullah Lutfy

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Ethanol; Morphine; Conditioned place preference; β-Endorphin, Enkephalins; Endogenous opioids; Knockout mice; Reward; Crosstalk

Online: 17 July 2023 (05:06:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.1215.v1

Dietary Supplementation of a Mixture of Nucleotides, β-Glucan and Vitamins C and E Improved the Growth and Health Performance of Olive Flounder,Paralichthys olivaceus

Nalin Medagoda, Rutchanee Chotikachinda, Mirasha Hasanthi, Kyeong-Jun Lee

Subject: Biology And Life Sciences, Aquatic Science Keywords: Nucleotides; Saccharomyces cerevisiae derived β-glucan; Vitamins C and E; Innate-immunity; Olive flounder

Online: 29 April 2023 (05:30:03 CEST)

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Preprint REVIEW | doi:10.20944/preprints202007.0137.v2

GM2 Gangliosidoses: Clinical Features, Pathophysiological Aspects and Current Therapies

Andres Felipe Leal, Eliana Benincore-Flórez, Daniela Solano-Galarza, Rafael Guillermo Garzón Jaramillo, Olga Yaneth Echeverri-Peña, Diego A. Suarez, Carlos Alméciga-Díaz, Angela Johana Espejo-Mojica

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: Lysosomal Storage Disorders; GM2 gangliosidoses; Tay-Sachs disease; Sandhoff disease; β-Hexosaminidases; Therapeutic alternatives

Online: 5 August 2020 (05:05:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201810.0167.v1

Phytosterol Composition of Arachis hypogaea Seeds from Different Maturity Classes

Wenxu Zhou, William D. Branch, Lissa Gilliam, Julie A. Marshall

Subject: Chemistry And Materials Science, Applied Chemistry Keywords: phytosterols; mesocarp; oilseed; maturity; pod-blast; α-tocopherol; oil bodies; campesterol; stigmasterol; β-sitosterol

Online: 9 October 2018 (04:02:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201801.0201.v1

Risk Factors of Extended-Spectrum β-Lactamase Producing Enterobacteriaceae Occurrence in Farms in Reunion, Madagascar and Mayotte Islands, 2016–2017

Noellie Gay, Alexandre Leclaire, Morgane Laval, Guillaume Miltgen, Mael Jego, Stéphane Ramin, Julien Jaubert, Olivier Belmonte, Eric Cardinale

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Indian ocean; livestock; Extended-Spectrum β-Lactamase producing Enterobacteriaceae; risk factors; CTX-M; enzymes

Online: 22 January 2018 (12:02:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.1072.v1

Cholesterol Modulation Attenuates the AD-Like Phenotype Induced by Herpes Simplex Virus Type 1 Infection

Blanca Salgado, Beatriz Izquierdo, Alba Zapata, Isabel Sastre, Henrike Kristen, Julia Terreros, Victor Mejías, María Jesús Bullido, Jesus Aldudo

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Alzheimer’s disease; HSV-1; cholesterol; neuroblastoma cells; methyl-beta-cyclodextrin; infection; neurodegeneration; lysosomal alterations; beta-amyloid; hyperphosphorylated tau

Online: 16 April 2024 (13:59:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1347.v1

Amyloid ß_1–42 Peptide Induces Galectin-1^S8 O-GlcNAcylation to Lead Microglia Migration

Alazne Arrazola Sastre, Miriam Luque Montoro, Francisco LLavero, José L Zugaza

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Amyloid ß1-42 peptide; OGT; O-GlcNAcylation; Galectin-1, Galectin-1Serine 8- O-GlcNAcylation; Gal-1S8A; microglia; migration

Online: 18 May 2023 (12:52:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.1265.v1

Nucleolar Stress-Induced Membrane-Less Organelles: Proteome Analysis through the Prism of Liquid-Liquid Phase Separation

Yakov I. Mokin, Anastasia A. Gavrilova, Anna S. Fefilova, Irina M. Kuznetsova, Konstantin K. Turoverov, Vladimir N. Uversky, Alexander V. Fonin

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: amyloid bodies; intrinsically disordered protein; liquid-liquid phase separation; membrane-less organelle; nuclear stress bodies; nucleolar biomolecular condensates

Online: 30 April 2023 (05:18:24 CEST)

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Preprint REVIEW | doi:10.20944/preprints202110.0197.v1

Two Opposing Functions of Angiotensin-Converting Enzyme (ACE) That Links Hypertension, Dementia, and Aging

Duc Le, Lindsay Brown, Kundan Malik, Shin Murakami

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: AGING; Age-related comorbidities; Angiotensin-Converting Enzyme; Amyloid-degrading enzyme; Alzheimer’s disease; Dementia; Hypertension; Life extension; Stress resistance

Online: 13 October 2021 (11:04:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0650.v1

Association between Disgust Sensitivity during Pregnancy and Endogenous Steroids: A Longitudinal Study

Šárka Kaňková, Daniela Dlouhá, Jana Ullmann, Marta Velíková, Josef Včelák, Martin Hill

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: steroids; disgust; pregnancy; behavioral immune system; testosterone; estrogens; androstenediol; DHEA; 7α/β-hydroxy-androgens; cortisol

Online: 9 April 2024 (13:01:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.1309.v1

Conserved Functions of Orthohepadnavirus X Proteins to Inhibit Type-I Interferon Signaling

Amonrat Choonnasard, Maya Shofa, Tamaki Okabayashi, Akatsuki Saito

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Orthohepadnavirus, X protein, domestic cat hepadnavirus (DCH), hepatitis B virus (HBV), interferon-β signaling pathway

Online: 22 February 2024 (13:25:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.1504.v2

Dual Release of Daptomycin and BMP-2 from a Composite of β-TCP Ceramic and ADA Gelatin for Bone Regeneration

Lucas Ritschl, Pia Schilling, Annette Wittmer, Annerose Serr, Hagen Schmal, Michael Seidenstuecker

Subject: Biology And Life Sciences, Life Sciences Keywords: dual release, daptomycin, BMP-2, β-TCP scaffold, ADA-gelatin gel, bone infection, bone regeneration

Online: 24 November 2023 (08:41:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.1790.v1

RAC1b Acts Upstream of TAp73α-SMAD4 Signaling to Induce Biglycan Expression and Inhibit Basal and TGF-β-Driven Cell Motility in Human Pancreatic Cancer

Hendrik Ungefroren, Julissa Reimann, Björn Konukiewitz, Rüdiger Braun, Ulrich Friedrich Wellner, Hendrik Lehnert, Jens U. Marquardt

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: TAp73; PDAC; RAC1b; Biglycan; SMAD3; SMAD4; transforming growth factor-β; epithelial-mesenchymal transition; cell migration

Online: 26 September 2023 (11:48:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1695.v1

First Optimization of Tomato Pomace in Diets for Tenebrio molitor (L.)(Coleoptera: Tenebrionidae)

Ferdinando Baldacchino, Anna Spagnoletta, Flutura Lamaj, Maria Luisa Vitale, Vincenzo Verrastro

Subject: Biology And Life Sciences, Insect Science Keywords: yellow mealworm, edible insects, by-products, rearing substrates, fatty acid, nutraceutical, antioxidant, lycopene, β-Carotene

Online: 26 September 2023 (04:33:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0978.v1

Long-Chain Acyl Coenzyme a Dehydrogenase, a Key Player in Metabolic Rewiring/Invasiveness in Experimental Tumors and Human Mesothelioma Cell Lines

Daniel L. Pouliquen, Giacomo Ortone, Letizia Rumiano, Alice Boissard, Cécile Henry, Stéphanie Blandin, Catherine Guette, Chiara Riganti, Joanna Kopecka

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: malignant mesothelioma; metabolism; mitochondria; long-chain specific acyl-CoA dehydrogenase; fatty acid β-oxidation, biomarker

Online: 15 May 2023 (05:27:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0539.v1

Potent Inhibitors Targeting Metallo-β-lactamases from the B1, B2 and B3 Subgroups: Promising Broad-spectrum Agents to Combat a Major Mechanism of Antibiotic Resistance

Julia L Kurz, Marcelo M Pedroso, Emmanuelle Richard, Ross P McGeary, Gerhard Schenk

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: Antibiotic resistance; metallo-β-lactamases; metal-dependent enzymes; broad-spectrum inhibitors; inhibition assays; enzyme kinetics

Online: 31 March 2023 (03:35:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0456.v1

Ethidium binding to Salmonella enterica ser. Typhimurium Cells and Salmon sperm DNA

Sandra Sakalauskaite, Valeryia Mikalayeva, Rimantas Daugelavičius

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: ethidium; tetraphenylphosphonium; multidrug resistance; outer membrane permeability; efflux inhibitor; phenylalanyl-arginyl-β-naphtylamide, Polymyxin B

Online: 18 April 2021 (10:14:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201901.0097.v1

Cavity Closure of 2-Hydroxypropyl-β-cyclodextrin: Replica Exchange Molecular Dynamics Simulations

Khanittha Kerdpol, Jintawee Kicuntod, Peter Wolschann, Seiji Mori, Chompoonut Rungnim, Manaschai Kunaseth, Hisashi Okumura, Nawee Kungwan, Thanyada Rungrotmongkol

Subject: Chemistry And Materials Science, Theoretical Chemistry Keywords: 2-Hydroxypropyl-β-cyclodextrin (HPβCD); Replica exchange molecular dynamics (REMD); Conformational change; Cavity self-closure

Online: 10 January 2019 (11:43:44 CET)

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Preprint REVIEW | doi:10.20944/preprints202010.0578.v1

Latest Therapies for Type 1 Diabetes: Exsisting Setup and “Post-Insulin” Standpoints

AMMIRA-SARAH AL-SHABEEB AKIL, Aljazi Al-Maraghi, ESRAA YASSIN, KHULOD AL-MALKI, KHALID FAKHRO

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Type 1 diabetes; insulin therapy; C-peptide; islet transplantation, mesenchymal stem cells; induced pluripotent stem cells; pancreatic β cell; gene therapy; β-cell regeneration and reprogramming, type 1 diabetes precision medicine, diabetes personalized care.

Online: 28 October 2020 (10:02:34 CET)

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Preprint REVIEW | doi:10.20944/preprints202306.0051.v1

Combination of Metal Nanoparticles With Hydrolytic Enzymes To Obtain Improved Antifungals

Ilya Lyagin, Aysel Aslanli, Maxim Domnin, Nikolay Stepanov, Olga Senko, Olga Maslova, Elena Efremenko

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: green synthesis; MOFs; amyloid proteins; prionase; mycotoxins; growth inhibition; quorum sensing; quorum quenching; lactamases; biofilms; chitinases; lactonases; His6-OPH

Online: 1 June 2023 (07:31:58 CEST)

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