Preprint Hypothesis Version 1 Preserved in Portico This version is not peer-reviewed

Intracellular Ion Changes Induced by the Exposure to Beta-Amyloid Can Be Explained by the Formation of Channels in the Lysosomal Membranes

Version 1 : Received: 2 August 2021 / Approved: 4 August 2021 / Online: 4 August 2021 (13:19:50 CEST)

How to cite: Zaretsky, D.V.; Zaretskaia, M.V. Intracellular Ion Changes Induced by the Exposure to Beta-Amyloid Can Be Explained by the Formation of Channels in the Lysosomal Membranes. Preprints 2021, 2021080115 (doi: 10.20944/preprints202108.0115.v1). Zaretsky, D.V.; Zaretskaia, M.V. Intracellular Ion Changes Induced by the Exposure to Beta-Amyloid Can Be Explained by the Formation of Channels in the Lysosomal Membranes. Preprints 2021, 2021080115 (doi: 10.20944/preprints202108.0115.v1).

Abstract

In this manuscript, we reassess the data on beta-amyloid-induced changes of intracellular ions concentrations published previously by Abramov et al. (2003, 2004). Their observations made using high-resolution confocal microscopy with fast temporal resolution of images formed by fluorescent ion-sensitive fluorescent probes in living cells represent an unequivocal support for the amyloid channel theory. However, closer look reveals multiple facts which cannot be explained by channel formation in plasma membrane. Recently proposed amyloid degradation toxicity hypothesis provides the interpretation to these facts by considering that channels are formed in the lysosomal membranes.

Keywords

beta-amyloid toxicity, proteolytic digestion, membrane channel, intracellular ion disturbances, calcium homeostasis, intracellular pH, lysosome

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