Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Role of Rheb1 and Rheb2 in Cancer Development and Therapeutic Prospects

Mostafizur Rahman
,
Tuan Minh Nguyen
ORCID logo ,
Gi Jeong Lee
,
Boram Kim
,
Mi Kyung Park
* ORCID logo ,
Chang Hoon Lee
* ORCID logo
Version 1 : Received: 19 December 2023 / Approved: 19 December 2023 / Online: 19 December 2023 (05:58:46 CET)

A peer-reviewed article of this Preprint also exists.

Rahman, M.; Nguyen, T.M.; Lee, G.J.; Kim, B.; Park, M.K.; Lee, C.H. Unraveling the Role of Ras Homolog Enriched in Brain (Rheb1 and Rheb2): Bridging Neuronal Dynamics and Cancer Pathogenesis through Mechanistic Target of Rapamycin Signaling. Int. J. Mol. Sci. 2024, 25, 1489. Rahman, M.; Nguyen, T.M.; Lee, G.J.; Kim, B.; Park, M.K.; Lee, C.H. Unraveling the Role of Ras Homolog Enriched in Brain (Rheb1 and Rheb2): Bridging Neuronal Dynamics and Cancer Pathogenesis through Mechanistic Target of Rapamycin Signaling. Int. J. Mol. Sci. 2024, 25, 1489.

Abstract

Ras homolog enriched in brain (Rheb1 and Rheb2), a small GTPase, regulates neuronal activity and has drawn attention for its implications in cancer development, especially breast cancer. This study explores the multifaceted role of Rheb1 in cancer, elucidating its involvement in crucial cel-lular processes such as proliferation, apoptosis resistance, migration, invasion, metastasis, and inflammatory responses. Despite these acknowledged connections, a comprehensive understanding of the intricate interplay between Rheb1 and cancer remains elusive. This review consolidates cur-rent knowledge on the impact of Rheb1 on cancer hallmarks and examines the potential of Rheb1 as a therapeutic target in cancer treatment. The review underscores the need for a more profound comprehension of the molecular mechanisms underlying Rheb1-mediated oncogenic processes. Furthermore, the review emphasizes the exploration of Rheb1 inhibitors as a promising avenue for cancer therapy. This study, by bringing to light the complex associations between Rheb1/Rheb2 and cancer, delivers valuable insights to the scientific community. These insights are instrumental in guiding the identification of novel targets and advancing the development of effective therapeu-tic strategies for treating cancer.

Keywords

Rheb1; Rheb2; Cancer; mTOR; Hallmarks; Neurons; Rheb1 inhibitors

Subject

Biology and Life Sciences, Biochemistry and Molecular Biology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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