Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Histone Deacetylases as Epigenetic Targets for Treating Parkinson’s Disease

Version 1 : Received: 12 May 2022 / Approved: 12 May 2022 / Online: 12 May 2022 (05:41:21 CEST)

A peer-reviewed article of this Preprint also exists.

Li, Y.; Gu, Z.; Lin, S.; Chen, L.; Dzreyan, V.; Eid, M.; Demyanenko, S.; He, B. Histone Deacetylases as Epigenetic Targets for Treating Parkinson’s Disease. Brain Sci. 2022, 12, 672. Li, Y.; Gu, Z.; Lin, S.; Chen, L.; Dzreyan, V.; Eid, M.; Demyanenko, S.; He, B. Histone Deacetylases as Epigenetic Targets for Treating Parkinson’s Disease. Brain Sci. 2022, 12, 672.

Journal reference: Brain Sci. 2022, 12, 672
DOI: 10.3390/brainsci12050672

Abstract

Parkinson’s disease (PD) is a chronic progressive neurodegenerative disease that increasingly become a global threat for the elder people's health and life. Although there are some drugs in clinic for treating PD, these treatments only can alleviate the symptoms of PD patients but fail in curative therapies. Therefore, seeking other potential mechanisms to develop more effective treatments that can modify the course of PD is still highly desirable. In the last two decades, histone deacetylases as an important group of epigenetic targets in drug discovery have attracted much attention. This review is focused on the current knowledge about histone deacetylases involved in PD pathophysiology and their inhibitors used in PD study. Further perspectives related to small molecules that can inhibit or degrade histone deacetylases to treat PD are also discussed.

Keywords

Parkinson’s disease; Epigenetic targets; Histone deacetylases; Inhibitors; PROTACs

Subject

MEDICINE & PHARMACOLOGY, Pathology & Pathobiology

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