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Preprint REVIEW | doi:10.20944/preprints202306.0453.v1

Soldering in Dentistry: An Updated Technical Review

Enzo Cumbo, Giuseppe Gallina, Pietro Messina, Giuseppa Bilello, Mohmed Isaqali Karobari, Giuseppe Alessandro Scardina

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: soldering; dentistry

Online: 6 June 2023 (11:48:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0312.v1

Effects of Ultrasonic Scaling and Teeth Brushing on Surface Properties of PEEK Prosthetic Restorations

Aleksandra Čairović, Mirjana Perić, Dragan Stanimirović, Vesna Maksimović, Sanja Stevanović, Aleksandra Špadijer Gostović

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: BioHPP; surface roughness; AFM; XRD; wetting; ultrasonic scaling; teeth brushing

Online: 6 June 2023 (04:00:54 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202306.0330.v1

Digital Design of Laser Sintered Metal Grids Supporting Orthodontic Treatment

Greta Roussanova Yordanova-Kostova, Milen Chalyovski, Gergana Gurgurova, Mirela Georgieva

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Laser sintered metal grid; Digitally printed orthodontic grid; Interceptive treatment; Anchorage area

Online: 5 June 2023 (13:52:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0149.v1

Resolution of Periodontal Inflammation Promotes Changes in Cytokine Expression in the Intestine and Gingival Tissues of Aged Rats with DSS-induced Colitis

João Martins de Mello-Neto, Edilson Ervolino, Gayathiri Elangovan, Luan Felipe Toro, Rachel Lee, Anders Gustafsson, Carlos Marcelo da Silva Figueredo

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Cytokines; Intestine; Rats; Periodontitis; Dextran Sulphate Sodium; Inflammatory Bowel Diseases

Online: 2 June 2023 (07:43:24 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0101.v1

Quorum Sensing in Oral Biofilms: Influence on Host Cells

Malee Nagi, Iain L.C. Chapple, Praveen Sharma, Sarah A. Kuehne, Josefine Hirschfeld

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Quorum sensing; Autoinducer-2 (AI-2); Acetyl homoserine lactones (AHL); Periodontal diseases; Oral Biofilm

Online: 1 June 2023 (13:54:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0040.v1

Evaluation of Osteogenic Potential of Fucoidan Containing Chitosan Hydrogel in the Treatment of Periodontal Intra-bony Defects

Shruthi Eshwar, Kranti K, Supriya Manvi, Aarya Bharadwaj, Sudarshan Sajjan, Vipin Jain

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Fucoidan-Chitosan; Injectable Hydrogel; osteogenic potential; periodontal intrabony defects; human experimental trial

Online: 1 June 2023 (05:48:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0037.v1

The Effects of Tricalcium Silicate Nanoparticle-containing Cement: In Vitro and In Vivo Studies

Naho Ezawa, Yoshihiko Akashi, Kei Nakajima, Katsutoshi Kokubun, Masahiro Furusawa, Kenichi Matsuzaka

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: tricalcium silicate nanoparticle-containing cement (NPC); mineral trioxide aggregate (MTA); human periodontal ligament fibroblasts (HPLFs)

Online: 1 June 2023 (05:30:27 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.2239.v1

Topical Oxygen Therapy: A novel Strategy for Oral Healthcare

Hamdan Alghamdi, Minas Leventis, Fahad Alshehri, Tatiana Deliberador

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: oral care; oxygen therapy; oral biofilm; dental caries; periodontitis; peri-implantitis

Online: 1 June 2023 (02:37:15 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.2184.v1

Narrative Review on Methods of Activating Irrigation Liquids for Root Canal Treatment

Martyna Raducka, Aleksandra Piszko, Paweł J. Piszko, Natalia Jawor, Maciej Dobrzynski, Wojciech Grzebieluch, Marcin Mikulewicz, Katarzyna Skośkiewicz-Malinowska

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: irrigation; activation; techniques; root canal treatment; endodontics; root canals

Online: 31 May 2023 (07:37:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.2082.v1

Characteristics Associated with Major Complications and Refractory Course in Patients with Osteomyelitis of the Jaw: Clinical, Radiological, and Bacteriological Features of 54 Patients

MATHILDE FENELON, Steven Gernandt, Romain Aymon, PAOLO SCOLOZZI

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Bone; Osteomyelitis; Decortication; Treatment Outcome; Oral and Maxillofacial Surgery

Online: 30 May 2023 (08:16:55 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.2076.v1

Effectiveness of Adjunctive Hyaluronic Acid Application in Surgical Treatment of Gingival Recession Sites: A Systematic Scoping Review

Mattia Manfredini, Mario Beretta, Carlo Maiorana, Marco Tandurella, Federica Euegnia Salina, Pier Paolo Poli

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: gingival recession; linear hyaluronic acid; cross-linked hyaluronic acid; root coverage procedure; surgical treatment of recession

Online: 30 May 2023 (08:02:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1999.v1

Oral Pathology in the Elderly: Prevalence in a Hub Hospital

Carla Frizzerin, Giulia Alberton, Armina Rushiti, Christian Bacci

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: 1; elderly 2; oral pathology 3; oral medicine

Online: 29 May 2023 (08:47:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1813.v1

Investigate the Effect of rh-BMP2 on the Healing Process of the Gingival Tissue using Ki-67 Marker

Mansour Chantiri, Toni Zeinoun

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: rh-BMP2; Ki67-Proliferation – Gingival Tissue

Online: 25 May 2023 (14:36:37 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.1601.v1

The Bidirectional Association Between Periodontitis and COVID-19: A Review of Current Evidence

Miriam Ting, Rodrigo Neiva, Leenus Tafline, Jon B Suzuki

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: COVID-19; SARS-CoV-2; Periodontitis; Herpesviruses; Periodontal; Biomarkers

Online: 23 May 2023 (07:43:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1527.v1

Evaluation of the Effects of Different Polishing Protocols on the Surface Characterizations of 3D-Printed Acrylic Denture Base Resins

Yousif A. A. Al-Dulaijan

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Additive manufacturing; Chairside kit; SEM; Surface roughness; Rapid prototype

Online: 22 May 2023 (12:40:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1475.v1

Analysis of Skull Anatomy for 3D Cephalometry – Normative Data Reveal Four Different Skull Types

Leon Ludwigs, Christian Pape, Helena Sophie Visse, Christoph Runte, Ulrich Meyer, Dieter Dirksen

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: 3D cephalometry; norm skull; skull anatomy; Procrustes analysis

Online: 22 May 2023 (08:41:02 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.1471.v1

Complete Full Arch Supported by Short Implant (>8MM) in Edentulous Jaw: A Systematic Review

Alessio Rosa, Alberto Maria Pujia, Claudio Arcuri

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: full arch; mandibular atrophy; short dental implants; short implants; prosthetic

Online: 22 May 2023 (07:26:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1464.v1

Influence of Dynamics of Changes in the Physical Properties of Osteoconductive Granulated Biopolymers on Scafold Stability in the Postoperative Period

Oleg V. Slesarev, Darya V. Malchikova, Vladimir I. Platonov, Natalia A. Maksimenko, Alexey A. Melnikov, Mariya A. Anikina, Ravshanbek B. Abdullaev

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: osteoconduction; osteoconductive granulated biopolymers; compaction coefficient; adsorption capacity; bone growth factors

Online: 22 May 2023 (05:09:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1254.v1

The Association of Oxidative Stress-Related Gene Polymorphisms with Pain-Related Temporomandibular Disorders and Oral Behavioural Habits

Ema Vrbanović, Marko Zlendić, Koraljka Gall Trošelj, Marko Tomljanović, Kristina Vuković Đerfi, Iva Zilic-Alajbeg

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: antioxidants; chronic orofacial pain; oxidative-stress related genes; temporomandibular disorders; oral behavioural habits; single nucleotide polymorphism

Online: 17 May 2023 (14:15:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1127.v1

Marginal and Para-Marginal Technique in Late Germectomy of Inferior Third Molars

Francesco Saverio Ludovichetti, Sergio Mazzoleni, Manuel Menin, Roberta Gaia Parcianello, Francielle Romanowski, Edoardo Stellini, Andrea Zuccon

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: germectomy; marginal flap; para-marginal flap; third molars; children

Online: 16 May 2023 (08:31:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1064.v1

The Influence of Cleaning Solutions on the Retention of Overdenture Attachment Systems

Sofia Monteiro, Pedro Barreiros, Joana Mendes, Carlos Aroso, António Sérgio Silva, José Manuel Mendes

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: denture cleanser; attachments; overdenture; oral health; quality of life

Online: 15 May 2023 (16:17:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0983.v1

Effect of Hesperidin on Barrier Function and Reactive Oxygen Species Production in an Oral Epithelial Cell Model, and on Se-Cretion of Macrophage-Derived Inflammatory Mediators During Porphyromonas gingivalis Infection

Patricia Milagros Maquera-Huacho, Denise Madalena Palomari Spolidorio, John Manthey, Daniel Grenier

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: hesperidin; inflammation; oxidative stress; macrophague; keratynocite; Porphyromonas gingivalis

Online: 15 May 2023 (07:05:38 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.0894.v1

Storage Media to Preserve Avulsioned Teeth Maintaining the Viability of Periodontal Cells: A Review

Nancy Estefanía Pérez Tenezaca, Juliana Rodríguez Castillo, Doris Eliana Calderón Alemán, Priscilla Medina-Sotomayor, María Augusta Delgado

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: storage media; avulsed teeth; periodontal ligament

Online: 12 May 2023 (05:37:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0711.v1

A Novel Irrigation System to Reduce Heat Generation During Guided Implantology: An In Vitro Study

Somayeh Parvizi, Andrew Cameron, Santosh Tadakamadla, Carlos Marcelo S. Figueredo, Peter Reher

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Dental implants; surgical guide; irrigation channels; Thermocouples; 3D printing; CAD/CAM

Online: 10 May 2023 (08:23:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0647.v1

Effects of Osseodensification on Primary Stability of Cylindrical and Conical Implants - An Ex Vivo Study

Márcio de Carvalho Formiga, Helio Doyle Pereira da Silva, Bruna Ghiraldini, Rafael Shinoske Siroma, Lavinia Cosmina Ardelean, Adriano Piattelli, Jamil Awad Shibli

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: dental implants; osseodensification; primary stability; macrogeometry

Online: 9 May 2023 (11:56:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0593.v1

Evaluation of Implant Stability Measurements According to Implant Placement Site and Duration in Elderly Patients: A Prospective Multi-Center Clinical Study

JI-SUK SHIM, MOON-YOUNG KIM, SE-JUN AN, EUN-SUNG KANG, YU-SUNG CHOI

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Implant stability; Implant stability quotient; Periotest value; Implant stability test; Prospective study; Elderly patient

Online: 9 May 2023 (08:08:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0391.v1

Precision and Accuracy Assessment of Cephalometric Analyses Performed by Deep Learning Artificial Intelligence with and without Human Augmentation

Sumer Panesar, Alyssa Zhao, Eric Hollensbe, Ariel Wong, Surya Sruthi Bhamidipalli, George Eckert, Vinicius Dutra, Hakan Turkkahraman

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: artificial intelligence; machine learning; orthodontics; radiology; cephalometry

Online: 6 May 2023 (08:33:31 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.0360.v1

Cannabidiol for Oral Health: A New Promising Therapeutical Tool in Dentistry

Luigi Bellocchio, Assunta Patano, Alessio Danilo Inchingolo, Francesco Inchingolo, Gianna Dipalma, Ciro Gargiulo Isacco, Elisabetta De Ruvo, Biagio Rapone, Antonio Mancini, Felice Lorusso, Antonio Scarano, Giuseppina Malcangi, Angelo Michele Inchingolo

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: plants; cannabinoids; CBD; pharmacology; dental medicine; patents

Online: 5 May 2023 (11:00:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0312.v1

The Use of Equimolar Mixtures of Nitrous Oxide and Oxygen in Oral Surgery – a Retrospective Study of Patients in a Swiss University Hospital Setting

Alexandre Perez, Steven Gernandt, Paolo Scolozzi

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Nitrous-oxide inhaled sedation; Oral surgery; Dental anxiety

Online: 5 May 2023 (06:26:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0216.v1

The Most Suitable System to Grind the Whole Tooth to Use It as Graft Material

Elio Minetti, Andrea Palermo, Giuseppina Malcangi, Giorgio Perfetti, Francesco Inchingolo, Federico Perfetti, Alessio Danilo Inchingolo, Gianna Dipalma, Assunta Patano, Angelo Michele Inchingolo

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: autogenous dentin particulate; bone regeneration; dental biomaterials; granules; grow factors; high-speed grinder; low-speed grinder; osteoclasts; tooth graft; tooth transformer

Online: 4 May 2023 (07:44:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0167.v1

Proposal of an Acoustic Simulation Method during Sustained Phonation of the Japanese Vowels /i/ and /u/ by Using the Boundary Element Method

Mami Shiraishi, Katsuaki Mishima, Masahiro Takekawa, Masaaki Mori, Hirotsugu Umeda

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: articulation; acoustic simulation; boundary element method; vocal tract model; Japanese vowels

Online: 4 May 2023 (03:04:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0141.v1

Comparative Fracture Resistance Analysis of Translucent Monolithic Zirconia Dioxide Milled in a CAD/CAM System

Cristian Abad-Coronel, Ángeles Paladines, Analiz Ulloa, Cesar A. Paltán, Jorge I. Fajardo

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: zirconia; monolithic; multilayer zirconia; fracture resistance; CAD/CAM materials.

Online: 3 May 2023 (11:06:41 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202304.1119.v1

Transoral Marsupialization of an Isolated Surgical Ciliated Cyst of the Infratemporal Fossa

Da-Woon Kwack, Jooha Yoon, Hae-Seo Park, Jung-Hwan Lee, Moon-Young Kim

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: nonodontogenic cysts; posttraumatic; skull base; infratemporal fossa; minimally invasive surgical procedures

Online: 28 April 2023 (05:03:39 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.1029.v1

Prevalence of Entamoeba gingivalis in Periodontal Disease- a Literature Review and Meta-analysis

Alexandru Vlasa, Anamaria Bud, Luminita Lazar, Ana-Petra Lazar, Alexander Herbert, Eugen Bud

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Entamoeba Gingivalis; Periodontal Disease; Prevalence; review

Online: 27 April 2023 (04:13:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.1015.v1

Antimicrobial Activity of Five Calcium Silicate Based Root Canal Sealers Against a Multispecies Biofilm

Wajih Hage, Dolla Karam Sarkis, Mireille Kallassy, Germain Sfeir, May Mallah, Issam Khalil, Carla Zogheib

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: bioceramics; multispecies’ biofilm; calcium silicate based root canal sealers; biofilm

Online: 27 April 2023 (03:41:10 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202304.0847.v1

Response of Cultured Primary Human Gingival and Periodontal Ligament Cells to Angiotensin II and IL1β Challenges

Thais Francini Garbieri, Thiago José Dionísio, Bella Luna Colombini-Ishikiriama, Rafaela Alves da Silva, Vanessa Soares Lara, Sandra Helena Penha de Oliveira, Maria Helena Fernandes, Andrew Seth Greene, Carlos Ferreira Santos

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Periodontium; Renin-Angiotensin System; Receptors; Angiotensin; Primary Cell Culture; Molecular Biology; Inflammation Mediators

Online: 24 April 2023 (10:16:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0824.v1

Saliva Decreases Sucrose-induced Cariogenicity in an Experimental Biological Caries Model

Rodrigo A Giacaman, Rodrigo Umaña, María José Nuñez, Natalia Díaz-Garrido, Constanza Echeverría, Natalia García-Manríquez, Alex Mira, Constanza E Fernández, Karla Gambetta-Tessini, Carla P. Lozano

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Saliva; Caries; Biofilm; Cariogenicity; Streptococcus mutans

Online: 24 April 2023 (04:58:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0715.v1

Analysis of Accuracy in Clinical Identification of the Implant Site: Pilot Study With Thermo-Printed Templates

Enzo Cumbo, Giuseppe Gallina, Pietro Messina, Giuseppe Alessandro Scardina

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Implantology; implant site; thermo-printed templates

Online: 21 April 2023 (10:11:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0587.v1

Salivary Levels of Inflammatory and Anti-inflammatory Biomarkers in Periodontitis Patients with and without Acute Myocardial Infarction: Implications for Cardiovascular Risk Assessment

Biju Thomas, Subrahmanyam K., Kimberly Duarte, Mohammed Amjed Alsaegh, Divya Gopinath, Sam Thomas Kuriadom, Jayaraj Narayanan, Vijay B. Desai, Al-Moutassem Billah Khair, Sudhir Rama Varma, Kelvin I. Afrashtehfar

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: cardiovascular diseases; salivary biomarkers; myocardial infarction; saliva; salivary glands; adiponectin; C-reactive protein; Chemokine CCL3; macrophage inflammatory proteins; periodontitis; inflammation mediators; risk assessment

Online: 19 April 2023 (10:40:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0517.v1

Availability of Primary Closure for Resection of Oral Cavity Cancer

Hyo-Joon Kim, Jun-Seok Choi, Ye-Joon Jo, And Seong-Yong Moon

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Reconstruction; Oral Cancer; Primary closure; Free flap; Local flap

Online: 18 April 2023 (10:39:52 CEST)

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Resection of malignant lesions in the oral and maxillofacial area causes functional and morphological defects. To recover from these defects, reconstruction surgery is needed such as a primary closure or a flap. There are advantages and disadvantages to the method of using the primary closure and the flap, and the choice of procedure is entirely up to a surgeon. The purpose of this study is to evaluate availability of primary closure in patients. For 10 years from January 2010 to May 2020, patients who recovered using flaps after removing malignant lesions from the oral cavity and those who closed the lesion using primary closure were investigated. The investigation was conducted by searching the database of the hospital. There were 85 patients who removed malignant lesions in the oral and maxillofacial area, and among them 16 patients closed the soft tissue defects using primary closure. Operation time, histologic types, stages, wound status, and period of hospitalization according to the patients' medical records were investigated retrospectively. Between the staging and the primary closure, statistically significant differences were observed between stage I and stage II patients in 13 patients using the primary closure. (P=0.046). Statistically significant differences were identified between operation time and primary closure, with an average of 4.02 hours (P=0.015). The average period of hospitality for patients who underwent primary closure was 13.4 days, compared to 26.7 days for those who underwent flap surgery. This difference was statistically significant (P=0.0003). This study evaluated the use of primary closure in patients who underwent resection of malignant lesions in the oral and maxillofacial area. Although the majority of patients underwent reconstruction with flaps, our results showed that primary closure can be a viable option for certain patients with early-stage lesions. Therefore, oral and maxillofacial surgeons should carefully consider various evaluation criteria and select appropriate reconstruction methods to optimize functional and aesthetic outcomes for each patient.

Preprint REVIEW | doi:10.20944/preprints202304.0295.v4

Treatments of COVID-19-Associated Taste and Saliva Secretory Disorders

Hironori Tsuchiya

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: COVID-19; taste disorder; saliva secretory disorder; treatment; pathogenic mechanism

Online: 14 April 2023 (03:34:06 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.0295.v3

Treatments of COVID-19-Associated Taste and Saliva Secretory Disorders

Hironori Tsuchiya

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: COVID-19; taste disorder; saliva secretory disorder; treatment; pathogenic mechanism

Online: 13 April 2023 (08:57:13 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.0295.v2

Treatments of COVID-19-Associated Taste and Saliva Secretory Disorders

Hironori Tsuchiya

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: COVID-19; taste disorder; saliva secretory disorder; treatment; pathogenic mechanism

Online: 13 April 2023 (07:05:41 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.0295.v1

Treatments of COVID-19-Associated Taste and Saliva Secretory Disorders

Hironori Tsuchiya

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: COVID-19; taste disorder; saliva secretory disorder; treatment; pathogenic mechanism

Online: 13 April 2023 (03:49:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0156.v1

Three-Dimensional Cranio-Facial Landmark Detection in Series of CT Slices, Using Multi-Phased Regression Networks

Soh Nishimoto, Takuya Saito, Hisako Ishise, Toshihiro Fujiwara, Kenichiro Kawai, Masao Kakibuchi

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Multi-phased deep learning; Regression neural network; Coordinate value; Computer assisted tomography (CT); Cranio-facial bone

Online: 10 April 2023 (07:59:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202302.0513.v1

The Thrills and Chills of ChatGPT: Implications for Assessments in Undergraduate Dental Education

KAMRAN ALI, Noha Barhom, Faleh Tamimi Marino, Monty Duggal

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: ChatGPT; artificial intelligence; chatbot; education technology; machine learning; dental education; natural language processing

Online: 28 February 2023 (08:18:33 CET)

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Background and Purpose: Open-source Artificial intelligence (AI) applications are fast transforming access to information and allow students to prepare assignments and offer quite accurate responses to a wide range of exam questions which are routinely used in assessments of students across the board including undergraduate dental students. This study aims to evaluate the performance ChatGPT, an AI-based application, on a wide range of dental assessments and discusses the implications for undergraduate dental education. Methods: This was an exploratory study investigating the accuracy of ChatGPT to attempt a range of recognized assessments in undergraduate dental curricula. ChatGPT was used to attempt ten items based on each of the five commonly used question formats including single-best answer (SBA) multiple-choice questions (MCQs); short answer questions (SAQs); short essay questions (SEQs); True/False questions and fill in the blanks items. In addition, ChatGPT was used to generate reflective reports based on multisource feedback (MSF); research methodology; critical appraisal of the literature. Results: ChatGPT application provided accurate responses to majority of knowledge-based assessments based on MCQs, SAQs, SEQs, Tue/False and fill in the blanks items. However, it was only able to answer text-based questions and did not allow processing of questions based on images. Responses generated to written assignments were also of good quality apart from those for critical appraisal of literature. Word count was the key limitation observed in outputs by ChatGPT as it was only able to produce reports limited to approximately 650 words. Conclusion: Notwithstanding their current limitations, AI-based applications have the potential to revolutionize virtual learning. Instead of treating it as a threat, dental educators need to adapt teaching and assessments in dental education to the benefits of the learners whilst mitigating against dishonest use of AI-based applications.

Preprint ARTICLE | doi:10.20944/preprints202302.0301.v1

Effect of Thermomechanical Aging of Orthodontic Aligners on Force and Torque Generation: An in vitro Study

Tarek Elshazly, Diva Nang, Bijan Golkhani, Hanaa Elattar, Ludger Keilig, Christoph Bourauel

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Dentistry; Orthodontics; Biomechanics; Torque; Force; Tooth Movement; Removable Thermoplastic Appliance; Thermoforming; Aging.

Online: 17 February 2023 (07:07:06 CET)

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Preprint REVIEW | doi:10.20944/preprints202302.0206.v1

Orthodontic Curricula in Undergraduate Dental Education: A Scoping Review

Shailaja Raghavan, Elham S. Abu Alhaija, Kamran ALI

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Orthodontic curriculum; Learning outcomes; Assessments; Competency

Online: 13 February 2023 (08:34:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202302.0199.v1

Exploring the Perception of Dental Undergraduate Students and Faculty on Environmental Sustainability in Dentistry: A Cross-sectional Survey in 26 Dental Schools in Saudi Arabia

Hasan Jamal, Abdullah Marghalani, Ahmed Al-Sharif, Albatool Shinawi, Balgis Gaffar, Ebtsam Al-Edaili, Ghaliah Al-Baqami, Mayson Abdullah

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: sustainable dentistry; environment; sustainable development goals; education

Online: 13 February 2023 (06:49:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202302.0167.v1

The Oral Health of a Group of 19th Century South Australian Settlers in Relation to Their General Health and Compared With That of Contemporaneous Samples

Angela Gurr, Maciej Henneberg, Jaliya Kumaratilake, Derek Lerche, Lindsay Richards, Alan Henry Brook

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Oral Health; Systemic Health; Colonial Dental Health

Online: 9 February 2023 (11:31:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202302.0112.v1

The Effect of Non-surgical Periodontal Therapy (NSPT) on the Systemic Inflammatory Markers (IL-6 and IL-8) in β-Thalassemia Patients with Gingivitis

Ayesha Hanif, Moazzam Ali Shahid, Komal Khan, Asim Qidwai

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Thalassemia major; periodontal diseases; interleukins; gingivitis

Online: 7 February 2023 (02:51:51 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202302.0028.v1

An Unusual Case of Nickel Induced Gingival Enlargement and Literature Review: Rare or Ignored?

Gabriela Fernandes, Saurabh R. Nagar, Nishant Pandey, Kamil Rajpari

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: : Gingival enlargement Nickel allergy Orthodontic treatment

Online: 2 February 2023 (04:15:48 CET)

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Preprint REVIEW | doi:10.20944/preprints202301.0416.v1

Possible Role of Inflammasomes in the Pathogenesis of Periodontal Diseases

Nada Hashim, Rasha Babiker, Riham Mohammed, Mohammed Mustahsen Rehman, Bakri Gismalla

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Inflammasome; NLRP3; periodontal disease; periodontal pathogen; IL-1β

Online: 23 January 2023 (15:07:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0363.v1

Feasibility Of Utilizing Longitudinal Electronic Dental Record Data to Track Periodontal Disease Change

Jay S. Patel, Krishna Kumar, Ahad Zai, Daniel Shin, Lisa Willis, Thankam P. Thyvalikakath

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Periodontal Disease; Electronic Dental Record; Longitudinal Data; Data Quality; Dental Infor-matics; Clinical Course of Periodontal Disease; Periodontal Cohort Generation

Online: 19 January 2023 (13:01:27 CET)

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Objective: Determine the feasibility of utilizing longitudinal electronic dental record (EDR) data to track change over time in patient periodontal disease (PD) and to generate three patient cohorts: 1) patients whose disease did not change over time, 2) patients whose PD progressed, and 3) patients whose disease improved over time using informatics approaches. Methods: We conducted a retrospective study of 28,908 patients who received a comprehensive oral evaluation between January 1, 2009, and December 31, 2014, at the Indiana University School of Dentistry (IUSD) clinics. We developed and tested three automated computer applications to: 1) diagnose periodontitis cases from periodontal charting, 2) retrieve clinician-documented diagnoses from clinical notes, and 3) track disease change over time. We also evaluated the density of longi-tudinal EDR data for the following follow-up times: 1) none, 2) up to 5 years, 3) >5 and <=10 years, and 4) >10 and <=15 years Results: Thirty-four percent (n=9,954) of the study cohort had up to five years of follow-up visits with an average of 2.78 visits with periodontal charting information. An average of three patient visits per year that contained periodontal charts (63,552) were utilized to obtain a diagnosis, which is considered excellent. For clinician-documented diagnoses from clinical notes, 42% of patients (n=5,562) had at least two PD diagnoses to determine their disease change. In this cohort with cli-nician-documented diagnoses, 72% percent of patients (n=3,919) did not have a disease status change between their first and last visits, 669 (13%) patients' disease status progressed, and 589 (11%) patients’ disease improved. Conclusions: This study demonstrated the feasibility of utilizing longitudinal EDR data to track disease changes over 15 years during the observation study period. We found excellent longitudinal data when diagnoses generated from periodontal charting were considered (three visits per pa-tient). This information can be now utilized for studying the clinical course of periodontitis.

Preprint ARTICLE | doi:10.20944/preprints202301.0301.v1

Caries Experience and Risk Indicators in a Portuguese Population: A Cross-sectional Study

Eduardo Guerreiro, João Botelho, Vanessa Machado, Luís Proença, José João Mendes, Ana Cristina Manso

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: dental caries; caries experience; epidemiology, prevalence; risk; public health

Online: 17 January 2023 (08:56:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0160.v1

Intermittent Fasting Resolves Dyslipidemia and Atherogenesis in Apolipoprotein E-deficient Mice in a Diet-Dependent Manner, Irrespective of Sex

Jules Mérian, Lamia Ghezali, Charlotte Trenteseaux, Thibaut Duparc, Diane Beuzelin, Vanessa Bouguetoch, Guillaume Combes, Nabil Sioufi, Laurent O. Martinez, Souad Najib

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Intermittent fasting; glucose tolerance; hepatic steatosis; adipose tissue; reverse cholesterol transport; atherosclerosis.

Online: 9 January 2023 (10:49:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0074.v1

How Well Prepared are Dental Students and New Graduates in Pakistan-A Cross-Sectional National Study

Muhammad Qasim Javed, Shazia Nawabi, Usman Anwer Bhatti, Sundus Atique, Mustafa Hussein AlAttas, Ayman M Abulhamael, Daniel Zahra, Kamran Ali

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Clinical Skills; Clinical Training; Competency; Cross-sectional Studies; Dental Education; Dentistry; Self-perception.

Online: 4 January 2023 (08:48:49 CET)

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Preprint REVIEW | doi:10.20944/preprints202301.0012.v1

Impact of Zinc on Insulin Resistance and Hepatic Fat Accumulation

Mojdeh Fatehi

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Insulin Resistance; Zinc supplementation; Oxidative stress; Inflammation; Gut microbiome; Hepatic lipophagy

Online: 3 January 2023 (07:35:39 CET)

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Preprint REVIEW | doi:10.20944/preprints202212.0497.v1

Association between Periodontal Disease and cognitive impairment in Adults

Najwane Said-Sadier, Batoul Sayegh, Raymond Farah, Linda Abou Abbas, Rania Dweik, Norina Tang, David M. Ojcius

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: cognitive impairment; dementia; oral pathogens; periodontitis; inflammatory biomarkers; anti-bodies; systematic review

Online: 27 December 2022 (01:41:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0480.v1

Burning Mouth Syndrome and Hypertension: Prevalence, Gender Differences and Correlation with Pain and Psycho-social Characteristics

Daniela Adamo, Federica Canfora, Calabria Elena, Noemi Coppola, Mattia Sansone, Gianrico Spagnuolo, Giuseppe Pecoraro, Massimo Aria, Luca D'Aniello, Michele Davide Mignogna, Stefania Leuci

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: burning mouth syndrome; hypertension; pain; mood disorder; systemic comorbidities

Online: 26 December 2022 (08:36:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0372.v1

Particulate Filler and Discontinuous Fiber Filler Resin Composite´S Adaptation and Bonding to Intra-Radicular Dentin

Marco Ferrari, Eugenia Lettieri, Denise Irene Karin Pontoriero, Pekka Vallittu, Edoardo Ferrari Cagidiaco

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Fiber-reinforced composite post; Short-glass fiber reinforced composite; Endodontically-treated teeth; Intra-radicular adhesion; Push-out bond strength

Online: 21 December 2022 (02:08:24 CET)

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: This study was aimed at assessing adaptation and bonding of discontinuous (short) glass fiber-reinforced composite to intraradicular dentin EverX Flow (GC Corporation, Tokyo, Japan), when used as intracanal composite filling and anchorage instead of traditional fiber posts. (2) Methods: Seventy intact extracted human teeth were endodontically treated and randomly divided into 6 groups (n=10), depending on the materials used in the post space. In Group 1, a 2-bottle universal adhesive G2 Bond Universal + EverX Flow were tested. In group 2, a single-component universal adhesive G-Premio Bond + EverX Flow were used. In groups 3 and 4 the same materials are tested, but after cleaning of the canal walls with 17% EDTA and final irrigation with 5.25% NaOCl Ultrasound Activated. In the last three Groups (5-7) traditional prefabricated GC Fiber Posts 1.6 mm silanized with G-Multi Primer for 1 minute are cemented with a dual-cured composite resin cement (GradiaCore), after ultrasonic irrigation in the groups 6 and 7. In each group, 1 mm-thick slices from each sample (n=10) were cut for light microscope and SEM inspection for study materials adaption to the dentin and for measuring push-out strength of post / cemement material to the dentin / prefabricated post. These results were statistically analyzed: as the data distribution was not normal, the Kruskal-Wallis Analysis of Variance by Ranks had to be applied. The level of significance was set at p<0.05. Results: Push-out forces varied between 6.66-8.37 MPa. No statistically significant differences were recorded among the groups. Microscopic examination showed that ultrasonic irri-gation increased adaptation of the materials to the dentin surface. There was a trend of higher bond strength among the tested groups when EverX Flow was used. Also, the type of failure was more often cohesive when ultrasonic irrigation and two-step adhesive system were used. Conclusions: Within the limitations of this in vitro study, it may be concluded that when EverX Flow was used for intracanal anchorage in the post-endodontic recon-struction, similar push-out retentive forces and strength to those of traditional fiber posts cemented with particulate filler resin composite cements were achieved. Although further studies are necessary, EverX Flow represents an effective alternative to traditional fiber post adhesion in particular when used in combination with the two-step adhesive system and ultrasonic activation.

Preprint ARTICLE | doi:10.20944/preprints202212.0340.v1

A Comparison of Effectiveness of Conventional and Rotary NiTi Instruments in the Removal of Gutta-Percha during Root Canal Retreatment: A Randomized Ex-vivo Study

Sundus Atique, Kamran Ali, Alia Ahmed

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Gutta-Percha (GP), ProTaper, Hedstrom (H) files, Retreatment

Online: 19 December 2022 (12:57:41 CET)

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Preprint REVIEW | doi:10.20944/preprints202212.0243.v1

Antioxidant and Antidiabetic Activity of Algae

Atef Mohamed Abo-Shady, Saly Farouk Gheda, Gehan Ahmed Ismail, João Cotas, Leonel Pereira, Omnia Hamdy Abdel-Karim

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: diabetes; antioxidant; antihyperglycemic; lipid profile; body weight; algal treatments

Online: 14 December 2022 (03:17:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0308.v1

Versertality of Bacteriome Dominated by Rothia mucilaginosa in a Group of Sri Lankan Oral Fibro Epithelial Polyp Male Patient: A Pilot Study

Manosha Perera, Irosha Perera

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Xenobiotic; Drug; Oral fibro epithelial polyps; Rothia mucilaginosa; Bacteriome

Online: 16 November 2022 (12:45:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0141.v1

Fabrication and In Vitro Characterization of Novel Hydroxyapatite Scaffolds 3D Printed Using Polyvinyl Alcohol as A Thermoplastic Binder

Andrej Thurzo, Paulína Gálfiová, Zuzana Varchulová Nováková, Štefan Polák, Ivan Varga, Martin Strunga, Renáta Urban, Jana Surovková, Ľuboš Leško, Zora Hajdúchová, Jozef Feranc, Marian Janek, Ľuboš Danišovič

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Regenerative dentistry; 3D printing; biomimetic; bioinspired materials; MSC; cell colonization; Tissue engineering; Regenerative medicine; Oral Bone; Tissue Regeneration; biocolonization; CDHA, MTT; LDH; SEM; FDM

Online: 8 November 2022 (03:03:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202210.0311.v1

Periodontal Tissue Regeneration by Recombinant Human Collagen Peptide Granules Applied With β-Tricalcium Phosphate Fine Particles

Yuto Yoshino, Hirofumi Miyaji, Erika Nishida, Yukimi Kanemoto, Asako Hamamoto, Akihito Kato, Tsutomu Sugaya, Tsukasa Akasaka

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Animal study; beagle dog; β-tricalcium phosphate (TCP); immunohistochemistry; micro computed tomography (CT); periodontal tissue engineering; periostin; recombinant human collagen peptide (RCP); scaffold material; 3-wall intrabony defect

Online: 20 October 2022 (12:24:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202210.0166.v1

A Randomized Trial of Home-Applied Dual-Light Photodynamic Therapy in Stable Chronic Periodontitis -Three-Month Interim Results

Saila Pakarinen, Riitta Saarela, Hanna-Mari Välimaa, Anna-Mari Heikkinen, Esko Kankuri, Marja Noponen, Heikki Alapulli, Taina Tervahartiala, Ismo T. Räisänen, Timo Sorsa, Tommi Pätilä

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: antibacterial photodynamic therapy; Oral hygiene; Periodontitis

Online: 12 October 2022 (08:59:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202210.0136.v1

Role of Patient's Ethnicity in Seeking Preventive Dental Services at the Community Health Centers of South-Central Texas: A Cross-Sectional Study

Girish Suresh Shelke, Rochisha Singh Marwaha, Pankil Shah, Suman N. Challa

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Rural dental care; Preventive visits; Rural Vs Urban; community health centers; Hispanic Vs Non-Hispanics

Online: 11 October 2022 (04:07:45 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202209.0409.v1

Comparison of 0.12% Chlorhexidine and a New Bone Bioactive Liquid, BBL, Mouthrinses on Oral Wound Healing: A Randomized, Double Blind Clinical Human Trial

Eduard Ferrés-Amat, Ashraf Al Madhoun, Elvira Ferrés-Amat, Neus Carreo, Miguel Barrajas, Areej Said Al-Madhoun, Eduard Ferrés-Padró, Carles Marti, Maher Atari

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: chlorhexidine; bioactive liquid; oral wound healing; pain index score; early wound healing score

Online: 27 September 2022 (03:37:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0220.v1

Smartphone-Based Facial Scanning as a Viable Tool for Facially Driven Orthodontics?

Andrej Thurzo, Martin Strunga, Romana Havlínová, Katarína Reháková, Renata Urban, Jana Surovková, Veronika Kurilová

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: TrueDepth; CBCT; Orthodontics; Face scan; Smartphone; Facial diagnostics; Smartphone-based sensors; Facially driven orthodontics

Online: 15 September 2022 (05:45:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0454.v1

Change in the Constricted Airway in Patients after Clear Aligner Treatment: Retrospective Study

Georgia Fountoulaki, Andrej Thurzo

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: orthodontics; airway; clear aligners; 3D diagnostics; sleep apnea; CBCT

Online: 29 July 2022 (09:37:56 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202207.0240.v1

Evolution of Necrotizing Periodontitis in a Patient with Multiple Sclerosis

J.M. Montoya Carralero, A. Sánchez Pérez, A. Jornet García, Moya Villaescusa M.J.

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: periodontitis; periodontal disease; necrotizing periodontitis; periodontal treatment; multiple sclerosis; relapsing-remitting multiple sclerosis

Online: 18 July 2022 (02:52:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0239.v1

Management of Patients with Coagulation Disorders Undergoing Minor Oral Surgery

Pier Carmine Passarelli, Antonio D'Addona, Luigi Svaluto Ferro, Michele Antonio Lopez

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Mouth; Dental diseases; Surgery

Online: 16 June 2022 (10:54:10 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202206.0220.v1

Interdisciplinary Management of Radicular Cyst in Anterior Maxilla - A Case Report

Ghada Hadj Ali, Fedia Ajili, Chaima Hammami, Ikdam Blouza

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: endodontic; periapical lesions; bioceramic

Online: 15 June 2022 (09:56:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0142.v1

Does Botulinum Toxin Type–a Improve Mandibular Motion and Muscle Sensibility in Myofascial Pain Tmd Subjects? A Randomized, Controlled Clinical Trial

Rodrigo Lorenzi Poluha, Célia Mariza Rizzatti-Barbosa, Natalia Alvarez Pinzón, Bruno Rodrigues Da Silva, Andre Mariz Almeida, Malin Ernberg, Ana Cristina Manso, Leonardo Rigoldi Bonjardim, Giancarlo De la Torre Canales

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Botulinum toxin type A; Myofascial pain; Temporomandibular disorders

Online: 9 June 2022 (10:59:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0140.v1

From Text to E-text: Perceptions of Medical, Dental and Allied Students About E-learning

Ayesha Fahim, Sadia Rana, Saira Atif, Sakeenabi Basha, Irsam Haider, Mohammad Khursheed Alam, Anil Kumar Nagarajappa

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Undergraduate; Medical; Online; Distance Education; Perception

Online: 9 June 2022 (10:53:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0107.v1

The Impact of COVID-19 on Dental Treatment in Kuwait – a Retrospective Analysis from the Nation’s Largest Hospital

Wasmiya Ali AlHayyan, Khalaf AlShammari, Falah AlAjmi, Sharat Chandra Pani

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Access to Dental Care; COVID-19; Dental Public Health

Online: 7 June 2022 (11:22:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0181.v2

Quality of Research in Residents of Medical Specialties after a Standardized Digital Training Program with Rubrics

Valeria Jimenez Baez, Maria Erika Gutierrez De la Cruz, Luis Sandoval Jurado, Luis Roberto Martínez Castro, Francisco Javier Alcocer Nuñez

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Scoring; Rubrics; Health; Personnel; Program Evaluation; Distance Education; Residency Education; Speciality

Online: 31 May 2022 (14:06:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0286.v1

In Vivo Analysis of the Immune Response to Strontium- and Copper-doped Bioglasses

Said Alkildani, Armando Mandlule, Milena Radenković, Stevo Najman, Sanja Stojanovic, Ole Jung, Yanru Ren, Baoyi Cai, Oliver Görke, Franziska Schmidt, Mike Barbeck

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: bioglass; ion release; hydroxyapatite deposition; bone tissue regeneration; macrophages; vascularization; copper doping; strontium doping; 45S5; ICIE16

Online: 23 May 2022 (05:24:12 CEST)

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Bioglasses are highly adoptable bone substitute materials, which can be combined with so-called therapeutic ions. These ions have shown to influence underlying molecular processes of the bone regeneration cascade. Moreover, it is known that bone substitutes induce an immune reaction within their implantation area involving macrophages and their pro- and anti-inflammatory subtypes dependent on their chemical composition. However, only poor knowledge exists regarding the influence of therapeutic ions onto the immune reactions and the associated bone healing. Thus, the aim of this work was to investigate the influence of strontium- and copper-doped bioglasses on the induction of M1- and M2-macrophages as well as the implant bed vascularization. (2) Methods: For this study, two alkali glasses were produced on basis of ICIE-16 bioglass via the melt-quench route with the addition of 5 wt% copper or strontium (ICIE16-Cu and ICIE16-Sr). Pure ICIE16 and 45S5 bioglasses were used as control materials. The bioactivity (ion release), chemical composition and the surface pattern were investigated, as well as an in vivo experiment was performed using the subcutaneous implantation model in rats. (3) Results: SEM imaging showed different formations of hydroxyapatite on the surfaces of the bioglass systems after submersion in simulated body fluid. EDX analysis confirmed the doping process by showing the release kinetics. Copper-doped bioglass exhibited a higher ion release than strontium-doped bioglass. Copper induced both a low immune cell migration and triggered a low number of M1- and M2-macrophages but also of blood vessels. The strontium-containing bioactive glass induced higher numbers of M1-macrophages after 30 days. Both copper- and strontium-doped bioglasses induced comparable numbers of M2-macrophages as found in the control groups. (4) Conclusions: Bioglass doping with copper and strontium did not exhibit significant influence on the foreign body response or the implantation bed vascularization in vivo. However, the prepared bioglass systems seemed to be biocompatible.

Preprint ARTICLE | doi:10.20944/preprints202205.0241.v1

A Novel Approach for Environmental Management of Dental Practice: The “Plan-Do-Check-Act” Model

Angela Rovera, Lorenzo Banducci

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: carbon-footprint; dentistry; environment; management; sustainability

Online: 18 May 2022 (10:43:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0078.v1

Radiographic Ratios for Classifying Furcation Anatomy. Proposal of a New Evaluation Method and an Intra-Rater and Inter-Rater Operator Reliability Study

Enrico Limiroli, Andrea Calò, Alessandro Limiroli, Giulio Rasperini

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: furcation anatomy; furcation measurement; furcation evaluation

Online: 6 May 2022 (13:50:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0146.v1

Affordability of Essential Medicines: The Case of Fluoride Toothpaste in 78 Countries

Athanasios Gkekas, Benoit Varenne, Habib Benzian, Nicole Stauf, Stefan Listl

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Essential medicines; affordability; NCD prevention; oral healthcare; access

Online: 15 April 2022 (10:46:26 CEST)

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Background: Fluoride toothpaste (FT) has recently been included in the World Health Organization’s (WHO) Model List of Essential Medicines. Whereas it is essential for preventing dental caries, its current affordability around the globe remains unclear. This study aimed to analyse the affordability of FT in as many as possible countries worldwide. Methods: A standardized protocol was developed to collect country-specific information about the characteristics of the cheapest FT at a common point of purchase. 82 members of the WHO Global Oral Health Network of Chief Dental Officers (CDOs), directors of WHO Collaborative Centres and other oral health experts collected data using mobile phone technology. The Fluoride Toothpaste Affordability Ratio (FTAR) was calculated as the price associated with the recommended annual consumption of FT, relative to the daily wage of the lowest-paid unskilled government worker (FTAR >1 = unaffordable spending on fluoride toothpaste). The daily expenditure per capita of the poorest 15% of the income distrubition was used as the main proxy of the daily wage, using World Bank data. Alternatively, we used the daily minimum wage as a proxy of the daily wage. Stratified descriptive statistics were undertaken with respect to different World Bank Income Groups and WHO Regions. Results: There are significant discrepancies in the affordability of FT across 78 countries. FT was strongly affordable in high-income countries, relatively affordable in upper middle-income countries, and strongly unaffordable in lower middle-income and low-income countries. The affordability of FT across WHO Regions was dependent upon the economic mix of WHO Regions’ member states. Conclusion: FT is still unaffordable for many people, particularly in low-resource settings. Health policy members should develop better strategies to address and improve the universal affordability of FTs, for the incidence of dental caries to be reduced at a global level.

Preprint ARTICLE | doi:10.20944/preprints202108.0413.v3

Hybrid HCNN-KNN Model Enhances Age Estimation Accuracy in Orthopantomography

Fatemeh Sharifonnasabi, Noor Jhanjhi, Jacob John, Peyman Obeidy, Shahab Shamshirband, Hamid Alinejad Rokny, Mohammed Baz

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Dental Age Measurement; Dental Radiography; Orthopantomogram; Convolutional Neural Network; K-Nearest Neighbour; Health Data Analytics; Biomedical Machine Learning

Online: 12 April 2022 (10:12:48 CEST)

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Age estimation in dental radiographs Orthopantomography (OPG) is a medical imaging technique that physicians and pathologists utilise for disease identification and legal matters. For example, for estimating post-mortem interval, detecting child abuse, drug trafficking, and identifying an unknown body. Recent development in automated image processing models improved the age estimation's limited precision to an approximate range of +/- one year. While this estimation is often accepted as accurate measurement, age estimation should be as precise as possible in most serious matters, such as homicide. Current age estimation techniques are highly dependent on manual and time-consuming image processing. Age estimation is often a time-sensitive matter in which the image processing time is vital. Recent development in Machine learning-based data processing methods has decreased the imaging time processing; however, the accuracy of these techniques remains to be further improved. We proposed an ensemble method of image classifiers and transfer learning techniques to enhance the accuracy of age estimation using OPGs from one year to a couple of months (1-3-6). This hybrid model is based on convolutional neural networks (CNN) and K nearest neighbours (KNN). The hybrid (HCNN-KNN) model was used to investigate 1,922 panoramic dental radiographs of patients aged 15 to 23. These OPGs were obtained from the various teaching institutes and private dental clinics in Malaysia. To minimise the chance of overfitting in our model, we used the principal component analysis (PCA) algorithm and eliminated the features with high correlation. To further enhance the performance of our hybrid model, we performed systematic image pre-processing. We applied a series of classifications to train our model. We have successfully demonstrated that combining these innovative approaches has improved the classification and segmentation and thus the age-estimation outcome of the model. Our findings suggest that our innovative model, for the first time, to the best of our knowledge, successfully estimated the age in classified studies of one year old, six months, three months and one-month-old cases with accuracies of 99.98, 99.96, 99.87, and 98.78 respectively.

Preprint ARTICLE | doi:10.20944/preprints202201.0315.v2

Biosafety in Dental Care Facing Highly Transmissible SARS-CoV-2 Variants: Introduction of Prospective Setting Protocol in Prevention of COVID-19

Andrej Thurzo, Alexandra Bražinová, Neda Markovská, Iveta Waczulíková, Martin Smatana, Wanda Urbanová, Martin Strunga, Veronika Kurilová, Jana Kaiferová, Peter Sabaka, Helena Kosnáčová, Bela Mriňáková, Ivan Varga, Ladislav Czakó, Branislav Gális, Georgia Fountoulaki, Bohuslav Novák

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: SARS-CoV-2; Omicron; biosafety protocol; dentistry; orthodontics; sustainability

Online: 8 April 2022 (03:58:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202203.0408.v1

Effects of Type 2 Diabetes Mellitus on Osteoclast Differentiation, Activity, and Cortical Bone Formation in Postmenopausal MRONJ Patient

Sung-Min Park, Jae-Hoon Lee

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Type 2 Diabetes; Osteoporosis; Bisphosphonate; MRONJ; Osteoclast

Online: 31 March 2022 (13:44:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202203.0317.v1

Tilted Implants and Sinus Floor Elevation Techniques Compared in Posterior Edentulous Maxilla: Retrospective Clinical Study of Four Years Follow-up

Gherlone Enrico Felice, D’Orto Bianca, Nagni Matteo, Capparè Paolo, Raffaele Vinci

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: posterior edentulous maxilla; maxillary sinus; sinus floor elevation; tilted implants

Online: 23 March 2022 (12:49:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202203.0073.v1

Perceptions of Teachers and School Nurses on Child and Adolescent Oral Health

Carl A. Maida, Mavin Marcus, Di Xiong, Paula Ortega-Verdugo, Elizabeth Agredano, Yilan Huang, Linyu Zhou, Steve Y. Lee, Jie Shen, Ron D. Hays, James J. Crall, Honghu Liu

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: focus group; patient reported outcome measures; oral health; education; COVID-19; dental problem

Online: 4 March 2022 (07:08:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202203.0006.v1

Immunohistochemical Evaluation of CD31 and D2-40, Expression in Oral Squamous Cell Carcinoma

Amr Mohamed Ibrahim, Emad Alqalshy, Ahmed Abdel-Shakour Abdel-Hafiz, Kamal Abd El-Rahman, Magdy Alazzazi, Mohamed Refaat Omar

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Immunohistochemistry; CD31; D2-40; Tumor angiogenesis; OSSC.

Online: 1 March 2022 (06:55:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0049.v2

Human Remains Identification Using Micro-CT, Chemometric and A.I. Methods in Forensic Experimental Reconstruction of Dental Patterns after Concentrated Acid Significant Impact

Andrej Thurzo, Viera Jančovičová, Miroslav Hain, Milan Thurzo, Bohuslav Novák, Helena Kosnáčová, Viera Lehotská, Ivan Varga, Norbert Moravanský

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: dental pattern; forensic anthropology; forensic odontology; forensic dentistry; forensic radiolo-gy; forensic chemistry; forensic science; machine learning; identification; dental materials; acid solution; dissolution; sulfuric acid; dentition; teeth; acid degradation

Online: 24 February 2022 (03:41:16 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202202.0291.v1

Granulomatous Cheilitis Revealing Latent Tuberculous Infection

Georgi Tomov, Parvan Voynov, Svitlana Bachurska

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: granulomatous cheilitis; latent tuberculosis; IGRA; antibiotic treatment

Online: 23 February 2022 (12:08:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0250.v2

Complicated Mandible Fracture Treatment With Xenogenic Bone Graft: A Case Report

Ekaterina Diachkova, Sofia Popova, Liana Arazashvili, Pavel Petruk, Igor' Cherkesov

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: follicular cyst; fracture; mandible; osteosynthesis; mini-plate; collagenic xenograft

Online: 8 February 2022 (12:41:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202108.0413.v2

Hybrid HCNN-KNN Transfer Learning Model Enhances Age Estimation Accuracy in Orthopantomography

Fatemeh Sharifonnasabi, Noor Jhanjhi, Jacob John, Peyman Obeidy, Shahab Shamshirband, Hamid Alinejad Rokny

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Dental Age Measurement; Dental Radiography; Orthopantomogram; Convolutional Neural Network; K-Nearest Neighbour; Health Data Analytics; Biomedical Machine Learning

Online: 31 January 2022 (12:44:55 CET)

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Age estimation in dental radiographs Orthopantomography (OPG) is a medical imaging technique that physicians and pathologists utilise for disease identification and legal matters. For example, for estimating post-mortem interval, detecting child abuse, drug trafficking, and identifying an unknown body. Recent development in automated image processing models improved the age estimation's limited precision to an approximate range of +/- one year. While this estimation is often accepted as accurate measurement, age estimation should be as precise as possible in most serious matters, such as homicide. Current age estimation techniques are highly dependent on manual and time-consuming image processing. Age estimation is often a time-sensitive matter in which the image processing time is vital. Recent development in Machine learning-based data processing methods has decreased the imaging time processing; however, the accuracy of these techniques remains to be further improved. We proposed an ensemble method of image classifiers and transfer learning techniques to enhance the accuracy of age estimation using OPGs from one year to a couple of months (1-3-6). This hybrid model is based on convolutional neural networks (CNN) and K nearest neighbours (KNN). The hybrid (HCNN-KNN) model was used to investigate 1,922 panoramic dental radiographs of patients aged 15 to 23. These OPGs were obtained from the various teaching institutes and private dental clinics in Malaysia. To minimise the chance of overfitting in our model, we used the principal component analysis (PCA) algorithm and eliminated the features with high correlation. To further enhance the performance of our hybrid model, we performed systematic image pre-processing. We applied a series of classifications to train our model. We have successfully demonstrated that combining these innovative approaches has improved the classification and segmentation and thus the age-estimation outcome of the model. Our findings suggest that our innovative model, for the first time, to the best of our knowledge, successfully estimated the age in classified studies of one year old, six months, three months and one-month-old cases with accuracies of 99.98, 99.96, 99.87, and 98.78 respectively.

Preprint ARTICLE | doi:10.20944/preprints202201.0315.v1

Dentistry after Omicron variant: Introducing a New Biosafety Protocol in Prevention of COVID-19 in Dental Care

Andrej Thurzo, Alexandra Bražinová, Neda Markovská, Iveta Waczulíková, Martin Smatana, Norbert Moravanský, Wanda Urbanová, Renáta Urban, Martin Strunga, Veronika Kurilová, Jana Kaiferová, Peter Sabaka, Pavol Vitovič, Helena Kosnáčová, Bela Mriňáková, Ivan Varga, Ladislav Czakó, Branislav Gális, Georgia Fountoulaki, Bohuslav Novák

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Biosafety; Dentistry; Orthodontics; SARS-CoV-2; Omicron; Sustainability; Patients; Biosafety protocol

Online: 21 January 2022 (03:01:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0307.v1

Effect of Docosahexaenoic Acid as a Chemopreventive Agent on Experimentally Induced Hamster Buccal Pouch Carcinogenesis

Emad Alqalshy, Amr Mohamed Ibrahim, Ahmed Abdel-Shakour Abdel-Hafiz, Kamal Abd AbdEl-Rahman, Magdy Alazzazi, Mohamed Omar, Amr Saad Abdel-Wahab

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Docosahexaenoic acid; Chemoprevention; Bcl-2 family; Experimental Study; Hamster Buccal Pouch Carcinogenesis.

Online: 20 January 2022 (13:41:39 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202201.0250.v1

Complicated Mandible Fracture Treatment With Xenogenic Bone Graft: A Case Report

Ekaterina Diachkova, Sofia Popova, Liana Arazashvili, Pavel Petruk, Igor' Cherkesov

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: case report; fracture; mandible; osteosynthesis; mini-plate; titanium nickelide; collagenic xenograft

Online: 18 January 2022 (10:33:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0167.v1

Midpalatal Suture Density CBCT Evaluation, Sex Gender and Growth Pattern Related Variability in 392 Adolescents Treated With Rapid Maxillary Expander Appliance

Monica Macrì, Elena Toniato, Giovanna Murmura, Giuseppe Varvara, Felice Festa

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: rapid palatal expander; midpalatal suture; bone density; cone-beam computed tomography, facial patterns, skeletal growth pattern.

Online: 12 January 2022 (13:42:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0157.v1

Roles of Proliferation and Angiogenesis in Locally Aggressive Biologic Behavior of Ameloblastoma versus Ameloblastic Fibroma

Amr Ibrahim, Emad Elqalshy, Ahmed El-Mohamadi, Kamal Abd El-Rahman, Magdy Alazzazi

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Proliferation; Angiogenesis; Biologic Behavior; Ameloblastoma; Ameloblastic Fibroma

Online: 12 January 2022 (08:20:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0150.v1

Oral Hygiene Practices and Knowledge among Adolescents Aged between 15 and 17 Years Old during Fixed Orthodontic Treatment: Multicentre Study Conducted in France

Camille Inquimbert, Celine Clement, Antoine Couatarmanach, Paul Tramini, Denis Bourgeois, Florence Carrouel

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Oral Health; Adolescent; Knowledge, Practice, Behaviour

Online: 11 January 2022 (15:48:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0049.v1

Human Remains Identification Using Micro-CT, Spectroscopic and A.I. Methods in Forensic Experimental Reconstruction of Dental Patterns After Concentrated Acid Significant Impact

Andrej Thurzo, Viera Jančovičová, Miroslav Hain, Milan Thurzo, Bohuslav Novák, Helena Kosnáčová, Viera Lehotská, Norbert Moravanský, Ivan Varga

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Dental Pattern; Forensic Anthropology; Forensic Odontology; Forensic Dentistry; Forensic Ra-diology; Forensic Chemistry; Forensic science; Machine Learning; Identification; Dental materials; Acid solution; Dissolution; Sulfuric acid; Dentition; Teeth; Acid degradation;

Online: 6 January 2022 (09:33:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0043.v1

Ectopic Eye Tooth Management: Photobiomodulation / low-level Laser Emission Role in Root Resorption After Fixed Orthodontic Treatment

Mohammad Khursheed Alam, Kiran Kumar Ganji, Ahmed Ali Alfawzan, Srinivas Munisekhar Manay, Kumar Chandan Srivastava, Prabhat Kumar Chaudhari, Hala A Hosni, Haytham Jamil Alswairki, Reem Alansari

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: Photobiomodulation; low level laser therapy; ectopic eye tooth; root resorption; treatment modalities.

Online: 5 January 2022 (13:15:17 CET)

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The orthodontic treatment brings numerous benefits and, in most cases, the benefits outweigh the possible disadvantages. Root resorption (RR) is a common adverse phenomenon associated with orthodontic treatment. This study evaluates the role of low-level laser emission / Photobiomodu-lation (LE/P) in quantitative measurements of root resorption (QRR). The application of LE/P was done after each orthodontic activation with 4 types of treatment intervention (TI) on the RR after fixed orthodontic treatment (FOT) of the upper arch with ectopic eye tooth/teeth [EET]. 32 Orthodontic patients scheduled for FOT were selected and assigned to the 4 groups. These were LE/P+Self ligating bracket (SLB), LE/P+Conventional bracket (CB), Non-Photobiomodulation (non-LE/P)+SLB, and non-LE/P+CB. Standard management stages of FOT were followed in the maxilla. Each patient received a single application of LE/P labially/buccally and palatally, a total of 5 different points during each activation or appointment. The main outcome measure was QRR in maxillary anteriors before and after FOT assessed via cone-beam computed tomography (CBCT) using 3D OnDemand software. Insignificant QRR was found between before and after FOT in SLB, CLB, and LE/P, non-LE/P groups (p > 0.05). QRR in the SLB vs CB and LE/P vs non-LE/P group was significantly different in 11, 13, and 23 (p < 0.05). QRR in the LE/P+SLB group (p < 0.05) was significantly different in 11, 13, and 23 than that in the other groups. The most severe QRR was found on the 13 (0.88 ± 0.28mm and 0.87±0.27mm) and 23 (1.19 ± 0.14 mm and 1.16±0.13mm) in the CB and non-LE/P group (p < 0.001). LE/P+SLB showed highly significant superior outcome (p < 0.001) in relation to non-LE/P+CB, the QRR of 23 were 0.813± 0.114mm and 1.156± 0.166mm respectively. Significantly higher amount of QRR found in EET patients after FOT treated with the CB, non-LE/P, and non-LE/P+CB system and warrants further investigation to explore potential specific causes.

Medicine and Pharmacology