Preprint Case Report Version 1 Preserved in Portico This version is not peer-reviewed

Complementary Use of a Next-Generation Emollient Plus and Pimecrolimus in Atopic Dermatitis: A Case Report

Version 1 : Received: 13 July 2023 / Approved: 13 July 2023 / Online: 14 July 2023 (09:18:55 CEST)

How to cite: Torres, T. Complementary Use of a Next-Generation Emollient Plus and Pimecrolimus in Atopic Dermatitis: A Case Report. Preprints 2023, 2023070971. https://doi.org/10.20944/preprints202307.0971.v1 Torres, T. Complementary Use of a Next-Generation Emollient Plus and Pimecrolimus in Atopic Dermatitis: A Case Report. Preprints 2023, 2023070971. https://doi.org/10.20944/preprints202307.0971.v1

Abstract

Atopic dermatitis (AD) is a chronic skin disease marked by inflammation, erythema, dryness and pruritic lesions. Due to the intermittent nature of the disease, management strategies for AD focus on flare prevention following remission. A 24-year-old patient with mild-to-moderate AD lesions, previously non-responsive to topical corticosteroids (TCS), was treated with pimecrolimus for 12 days and emollient plus cream (EC) every day. After the initial 12-day treatment course, the patient was advised to use pimecrolimus if his symptoms reoccured. AD symptoms improved substantially between Weeks 0 and 12 with daily use of EC. However, by Week 12, his symptoms had relapsed, necessitating retreatment with pimecrolimus. Overall, the patient experienced flare-free periods between Weeks 3 and 12 and between Weeks 13 and 16. No tolerability issues were reported. This case report demonstrates the use of a complementary approach of daily administration of maintenance EC and intermittent application of pimecrolimus for flare management, which was effective for treating a patient with mild-to-moderate AD resistant to TCS.

Keywords

atopic dermatitis; emollient plus cream; topical corticosteroids; topical calcineurin inhibitors; case report

Subject

Medicine and Pharmacology, Dermatology

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