Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Combination of Metal Nanoparticles With Hydrolytic Enzymes To Obtain Improved Antifungals

Ilya Lyagin
ORCID logo ,
Aysel Aslanli
ORCID logo ,
Maxim Domnin
,
Nikolay Stepanov
,
Olga Senko
ORCID logo ,
Olga Maslova
ORCID logo ,
Elena Efremenko
* ORCID logo
Version 1 : Received: 31 May 2023 / Approved: 1 June 2023 / Online: 1 June 2023 (07:31:58 CEST)

A peer-reviewed article of this Preprint also exists.

Lyagin, I.; Aslanli, A.; Domnin, M.; Stepanov, N.; Senko, O.; Maslova, O.; Efremenko, E. Metal Nanomaterials and Hydrolytic Enzyme-Based Formulations for Improved Antifungal Activity. Int. J. Mol. Sci. 2023, 24, 11359. Lyagin, I.; Aslanli, A.; Domnin, M.; Stepanov, N.; Senko, O.; Maslova, O.; Efremenko, E. Metal Nanomaterials and Hydrolytic Enzyme-Based Formulations for Improved Antifungal Activity. Int. J. Mol. Sci. 2023, 24, 11359.

Abstract

Active research of metal-containing compounds and enzymes as effective antifungal agents is currently noted. The interest in metals is due to the wide variety of ligands that can be used for metals, including chemically synthesized and naturally obtained variants as a result of the so-called "green synthesis". The main mechanism of antifungal action of metals is the triggering of generation and accumulation of reactive oxygen species (ROS). Further action of ROS on various biomolecules is nonspecific. This review highlights various hydrolytic enzymes (glucanases and proteases) that affect the structural elements of fungal cells (cell walls, membranes), fungal quorum sensing molecules, fungal own protective agents (mycotoxins and antibiotics), proteins responsible for the adhesion and formation of stable highly concentrated populations in the form of biofilms. A wide range of the substrates for enzymes allows the use of various mechanisms of their antifungal actions. The prospects of combining two different types of antifungal agents (metals and enzymes) for mycelial fungi and yeast cells are discussed in this review. Special attention is paid to the possible influence of metals on activity of the enzymes and the possible effects of proteins on antifungal activity of metal-containing compounds.

Keywords

green synthesis; MOFs; amyloid proteins; prionase; mycotoxins; growth inhibition; quorum sensing; quorum quenching; lactamases; biofilms; chitinases; lactonases; His6-OPH

Subject

Biology and Life Sciences, Biology and Biotechnology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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