Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Chromobacterium violaceum: Model for Evaluating Anti-Quorum Sensing Activity of Plant Substances

Version 1 : Received: 12 May 2023 / Approved: 15 May 2023 / Online: 15 May 2023 (05:07:34 CEST)

A peer-reviewed article of this Preprint also exists.

Dimitrova, P.D.; Damyanova, T.; Paunova-Krasteva, T. Chromobacterium Violaceum: A Model for Evaluating the Anti-Quorum Sensing Activities of Plant Substances. Sci. Pharm. 2023, 91, 33. Dimitrova, P.D.; Damyanova, T.; Paunova-Krasteva, T. Chromobacterium Violaceum: A Model for Evaluating the Anti-Quorum Sensing Activities of Plant Substances. Sci. Pharm. 2023, 91, 33.

Abstract

In the new antibiotic era, the exponential increase of multiresistant bacterial strains become the main global health problem. Many researchers focused their efforts to explore novel or combined strategies for combating bacterial resistance. The good knowledge of molecular mechanisms of resistance and bacterial virulence factors as key targets gives us a good scenario to resolve the problem. One particularly attractive and promising way is to attack the main regulatory “network” of bacterial virulence determinants known as Quorum sensing (QS). The inhibition of QS signals will be a novel way for screening more effective Quorum sensing inhibitors (QSIs) and will put a key role in next-generation antimicrobials in the resistance battle. This determined the aim of the present review: comprehensive clarification of the regulatory mechanisms of quorum-sensing signaling pathways in Chromobacterium violaceum and discovery of potential plant quorum sensing inhibitors.

Keywords

quorum sensing; quorum sensing inhibitors; Chromobacterium violaceum; plant extracts

Subject

Biology and Life Sciences, Immunology and Microbiology

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