Bruno, F.; Abondio, P.; Montesanto, A.; Luiselli, D.; Bruni, A.C.; Maletta, R. The Nerve Growth Factor Receptor (NGFR/p75NTR): A Major Player in Alzheimer’s Disease. Int. J. Mol. Sci.2023, 24, 3200.
Bruno, F.; Abondio, P.; Montesanto, A.; Luiselli, D.; Bruni, A.C.; Maletta, R. The Nerve Growth Factor Receptor (NGFR/p75NTR): A Major Player in Alzheimer’s Disease. Int. J. Mol. Sci. 2023, 24, 3200.
Bruno, F.; Abondio, P.; Montesanto, A.; Luiselli, D.; Bruni, A.C.; Maletta, R. The Nerve Growth Factor Receptor (NGFR/p75NTR): A Major Player in Alzheimer’s Disease. Int. J. Mol. Sci.2023, 24, 3200.
Bruno, F.; Abondio, P.; Montesanto, A.; Luiselli, D.; Bruni, A.C.; Maletta, R. The Nerve Growth Factor Receptor (NGFR/p75NTR): A Major Player in Alzheimer’s Disease. Int. J. Mol. Sci. 2023, 24, 3200.
Abstract
Alzheimer’s disease (AD) represents the most prevalent type of dementia in elderly people, primarily characterized by brain accumulation of beta-amyloid (Aβ) peptides, derived from Amyloid Precursor Protein (APP), in the extracellular space (amyloid plaques) and intracellular deposits of the hyperphosphorylated form of the protein tau (p-tau; tangles or neurofibrillary aggregates). The Nerve growth factor receptor (NGFR/p75NTR) represents a low-affinity receptor for all known mammalians neurotrophins (i.e., pro-NGF, NGF, BDNF, NT-3 e NT-4/5) and it is involved in pathways that determine both survival and death of neurons. Interestingly, also Aβ peptides can blind to NGFR/p75NTR making it the “ideal” candidate in mediating Aβ-induced neuropathology. Besides pathogenesis and neuropathology, several data indicated that NGFR/p75NTR could play a key role in AD also from a genetic perspective. Other studies suggested that NGFR/p75NTR could represent a good diagnostic tool, as well as a promising therapeutic target for AD. Here, we comprehensively summarize and review the current experimental evidence on this topic.
Biology and Life Sciences, Cell and Developmental Biology
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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