Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

SGLT -2 Inhibitors and the Inflammasome: What's next in the 21st century?

Dimitris Kounatidis
,
Natalia Vallianou
* ORCID logo ,
Angelos Evangelopoulos
,
Ioannis Vlachodimitris
,
Eugenia Grivakou
,
Evangelia Kotsi
,
Krystalia Dimitriou
,
Alexandros Skourtis
,
Iordanis Mourouzis
Version 1 : Received: 18 April 2023 / Approved: 18 April 2023 / Online: 18 April 2023 (10:33:39 CEST)

A peer-reviewed article of this Preprint also exists.

Kounatidis, D.; Vallianou, N.; Evangelopoulos, A.; Vlahodimitris, I.; Grivakou, E.; Kotsi, E.; Dimitriou, K.; Skourtis, A.; Mourouzis, I. SGLT-2 Inhibitors and the Inflammasome: What’s Next in the 21st Century? Nutrients 2023, 15, 2294. Kounatidis, D.; Vallianou, N.; Evangelopoulos, A.; Vlahodimitris, I.; Grivakou, E.; Kotsi, E.; Dimitriou, K.; Skourtis, A.; Mourouzis, I. SGLT-2 Inhibitors and the Inflammasome: What’s Next in the 21st Century? Nutrients 2023, 15, 2294.

Abstract

Nucleotide-binding domain like receptor protein 3 (NLRP3) inflammasome in the kidney and the heart is increasingly being suggested to play a key role in mediating inflammation. In the kidney, NLRP3 activation has been associated with the progression of diabetic kidney disease. In the heart, activation of the NLRP3 inflammasome has been related to enhanced release of interleukin-1β (IL-1β) and the subsequent induction of atherosclerosis and heart failure. Apart from their glucose-lowering effects, SGLT-2 Inhibitors have been documented to attenuate activation of the NLRP3, thus, resulting in the constellation of an anti-inflammatory milieu. In this review, we will focus on the interplay between SGLT-2 Inhibitors and the inflammasome in the kidney, the heart and the neurons in the context of diabetes mellitus and its complications.

Keywords

SGLT-2 Inhibitors; Inflammasome; NLRP3; reno-protective effects; Cardio-protective effects; neuro-protective effects.

Subject

Medicine and Pharmacology, Internal Medicine

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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