Nugraha, A.P.; Yang, H.; Chen, J.; Yang, K.; Kraisintu, P.; Zaww, K.; Ma, A.; Wang, R.; Alhadi, N.E.A.M.; Vanegas Sáenz, J.R.; Hong, G. β-Tricalcium Phosphate as Alveolar Bone Grafting in Cleft Lip/Palate: A Systematic Review. Dent. J.2023, 11, 234.
Nugraha, A.P.; Yang, H.; Chen, J.; Yang, K.; Kraisintu, P.; Zaww, K.; Ma, A.; Wang, R.; Alhadi, N.E.A.M.; Vanegas Sáenz, J.R.; Hong, G. β-Tricalcium Phosphate as Alveolar Bone Grafting in Cleft Lip/Palate: A Systematic Review. Dent. J. 2023, 11, 234.
Nugraha, A.P.; Yang, H.; Chen, J.; Yang, K.; Kraisintu, P.; Zaww, K.; Ma, A.; Wang, R.; Alhadi, N.E.A.M.; Vanegas Sáenz, J.R.; Hong, G. β-Tricalcium Phosphate as Alveolar Bone Grafting in Cleft Lip/Palate: A Systematic Review. Dent. J.2023, 11, 234.
Nugraha, A.P.; Yang, H.; Chen, J.; Yang, K.; Kraisintu, P.; Zaww, K.; Ma, A.; Wang, R.; Alhadi, N.E.A.M.; Vanegas Sáenz, J.R.; Hong, G. β-Tricalcium Phosphate as Alveolar Bone Grafting in Cleft Lip/Palate: A Systematic Review. Dent. J. 2023, 11, 234.
Abstract
The aim of this systematic review is to describe and to identify prospect of β-Tricalcium Phosphate (β-TCP) as Alveolar Bone Grafting (ABG) in Cleft Lip/Palate (CL/P) or alveolar bone cleft defect. A systematic review protocol based on Preferred Reporting Items for Systematic Reviews and Meta Analyses 2020 (PRISMA 2020) was drafted. The literature search was conducted with MEDLINE/PubMed, Web of Science/ ISI-Web of Knowledge, Scopus and Cochrane Library with English language and no publication year limits. The keywords yielded a total of 5824 publications. There are 3196 suitable articles to evaluate after removing duplicates and languages. Afterward, 1315 studies left after doing title and abstract reading. In addition, 85 full-articles were assessed for eligibility. The read the complete texts of those papers and eventually chose 20 that matched the inclusion requirements. Thirteen of the twenty studies included in this systematic review had a low risk of bias, one had a high risk of bias, and six had moderate bias which not report the randomization. β-TCP as ABG is biocompatible, visible and practical, offers a less invasive procedure, and does not interfere with orthodontic treatment. β-TCP as synthetic ABG can be the alternative to autologous bone grafts with several terms and conditions. Improvement of β-TCP efficacy for ABG in CL/P or alveolar bone cleft defects can be done by a tissue engineering approach combining β-TCP with growth factor, mesenchymal stem cells, or other graft materials and modification of β-TCP physical properties.
Medicine and Pharmacology, Dentistry and Oral Surgery
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