Vinţeler, N.; Feurdean, C.N.; Petkes, R.; Barabas, R.; Boşca, B.A.; Muntean, A.; Feștilă, D.; Ilea, A. Biomaterials Functionalized with Inflammasome Inhibitors—Premises and Perspectives. J. Funct. Biomater.2024, 15, 32.
Vinţeler, N.; Feurdean, C.N.; Petkes, R.; Barabas, R.; Boşca, B.A.; Muntean, A.; Feștilă, D.; Ilea, A. Biomaterials Functionalized with Inflammasome Inhibitors—Premises and Perspectives. J. Funct. Biomater. 2024, 15, 32.
Vinţeler, N.; Feurdean, C.N.; Petkes, R.; Barabas, R.; Boşca, B.A.; Muntean, A.; Feștilă, D.; Ilea, A. Biomaterials Functionalized with Inflammasome Inhibitors—Premises and Perspectives. J. Funct. Biomater.2024, 15, 32.
Vinţeler, N.; Feurdean, C.N.; Petkes, R.; Barabas, R.; Boşca, B.A.; Muntean, A.; Feștilă, D.; Ilea, A. Biomaterials Functionalized with Inflammasome Inhibitors—Premises and Perspectives. J. Funct. Biomater. 2024, 15, 32.
Abstract
The aim of this review was to search in literature, data regarding the inflammasome, involvement in, oral pathologies (mainly periodontitis) and other diseases and the approaches to control the inflammasome-related pathogenic mechanisms. The review also investigated how phytochemicals and pharmaceutical substances could be used to inhibit the inflammasome activity. Inflammasomes are involved in inflammatory, autoimmune and autoinflammatory diseases. Pharmaceutical substances can control the inflammasome by three mechanisms: inhibiting of intracellular signaling pathways (Allopurinol and SS-31), blocking inflammasome components (VX-765, Emricasan and VX-740), and inhibiting cytokines mediated by the inflammasome (Canakinumab, Anakinra and Rilonacept). Phytochemical inhibit the inflammasome, by neutralization of reactive oxygen species. Biomaterials functionalized by the adsorption of therapeutic agents on different nanomaterials may represent a future research direction to facilitate multimodal and sequential treatment in oral pathologies.
Keywords
inflammation; inflammasome; inhibitors of the inflammasome; nanomaterials; functionalized biomaterials; periodontitis; general pathology
Subject
Medicine and Pharmacology, Dentistry and Oral Surgery
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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