Preprint Review Version 1 This version is not peer-reviewed

Stem Cell Therapy for Diabetes: Beta Cells versus Pancreatic Progenitors

Version 1 : Received: 7 January 2020 / Approved: 8 January 2020 / Online: 8 January 2020 (05:30:34 CET)

A peer-reviewed article of this Preprint also exists.

Memon, B.; Abdelalim, E.M. Stem Cell Therapy for Diabetes: Beta Cells versus Pancreatic Progenitors. Cells 2020, 9, 283. Memon, B.; Abdelalim, E.M. Stem Cell Therapy for Diabetes: Beta Cells versus Pancreatic Progenitors. Cells 2020, 9, 283.

Journal reference: Cells 2020, 9, 283
DOI: 10.3390/cells9020283

Abstract

Diabetes mellitus (DM) is one of the most prevalent metabolic disorders. In order to replace the function of the destroyed pancreatic beta cells in diabetes, islet transplantation is the widely practiced treatment; however, it has several limitations. As an alternative approach, human pluripotent stem cells (hPSCs) can provide an unlimited source of pancreatic cells that have the ability to secrete insulin in response to high blood glucose level. However, determination of the appropriate pancreatic lineage candidate for the purpose of cell therapy for treatment of diabetes is still debated upon. While hPSC-derived beta cells are perceived as the ultimate candidate, the efficiency needs further improvement in order to obtain a sufficient number of glucose responsive β-cells for transplantation therapy. On the other hand, hPSC-derived pancreatic progenitors can be efficiently generated in vitro and can further mature into glucose responsive beta cells in vivo after transplantation. Herein, we discuss the advantages and predicted challenges associated with the use of each of the two pancreatic lineage products for diabetes cell therapy. Furthermore, we address co-generation of functionally relevant islet cell subpopulations and structural properties contributing to glucose responsiveness of beta cells, as well as the available encapsulation technology for these cells.

Subject Areas

hPSCs; hyperglycemia; insulin-secreting cells; β-cell precursors; pancreatic islets; transplantation.

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