REVIEW
|
doi:10.20944/preprints202205.0158.v1
Subject:
Medicine And Pharmacology,
Pathology And Pathobiology
Keywords:
Parkinson’s disease; Epigenetic targets; Histone deacetylases; Inhibitors; PROTACs
Online: 12 May 2022 (05:41:21 CEST)
ARTICLE
|
doi:10.20944/preprints202110.0145.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
immune checkpoint inhibitors; PD-1; PD-L1; CTLA-4; immunotherapy; target therapy; BRAF; MET; melanoma; [18F]FDG PET/CT
Online: 8 October 2021 (14:14:14 CEST)
REVIEW
|
doi:10.20944/preprints202207.0256.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
cancer; immunotherapy; adverse events; immune checkpoints inhibitors; chimeric antigen receptor therapy; bispecific antibodies; toxicity; renal; oncology
Online: 18 July 2022 (09:21:56 CEST)
REVIEW
|
doi:10.20944/preprints202312.1388.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Rheb1; Rheb2; Cancer; mTOR; Hallmarks; Neurons; Rheb1 inhibitors
Online: 19 December 2023 (05:58:46 CET)
REVIEW
|
doi:10.20944/preprints202011.0005.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
aminoacyl-tRNA synthetase, small molecule inhibitors, human diseases
Online: 2 November 2020 (09:09:37 CET)
ARTICLE
|
doi:10.20944/preprints202010.0032.v1
Subject:
Chemistry And Materials Science,
Biomaterials
Keywords:
Nanomedicine; human ferritin; gastrointestinal tumors; non-camptothecin topoisomerase I inhibitors; drug-delivery; CD71
Online: 2 October 2020 (09:21:53 CEST)
ARTICLE
|
doi:10.20944/preprints202111.0125.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
artificial intelligence; de novo design; fragment-based drug discovery; HIV-1 inhibitors; pseudo natural products
Online: 8 November 2021 (09:23:49 CET)
REVIEW
|
doi:10.20944/preprints202009.0084.v1
Subject:
Medicine And Pharmacology,
Gastroenterology And Hepatology
Keywords:
programmed cell death; inflammation; intestinal disease; cancer; inhibitors
Online: 4 September 2020 (07:21:17 CEST)
ARTICLE
|
doi:10.20944/preprints202011.0395.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
TNBC; Ca2+-ATPase; SICE; HDAC inhibitors; EMT; WNT signaling; vorinostat; romidepsin; vimentin
Online: 13 November 2020 (20:50:48 CET)
CASE REPORT
|
doi:10.20944/preprints202005.0220.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
checkpoint inhibitors; tuberculosis; non-small cell lung cancer (NSCLC); Anti-PD-1; toxicity management; immunotherapy; pembrolizumab
Online: 13 May 2020 (04:38:50 CEST)
REVIEW
|
doi:10.20944/preprints202010.0338.v1
Subject:
Medicine And Pharmacology,
Immunology And Allergy
Keywords:
Urothelial carcinoma; immune checkpoint inhibitors; immunotherapy; tumor microenvironment; metabolic pathway
Online: 16 October 2020 (08:00:41 CEST)
REVIEW
|
doi:10.20944/preprints202012.0441.v1
Subject:
Medicine And Pharmacology,
Immunology And Allergy
Keywords:
dystrohinopathy; Duchenne muscular disease; Becker muscular disease; dystrophic deficient cardiomyopathy; cardiac fibrosis; renin angiotensin system; angiotensin 2; angiotensin converter enzyme inhibitors; angiotensin receptor blockers; heart failure
Online: 18 December 2020 (07:18:16 CET)
ARTICLE
|
doi:10.20944/preprints202310.0713.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
colon cancer; cathepsin B; radiotherapy; radioresistance; cathepsin inhibitors; CA074
Online: 11 October 2023 (10:48:48 CEST)
REVIEW
|
doi:10.20944/preprints202003.0251.v2
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
gastric acid suppressant; chemotherapy; tyrosine kinase inhibitors; proton pump inhibitors
Online: 31 March 2020 (03:40:46 CEST)
ARTICLE
|
doi:10.20944/preprints202308.0332.v2
Subject:
Biology And Life Sciences,
Biology And Biotechnology
Keywords:
homologous recombination deficiency (HRD); biomarkers; ovarian cancer; DNA repair; BRCA1/2; poly (ADP–ribose) polymerase inhibitors (PARPi); next generation sequencing (NGS)
Online: 6 September 2023 (09:09:09 CEST)
REVIEW
|
doi:10.20944/preprints202111.0317.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Non-Hodgkin lymphoma; Epigenetics; DNA methylation; HAT; HDAC; EZH2; bromodomain inhibitors; Drug combination; clinical testing
Online: 17 November 2021 (23:45:00 CET)
REVIEW
|
doi:10.20944/preprints202304.0564.v1
Subject:
Medicine And Pharmacology,
Psychiatry And Mental Health
Keywords:
serotonin antagonist/reuptake inhibitors; comorbidity; psychiatric disorders; trazodone; neurobiology; emotion
Online: 19 April 2023 (07:52:17 CEST)
REVIEW
|
doi:10.20944/preprints202308.0055.v1
Subject:
Medicine And Pharmacology,
Medicine And Pharmacology
Keywords:
COVID-19; SARS-CoV-2 Mpro; protease inhibitors; coronavirus; peptidomimetics; Paxlovid; Nirmatrelvir
Online: 2 August 2023 (05:25:21 CEST)
REVIEW
|
doi:10.20944/preprints202302.0380.v1
Subject:
Medicine And Pharmacology,
Psychiatry And Mental Health
Keywords:
serotonin antagonist/reuptake inhibitors; comorbidity; psychiatric disorders; neurological disorders; dementia; primary care
Online: 22 February 2023 (08:42:51 CET)
CASE REPORT
|
doi:10.20944/preprints202307.0971.v1
Subject:
Medicine And Pharmacology,
Dermatology
Keywords:
atopic dermatitis; emollient plus cream; topical corticosteroids; topical calcineurin inhibitors; case report
Online: 14 July 2023 (09:18:55 CEST)
REVIEW
|
doi:10.20944/preprints202305.0976.v1
Subject:
Biology And Life Sciences,
Immunology And Microbiology
Keywords:
quorum sensing; quorum sensing inhibitors; Chromobacterium violaceum; plant extracts
Online: 15 May 2023 (05:07:34 CEST)
ARTICLE
|
doi:10.20944/preprints202212.0206.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Cell-to-cell fusion; proprotein convertases; metalloproteases; mutagenesis; PCSK9; protease inhibitors; SARS-CoV-2; shedding; SKI-1/S1P; SREBP-2.
Online: 12 December 2022 (14:20:01 CET)
REVIEW
|
doi:10.20944/preprints202309.0229.v1
Subject:
Medicine And Pharmacology,
Hematology
Keywords:
acute myeloid leukemia; immunotherapy; checkpoint inhibitors; new therapeutic landscapes
Online: 6 September 2023 (14:36:13 CEST)
ARTICLE
|
doi:10.20944/preprints202307.1154.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Uterine fibroids; BRD9 inhibitors; Cell proliferation; Extracellular Matrix; Transcriptome; Epigenome; m6A regulators; Epitranscriptome
Online: 18 July 2023 (04:30:08 CEST)
REVIEW
|
doi:10.20944/preprints202304.0843.v2
Subject:
Medicine And Pharmacology,
Hematology
Keywords:
CLL, Zanubrutinib, BTK inhibitors, efficacy, safety, chronic lymphocytic leukemia
Online: 22 May 2023 (16:15:16 CEST)
REVIEW
|
doi:10.20944/preprints202306.0994.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
hepatocellular carcinoma (HCC); LOXL2; tumor microenvironment (TME); extracellular matrix (ECM); LOXL2 inhibitors; target therapy
Online: 14 June 2023 (07:18:34 CEST)
REVIEW
|
doi:10.20944/preprints202307.0043.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
Gliomas; Tumour Microenvironment; Immunotherapy; Immune Checkpoint Inhibitors; Vaccines
Online: 4 July 2023 (02:39:07 CEST)
ARTICLE
|
doi:10.20944/preprints202212.0542.v2
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
safety analysis; targeted therapy; monoclonal antibody therapy; immune checkpoint inhibibitors; tyrosine kinase inhibitors; breast cancer; gynecological cancer; Helixor; Viscum album L.; PARP inhibitors; CDK 4/6 inhibitors
Online: 30 December 2022 (12:00:35 CET)
ARTICLE
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
CYP3A5; androgen receptor; African American; CYP3A5 inhibitors/inducers
Online: 6 March 2020 (03:33:52 CET)
REVIEW
|
doi:10.20944/preprints202311.0529.v1
Subject:
Public Health And Healthcare,
Primary Health Care
Keywords:
SARS-CoV-2; Papain-like protease; COVID-19; Molecular modelling; Molecular dynamics simulations; Drug discovery; Antiviral drugs; Inhibitors; Therapeutic agents; therapeutic targets; Irreversible inhibitors; Repurposing drugs
Online: 8 November 2023 (16:11:55 CET)
REVIEW
|
doi:10.20944/preprints202306.0041.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
APE1; inhibitors; cancer.
Online: 1 June 2023 (07:05:48 CEST)
ARTICLE
|
doi:10.20944/preprints202306.2038.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
Neurodegenerative diseases; cholinesterase inhibitors; monoaminoxidase inhibitors; photo-pharmacology
Online: 29 June 2023 (02:47:23 CEST)
REVIEW
|
doi:10.20944/preprints202208.0008.v3
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
adamantanes; antivirals; cap-dependent endonuclease inhibitors; influenza; neuraminidase inhibitors; umifenovir
Online: 19 September 2023 (04:16:16 CEST)
REVIEW
|
doi:10.20944/preprints202302.0205.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
breast cancer; ovarian cancer; PARP inhibitors; Alu repeats; protein-protein interactions
Online: 13 February 2023 (07:54:35 CET)
REVIEW
|
doi:10.20944/preprints202304.1236.v1
Subject:
Medicine And Pharmacology,
Hematology
Keywords:
FLT3 mutations; resistant/relapsed acute myeloid leukemia; tyrosine kinase inhibitors; gilteritinib
Online: 29 April 2023 (10:55:21 CEST)
ARTICLE
|
doi:10.20944/preprints202308.0290.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
RNA-binding protein; human antigen R (HuR); high-throughput virtual screening; small molecule inhibitors; RNA pulldown assay
Online: 3 August 2023 (10:11:15 CEST)
ARTICLE
|
doi:10.20944/preprints202304.0327.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Ovarian cancer; PARP inhibitors; epithelial to mesenchymal transition; drug response
Online: 13 April 2023 (14:30:07 CEST)
REVIEW
|
doi:10.20944/preprints202401.0800.v1
Subject:
Medicine And Pharmacology,
Dermatology
Keywords:
psoriasis; oral therapies; topical therapies; biologics; Jak inhibitors; PDE4 inhibitors; systemic treatment; IL-17 inhibitors; IL-23 inhibitors; tapinarof; roflumilast
Online: 10 January 2024 (08:49:06 CET)
REVIEW
|
doi:10.20944/preprints202307.0979.v1
Subject:
Biology And Life Sciences,
Immunology And Microbiology
Keywords:
breast cancer; microbiota; estrobolome; β-glucuronidase; dysbiosis; inhibitors; metabolomics; personalized medicine; review
Online: 14 July 2023 (07:08:34 CEST)
HYPOTHESIS
|
doi:10.20944/preprints202309.0196.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Neurodegenerative disorders; schizophremia; PDK1 inhibitors; Lipid replacement therapy; Aryl hydrocarbon receptor antagonists
Online: 4 September 2023 (14:29:13 CEST)
REVIEW
|
doi:10.20944/preprints202310.1318.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
advanced melanoma; immunotherapy; target therapy; lysine histone methyl transferase inhibitors; UNC0642
Online: 20 October 2023 (08:35:45 CEST)
ARTICLE
|
doi:10.20944/preprints202305.0276.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
fibroblast activation protein α (FAP-α); cancer-associated fibroblasts (CAFs); FAP inhibitors (FAPIs); PET imaging; gallium-68; (R)-pyrrolidin-2-yl-boronic acid-based radiopharmaceuticals
Online: 5 May 2023 (02:40:01 CEST)
ARTICLE
|
doi:10.20944/preprints202304.0530.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
Poly (ADP-Ribose) Polymerase-1; PARP inhibitors; neoplasm; cancer; animal disease models
Online: 19 April 2023 (03:30:59 CEST)
REVIEW
|
doi:10.20944/preprints202402.1384.v1
Subject:
Biology And Life Sciences,
Immunology And Microbiology
Keywords:
Cystic fibrosis; Pseudomonas aeruginosa; Antivirulence therapy; Quorum quenching and biofilm inhibition; Lectin and efflux pump inhibitors; Iron chelation
Online: 23 February 2024 (15:01:30 CET)
ARTICLE
|
doi:10.20944/preprints202403.0717.v1
Subject:
Biology And Life Sciences,
Animal Science, Veterinary Science And Zoology
Keywords:
Lumpy skin disease; DNA polymerase; potential inhibitors; phytocompounds; antiviral drug compounds; molecular docking
Online: 13 March 2024 (07:58:39 CET)
REVIEW
|
doi:10.20944/preprints202306.1853.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
interleukin-1 beta (IL-1β); immune-checkpoint inhibitors (ICIs); non-small cell lung cancer (NSCLC); programmed death ligand 1 (PD-L1); therapeutic resistance
Online: 27 June 2023 (07:16:09 CEST)
REVIEW
|
doi:10.20944/preprints202305.1317.v1
Subject:
Chemistry And Materials Science,
Food Chemistry
Keywords:
Starchy food; potato protease inhibitors; phytochemicals; antioxidants; cancer prevention
Online: 18 May 2023 (09:48:15 CEST)
REVIEW
|
doi:10.20944/preprints202401.0407.v1
Subject:
Medicine And Pharmacology,
Urology And Nephrology
Keywords:
prostatic neoplasm; biochemical recurrence; androgen receptor signaling inhibitors; androgen deprivation therapy
Online: 4 January 2024 (11:22:30 CET)
ARTICLE
|
doi:10.20944/preprints202305.2032.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Hep-G2 hepatocarcinoma cell; Deuterium-depleted water; Deuterium-enriched water; Cyclooxygenase inhibitors; MAPK pathway; Apoptosis
Online: 30 May 2023 (04:02:57 CEST)
REVIEW
|
doi:10.20944/preprints202308.1518.v1
Subject:
Medicine And Pharmacology,
Medicine And Pharmacology
Keywords:
SARS-CoV-2; main protease; inhibitors; molecular modeling; molecular dynamics simulations; binding energy calculation; ADME properties; potential therapeutics; drug discovery
Online: 22 August 2023 (07:19:37 CEST)
ARTICLE
|
doi:10.20944/preprints202307.0031.v1
Subject:
Chemistry And Materials Science,
Applied Chemistry
Keywords:
Ionic Liquids; Corrosion Inhibitors; Bio-based
Online: 4 July 2023 (02:23:59 CEST)
REVIEW
|
doi:10.20944/preprints202306.0609.v1
Subject:
Medicine And Pharmacology,
Medicine And Pharmacology
Keywords:
Kinases; human diseases; macrocyclic inhibitors; drug discovery
Online: 8 June 2023 (08:54:08 CEST)
REVIEW
|
doi:10.20944/preprints202401.0541.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
NSCLC; ALK inhibitors; lung cancer; targeted therapy; precision medicine
Online: 8 January 2024 (11:27:23 CET)
REVIEW
|
doi:10.20944/preprints202402.1593.v1
Subject:
Medicine And Pharmacology,
Endocrinology And Metabolism
Keywords:
type 2 diabetes; therapeutic inertia; clinical guidelines; sodium-glucose cotransporter-2 inhibitors; glucagon-like peptide-1 receptor agonists; primary health care
Online: 28 February 2024 (10:53:42 CET)
REVIEW
|
doi:10.20944/preprints202302.0030.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
angiogenesis inhibitors; VEGF inhibitors; ovarian cancer; progression-free survival; overall sur-vival; toxicity; systematic review; meta-analysis; randomized controlled trials; FDA approval of cancer drugs
Online: 2 February 2023 (05:26:47 CET)
ARTICLE
|
doi:10.20944/preprints202309.1391.v1
Online: 21 September 2023 (03:32:12 CEST)
COMMUNICATION
|
doi:10.20944/preprints202305.1298.v1
Subject:
Biology And Life Sciences,
Life Sciences
Keywords:
Mass spectrometry; RAS; ACE; ACE2; CPN; bradykinin; hypertension; cardiovascular disease; antihypertensiva; ACE inhibitors; angiotensin receptor blockers; bradykinin; neuropeptide re-porter assay
Online: 18 May 2023 (08:13:10 CEST)
REVIEW
|
doi:10.20944/preprints202309.0120.v1
Subject:
Biology And Life Sciences,
Cell And Developmental Biology
Keywords:
Melanoma; BRAF mutations; BRAF inhibitors; MEK inhibitors; Immunotherapy
Online: 4 September 2023 (15:46:20 CEST)
ARTICLE
|
doi:10.20944/preprints202301.0325.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
Immune checkpoint inhibitors; Anti-tumor immunity; Predictive biomarker; Malignant melanoma; NSCLC
Online: 18 January 2023 (08:39:18 CET)
ARTICLE
|
doi:10.20944/preprints202304.0063.v1
Subject:
Medicine And Pharmacology,
Medicine And Pharmacology
Keywords:
Cx43; gap junctions; conductance; inhibitors; docking; IC50
Online: 5 April 2023 (12:30:58 CEST)
REVIEW
|
doi:10.20944/preprints202212.0026.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
Advanced Hepatocellular carcinoma; Immune checkpoint inhibitors; Low middle-income countries; Financial Toxicity
Online: 1 December 2022 (10:33:14 CET)
REVIEW
|
doi:10.20944/preprints202305.1761.v1
Subject:
Medicine And Pharmacology,
Gastroenterology And Hepatology
Keywords:
checkpoint inhibitors; colitis; immune-related adverse events; enterocolitis; diarrhea
Online: 25 May 2023 (08:03:37 CEST)
REVIEW
|
doi:10.20944/preprints202305.0914.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
pancreatic cancer; KRAS; KRAS inhibitors; KRAS-dependency; resistance; escaping.
Online: 12 May 2023 (09:33:30 CEST)
REVIEW
|
doi:10.20944/preprints202401.0310.v1
Subject:
Medicine And Pharmacology,
Dentistry And Oral Surgery
Keywords:
inflammation; inflammasome; inhibitors of the inflammasome; nanomaterials; functionalized biomaterials; periodontitis; general pathology
Online: 4 January 2024 (09:25:17 CET)
REVIEW
|
doi:10.20944/preprints202305.0041.v1
Subject:
Biology And Life Sciences,
Endocrinology And Metabolism
Keywords:
endothelial dysfunction; chronic kidney disease; heart failure; sodium-glucose cotransporter 2 inhibitors
Online: 2 May 2023 (02:18:51 CEST)
ARTICLE
|
doi:10.20944/preprints202305.0742.v1
Subject:
Medicine And Pharmacology,
Urology And Nephrology
Keywords:
renal lithiasis; phytate; lower inositol phosphates; crystallization inhibitors; calcium oxalate; calcium phosphates
Online: 10 May 2023 (10:45:26 CEST)
REVIEW
|
doi:10.20944/preprints202311.1805.v1
Subject:
Biology And Life Sciences,
Cell And Developmental Biology
Keywords:
HDAC6; histone deacetylases inhibitors; colorectal cancer
Online: 28 November 2023 (10:13:23 CET)
REVIEW
|
doi:10.20944/preprints202311.0295.v1
Subject:
Medicine And Pharmacology,
Cardiac And Cardiovascular Systems
Keywords:
Atrial fibrillation, SGLT2 inhibitors, cardiovascular outcomes, hemodynamic effects, AF risk reduction
Online: 6 November 2023 (08:13:49 CET)
REVIEW
|
doi:10.20944/preprints202304.0516.v1
Subject:
Medicine And Pharmacology,
Internal Medicine
Keywords:
SGLT-2 Inhibitors; Inflammasome; NLRP3; reno-protective effects; Cardio-protective effects; neuro-protective effects.
Online: 18 April 2023 (10:33:39 CEST)
REVIEW
|
doi:10.20944/preprints202306.1788.v1
Subject:
Medicine And Pharmacology,
Medicine And Pharmacology
Keywords:
Meningioma; Cabozantinib; VEGF; Targeted treatment Cabozantinib; METs; VEGFR2; Inhibitors; Angiogen-esis; Oncology
Online: 26 June 2023 (10:57:00 CEST)
ARTICLE
|
doi:10.20944/preprints202307.1626.v1
Subject:
Medicine And Pharmacology,
Medicine And Pharmacology
Keywords:
Proton pump inhibitors; Clopidogrel; Stroke; Myocardial infarction
Online: 25 July 2023 (07:26:31 CEST)
REVIEW
|
doi:10.20944/preprints202309.1934.v1
Subject:
Medicine And Pharmacology,
Obstetrics And Gynaecology
Keywords:
uterine leiomyoma; fibroid; pregnancy; therapy; targets; inhibitors; vaccines; humanized antibodies; MED12; HMGA2; fumarate hydratase; IL17B; MMP11; MMP16
Online: 28 September 2023 (04:38:19 CEST)
REVIEW
|
doi:10.20944/preprints202308.0688.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
Urothelial cell cancer; metastasis, drug resistance, immunotherapy; immune checkpoint inhibitors; tumorigenesis; antibody–drug conjugate.
Online: 9 August 2023 (08:23:29 CEST)
ARTICLE
|
doi:10.20944/preprints202303.0539.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
Antibiotic resistance; metallo-β-lactamases; metal-dependent enzymes; broad-spectrum inhibitors; inhibition assays; enzyme kinetics
Online: 31 March 2023 (03:35:02 CEST)
ARTICLE
|
doi:10.20944/preprints202305.2226.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
melanoma; cutaneous melanoma; mucosal melanoma; uveal melanoma; immune-checkpoint inhibitors; metabolomics; tryptophan; kynurenine; spermine
Online: 31 May 2023 (10:45:46 CEST)
ARTICLE
|
doi:10.20944/preprints202307.0781.v1
Subject:
Biology And Life Sciences,
Life Sciences
Keywords:
DNA repair; homologous recombination deficiency; biomarkers; precision oncology; loss of heterozygosity; inhibitors of poly (ADP-ribose) polymerase (PARP)
Online: 12 July 2023 (07:50:04 CEST)
CASE REPORT
|
doi:10.20944/preprints202312.0123.v1
Subject:
Medicine And Pharmacology,
Neuroscience And Neurology
Keywords:
Capgras syndrome; Delusions; Parkinson disease; Dementia; Cholinesterase Inhibitors
Online: 4 December 2023 (04:27:03 CET)
REVIEW
|
doi:10.20944/preprints202305.1239.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
Hodgkin lymphoma; non-Hodgkin lymphoma; PD1 / PD-L1 checkpoint inhibitors; tumor mutational burden; predictive biomarkers
Online: 17 May 2023 (10:52:16 CEST)
REVIEW
|
doi:10.20944/preprints202305.0122.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
Non-small cell lung cancer (NSCLC); EGFR; Tyrosine kinase inhibitors (TKIs); Uncommon mutation; Compound mutation; Intracranial activity; Immunotherapy
Online: 3 May 2023 (09:29:08 CEST)
ARTICLE
|
doi:10.20944/preprints202401.0661.v1
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
Protozoan diseases; Drug repurposing; Cytotoxicity; Dihydrofolate reductase inhibitors; Potassium (K+) channel blocker; ADME properties
Online: 9 January 2024 (10:30:36 CET)
REVIEW
|
doi:10.20944/preprints202306.1643.v1
Subject:
Medicine And Pharmacology,
Medicine And Pharmacology
Keywords:
metastasis treatment; small molecules; tyrosine kinase inhibitors; integrins; siRNA
Online: 22 June 2023 (16:10:15 CEST)
ARTICLE
|
doi:10.20944/preprints202402.0449.v1
Subject:
Medicine And Pharmacology,
Internal Medicine
Keywords:
herpes zoster; immune checkpoint inhibitors; standardized incidence ratio; cancer patients
Online: 7 February 2024 (14:34:28 CET)
REVIEW
|
doi:10.20944/preprints202401.2222.v1
Subject:
Medicine And Pharmacology,
Pediatrics, Perinatology And Child Health
Keywords:
gastroesophageal reflux disease; efficacy; safety; proton-pump inhibitors; pediatric patients; systematic review
Online: 31 January 2024 (14:59:40 CET)
REVIEW
|
doi:10.20944/preprints202401.1747.v1
Subject:
Medicine And Pharmacology,
Hematology
Keywords:
chronic lymphocytic leukemia; BTK inhibitors; BCL-2 inhibitors; prognostic scores; predictive factors; TP53 abnormalities; IGHV; complex karyotype
Online: 24 January 2024 (13:39:51 CET)
CASE REPORT
|
doi:10.20944/preprints202402.0658.v3
Subject:
Medicine And Pharmacology,
Medicine And Pharmacology
Keywords:
pharmacokinetic-pharmacodynamic interactions; low-dose methotrexate; proton pump inhibitors; analgesics; pancytopenia; hepatotoxicity
Online: 1 April 2024 (11:53:15 CEST)
HYPOTHESIS
|
doi:10.20944/preprints202305.1129.v1
Subject:
Biology And Life Sciences,
Anatomy And Physiology
Keywords:
Lymphangiontrope; salt sensitivity; cardiorenal syndrome; SGLT2 inhibitors; Down’s syndrome; depression; schizophrenia; C Reactive Protein
Online: 16 May 2023 (08:51:13 CEST)
ARTICLE
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doi:10.20944/preprints202311.0483.v1
Subject:
Medicine And Pharmacology,
Pharmacy
Keywords:
MRONJ; CDK4/6 inhibitors; metastatic breast cancer; oral epidemiology
Online: 8 November 2023 (08:42:55 CET)
REVIEW
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doi:10.20944/preprints202309.1061.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
prodrugs; HIV; AIDS; Nucleoside Reverse Transcriptase Inhibitors (NRTI); co-drugs; new drugs; medicinal chemistry
Online: 18 September 2023 (05:47:07 CEST)
ARTICLE
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doi:10.20944/preprints202308.0458.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
polyamine analogs; monoamine oxidases; antiproliferative activity; inhibitors; docking studies; LN-229 cells
Online: 7 August 2023 (11:57:36 CEST)
REVIEW
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doi:10.20944/preprints202401.0165.v1
Subject:
Medicine And Pharmacology,
Pulmonary And Respiratory Medicine
Keywords:
lung vascular endothelium; endothelial barrier integrity; zinc-dependent HDACs; deacetylation; HDAC inhibitors; acute lung injury; acute respiratory distress syndrome
Online: 3 January 2024 (07:42:38 CET)
REVIEW
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doi:10.20944/preprints202306.1029.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
immune checkpoint inhibitors; CAR-T cell therapy; new cancer therapies and perioperative implications; perioperative chemotherapy toxicity; pneumonitis
Online: 15 June 2023 (07:37:26 CEST)
REVIEW
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doi:10.20944/preprints202308.1547.v1
Subject:
Medicine And Pharmacology,
Medicine And Pharmacology
Keywords:
Main Protease Inhibitors; SARS-CoV-2; COVID-19; mutations; vaccines; therapeutics; drug repurposing; management strategies
Online: 22 August 2023 (09:31:05 CEST)
ARTICLE
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doi:10.20944/preprints202308.0880.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
tyrosyl-DNA phosphodiesterase 1 (Tdp1); tyrosyl-DNA phosphodiesterase 2 (Tdp2); usnic acid; Tdp2 inhibitors; Tdp1 inhibitors
Online: 11 August 2023 (08:18:31 CEST)
REVIEW
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doi:10.20944/preprints202307.1242.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
Immune checkpoint inhibitors (ICIs); Non–small cell lung cancer (NSCLC); PD-1 , PD-L1; CTLA-4
Online: 19 July 2023 (02:48:47 CEST)
REVIEW
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doi:10.20944/preprints202304.0736.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
advanced breast cancer; germline BRCA1/2 mutations; pathogenic/likely pathogenic variants; CDK4/6 inhibitors; Pi3Ka inhibitors; HER2-low
Online: 23 April 2023 (03:12:48 CEST)
REVIEW
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doi:10.20944/preprints202307.2046.v1
Subject:
Medicine And Pharmacology,
Pharmacy
Keywords:
CADD; SBDD; LBDD; kinase; small molecule kinase inhibitors
Online: 31 July 2023 (03:05:42 CEST)
REVIEW
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doi:10.20944/preprints202404.0091.v1
Subject:
Medicine And Pharmacology,
Hematology
Keywords:
menin; menin inhibitors; leukemia; KMT2A; NPM1
Online: 2 April 2024 (02:51:43 CEST)
SHORT NOTE
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doi:10.20944/preprints202212.0230.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
monoamine oxidase; inhibitors; indole; 1,2,4-oxadiazole; drug research; neuroprotective drugs; Parkinson’s disease; MAO
Online: 13 December 2022 (07:12:01 CET)
REVIEW
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doi:10.20944/preprints202306.1955.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
breast cancer; CDK4/6 inhibitors; estrogen receptor; therapeutic resistance
Online: 28 June 2023 (07:39:44 CEST)
ARTICLE
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doi:10.20944/preprints202309.1065.v1
Subject:
Medicine And Pharmacology,
Dermatology
Keywords:
psoriasis; plasma cytokines; TNFα inhibitors; etanercept; infliximab; adalimumab
Online: 18 September 2023 (02:32:17 CEST)