Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Multiple Roles of LOXL2 in the Progression of Hepatocellular Carcinoma and Potential for Therapeutic Targeting

Jelena Radić
ORCID logo ,
Bojana Kožik
ORCID logo ,
Ivan Nikolić
,
Ivana Kolarov-Bjelobrk
ORCID logo ,
Tijana Vasiljević
,
Bojana Vranjković
,
Sanja Despotović
*
Version 1 : Received: 13 June 2023 / Approved: 14 June 2023 / Online: 14 June 2023 (07:18:34 CEST)

A peer-reviewed article of this Preprint also exists.

Radić, J.; Kožik, B.; Nikolić, I.; Kolarov-Bjelobrk, I.; Vasiljević, T.; Vranjković, B.; Despotović, S. Multiple Roles of LOXL2 in the Progression of Hepatocellular Carcinoma and Its Potential for Therapeutic Targeting. Int. J. Mol. Sci. 2023, 24, 11745. Radić, J.; Kožik, B.; Nikolić, I.; Kolarov-Bjelobrk, I.; Vasiljević, T.; Vranjković, B.; Despotović, S. Multiple Roles of LOXL2 in the Progression of Hepatocellular Carcinoma and Its Potential for Therapeutic Targeting. Int. J. Mol. Sci. 2023, 24, 11745.

Abstract

LOXL2, a copper-dependent amine oxidase, has emerged as a promising therapeutic target in hepatocellular carcinoma (HCC). Increased LOXL2 expression in HCC has been linked with aggressive phenotype and represents a poor prognostic factor. Here, we focus on mechanisms by which LOXL2 orchestrates multiple oncogenic functions in HCC development. We are reviewing current knowledge about the roles of LOXL2 in the modulation of the HCC tumor microenvironment, formation of premetastatic niches, and epithelial-mesenchymal transition. Also, we are highlighting the complex interplay between LOXL2 and hypoxia, angiogenesis, and vasculogenic mimicry in HCC. At the end of the review, we summarize current LOXL2 inhibitors and discuss their potential in HCC precision treatment.

Keywords

hepatocellular carcinoma (HCC); LOXL2; tumor microenvironment (TME); extracellular matrix (ECM); LOXL2 inhibitors; target therapy

Subject

Biology and Life Sciences, Biochemistry and Molecular Biology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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